Tumor irradiation role in adenosine signaling
This technology assesses the role of irradiation therapy for cancer treatment and its impact on adenosine signaling.
Unmet Need: Targeting adenosine signaling via radiotherapy for cancer therapies
Adenosine signaling is a immune response mediating pathway through which sustained signaling is implicated in promoting cancer progression via disruption of anti-tumor immunity. Adenosine signaling has been suggested to have prognostic value for cancer treatment and outcomes. However, current understanding of the underlying mechanisms in this pathway and their role in promoting tumor progression is limited. As adenosine signaling is a conserved signaling pathway, further study of its relationship with immune signaling and the tumor microenvironment may identify potential therapeutic targets across multiple cancers.
The Technology: Radiotherapy and modulation of adenosine signaling in cancer
This technology assesses the impact of tumor irradiation on adenosine signaling and the tumor immune microenvironment. Pre-clinical data was collected and a preclinical pipeline was established to study the relationship between radiotherapy and the adenosine signaling pathway. Chemical compounds to therapeutically modulate and target the adenosine signaling pathway were identified. Similarly, this technology evaluates these chemical compounds in combination with radiotherapy. As such, this technology has therapeutic potential involving the use of radiotherapy, development of immunotherapies for cancers and autoimmune diseases, and further research on molecular mechanisms underlying the adenosine signaling pathway.
This technology has been validated with pre-clinical data and tumor models.
Applications:
- Radiotherapy for cancer treatment
- Research tool to study the role of adenosine signaling in cancer
- Research tool to study the relationship between adenosine signaling and immune signaling
- Platform to develop immunotherapies for cancer and autoimmune diseases
- Research tool for study and development of cancer vaccines
- Research tool for analysis of chemical compounds for cancer therapeutics and combinatorial treatments
Advantages:
- Study of signaling pathway relevant to various cancers as well as autoimmune diseases
- Potential prognostic value for predicting response to immunotherapies in cancer
- Targeting of highly conserved signaling pathway
- Potential as a pan cancer therapeutic approach
- Assessment of broader impacts and molecular mechanisms impacted by irradiation therapy
Lead Inventor:
Patent Information:
Related Publications:
Tech Ventures Reference:
IR CU22323
Licensing Contact: Joan Martinez