This technology is a cavity-separated multi-nanopore device for single-molecule protein sequencing.
Standard protein sequencing techniques like Edman degradation and mass spectrometry approaches suffer from throughput, sensitivity, and protein size limitations. Newer technologies for next-generation protein sequencing utilize fluorescence technologies that require a previously sequenced protein database and have high error-rates.
This technology is a cavity-separated multi-nanopore (CSMP) device for single-molecule protein sequencing. This CSMP device uses fluidic compartments containing electrolytic solutions and a metal-oxide-semiconductor to measure and record information on ion current modulation and dwell times as the molecule translocates, in order to identify the fragmented peptide. Protein sequencing error is reduced using multiple protein cleavage sites during analysis.
IR CU22073
Licensing Contact: Greg Maskel