Columbia Technology Ventures

Truncated ATF5, CEBPB, and CEBPD inhibitors for effective cancer treatment

This technology is a shortened version of cell-penetrating, dominant-negative peptides of ATF5, CEBPB, CEBPD for cancer treatment.

Unmet Need: Inhibitors of ATF5, CEBPB, CEBPD to suppress tumor proliferation

Activating transcription factor 5 (ATF5) is important for cancer cell survival and proliferation in a number of tumor types. ATF5 also associates with leucine zipper proteins, CEBPB and CEBPD, to regulate gene expression. However, there are currently no effective ATF5, CEBPB, or CEBPD inhibitors available.

The Technology: Short cell-penetrating effective inhibitors to suppress cancer survival

This technology describes truncated versions of cell-penetrating, dominant-negative peptides of human ATF5, CEBPB, CEBPD to suppress cancer survival. Shortened peptides allow greater mobility and penetration into tumors and demonstrate similar inhibitor effects as the full-length peptides. As such, this technology would be useful in cancer treatment.

Applications:

  • Therapeutics for various cancers (glioblastoma, colon, breast, skin, etc.)
  • Neurodegenerative disease treatments
  • Treatment for diabetes, immune disorders, autoimmune diseases, and inflammatory diseases
  • Tool for leucine zipper modulation research
  • Dominant-negative peptide development

Advantages:

  • Greater mobility into tumors
  • Higher penetration into tumors
  • Improved compound stability

Lead Inventor:

Lloyd Greene, Ph.D.

Patent Information:

Patent Pending

Related Publications:

Tech Ventures Reference:

  • IR CU21274, CU22282, CU23024, CU23025

  • Licensing Contact: Jerry Kokoshka