Targeted gene therapy for retinopathiesCU21122CRB1-targeted gene therapy delivers isoform-specific CRB1 to Müller glia and photoreceptors, treating CRB1-retinopathies.TagsGene expressionGene therapyGenetic disorderInventorsPeter M.J. QuinnStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Release Date2023-07-06CollectionsOphthalmologyGene Therapy
Gene therapy for metabolic dysfunction-associated steatohepatitis (MASH)CU25230Gene therapy restoring retromer activity to treat MASH by normalizing lipid metabolism and reducing fibrosis risk.TagsCirrhosisDrug discoveryFibrosisInventorsGregory A. PetskoScott A. Small M.D.ManagerJerry KokoshkaDepartmentsAnn Romney Center for Neurologic DiseasesNeurologyDivisionsColumbia University Medical Center (CUMC)Harvard Medical School and Brigham & Women’s HospitalRelease Date2025-07-31
Therapeutic prime editing for gene therapy against ocular dystrophyCU22243Prime-editing therapy targets PRPH2 splice mutations (c.828+) for retinal dystrophies, enabling precise in-eye gene corrections.TagsAnimal husbandryCas9GenomeInventorsBruna Lopes da CostaPeter M.J. QuinnSalvatore M. CarusoManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-04-25CollectionsOphthalmologyGene Therapy
Universal gene therapy for retinal degenerationCU18340Broad, gene-agnostic retinal therapy using AAV-delivered PGC1α/NRF2 or inhibitors to rebalance metabolism, reduce oxidative stress, slow degeneration.TagsAntioxidantGene therapyGenetic disorderInventorsStephen H. Tsang M.D., Ph.D.Xuan CuiManagerKristin NeumanDepartmentsOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Release Date2023-05-15CollectionsOphthalmologyGene TherapyCNS/Neurology
Combined small molecule treatment as a synergistic epigenetic therapy for pancreatic cancerCU23218Combined HDAC and eIF4A inhibition reprograms pancreatic cancer epigenetically, boosting efficacy and tumor suppression in vivo.TagsAdenocarcinomaApoptosisChemotherapyInventorsAntonio FojoMaryam SafariSusan BatesManagerJerry KokoshkaDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-08-22
Conformational DNA aptamers enabling small-molecule lateral flow assaysCU26117Conformational DNA aptamers enable rapid, cost-effective small-molecule detection in lateral flow assays via structure-switching binding.TagsAnalyteAntibodyAptamerInventorsKyungae YangManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-01
Modified prime editor for gene therapy optimizationCU22084AAV-compatible, compact prime editor enables single-delivery gene therapy and research tools by packaging smaller genome-editing payloads.TagsAchromatopsiaAcidAdeno-associated virusInventorsBruna Lopes da CostaPeter M.J. QuinnStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2022-09-23CollectionsGene Therapy
Nanofibrous scaffold for controlled release of small molecule immunomodulatorsCU24040Nanofibrous scaffold locally releases ACHP to inhibit NF-kB, enabling targeted immunomodulation with reduced systemic effects.TagsAutoimmune diseaseBiomaterialDrug deliveryInventorsFereshteh ZandkarimiHannah ChildsHelen Lu Ph.D.ManagerJoan MartinezDepartmentsBiological SciencesBiomedical EngineeringDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-12-18CollectionsSmall Molecule
Small molecule activators for preventing vision loss in Best vitelliform macular dystrophyCU25176Small molecule activators restore Best1 function to slow BVMD vision loss; targeted, potentially non-invasive retinal therapy.Tags4-Aminobenzoic acidDrug developmentGene therapyInventorsBingchen YuTingting YangYu ZhangManagerJoan MartinezDepartmentsChemistryOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-05-01CollectionsOphthalmology
Gene therapy for thymidine kinase 2 (TK2) deficiencyCU18199Engineered AAV9 gene therapy replaces TK2 to treat TK2 deficiency mitochondrial diseases, potentially correcting DNA depletion and symptoms.TagsComorbidityEnzymeGene therapyInventorsCarlos Lopez-GomezHasan Orhan AkmanMichio Hirano M.D.ManagerKristin NeumanDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-01-17CollectionsGene Therapy
Adeno-associated virus Glut1 gene therapy for rescuing glucose transport in Glut1 deficiency syndromeCU15054AAV-based Glut1 gene therapy restores brain glucose transport in Glut1 deficiency, offering a one-time, long-term treatment.TagsAdeno-associated virusBlood–brain barrierCognitive deficitInventorsDarryl C. De VivoGuangping GaoKristin EngelstadManagerKristin NeumanDepartmentsNeurologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Office of Technology ManagementRelease Date2025-08-19
Topical gene therapy for the treatment of AP-1-associated genetic skin disordersCU26038Topical gene therapy restores AP-1 function in skin, enabling localized, repeatable treatment for monogenic ichthyosis and keratoderma.TagsAP-1 transcription factorCarcinogenesisCombination therapyInventorsStephen KalerTarun KanigantiManagerKristin NeumanDepartmentsPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-26
Gene therapy for Bestrophin-1 (BEST1) mutations in retinal degenerative diseasesCU21279AAV BEST1 gene therapy targets dominant BEST1 retinal mutations to restore function and potentially cure associated degeneration.TagsAdeno-associated virusGene therapyGenetic disorderInventorsStephen H. Tsang M.D., Ph.D.Tingting YangYu ZhangManagerKristin NeumanDepartmentsOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Release Date2023-09-08CollectionsOphthalmologyGene Therapy
Small molecule inhibitor of cognitive impairment associated with neurodegenerative diseaseCU23096Small molecule minaprine analog targets 5-HT2B to curb cognitive/behavioral deficits in neurodegenerative diseases, including Alzheimer's.Tags5-HT receptor5-HT2B receptorAmyloid betaInventorsDaniel M. WattersonErica AcquaroneOttavio ArancioManagerJerry KokoshkaDepartmentsPathologyPharmacologyTaub InstituteDivisionsColumbia University Medical Center (CUMC)Feinberg School of MedicineRelease Date2025-04-10
Small molecule inhibitors of the ID2/VHL interactionCU17182Four small molecules block ID2/VHL, promote HIF degradation, potentially slowing tumor growth and angiogenesis in cancers.TagsAngiogenesisCell growthChemotherapyInventorsAnna LasorellaAntonio IavaroneDan ShermanManagerKristin NeumanDepartmentsInstitute for Cancer GeneticsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-19CollectionsSmall MoleculeOncology
Immature myeloid cell activation pathway in inflammation-linked cancerCU26121IL-8–driven immature myeloid cell mobilization fuels inflammation-linked GI cancer; targets IMCs for therapy and biomarkers.TagsAngiogenesisBiomarkerBone marrowInventorsTimothy Wang M.D.ManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Predicting breast cancer treatment response through PIK3R1 mutation profilingCU26021Predicts breast cancer drug response via endogenous kinase inhibition models using PIK3R1 mutations; rapid, high-throughput screening.TagsAKT1AdenineBreast cancerInventorsNeil Vasan MD, PhDManagerJerry KokoshkaRelease Date2025-10-09
Small molecule treatment for MAPK-regulated cancersCU20013MAP4K2-targeted small molecule inhibits MAPK signaling to curb multiple myeloma growth, offering therapy for resistant hematologic cancers.TagsApoptosisB cellCell proliferationInventorsDonald William Landry MD, Ph.D.Jing Fu Ph.D.Shi-xian DengManagerJerry KokoshkaDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2022-08-05CollectionsSmall MoleculeOncology
Multiplexed T cell profiling for generating engineered regulatory T cell therapiesCU23310High-throughput platform maps patient TCR–antigen pairs to create CRISPR‑engineered, autologous Tregs for precise local immune suppression.TagsAmyotrophic lateral sclerosisAntigenCRISPRInventorsElizabeth M. BradshawNeil ShneiderRyan HobsonManagerJoan MartinezDepartmentsMolecular MedicineNeurologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-01-02
Parameters to maximize nebulized drug delivery to larynxCU24050Patient-specific CT-based nebulization parameters optimize aerosol size and velocity to maximize laryngeal drug deposition.TagsAerosolDrug deliveryHypersensitivityInventorsMichael Pitman MDManagerCynthia LangDepartmentsOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05
Multi-lumen microneedle for intracochlear drug delivery and samplingCU21117Ultra-sharp multi-lumen microneedles enable simultaneous intracochlear drug delivery and perilymph sampling with zero net volume change.TagsCochleaDiffusionDrug deliveryInventorsAnil LalwaniAykut AksitJeffrey W. KysarManagerDovina QuDepartmentsMechanical EngineeringOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-09-26
Chop-Stick gene therapy for retinitis pigmentosa and other autosomal dominant ocular diseasesCU15206Chop-Stick CRISPR therapy edits dominant ocular genes to disable mutations and replace with wild-type function for RP and related diseases.TagsAlleleCRISPRComplementary DNAInventorsLawrence ChanStephen H. Tsang M.D., Ph.D.Wen-Hsuan WuManagerKristin NeumanDepartmentsNutritional and Metabolic BiologyOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2022-09-23CollectionsOphthalmologyGene Therapy
Computational tool to predict RNA binding protein targets for gene therapy and agricultural bioengineeringCU23342PPRDecoder: a genome-wide, unbiased algorithm predicting RNA targets of PPR proteins, accelerating gene regulation research.TagsAlgorithmBiological engineeringBiotechnologyInventorsChaolin Zhang PhDManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2023-08-04CollectionsGene Therapy
Machine learning tool for diagnosis of cutaneous T-cell lymphoma (CTCL)CU24366AI-powered CTCL diagnosis tool links genetic markers with EHR data to improve accuracy, staging, and prognosis.TagsAssayCancerCutaneous T cell lymphomaInventorsLarisa GeskinManagerCynthia LangDepartmentsDermatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-30
Ultrasound-responsive microcapsules for localized and on-demand drug deliveryCU22072Ultrasound-triggered, biphasic microcapsules enable on-demand, localized drug release with reduced systemic toxicity and long-term payload stability.TagsChemotherapyDextranDrug deliveryInventorsMargaret JakusRachel D. FieldSamuel Sia Ph.D.ManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-07-20
Highly efficient T cell base editing for enhanced immunotherapiesCU24092Ultra-efficient base editing in human T cells using adenine/cytosine editors; enhances CAR-T, autoimmune therapies with lower toxicity.TagsAdenineCancerChimeric antigen receptor T cellInventorsBenjamin Izar MD, PhDZachary WalshManagerJoan MartinezDepartmentsMedicineMedicine - Hematology/OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08
Recombinant protein to treat inflammationCU23248Recombinant FSTL-1 protein targets and reduces cardiac inflammation, aiding Kawasaki disease research and myocarditis treatment.TagsAnti-inflammatoryAtherosclerosisBiomarkerInventorsMark GorelikManagerSara GusikDepartmentsPediatrics/RheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-10CollectionsCardiovascular
Non-invasive laser therapy for cytokine modulation and corneal inflammation managementCU18315Femtosecond laser therapy non-invasively modulates corneal cytokines to reduce inflammation and keratocyte apoptosis, preserving tissue.TagsAnalgesicAntibioticApoptosisInventorsSinisa VukelicManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-08-17CollectionsOphthalmology
Rapid assessment of T cell health for enhanced cancer immunotherapyCU24313A rapid platform uses biomaterials, imaging, and deep learning to assess T cell functionality and predict proliferation for immunotherapy.TagsAlgorithmAssayBiomaterialInventorsJia GuoLance KamNicole LamannaManagerDovina QuDepartmentsBiomedical EngineeringMedicinePsychiatryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-12-18
Calibration-free affinity biosensors for rapid, accurate biomarker detectionCU22223Calibration-free graphene FET biosensor uses aptamer kinetics for rapid, device-wide reproducible biomarker detection without per-sensor calibration.TagsAptamerBiomarkerBiosensorInventorsMilan N. Stojanovic M.D.Qiao LinWenting DaiManagerDovina QuDepartmentsMechanical EngineeringMedicineDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-08-21
Mechanosensitive regulatory T cell induction for improved adoptive immunotherapyCU23392Mechanosensitive substrate stiffness boosts stable regulatory T cell induction, improving durability and effectiveness for adoptive immunotherapy.TagsAutoimmune diseaseCoatingImmune systemInventorsLance KamLingting ShiManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-12-12
Biomarker and treatment for autoimmune hemolytic anemia (AIHA)CU24097Biomarker predicts AIHA onset; apyrase therapy prevents/mitigates AIHA in preclinical models by modulating purinergic signaling.TagsAnemiaAutoantibodyB cellInventorsFlavia Dei ZottiKrystalyn HudsonManagerJerry KokoshkaDepartmentsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-12-18CollectionsRare Disease
Small molecule therapeutics to treat treatment-resistant ALL and T-ALLCU19220NT5C2 inhibitors (e.g., HTP-2) boost chemotherapy efficacy in relapsed ALL/T-ALL, enabling combo treatments against resistance.TagsAcute lymphoblastic leukemiaAssayCancer cellInventorsAdolfo A. Ferrando M.D., Ph.D.Arie ZaskBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesInstitute for Cancer GeneticsProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2021-02-03CollectionsSmall MoleculeOncology
Preclinical models of angioimmunoblastic T-cell lymphoma for therapeutic investigationCU23322RhoA G17V-driven mouse model of angioimmunoblastic T-cell lymphoma enables translational drug screening and pathogenesis study.TagsCancer cellChemotherapyGene expressionInventorsAdolfo A. Ferrando M.D., Ph.D.Teresa Palomero VasquezManagerJoan MartinezDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-06-15CollectionsOncology
CRISPR deletion of endogenous T cell receptor chains for optimized immunotherapiesCU20245CRISPR deletes endogenous TCR chains while preserving transgenic TCRs, enabling safer, off-the-shelf CAR-T/TCR therapies.TagsCancerChimeric antigen receptor T cellGraft-versus-host diseaseInventorsMegan Sykes M.D.Mohsen Khosravi MaharlooeiRemi CreusotManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-30
Method for disease phenotype prediction from genetic mutationCU21310Phenotype dosage sensitivity: predicts disease phenotypes from LGD mutations via NMD, enabling personalized ASD outcomes and targeted therapeutics.TagsAutism spectrumExonGeneInventorsAndrew ChiangDennis VitkupJiayao WangManagerJoan MartinezDepartmentsBiomedical InformaticsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2022-09-11CollectionsCNS/NeurologyPlatform/Research Tool
High-throughput method for gene insertionCU19411A high-throughput, vector-based CRISPR system enabling parallel, precise DNA insertions in human cells for scalable genome editing.TagsBacteriaCas9Gene therapyInventorsAlejandro ChavezBrijesh Kumar SinghManagerCynthia LangDepartmentsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-17
T cell co-receptor clustering for cancer treatmentCU22398Bispecific SLAMF6 antibodies compartmentalize T cells to enhance activation, enabling targeted cancer immunotherapy with fewer off-target effects.TagsCancer immunotherapyCo-receptorImmunotherapyInventorsAdam MorManagerCynthia LangDepartmentsRheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-09-05CollectionsOncology
TLX1 mouse model recapitulates clinical symptoms of T cell acute lymphoblastic leukemiaCU23147TLX1 transgenic mouse models human T-ALL, mirroring clinical progression to study pathogenesis, microenvironment, and drug responses.TagsAcute lymphoblastic leukemiaAneuploidyAortic dissectionInventorsAdolfo A. Ferrando M.D., Ph.D.Teresa Palomero VasquezManagerJoan MartinezDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-04-15CollectionsOncology
Method of biomarker testing for autism spectrum disorder for early interventionCU23349Biomarker-based newborn metabolomic profiling enables early ASD risk identification and intervention, enhancing timely, personalized treatment.TagsApplied behavior analysisAutism spectrumBlood plasmaInventorsCamilla StoltenbergOliver FiehnW. Ian Lipkin M.D.ManagerKristin NeumanDepartmentsBiostatisticsEpidemiologyMolecular and Cellular BiologyDivisionsMailman School Of Public Health (MSPH)Technology Transfer ServicesRelease Date2024-02-15CollectionsCNS/NeurologyMedical Device
Universal gene editing strategy for cardiac arrhythmiaCU24243Universal gene-editing of Rad phosphorylation sites to curb adrenergic CaV1.2 signaling, offering targeted, long-term arrhythmia therapy.TagsArrhythmiaBeta blockerFight-or-flight responseInventorsGregory NewbyGuoxia LiuSteven MarxManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-14
Modulating inflammation by altering 3’ Untranslated Region (3’ UTR) lengthCU23300Modulates inflammation by lengthening 3’ UTRs to control immunogenic dsRNA, enabling tunable neuroinflammation therapies and cancer immunotherapy.TagsCancer immunotherapyHomeostasisImmunogenicityInventorsHachung ChungHeegwon ShinTyler DorrityManagerJerry KokoshkaDepartmentsMicrobiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-07-01CollectionsOncologyCNS/Neurology
Peptide nucleic acid conjugates for altering gene expression in cancerCU16241Selective peptide nucleic acid polymers block cancer gene expression, targeting mutations like BRAFV600E with improved delivery and specificity.TagsBioavailabilityBiosensorCell cultureInventorsGary Schwartz M.D.Jeffrey Rothman M.D.ManagerJoan MartinezDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-03CollectionsGene TherapyOncology
Mouse line as a model for Peripheral T-cell Lymphoma with GATA3+ featuresCU23321Mouse model for Vav1-Myof1-driven Peripheral T-cell Lymphoma (GATA3+) enabling targeted therapy screening and pathogenesis study.TagsCD4CarcinogenesisGenetic testingInventorsAdolfo A. Ferrando M.D., Ph.D.Teresa Palomero VasquezManagerJoan MartinezDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-06-15CollectionsOncology
ARP-154 (HeLa T4+) human cancer cell line generated by gene transfer for AIDS researchCU24290CD4-expressing HeLa-derived cell line enables AIDS research; facilitates HIV binding studies, drug screening, and therapeutic development.TagsAIDSAntigenAutoimmune diseaseInventorsPaul J. MaddonRichard Axel M.D.ManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2024-05-29
Gene editing to treat retinal dystrophiesCU22019Prime editing corrects CRB1 mutations in retinal dystrophy, offering isoform-independent gene therapy and research tool potential.TagsCell therapyGene expressionGene therapyInventorsBruna Lopes da CostaPeter M.J. QuinnStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2022-10-31CollectionsOphthalmologyGene Therapy
Gene editing for treatment of retinitis pigmentosaCU23293CRISPR-based retinal metabolism reprogramming targets PHD2 to slow retinitis pigmentosa progression, offering broad RP treatment potential.TagsAdeno-associated virusCRISPRCRISPR gene editingInventorsStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCRelease Date2024-11-26CollectionsOphthalmology
Gene silencing for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)CU23021Silencing CASP8-METRN halts progression from steatosis to MASH, offering non-invasive therapy and diagnostic biomarkers.TagsBiomarkerBlood plasmaCaspase 8InventorsDanish SaleheenIra Tabas MD, PhDShareef KhalidManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08
Microneedle array for cross-barrier drug delivery in the eye, ear and central nervous systemCU18171Biodegradable microneedle arrays enable precise, cross-barrier drug delivery to the eye, ear, and CNS with controlled release.Tags3D printingBiodegradationCentral nervous systemInventorsAnil LalwaniAykut AksitDaniel N. ArteagaManagerDovina QuDepartmentsMechanical EngineeringOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-01-24
Convection-enhanced delivery of topotecan and dexamethasone for malignant gliomasCU25031Implantable pump enables chronic, targeted brain delivery of topotecan plus dexamethasone via convection-enhanced delivery for glioma.TagsAdjuvant therapyAnimal disease modelBlood–brain barrierInventorsJeffrey BrucePeter CanollManagerJerry KokoshkaDepartmentsNeurological SurgeryPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-29
