Broadly neutralizing antibody against SARS-CoV-2 variants and related sarbecovirusesCU24218Broadly neutralizing antibody targets SARS-CoV-2 variants and related sarbecoviruses, enabling versatile, durable treatment and prophylaxis.TagsAntibodyAntiviral drugCladeInventorsDavid Da-i Ho M.D.Jian YuLawrence S. Shapiro Ph.D.ManagerKristin NeumanDepartmentsMedicineAaron Diamond AIDS Research Center (ADARC)Biochemistry and Molecular Biophysics / OphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-09-16
MicronuclAI: pipeline for automated and reliable micronuclei quantification to assess chromosomal instabilityCU24358MicronuclAI automates and standardizes micronuclei quantification across cell lines, boosting speed, accuracy, and chromosomal instability assessment.TagsCancerCell nucleusCytogeneticsInventorsAroj HadaBenjamin Izar MD, PhDDenis SchapiroManagerJoan MartinezDepartmentsMedicineInstitute for Computational BiomedicineProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2024-07-05
Sensitive SARS-CoV-2 antigen testCU21002Ultra-sensitive SARS-CoV-2 antigen sandwich ELISA using dual nucleocapsid antibodies for rapid, low-viral-load detection.TagsAntibodyAntigenAssayInventorsDavid Da-i Ho M.D.Lihong LiuManagerKristin NeumanDepartmentsMedicinePhysicians & SurgeonsDivisionsColumbia University Medical Center (CUMC)Release Date2024-04-25
3D organoids for modeling squamous epithelial pathology and personalized medicineCU223013D squamous epithelial organoids enable patient-specific disease modeling and rapid, predictive drug testing for ESCC/EAC.TagsAdenocarcinomaCarcinomaEpitheliumInventorsAnil K. Rustgi M.D.Hiroshi NakagawaManagerJoan MartinezDepartmentsMedicineHerbert Irving Comprehensive Cancer CenterDivisionsColumbia University Medical Center (CUMC)Release Date2024-01-04CollectionsOncology
Colorectal cancer organoid model for therapeutic testingCU26010Patient-derived 3D colorectal cancer organoids enable precise drug screening, personalized therapy, and biomarker discovery.TagsColorectal cancerExtracellular matrixHigh-throughput screeningInventorsCasidhe-Nicole BethancourtDavid CohenJoel T. Gabre MDManagerJoan MartinezDepartmentsMedicineHerbert Irving Comprehensive Cancer CenterSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2025-10-09
Combination therapy to increase the efficacy of antibody-drug conjugates in bladder cancerCU24095Small molecule reprograms bladder cancer cells to upregulate antigens, boosting antibody-drug conjugate efficacy. 14 words.TagsAntibody-drug conjugateAntigenBiopharmaceuticalInventorsJohn Robert ChristinMichael Shen Ph.D.ManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-09
Wearable device for automated nutrition monitoringCU25198A non-invasive wearable using machine learning to auto-monitor dietary intake and biometric data for real-time nutrition tracking.TagsActivity trackerBiometricsCardiovascular diseaseInventorsAlexander GoldbergWeihao XuManagerJerry KokoshkaDepartmentsMedicineBiomedical EngineeringDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-04-08
CRISPR deletion of endogenous T cell receptor chains for optimized immunotherapiesCU20245CRISPR deletes endogenous TCR chains while preserving transgenic TCRs, enabling safer, off-the-shelf CAR-T/TCR therapies.TagsCancerChimeric antigen receptor T cellGraft-versus-host diseaseInventorsMegan Sykes M.D.Mohsen Khosravi MaharlooeiRemi CreusotManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-30
Highly efficient T cell base editing for enhanced immunotherapiesCU24092Ultra-efficient base editing in human T cells using adenine/cytosine editors; enhances CAR-T, autoimmune therapies with lower toxicity.TagsAdenineCancerChimeric antigen receptor T cellInventorsBenjamin Izar MD, PhDZachary WalshManagerJoan MartinezDepartmentsMedicineMedicine - Hematology/OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08
Lung organoid cells for therapeutic interventionCU23361Therapeutic lung regeneration via patient-specific stem cell–derived distal lung organoids with graftable basal and secretory cells.TagsCell therapyChronic obstructive pulmonary diseaseCoatingInventorsHans-Willem SnoeckManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-09-08
γ-secretase complex inhibitor nanoparticles for NASHCU20227Liver-targeted γ-secretase inhibitor nanoparticles reverse NASH fibrosis, reducing Notch-associated toxicity and enabling liver-specific therapy.TagsAtherosclerosisDrug deliveryDyslipidemiaInventorsLi QiangUtpal PajvaniZhen GuManagerCynthia LangDepartmentsMedicinePathology and Cell BiologyDivisionsColumbia University Medical Center (CUMC)Naomi Berrie Diabetes CenterRelease Date2023-01-31
Glycolipids and analogues as antigens for natural killer T cellsCU22361Glycolipid analogues activate natural killer T cells via CD1d, boosting immune responses for vaccines and immunotherapy.TagsAdjuvant therapyAntigenCytokineInventorsDavid Da-i Ho M.D.Moriya TsujiManagerKristin NeumanDepartmentsMedicinePhysicians & SurgeonsDivisionsColumbia University Medical Center (CUMC)Release Date2022-07-21CollectionsImmunology & Inflammation
Inducible mouse line for cardiac NOX2 inhibitionCU22219Inducible cardiac NRROS-based NOX2 inhibition in mice; tissue-specific ROS control to protect against diet-induced arrhythmias.TagsAntioxidantAtherosclerosisCardiac muscleInventorsJohn MorrowManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2022-02-16CollectionsCardiovascular
Gut endocrine Rbp2 knockout mouse model for metabolic hormone studiesCU25453Gut-endocrine cell-specific Rbp2 knockout mouse enables retinoid-driven regulation study of gut hormones and metabolic outcomes.TagsAlleleCausal inferenceCre recombinaseInventorsRossana M. CalderonManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-10-16
Neutralizing monoclonal antibodies targeting SARS-CoV-2 variants and related coronavirusesCU22012Broadly neutralizing monoclonal antibodies block diverse SARS-CoV-2 variants, enabling prophylaxis, treatment, and multi-epitope cocktail strategies.TagsAntiviral drugAssayB cellInventorsDavid Da-i Ho M.D.Jian YuLihong LiuManagerKristin NeumanDepartmentsMedicineMicrobiologyPhysicians & SurgeonsDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-21
CD58 modulation for improved cancer immunotherapy outcomesCU21046CD58 modulation enhances antitumor immunity, overcoming resistance and informing biomarkers for optimized, combinational cancer immunotherapy.TagsAntigen presentationBiomarkerCancer cellInventorsBenjamin Izar MD, PhDJohannes MelmsManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-10-17
Human protective antibodies for use against H7N9 influenza virusCU23380Human-derived monoclonal antibodies neutralize H7N9, blocking entry and enabling post-exposure prevention and diagnostics.TagsAntiviral drugAvian influenzaB cellInventorsDavid Da-i Ho M.D.Kelvin Kai-Wang ToKwok-Yung YuenManagerKristin NeumanDepartmentsMedicineAaron Diamond AIDS Research Center (ADARC)Dept. of Biochemistry and Molecular Biophysics / OphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-18CollectionsImmunology & Inflammation
MBOAT7-targeted therapies for the personalized treatment of NASH fibrosisCU22159MBOAT7-targeted, personalized NASH therapy using rs641738 variant; MBOAT7 restoration and TAZ silencing reduce fibrosis.TagsCirrhosisFibrosisGene therapyInventorsIra Tabas MD, PhDMary MooreXiaobo WangManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-18
Generation of pure alveolar cells for disease modeling and cell therapyCU22319Pure alveolar type II cells from lung bud organoids; scalable, purification-free platform for disease modeling and cell therapy.TagsHigh-throughput screeningIn vitroLungInventorsHans-Willem SnoeckIvana Matkovic LekoManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-03-24
Method to target T cell regulatory pathways for treatment of immunological diseases1779-aTargeting HLA-E restricted CD8+ T cells to induce self-tolerance, treating autoimmunity without compromising pathogen defense.TagsAntigenAutoimmune diseaseCytotoxic T cellInventorsHong JiangLeonard Chess MDManagerOfra WeinbergerDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2018-09-28
Method for generating progenitor cells to treat lung diseaseCU18150Regenerative lung organoids from stem cells generate fetal lung progenitors for disease therapy, modeling, and drug screening.TagsEmbryonic stem cellEpitheliumHigh-throughput screeningInventorsHans-Willem SnoeckYa-Wen ChenManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2017-10-30
Targeting the CD58:CD2 axis for cancer immunotherapyCU21140Activates CD28-CD8+ T-cells via CD58:CD2 axis, offering an immunotherapy option for PD-1–unresponsive cancers.TagsAntibodyAntigen-presenting cellCD28InventorsBenjamin Izar MD, PhDJohannes MelmsPatricia HoManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-06-23CollectionsOncology
Clinical management of Interstitial Lung Disease using a multiplex real-time PCR assay to quantify leukocyte telomere lengthCU24245Multiplex real-time PCR quantifies average leukocyte telomere length to guide ILD treatment decisions and outcomes.TagsAssayBiomarkerImmunosuppressionInventorsChad NewtonChristine K. GarciaDavid ZhangManagerKristin NeumanDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-13
Exogenous Rac1 analogs to treat acute lung injuryCU23206Exogenous activated Rac1 (V12Rac1) protects lungs from ALI/ARDS by stabilizing actin and blocking proinflammatory signaling.TagsActinAcute respiratory distress syndromeEpitheliumInventorsFrancine KatzGalina GusarovaJahar BhattacharyaManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-26
Generation of self-renewed CD4+ T cells for cancer and viral disease immunotherapyCU24385Ex vivo culture method yields durable, polyfunctional cytotoxic CD4+ T cells for enhanced cancer and viral immunotherapies.TagsAntigenCell cultureCell therapyInventorsMithil SoniPawel MuranskiPrabesh KhatiwadaManagerJerry KokoshkaDepartmentsMedicineColumbia Center for Translational ImmunologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-09-16
Combined small molecule treatment as a synergistic epigenetic therapy for pancreatic cancerCU23218Combined HDAC and eIF4A inhibition reprograms pancreatic cancer epigenetically, boosting efficacy and tumor suppression in vivo.TagsAdenocarcinomaApoptosisChemotherapyInventorsAntonio FojoMaryam SafariSusan BatesManagerJerry KokoshkaDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-08-22
Machine learning-guided software for the ablation of cardiac arrhythmiasCU22127Machine-learning software analyzes electroanatomic data to automatically identify arrhythmia isthmuses, speeding and simplifying ablation.TagsAlgorithmCardiac muscleCatheterInventorsAmardeep SalujaChristine P. HendonZiyi HuangManagerDovina QuDepartmentsMedicineElectrical EngineeringDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-05-27
Treatment of systolic heart failure without increased heart rate (tachycardia)CU19251Small-molecule protein therapy boosts cardiac contractility by raising calcium without increasing heart rate, reducing tachycardia risk.TagsBiopharmaceuticalBlood pressureCardiac arrestInventorsAlexander KushnirArianne PapaGuoxia LiuManagerJoan MartinezDepartmentsMedicineCardiologyPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-03CollectionsSmall MoleculeCardiovascular
Low-dose vaccine effective against malariaCU22363Low-dose malaria vaccine with glycolipid adjuvant boosts immunity, enabling fewer doses and simpler, cheaper deployment.TagsAdjuvantApicomplexan life cycleCytokineInventorsDavid Da-i Ho M.D.Moriya TsujiManagerKristin NeumanDepartmentsMedicinePhysicians & SurgeonsDivisionsColumbia University Medical Center (CUMC)Release Date2022-07-22
Microfluidic based system for purification and extraction of target moleculesM08-036Microfluidic device uses biotin-avidin with RNA aptamers for selective capture, heat or competitive release of target molecules.TagsAnalyteAptamerBiotinInventorsChenmui QiuJingyue JuMilan N. Stojanovic M.D.ManagerDovina QuDepartmentsMedicineChemical Engineering/Applied ChemistryMechanical EngineeringDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2009-12-23
Method to augment efferocytosis for treatment of autoimmune diseasesCU23287Augments macrophage efferocytosis by activating WDFY3 to reduce autoimmune inflammation across multiple diseases.TagsApoptosisAsthmaAtherosclerosisInventorsAi YamamotoHanrui ZhangKatherine R. CroceManagerKristin NeumanDepartmentsMedicineCardiologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05
Sigma non-opioid receptor 1 agonist for the treatment for Timothy SyndromeCU23081BBB-nonpermeable SIGMAR1 agonists MY33-1/2 treat Timothy Syndrome, reducing cardiac arrhythmias via targeted stem-cell model rescue.TagsBlood–brain barrierCalcium signalingCyclin-dependent kinaseInventorsDonald William Landry MD, Ph.D.Kirsten Alison RinderspacherMasayuki Yazawa Ph.D.ManagerKristin NeumanDepartmentsMedicineRehabilitation & Regenerative MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-01-10CollectionsSmall MoleculeCardiovascular
Cell-based model for early-onset restrictive cardiomyopathy (RCM)CU22246Patient-derived iPSC heart tissue model reproduces FLNC-linked RCM for drug screening and therapy discovery.TagsCardiac muscle cellCardiomyopathyDrug discoveryInventorsBarry FineBryan WangGordana Vunjak-NovakovicManagerKristin NeumanDepartmentsMedicineBiomedical EngineeringProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-11-10CollectionsCardiovascular
Conformational DNA aptamers enabling small-molecule lateral flow assaysCU26117Conformational DNA aptamers enable rapid, cost-effective small-molecule detection in lateral flow assays via structure-switching binding.TagsAnalyteAntibodyAptamerInventorsKyungae YangManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-01
Gene silencing for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)CU23021Silencing CASP8-METRN halts progression from steatosis to MASH, offering non-invasive therapy and diagnostic biomarkers.TagsBiomarkerBlood plasmaCaspase 8InventorsDanish SaleheenIra Tabas MD, PhDShareef KhalidManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08
cGAS inhibitor for robust anti-tumor immunity activationCU23316Bioavailable, chemically modified cGAS inhibitors enhance oral bioavailability to boost anti-tumor immunity via the cGAS–STING pathway.TagsAminopeptidaseAutoimmune diseaseBioavailabilityInventorsBenjamin Izar MD, PhDDonald William Landry MD, Ph.D.Lindsay CaprioManagerJoan MartinezDepartmentsMedicineProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2024-09-26
Cell therapy methods for improved transplant acceptanceCU22264Hematopoietic stem cell therapy induces immune tolerance to transplanted organs, reducing rejection and long-term immunosuppression needs.TagsAllotransplantationCD34Cell therapyInventorsAubrey Marie SherryBrian H. JohnstoneDongsheng GuManagerJerry KokoshkaDepartmentsMedicineSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2024-09-05
Immunosuppressant for treating inflammatory and autoimmune diseasesCU21025A novel immunosuppressant blocks T cell expansion to treat organ transplant rejection and autoimmune/inflammatory diseases.TagsEnzymeImmunosuppressive drugInflammationInventorsHuihui MaJing Fu Ph.D.Markus MaparaManagerJerry KokoshkaDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-03-23CollectionsSmall Molecule
Mouse model to study prelamin A in agingCU22366A knock-in mouse model producing only prelamin A with near-normal lifespan to study long-term effects of farnesylated prelamin A.TagsAdipose tissueEnzymeFibroblastInventorsHoward WormanYuexia WangManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2022-08-20
Raman-tagged aptamer sensor for ultra-stable, multiplexed biomolecule detectionCU25105Ultra-stable Raman-tagged aptamer sensor enables multiplexed, environment-insensitive biomolecule detection via structure-switching aptamers.TagsAptamerBiomoleculeConformational changeInventorsAchut SilwalMilan N. Stojanovic M.D.ManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-20
Patient-specific organoid system for pancreatic ductal adenocarcinoma (PDAC) drug screeningCU24025Patient-specific pancreatic cancer organoids with patient immune cells enable high-throughput drug screening and personalized therapy insights.TagsCell therapyHigh-throughput screeningImmune systemInventorsGulam ManjiIlenia PellicciottaManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-30CollectionsOncology
Algorithm for Identification of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-associated Steatohepatitis (MASH) detectionCU19281AI-driven EHR algorithm rapidly detects MASLD/MASH risk across disease stages, enabling early intervention and scalable screening.TagsAlgorithmDatabaseElectronic health recordInventorsAnna BasileJulia WattacherilNicholas P. TatonettiManagerKristin NeumanDepartmentsMedicineBiomedical InformaticsDivisionsColumbia University Medical Center (CUMC)Release Date2020-06-08
Scalable, reproducible, immune-intact tumor organoid co-culture platformCU24328Patient-derived immune-intact tumor organoids enable scalable, reproducible co-culture for personalized immunotherapy and drug screening.TagsBiomarkerBiotechnologyCancer immunotherapyInventorsDavid CohenJoel T. Gabre MDManagerJoan MartinezDepartmentsMedicineHerbert Irving Comprehensive Cancer CenterDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Dual targeting of epigenetically amplified lymphomas via epigenetic modifiers and immune checkpoint inhibitionCU24177Dual-targeted PMBCL therapy: epigenetic reprogramming plus anti-PD-1 immune blockade enhances immunogenicity and overcomes resistance.TagsCancerCancer immunotherapyChromosomeInventorsJennifer AmengualSeda Serra ToluManagerKristin NeumanDepartmentsMedicineMedicine - Hematology/OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-17CollectionsOncology
Novel prognostic marker for survival in myeloid malignanciesCU18296Multi-gene transcriptomic classifier using TED markers to predict MDS progression to AML, enabling earlier, accurate prognosis.TagsAcute myeloid leukemiaAssayGene expressionInventorsAbdullah Ali Ph.D.Azra Raza M.D.Etienne De ClaraManagerJoan MartinezDepartmentsMedicineHerbert Irving Comprehensive Cancer CenterMedical OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-05-28
High throughput, automated method for chromatin profiling using low-cell input samplesCU23333Automated, high-throughput ChIP-seq profiling from low-cell inputs enables scalable chromatin mapping and clinical diagnostics.TagsAutomationChIP sequencingChromatinInventorsAaron VinyManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-03-13
Antibody-like molecule for specific and potent HIV latency reversalCU23253Bispecific antibody targets CD4+ T cells and IL-15 receptor to deliver potent latency reversal agents, reactivating HIV reservoirs.TagsAntiviral drugCD4Combination therapyInventorsDavid Da-i Ho M.D.Hiroshi MohriJian YuManagerKristin NeumanDepartmentsMedicineAaron Diamond AIDS Research Center (ADARC)DivisionsColumbia University Medical Center (CUMC)Release Date2024-10-25CollectionsImmunology & Inflammation
Tumor-infiltrating lymphocyte and organoid co-culture for patient-specific immunotherapyCU22128Ex vivo tumor-lymphocyte co-culture screens patient TILs for tumor killing, guiding pre-treatment immunotherapy choices and cost savings.TagsCell cultureCytotoxicityDrug resistanceInventorsAlana NguyenMichael Shen Ph.D.ManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2022-08-22CollectionsOncologyPlatform/Research Tool
Small molecule treatment for MAPK-regulated cancersCU20013MAP4K2-targeted small molecule inhibits MAPK signaling to curb multiple myeloma growth, offering therapy for resistant hematologic cancers.TagsApoptosisB cellCell proliferationInventorsDonald William Landry MD, Ph.D.Jing Fu Ph.D.Shi-xian DengManagerJerry KokoshkaDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2022-08-05CollectionsSmall MoleculeOncology
Electrocardiogram-compatible deep learning algorithm for aortic stenosis detectionCU21335ECG-driven deep learning enables universal, cost-effective screening for valvular disease (aortic/mitral regurgitation, stenosis).TagsAortic regurgitationAortic stenosisDeep learningInventorsPierre EliasTimothy Joseph PoteruchaManagerJoan MartinezDepartmentsMedicineCardiologyDivisionsColumbia University Medical Center (CUMC)Release Date2021-05-25CollectionsMedical DeviceCardiovascular
