Parameters to maximize nebulized drug delivery to larynx
This technology describes methods and systems for maximizing nebulized drug delivery to the larynx to treat conditions such as laryngeal hypersensitivity.
Unmet Need: Methods for delivering oral nebulized drugs to the larynx
Treatment of conditions such as laryngeal hypersensitivity requires recognition of laryngeal dysfunction to identify optimal methods for targeted treatment and drug delivery. Laryngeal dysfunction and hypersensitivity can induce laryngeal sensory symptoms which often require treatments with steroids via various routes. Such treatments can differ in effective and efficient drug delivery and deposition as well as subsequent therapeutic monitoring. Optimizing drug delivery methods and developing patient-specific protocols and parameters for targeted drug delivery would greatly increase targeted drug deposition efficacy and reduce the likelihood of complications.
The Technology: Maximized oral nebulized drug delivery for larynx hypersensitivity
This technology describes parameters to maximize delivery of oral nebulized drugs for conditions such as laryngeal hypersensitivity. The technology involves computational approaches to generate patient-specific laryngeal airway models from computed-tomography images to assess drug delivery characteristics. The technology employs oral nebulization while assessing appropriate aerosol particle velocity and size to optimize drug delivery. In doing so, the technology describes a protocol and systems for treating laryngeal hypersensitivity in a patient-based manner for individuals with an anatomically normal larynx.
This technology has been validated with laryngeal airway models generated from patient computed-tomography images.
Applications:
- Systems for treating laryngeal hypersensitivity
- Parameters for optimizing oral nebulized drug delivery
- Research tool for further assessment of anatomically normal larynx
- Method for therapeutic monitoring of drug delivery and efficacy
Advantages:
- Maximized delivery of oral nebulized drugs
- Alternative or supplemental treatment for laryngeal hypersensitivity
- Allows the generation of patient-specific models to account for anatomical variability
- Compatible with aerosols and optimization of aerosol particle size and velocity
Lead Inventor:
Patent Information:
Patent Pending
Related Publications:
Tech Ventures Reference:
IR CU24050
Licensing Contact: Sara Gusik