This technology describes lipid-containing perfusion buffers that prolong the viability of organs during transplantation.
A significant factor limiting the clinical application of organ transplantation is the decrease in viability of the organ after removal from the donor. Isolated organs immediately begin to deteriorate, leading to loss of structure and function. Simple cooling is only viable for very short-term storage, as extended periods of hypothermia will lead to tissue damage upon reperfusion. Although cold storage combined with continuous perfusion can extend the viability of organs, current perfusion solutions are not effective enough to prevent reperfusion damage and subsequent adverse events.
This technology describes perfusion buffers that employ a lipid emulsion to maintain the viability of the organs by preventing tissue deterioration. Omega-3 glycerides are supplied to the organ by adding it to typical perfusion buffers used for organ transplantation. These therapeutic lipids elicit an anti-inflammatory and anti-apoptotic response by effectively reducing the levels of harmful proteins while promoting the activity of factors that prevent cell death. As such, this technology can greatly improve the outcome of organ transplantation for patients by extending organ viability during storage and by greatly reducing the risk of reperfusion injury.
This technology has been successfully used to preserve viability in isolated mouse hearts.
IR CU13217
Licensing Contact: Sara Gusik
