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Medicine
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Broadly neutralizing antibody against SARS-CoV-2 variants and related sarbecoviruses
CU24218
Broadly neutralizing antibody targets SARS-CoV-2 variants and related sarbecoviruses, enabling versatile, durable treatment and prophylaxis.
Tags
Antibody
Antiviral drug
Clade
Inventors
David Da-i Ho M.D.
Jian Yu
Lawrence S. Shapiro Ph.D.
Manager
Kristin Neuman
Departments
Medicine
Aaron Diamond AIDS Research Center (ADARC)
Biochemistry and Molecular Biophysics / Ophthalmology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-09-16
MicronuclAI: pipeline for automated and reliable micronuclei quantification to assess chromosomal instability
CU24358
MicronuclAI automates and standardizes micronuclei quantification across cell lines, boosting speed, accuracy, and chromosomal instability assessment.
Tags
Cancer
Cell nucleus
Cytogenetics
Inventors
Aroj Hada
Benjamin Izar MD, PhD
Denis Schapiro
Manager
Joan Martinez
Departments
Medicine
Institute for Computational Biomedicine
Program in Cellular, Molecular, Structural and Genetic Studies
Divisions
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2024-07-05
Sensitive SARS-CoV-2 antigen test
CU21002
Ultra-sensitive SARS-CoV-2 antigen sandwich ELISA using dual nucleocapsid antibodies for rapid, low-viral-load detection.
Tags
Antibody
Antigen
Assay
Inventors
David Da-i Ho M.D.
Lihong Liu
Manager
Kristin Neuman
Departments
Medicine
Physicians & Surgeons
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-04-25
3D organoids for modeling squamous epithelial pathology and personalized medicine
CU22301
3D squamous epithelial organoids enable patient-specific disease modeling and rapid, predictive drug testing for ESCC/EAC.
Tags
Adenocarcinoma
Carcinoma
Epithelium
Inventors
Anil K. Rustgi M.D.
Hiroshi Nakagawa
Manager
Joan Martinez
Departments
Medicine
Herbert Irving Comprehensive Cancer Center
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-01-04
Collections
Oncology
Colorectal cancer organoid model for therapeutic testing
CU26010
Patient-derived 3D colorectal cancer organoids enable precise drug screening, personalized therapy, and biomarker discovery.
Tags
Colorectal cancer
Extracellular matrix
High-throughput screening
Inventors
Casidhe-Nicole Bethancourt
David Cohen
Joel T. Gabre MD
Manager
Joan Martinez
Departments
Medicine
Herbert Irving Comprehensive Cancer Center
Surgery
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-10-09
Combination therapy to increase the efficacy of antibody-drug conjugates in bladder cancer
CU24095
Small molecule reprograms bladder cancer cells to upregulate antigens, boosting antibody-drug conjugate efficacy. 14 words.
Tags
Antibody-drug conjugate
Antigen
Biopharmaceutical
Inventors
John Robert Christin
Michael Shen Ph.D.
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-07-09
Wearable device for automated nutrition monitoring
CU25198
A non-invasive wearable using machine learning to auto-monitor dietary intake and biometric data for real-time nutrition tracking.
Tags
Activity tracker
Biometrics
Cardiovascular disease
Inventors
Alexander Goldberg
Weihao Xu
Manager
Jerry Kokoshka
Departments
Medicine
Biomedical Engineering
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2025-04-08
CRISPR deletion of endogenous T cell receptor chains for optimized immunotherapies
CU20245
CRISPR deletes endogenous TCR chains while preserving transgenic TCRs, enabling safer, off-the-shelf CAR-T/TCR therapies.
Tags
Cancer
Chimeric antigen receptor T cell
Graft-versus-host disease
Inventors
Megan Sykes M.D.
Mohsen Khosravi Maharlooei
Remi Creusot
Manager
Jerry Kokoshka
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-01-30
Highly efficient T cell base editing for enhanced immunotherapies
CU24092
Ultra-efficient base editing in human T cells using adenine/cytosine editors; enhances CAR-T, autoimmune therapies with lower toxicity.
Tags
Adenine
Cancer
Chimeric antigen receptor T cell
Inventors
Benjamin Izar MD, PhD
Zachary Walsh
Manager
Joan Martinez
Departments
Medicine
Medicine - Hematology/Oncology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-11-08
Lung organoid cells for therapeutic intervention
CU23361
Therapeutic lung regeneration via patient-specific stem cell–derived distal lung organoids with graftable basal and secretory cells.
Tags
Cell therapy
Chronic obstructive pulmonary disease
Coating
Inventors
Hans-Willem Snoeck
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-09-08
γ-secretase complex inhibitor nanoparticles for NASH
CU20227
Liver-targeted γ-secretase inhibitor nanoparticles reverse NASH fibrosis, reducing Notch-associated toxicity and enabling liver-specific therapy.
Tags
Atherosclerosis
Drug delivery
Dyslipidemia
Inventors
Li Qiang
Utpal Pajvani
Zhen Gu
Manager
Cynthia Lang
Departments
Medicine
Pathology and Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Naomi Berrie Diabetes Center
Release Date
2023-01-31
Identification and synthesis method for small molecules that inhibit stress granule formation and pathological tau aggregation as a novel approach for treating neurodegenerative disorders
CU22124
FRET-based screen identifies CNS-penetrant small molecules inhibiting TIA1-driven stress granules and toxic tau aggregation.
Tags
Amyotrophic lateral sclerosis
Antibody
Blood–brain barrier
Inventors
Donald William Landry MD, Ph.D.
Joseph B. Rayman Ph.D.
Shi-xian Deng
Manager
Jerry Kokoshka
Departments
Medicine
Neuroscience
Divisions
Columbia University Medical Center (CUMC)
Release Date
2022-11-21
Collections
Small Molecule
CNS/Neurology
Glycolipids and analogues as antigens for natural killer T cells
CU22361
Glycolipid analogues activate natural killer T cells via CD1d, boosting immune responses for vaccines and immunotherapy.
Tags
Adjuvant therapy
Antigen
Cytokine
Inventors
David Da-i Ho M.D.
Moriya Tsuji
Manager
Kristin Neuman
Departments
Medicine
Physicians & Surgeons
Divisions
Columbia University Medical Center (CUMC)
Release Date
2022-07-21
Collections
Immunology & Inflammation
Inducible mouse line for cardiac NOX2 inhibition
CU22219
Inducible cardiac NRROS-based NOX2 inhibition in mice; tissue-specific ROS control to protect against diet-induced arrhythmias.
Tags
Antioxidant
Atherosclerosis
Cardiac muscle
Inventors
John Morrow
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2022-02-16
Collections
Cardiovascular
Gut endocrine Rbp2 knockout mouse model for metabolic hormone studies
CU25453
Gut-endocrine cell-specific Rbp2 knockout mouse enables retinoid-driven regulation study of gut hormones and metabolic outcomes.
Tags
Allele
Causal inference
Cre recombinase
Inventors
Rossana M. Calderon
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-10-16
Neutralizing monoclonal antibodies targeting SARS-CoV-2 variants and related coronaviruses
CU22012
Broadly neutralizing monoclonal antibodies block diverse SARS-CoV-2 variants, enabling prophylaxis, treatment, and multi-epitope cocktail strategies.
Tags
Antiviral drug
Assay
B cell
Inventors
David Da-i Ho M.D.
Jian Yu
Lihong Liu
Manager
Kristin Neuman
Departments
Medicine
Microbiology
Physicians & Surgeons
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-08-21
CD58 modulation for improved cancer immunotherapy outcomes
CU21046
CD58 modulation enhances antitumor immunity, overcoming resistance and informing biomarkers for optimized, combinational cancer immunotherapy.
Tags
Antigen presentation
Biomarker
Cancer cell
Inventors
Benjamin Izar MD, PhD
Johannes Melms
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-10-17
Human protective antibodies for use against H7N9 influenza virus
CU23380
Human-derived monoclonal antibodies neutralize H7N9, blocking entry and enabling post-exposure prevention and diagnostics.
Tags
Antiviral drug
Avian influenza
B cell
Inventors
David Da-i Ho M.D.
Kelvin Kai-Wang To
Kwok-Yung Yuen
Manager
Kristin Neuman
Departments
Medicine
Aaron Diamond AIDS Research Center (ADARC)
Dept. of Biochemistry and Molecular Biophysics / Ophthalmology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-07-18
Collections
Immunology & Inflammation
MBOAT7-targeted therapies for the personalized treatment of NASH fibrosis
CU22159
MBOAT7-targeted, personalized NASH therapy using rs641738 variant; MBOAT7 restoration and TAZ silencing reduce fibrosis.
Tags
Cirrhosis
Fibrosis
Gene therapy
Inventors
Ira Tabas MD, PhD
Mary Moore
Xiaobo Wang
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-07-18
Generation of pure alveolar cells for disease modeling and cell therapy
CU22319
Pure alveolar type II cells from lung bud organoids; scalable, purification-free platform for disease modeling and cell therapy.
Tags
High-throughput screening
In vitro
Lung
Inventors
Hans-Willem Snoeck
Ivana Matkovic Leko
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-03-24
Method to target T cell regulatory pathways for treatment of immunological diseases
1779-a
Targeting HLA-E restricted CD8+ T cells to induce self-tolerance, treating autoimmunity without compromising pathogen defense.
Tags
Antigen
Autoimmune disease
Cytotoxic T cell
Inventors
Hong Jiang
Leonard Chess MD
Manager
Ofra Weinberger
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2018-09-28
Method for generating progenitor cells to treat lung disease
CU18150
Regenerative lung organoids from stem cells generate fetal lung progenitors for disease therapy, modeling, and drug screening.
Tags
Embryonic stem cell
Epithelium
High-throughput screening
Inventors
Hans-Willem Snoeck
Ya-Wen Chen
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2017-10-30
Targeting the CD58:CD2 axis for cancer immunotherapy
CU21140
Activates CD28-CD8+ T-cells via CD58:CD2 axis, offering an immunotherapy option for PD-1–unresponsive cancers.
Tags
Antibody
Antigen-presenting cell
CD28
Inventors
Benjamin Izar MD, PhD
Johannes Melms
Patricia Ho
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-06-23
Collections
Oncology
Clinical management of Interstitial Lung Disease using a multiplex real-time PCR assay to quantify leukocyte telomere length
CU24245
Multiplex real-time PCR quantifies average leukocyte telomere length to guide ILD treatment decisions and outcomes.
Tags
Assay
Biomarker
Immunosuppression
Inventors
Chad Newton
Christine K. Garcia
David Zhang
Manager
Kristin Neuman
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-01-13
Exogenous Rac1 analogs to treat acute lung injury
CU23206
Exogenous activated Rac1 (V12Rac1) protects lungs from ALI/ARDS by stabilizing actin and blocking proinflammatory signaling.
Tags
Actin
Acute respiratory distress syndrome
Epithelium
Inventors
Francine Katz
Galina Gusarova
Jahar Bhattacharya
Manager
Jerry Kokoshka
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-11-26
Generation of self-renewed CD4+ T cells for cancer and viral disease immunotherapy
CU24385
Ex vivo culture method yields durable, polyfunctional cytotoxic CD4+ T cells for enhanced cancer and viral immunotherapies.
Tags
Antigen
Cell culture
Cell therapy
Inventors
Mithil Soni
Pawel Muranski
Prabesh Khatiwada
Manager
Jerry Kokoshka
Departments
Medicine
Columbia Center for Translational Immunology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-09-16
Combined small molecule treatment as a synergistic epigenetic therapy for pancreatic cancer
CU23218
Combined HDAC and eIF4A inhibition reprograms pancreatic cancer epigenetically, boosting efficacy and tumor suppression in vivo.
Tags
Adenocarcinoma
Apoptosis
Chemotherapy
Inventors
Antonio Fojo
Maryam Safari
Susan Bates
Manager
Jerry Kokoshka
Departments
Medicine
Oncology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-08-22
Machine learning-guided software for the ablation of cardiac arrhythmias
CU22127
Machine-learning software analyzes electroanatomic data to automatically identify arrhythmia isthmuses, speeding and simplifying ablation.
Tags
Algorithm
Cardiac muscle
Catheter
Inventors
Amardeep Saluja
Christine P. Hendon
Ziyi Huang
Manager
Dovina Qu
Departments
Medicine
Electrical Engineering
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-05-27
Treatment of systolic heart failure without increased heart rate (tachycardia)
CU19251
Small-molecule protein therapy boosts cardiac contractility by raising calcium without increasing heart rate, reducing tachycardia risk.
Tags
Biopharmaceutical
Blood pressure
Cardiac arrest
Inventors
Alexander Kushnir
Arianne Papa
Guoxia Liu
Manager
Joan Martinez
Departments
Medicine
Cardiology
Physiology and Cellular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-11-03
Collections
Small Molecule
Cardiovascular
Low-dose vaccine effective against malaria
CU22363
Low-dose malaria vaccine with glycolipid adjuvant boosts immunity, enabling fewer doses and simpler, cheaper deployment.
Tags
Adjuvant
Apicomplexan life cycle
Cytokine
Inventors
David Da-i Ho M.D.
Moriya Tsuji
Manager
Kristin Neuman
Departments
Medicine
Physicians & Surgeons
Divisions
Columbia University Medical Center (CUMC)
Release Date
2022-07-22
Microfluidic based system for purification and extraction of target molecules
M08-036
Microfluidic device uses biotin-avidin with RNA aptamers for selective capture, heat or competitive release of target molecules.
Tags
Analyte
Aptamer
Biotin
Inventors
Chenmui Qiu
Jingyue Ju
Milan N. Stojanovic M.D.
Manager
Dovina Qu
Departments
Medicine
Chemical Engineering/Applied Chemistry
Mechanical Engineering
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2009-12-23
Method to augment efferocytosis for treatment of autoimmune diseases
CU23287
Augments macrophage efferocytosis by activating WDFY3 to reduce autoimmune inflammation across multiple diseases.
Tags
Apoptosis
Asthma
Atherosclerosis
Inventors
Ai Yamamoto
Hanrui Zhang
Katherine R. Croce
Manager
Kristin Neuman
Departments
Medicine
Cardiology
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-07-05
Sigma non-opioid receptor 1 agonist for the treatment for Timothy Syndrome
CU23081
BBB-nonpermeable SIGMAR1 agonists MY33-1/2 treat Timothy Syndrome, reducing cardiac arrhythmias via targeted stem-cell model rescue.
Tags
Blood–brain barrier
Calcium signaling
Cyclin-dependent kinase
Inventors
Donald William Landry MD, Ph.D.
Kirsten Alison Rinderspacher
Masayuki Yazawa Ph.D.
Manager
Kristin Neuman
Departments
Medicine
Rehabilitation & Regenerative Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-01-10
Collections
Small Molecule
Cardiovascular
Cell-based model for early-onset restrictive cardiomyopathy (RCM)
CU22246
Patient-derived iPSC heart tissue model reproduces FLNC-linked RCM for drug screening and therapy discovery.
Tags
Cardiac muscle cell
Cardiomyopathy
Drug discovery
Inventors
Barry Fine
Bryan Wang
Gordana Vunjak-Novakovic
Manager
Kristin Neuman
Departments
Medicine
Biomedical Engineering
Program in Cellular, Molecular, Structural and Genetic Studies
Divisions
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-11-10
Collections
Cardiovascular
Conformational DNA aptamers enabling small-molecule lateral flow assays
CU26117
Conformational DNA aptamers enable rapid, cost-effective small-molecule detection in lateral flow assays via structure-switching binding.
Tags
Analyte
Antibody
Aptamer
Inventors
Kyungae Yang
Manager
Jerry Kokoshka
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-12-01
Gene silencing for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)
CU23021
Silencing CASP8-METRN halts progression from steatosis to MASH, offering non-invasive therapy and diagnostic biomarkers.
Tags
Biomarker
Blood plasma
Caspase 8
Inventors
Danish Saleheen
Ira Tabas MD, PhD
Shareef Khalid
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-11-08
cGAS inhibitor for robust anti-tumor immunity activation
CU23316
Bioavailable, chemically modified cGAS inhibitors enhance oral bioavailability to boost anti-tumor immunity via the cGAS–STING pathway.
Tags
Aminopeptidase
Autoimmune disease
Bioavailability
Inventors
Benjamin Izar MD, PhD
Donald William Landry MD, Ph.D.
Lindsay Caprio
Manager
Joan Martinez
Departments
Medicine
Program in Cellular, Molecular, Structural and Genetic Studies
Divisions
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2024-09-26
Cell therapy methods for improved transplant acceptance
CU22264
Hematopoietic stem cell therapy induces immune tolerance to transplanted organs, reducing rejection and long-term immunosuppression needs.
Tags
Allotransplantation
CD34
Cell therapy
Inventors
Aubrey Marie Sherry
Brian H. Johnstone
Dongsheng Gu
Manager
Jerry Kokoshka
Departments
Medicine
Surgery
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-09-05
Immunosuppressant for treating inflammatory and autoimmune diseases
CU21025
A novel immunosuppressant blocks T cell expansion to treat organ transplant rejection and autoimmune/inflammatory diseases.
Tags
Enzyme
Immunosuppressive drug
Inflammation
Inventors
Huihui Ma
Jing Fu Ph.D.
Markus Mapara
Manager
Jerry Kokoshka
Departments
Medicine
Oncology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-03-23
Collections
Small Molecule
Mouse model to study prelamin A in aging
CU22366
A knock-in mouse model producing only prelamin A with near-normal lifespan to study long-term effects of farnesylated prelamin A.
Tags
Adipose tissue
Enzyme
Fibroblast
Inventors
Howard Worman
Yuexia Wang
Manager
Jerry Kokoshka
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2022-08-20
Raman-tagged aptamer sensor for ultra-stable, multiplexed biomolecule detection
CU25105
Ultra-stable Raman-tagged aptamer sensor enables multiplexed, environment-insensitive biomolecule detection via structure-switching aptamers.
Tags
Aptamer
Biomolecule
Conformational change
Inventors
Achut Silwal
Milan N. Stojanovic M.D.
Manager
Jerry Kokoshka
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-02-20
Patient-specific organoid system for pancreatic ductal adenocarcinoma (PDAC) drug screening
CU24025
Patient-specific pancreatic cancer organoids with patient immune cells enable high-throughput drug screening and personalized therapy insights.
Tags
Cell therapy
High-throughput screening
Immune system
Inventors
Gulam Manji
Ilenia Pellicciotta
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-11-30
Collections
Oncology
Algorithm for Identification of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-associated Steatohepatitis (MASH) detection
CU19281
AI-driven EHR algorithm rapidly detects MASLD/MASH risk across disease stages, enabling early intervention and scalable screening.
Tags
Algorithm
Database
Electronic health record
Inventors
Anna Basile
Julia Wattacheril
Nicholas P. Tatonetti
Manager
Kristin Neuman
Departments
Medicine
Biomedical Informatics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2020-06-08
Scalable, reproducible, immune-intact tumor organoid co-culture platform
CU24328
Patient-derived immune-intact tumor organoids enable scalable, reproducible co-culture for personalized immunotherapy and drug screening.
Tags
Biomarker
Biotechnology
Cancer immunotherapy
Inventors
David Cohen
Joel T. Gabre MD
Manager
Joan Martinez
Departments
Medicine
Herbert Irving Comprehensive Cancer Center
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-01-08
Dual targeting of epigenetically amplified lymphomas via epigenetic modifiers and immune checkpoint inhibition
CU24177
Dual-targeted PMBCL therapy: epigenetic reprogramming plus anti-PD-1 immune blockade enhances immunogenicity and overcomes resistance.
Tags
Cancer
Cancer immunotherapy
Chromosome
Inventors
Jennifer Amengual
Seda Serra Tolu
Manager
Kristin Neuman
Departments
Medicine
Medicine - Hematology/Oncology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-07-17
Collections
Oncology
Novel prognostic marker for survival in myeloid malignancies
CU18296
Multi-gene transcriptomic classifier using TED markers to predict MDS progression to AML, enabling earlier, accurate prognosis.
Tags
Acute myeloid leukemia
Assay
Gene expression
Inventors
Abdullah Ali Ph.D.
Azra Raza M.D.
Etienne De Clara
Manager
Joan Martinez
Departments
Medicine
Herbert Irving Comprehensive Cancer Center
Medical Oncology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-05-28
High throughput, automated method for chromatin profiling using low-cell input samples
CU23333
Automated, high-throughput ChIP-seq profiling from low-cell inputs enables scalable chromatin mapping and clinical diagnostics.
Tags
Automation
ChIP sequencing
Chromatin
Inventors
Aaron Viny
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-03-13
Antibody-like molecule for specific and potent HIV latency reversal
CU23253
Bispecific antibody targets CD4+ T cells and IL-15 receptor to deliver potent latency reversal agents, reactivating HIV reservoirs.
Tags
Antiviral drug
CD4
Combination therapy
Inventors
David Da-i Ho M.D.
Hiroshi Mohri
Jian Yu
Manager
Kristin Neuman
Departments
Medicine
Aaron Diamond AIDS Research Center (ADARC)
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-10-25
Collections
Immunology & Inflammation
Tumor-infiltrating lymphocyte and organoid co-culture for patient-specific immunotherapy
CU22128
Ex vivo tumor-lymphocyte co-culture screens patient TILs for tumor killing, guiding pre-treatment immunotherapy choices and cost savings.
Tags
Cell culture
Cytotoxicity
Drug resistance
Inventors
Alana Nguyen
Michael Shen Ph.D.
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2022-08-22
Collections
Oncology
Platform/Research Tool
Small molecule treatment for MAPK-regulated cancers
CU20013
MAP4K2-targeted small molecule inhibits MAPK signaling to curb multiple myeloma growth, offering therapy for resistant hematologic cancers.
Tags
Apoptosis
B cell
Cell proliferation
Inventors
Donald William Landry MD, Ph.D.
Jing Fu Ph.D.
Shi-xian Deng
Manager
Jerry Kokoshka
Departments
Medicine
Oncology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2022-08-05
Collections
Small Molecule
Oncology
