Departments

Neurology

49 results

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Patient-reported outcome measure for perceived physical fatigability in spinal muscular atrophy

CU26017

SMA EFFORT: a disease-specific PROM tying perceived fatigability to real-world activity intensity, enabling sensitive SMA treatment assessment.

Tags: Clinical trial
Energy
Neuromuscular disease
Inventors: Cara H. Kanner
Jacqueline Montes
Rafael Rodriguez-Torres
Manager: Dovina Qu
Departments: Neurology
Rehabilitation & Regenerative Medicine
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-09-29

Transgenic zebrafish lines for Alzheimer’s disease models

CU23304

Transgenic zebrafish expressing amyloid beta and Tau model Alzheimer's pathology for in vivo drug screening and biomarker research.

Tags: Amyloid beta
Biomarker
Drug development
Inventors: Caghan Kizil
Manager: Joan Martinez
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-09-25
Collections: CNS/Neurology

Machine-learning algorithm to improve disease diagnosis using magnetic resonance spectroscopy

CU24256

A deep learning system automates and speeds up in vivo metabolite quantification from MRS, improving disease diagnosis with telecoms-ready MRI integration.

Tags: Algorithm
Deep learning
Dementia
Inventors: Christopher Wu
Jia Guo
Scott A. Small M.D.
Manager: Jerry Kokoshka
Departments: Neurology
Biomedical Engineering
Psychiatry
Divisions: Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date: 2025-05-30

Multi-target directed ligand drug development pipeline for Alzheimer's Disease

CU23303

A high-throughput, cost-efficient preclinical pipeline synthesizes and tests multi-target ligands for Alzheimer's, using zebrafish models.

Tags: Biomarker
Cholinesterase
Drug development
Inventors: Caghan Kizil
Manager: Joan Martinez
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2024-06-21

Computational pipeline for identifying kinase drug targets in cancer

CU23037

An integrative multi-omics pipeline uses ML to identify master kinases per cancer subtype, enabling precision targeted therapies.

Tags: Drug development
Glioblastoma
Kinase
Inventors: Anna Lasorella
Antonio Iavarone
Manager: Kristin Neuman
Departments: Neurology
Pediatrics
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-07-20
Collections: Oncology

Efficient drug discovery pipeline and lead compounds for Alzheimer's disease

CU23156

Multi-target Alzheimer’s drug discovery platform accelerates preclinical lead compounds with in vitro/in vivo efficacy and safety.

Tags: Agonist
Amyloid beta
Animal testing
Inventors: Caghan Kizil
Manager: Joan Martinez
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-05-10
Collections: Small Molecule
CNS/Neurology
Platform/Research Tool

VPS35 floxed mouse model for Alzheimer's drug discovery

CU25395

Inducible, tissue-specific VPS35 knockout mouse enabling controlled adult-onset retromer disruption for Alzheimer’s research.

Tags: Biomarker
Cerebrospinal fluid
Drug discovery
Inventors: Scott A. Small M.D.
Manager: Jerry Kokoshka
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-07-31

A self-reportable scale for measuring perceived cognitive change

CU25123

A self-report scale (Cognitive Change Scale) tracks subtle, year-over-year cognitive changes in neurologic patients, especially MS.

Tags: Cognition
Mild cognitive impairment
Multiple sclerosis
Inventors: Victoria Leavitt
Manager: Joan Martinez
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-04-10

Mouse model for studying CA2 region in the hippocampus

CU23371

Transgenic Amigo2-Cre mouse model enables CA2-specific studies of social memory and hippocampal projections for preclinical research.

Tags: CREB
Cre recombinase
Drug discovery
Inventors: Chyuan-Sheng (Victor) Lin
Frederick Luke Hitti
Steven A. Siegelbaum PhD
Manager: Jerry Kokoshka
Departments: Neurology
Opthamology
Pharmacology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-09-08
Collections: CNS/Neurology

Digitized analysis and scoring of spiral drawing test

CU20146

Digitized spiral analysis automates recording and scoring of hand-drawn spirals for objective motor dysfunction diagnosis and monitoring.

Tags: Algorithm
Ataxia
Biomarker
Inventors: Seth Pullman
Manager: Kristin Neuman
Departments: Neurology
Release Date: 2020-06-04
Collections: Medical Device
Digital Health (Software, AI, bioinformatics, etc)

Focused ultrasound system for localized drug delivery across the blood brain barrier

2039

Focused ultrasound with microbubbles locally and reversibly opens the BBB, enabling targeted brain drug delivery and CNS research.

Tags: Aperture
Blood–brain barrier
Brain
Inventors: Elisa Konofagou
James Junesik J. Choi
Mathieu Pernot
Manager: Dovina Qu
Departments: Neurology
Biomedical Engineering
Divisions: Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date: 2014-09-15

Microvasculature-targeted therapeutic AAV vectors for selective brain delivery

CU24146

Brain-endothelium-targeted AAV gene therapy enables non-invasive, selective CNS delivery, treating Glut1DS and neurovascular diseases.

Tags: Adeno-associated virus
Blood–brain barrier
Central nervous system
Inventors: Shashi Kumar
Umrao R. Monani Ph.D.
Manager: Kristin Neuman
Departments: Neurology
Pathology & Cell Biology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2026-03-17

Interventional Style Transfer (IST) for improving model generalization

CU23355

Generative intervention creates environment-agnostic training images to reduce confounding and improve OOD model generalization.

Tags: Artificial intelligence
Computer vision
Machine learning
Inventors: Juan C. Caicedo
Michio Hirano M.D.
Wolfgang M. A. Pernice
Manager: Kristin Neuman
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-12-18

Targeting IL-17A for treating neuroinflammation from Group A Streptococcus infections

CU19125

IL-17A neutralization targets GAS-induced neuroinflammation, offering PANDAS/Sydenhams treatment potential and Th17 pathway insights.

Tags: Antibiotic
Antibody
Autoantibody
Inventors: Andrew Sproul Ph.D.
Dritan Agalliu
Ilir Agalliu
Manager: Sara Gusik
Departments: Neurology
Epidemiology & Population Health, Urology
Pathology & Cell Biology
Divisions: Columbia University Medical Center (CUMC)
Yeshiva University
Release Date: 2024-04-12
Collections: CNS/Neurology

Targeting ID2 to impair hypoxic cancer stem cell proliferation

CU16166

Targeting ID2–DYRK1A/B axis degrades HIF2a in hypoxic cancer stem cells, offering glioblastoma–focused, broad oncologic potential.

Tags: Angiogenesis
Cancer stem cell
Cell proliferation
Inventors: Anna Lasorella
Antonio Iavarone
Manager: Kristin Neuman
Departments: Neurology
Pediatrics
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-05-19
Collections: Oncology

Metabolic biomarkers for targeted treatment of schizophrenia and related disorders

CU25032

Metabolic biomarkers identify GLS1-driven glutamate elevation in early schizophrenia via 3T 1H-MRS, enabling targeted therapies and trials.

Tags: Atrophy
Attention deficit hyperactivity disorder
Biomarker
Inventors: Douglas Rothman
Jia Guo
Scott A. Small M.D.
Manager: Jerry Kokoshka
Departments: Neurology
Psychiatry
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2024-12-06

Antibodies for detecting ALS and frontotemporal dementia

CU26296

Monoclonal antibodies specifically detect HDGFL2 cryptic exon in ALS-FTD, enabling early biomarker-based diagnosis and research tools.

Inventors: Mason Kralovec
Neil Shneider
Susan Brenner-Morton
Manager: Jerry Kokoshka
Departments: Neurology
Biochemistry
Pathology & Cell Biology
Divisions: College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date: 2026-05-22

Patient-specific co-culture model of microglia-like cells for neurodegenerative disorder research

CU19086

Patient-specific microglia-like cell co-culture with neurons enables disease modeling and high-throughput neurodegenerative drug screening.

Tags: High-throughput screening
Microglia
Monocyte
Inventors: Elizabeth M. Bradshaw
Wassim Elyaman
Manager: Joan Martinez
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2018-10-03
Collections: CNS/Neurology
Platform/Research Tool

Adeno-associated virus Glut1 gene therapy for rescuing glucose transport in Glut1 deficiency syndrome

CU15054

AAV-based Glut1 gene therapy restores brain glucose transport in Glut1 deficiency, offering a one-time, long-term treatment.

Tags: Adeno-associated virus
Blood–brain barrier
Cognitive deficit
Inventors: Darryl C. De Vivo
Guangping Gao
Kristin Engelstad
Manager: Kristin Neuman
Departments: Neurology
Divisions: College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Office of Technology Management
Release Date: 2025-08-19

Multiplexed T cell profiling for generating engineered regulatory T cell therapies

CU23310

High-throughput platform maps patient TCR–antigen pairs to create CRISPR‑engineered, autologous Tregs for precise local immune suppression.

Tags: Amyotrophic lateral sclerosis
Antigen
CRISPR
Inventors: Elizabeth M. Bradshaw
Neil Shneider
Ryan Hobson
Manager: Joan Martinez
Departments: Neurology
Molecular Medicine
Divisions: College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date: 2025-01-02

Mouse model for KCNQ3-related disorders

CU21045

CRISPR-generated KCNQ3 R231H mouse model for in vivo study of developmental and epileptic encephalopathy mechanisms and therapies.

Tags: Cognitive deficit
Encephalopathy
Genome editing
Inventors: Tristan Timothy Sands
Wayne Frankel
Manager: Joan Martinez
Departments: Neurology
Genetics & Development
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2020-10-23
Collections: CNS/Neurology

Cell Lines from Adult Human Ventricular Cardiomyocytes for Cardiac Research

823

Immortal human ventricular cardiomyocyte line for proliferative, differentiable cardiac research; enables drug testing, regeneration studies. Licenseable.

Tags: Actin
Cardiac muscle
Cardiac muscle cell
Inventors: Mercy Davidson
Manager: Cynthia Lang
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)

Alzheimer's disease detection and treatment based on ceramide and sphingolipid levels

CU15147

Gene-targeted reduction of ER-MAM APP-C99 via ceramide/sphingolipid biomarkers enables early Alzheimer’s detection and therapeutic modulation.

Tags: Amyloid beta
Biomarker
Cell membrane
Inventors: Eric A. Schon Ph.D.
Estela Area-Gomez
Manager: Kristin Neuman
Departments: Neurology
Divisions: College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Release Date: 2024-04-25
Collections: CNS/Neurology

Combinatorial treatment LZTR1 mutant tumors by inhibiting oncogenic substrates

CU23141

Combinatorial inhibitors target LZTR1-mutant cancers by suppressing EGFR, AXL, and RIT1 to reduce tumor growth.

Tags: Breast cancer
Colorectal cancer
Combinatorics
Inventors: Anna Lasorella
Antonio Iavarone
Aram Ko
Manager: Kristin Neuman
Departments: Neurology
Pediatrics
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2024-06-06

Diagnostic tool for schizophrenia using magnetic resonance spectroscopy (MRS)

CU21216

MRS-based schizophrenia diagnostic: non-invasive, quantitative brain metabolite profiling via ML-enhanced spectroscopy for accurate diagnosis.

Tags: Gamma-Aminobutyric acid
Glutamic acid
Glutamine
Inventors: Jia Guo
Scott A. Small M.D.
Manager: Jerry Kokoshka
Departments: Neurology
Psychiatry
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-08-04
Collections: CNS/Neurology

Deep learning method to reduce contrast agent usage in MRI

CU20041

Deep learning cuts gadolinium contrast in MRI by at least 5x without sacrificing image quality, reducing toxicity and costs.

Tags: Deep learning
Magnetic resonance imaging
Inventors: Jia Guo
Scott A. Small M.D.
Manager: Jerry Kokoshka
Departments: Neurology
Psychiatry
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2019-08-08
Collections: Digital Health (Software, AI, bioinformatics, etc)

Small molecule inhibitors of the ID2/VHL interaction

CU17182

Four small molecules block ID2/VHL, promote HIF degradation, potentially slowing tumor growth and angiogenesis in cancers.

Tags: Angiogenesis
Cell growth
Chemotherapy
Inventors: Anna Lasorella
Antonio Iavarone
Dan Sherman
Manager: Kristin Neuman
Departments: Neurology
Institute for Cancer Genetics
Pediatrics
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-05-19
Collections: Small Molecule
Oncology

Computational method for brain tumor classification and improved prognosis

CU21156

Integrates multi-omics to subtype glioblastoma, revealing four functional states and subtype-specific treatment targets.

Tags: Breast cancer
Glioblastoma
Glioma
Inventors: Anna Lasorella
Antonio Iavarone
Manager: Kristin Neuman
Departments: Neurology
Pediatrics
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-05-01
Collections: Oncology

Targeting the RhoA signaling pathway for the treatment of Alzheimer's disease

CU25028

Targeting RhoA signaling to restore retromer-dependent endosomal trafficking, using ARHGEF12/ROCK2 inhibitors and shRNA for Alzheimer’s therapy.

Tags: Cell surface receptor
Central nervous system
Drug development
Inventors: Gregory A. Petsko
Scott A. Small M.D.
Yasir H. Qureshi
Manager: Jerry Kokoshka
Departments: Neurology
Ann Romney Center for Neurologic Diseases
Taub Institute
Divisions: Columbia University Medical Center (CUMC)
Harvard Medical School and Brigham & Women’s Hospital
Release Date: 2025-07-31

Fusion protein as target for brain cancer therapy

CU12240

Targeting FGFR-TACC gene fusions in glioblastoma with kinase inhibitors; precision therapy and diagnostic tools.

Tags: Assay
Chemotherapy
Glioblastoma
Inventors: Anna Lasorella
Antonio Iavarone
Raul Rabadan
Manager: Kristin Neuman
Departments: Neurology
Biomedical Informatics
Pediatrics
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2022-09-15
Collections: Small Molecule
Oncology

A predictive model and algorithm forecasting time to outcomes in Alzheimer's disease patients

CU12330

Predicts timing of key Alzheimer’s milestones (care needs, institutionalization, death) using a heterogeneous, longitudinal progression model.

Tags: Cognitive neuroscience
Medication
Public health
Inventors: P.J. Eric Stallard
Qolamreza (Ray) Razlighi
Yaakov Stern PhD
Manager: Dovina Qu
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2014-05-14

Vps26a heterozygous mice for studying the retromer core in Alzheimer's disease

CU25396

Transgenic Vps26a+/− mice model retromer function in Alzheimer’s, enabling hippocampal research and targeted therapeutic testing.

Tags: Endosome
Hippocampus
Memory
Inventors: Scott A. Small M.D.
Manager: Jerry Kokoshka
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-07-31

Gene therapy for thymidine kinase 2 (TK2) deficiency

CU18199

Engineered AAV9 gene therapy replaces TK2 to treat TK2 deficiency mitochondrial diseases, potentially correcting DNA depletion and symptoms.

Tags: Comorbidity
Enzyme
Gene therapy
Inventors: Carlos Lopez-Gomez
Hasan Orhan Akman
Michio Hirano M.D.
Manager: Kristin Neuman
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-01-17
Collections: Gene Therapy

Automated detection of cerebral microbleeds using magnetic resonance imaging (MRI)

CU20112

Algorithm-assisted MRI pipeline detects cerebral microbleeds, increasing speed and objectivity over manual analysis for risk assessment.

Tags: Algorithm
Bleeding
Cerebrovascular disease
Inventors: Adam Brickman
Anthony G. Chesebro
Manager: Cynthia Lang
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-12-04

Artificial intelligence contrast algorithm for safer stroke diagnosis

CU25197

AI contrast enhancement lowers gadolinium dose for safer, cheaper stroke diagnosis via deep learning.

Tags: Artificial intelligence
Blood–brain barrier
CT scan
Inventors: Frank Provenzano
Jia Guo
Scott A. Small M.D.
Manager: Jerry Kokoshka
Departments: Neurology
Psychiatry
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-10-23

Neuroproteasome-inhibiting bioconjugate for prevention of tau aggregation in Alzheimer's disease

CU23159

A neuronal proteasome-targeting bioconjugate inhibits early Tau aggregation, offering ApoE-selective, precise tauopathy intervention.

Tags: Apolipoprotein E
Bioconjugation
Biomarker
Inventors: Kapil Ramachandran
Manager: Jerry Kokoshka
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-07-01

Targeted Cdkn2a suppression to prevent muscle degeneration in spinal muscular atrophy

CU23330

Targeted Cdkn2a suppression preserves muscle stem cell function to counteract SMA-related degeneration and enhance therapy.

Tags: Atrophy
Combination therapy
Gene therapy
Inventors: Narendra Jha
Umrao R. Monani Ph.D.
Manager: Kristin Neuman
Departments: Neurology
Pathology & Cell Biology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-01-30
Collections: Gene Therapy

Deep learning algorithm for early diagnosis of Alzheimer's disease

CU19273

Early deep-learning MRI tool accurately classifies Alzheimer’s and flags risk, enabling earlier, automated diagnosis.

Tags: Convolutional neural network
Deep learning
Longitudinal study
Inventors: Frank Provenzano
Scott A. Small M.D.
Xinyang Feng
Manager: Jerry Kokoshka
Departments: Neurology
Biomedical Engineering
Divisions: Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date: 2019-03-21
Collections: CNS/Neurology

Microarray of the wheat proteome to detect and classify gluten and non-gluten wheat sensitivity

CU12253

A high-throughput microarray profiles immune responses to gluten and non-gluten wheat proteins, aiding personalized wheat sensitivity insights.

Tags: Antibody
Antigen
Assay
Inventors: Armin Alaedini
Manager: Jerry Kokoshka
Departments: Neurology
Release Date: 2014-12-31

Identification of EGFR fusion proteins enables diagnosis and targeted treatment of cancer

CU13242

EGFR fusion detection enables cancer diagnosis and targeted therapies, improving precision treatment with fusion-specific inhibition.

Tags: Breast cancer
Cancer
Carcinogenesis
Inventors: Anna Lasorella
Antonio Iavarone
Raul Rabadan
Manager: Kristin Neuman
Departments: Neurology
Biomedical Informatics
Pediatrics
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2013-06-17

Gene Transduction Therapy in Neurodegenerative Disorders

CU12241

Viral transduction triggers constitutively active p70S6K to regenerate axons in neurodegenerative models, aiming to restore motor/cognitive function.

Tags: Axon
Cognitive deficit
Dopamine
Inventors: Robert E. Burke
Manager: Kristin Neuman
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2013-03-08

Novel diagnostic and treatment method for Alzheimer's disease

2312

Detects Alzheimer’s by organelle redistribution from mutated proteins; enables screening and drugs targeting subcellular rearrangements.

Tags: Assay
Dementia
Endoplasmic reticulum
Inventors: Eric A. Schon PhD
Estela Area-Gomez
Manager: Kristin Neuman
Departments: Neurology
Genetics & Development
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2009-06-02

Method for quantifying and analyzing brain white matter

CU14154

Automates precise, unbiased quantification and 3D mapping of brain white matter hyperintensities from MRI for diagnosis and monitoring.

Tags: Atrophy
Cerebrospinal fluid
Dementia
Inventors: Adam Brickman
Atul Narkhede
Frank Provenzano
Manager: Cynthia Lang
Departments: Neurology
Biomedical Engineering
Taub Institute
Divisions: Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date: 2018-04-13

Peptide targeting CD33 to treat cognitive decline in Alzheimer's Disease patients

CU21001

A cost-effective peptide disrupts CD33-CD45, activates microglia, reduces amyloid, potentially slowing cognitive decline in Alzheimer's.

Tags: Acetylcholinesterase
Acute myeloid leukemia
Amyloid
Inventors: Elizabeth M. Bradshaw
Wassim Elyaman
Manager: Joan Martinez
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-02-02
Collections: CNS/Neurology

Gene therapy for metabolic dysfunction-associated steatohepatitis (MASH)

CU25230

Gene therapy restoring retromer activity to treat MASH by normalizing lipid metabolism and reducing fibrosis risk.

Tags: Cirrhosis
Drug discovery
Fibrosis
Inventors: Gregory A. Petsko
Scott A. Small M.D.
Manager: Jerry Kokoshka
Departments: Neurology
Ann Romney Center for Neurologic Diseases
Divisions: Columbia University Medical Center (CUMC)
Harvard Medical School and Brigham & Women’s Hospital
Release Date: 2025-07-31

Cerebral blood volume mapping software for diagnosis and monitoring of brain disorders

CU14249

CBV-mapping fMRI toolkit enabling multi-region brain function maps for diagnostics, drug testing, and disease monitoring.

Tags: Blood volume
Computer
Drug development
Inventors: Frank Provenzano
Scott A. Small M.D.
Manager: Jerry Kokoshka
Departments: Neurology
Biomedical Engineering
Divisions: Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date: 2025-12-17

Scale for Assessing Fluctuating Cognition in Dementia Diagnosis

CU22136

A concise clinician-rated 2-item scale measuring fluctuating cognition to improve DLB diagnosis, reliability, and cross-rater use.

Tags: Cognition
Cognitive deficit
Consciousness
Inventors: Yaakov Stern PhD
Manager: Dovina Qu
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2021-11-29
Collections: CNS/Neurology

Pharmacological inhibitors and mouse models of mitochondrial DNA depletion-deletion syndromes (MDDS)

CU23197

Therapeutic mouse models and deoxynucleoside-based treatment restore mtDNA balance in GUK1-related MDDS, enabling mtDNA repair.

Tags: Acute respiratory distress syndrome
Biomarker
Biopharmaceutical
Inventors: Agustin Hidalgo Gutierrez
Jonathan Shintaku
Michio Hirano M.D.
Manager: Kristin Neuman
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2024-11-08
Collections: Rare Disease

Restoring cerebellar circuit function to treat ataxia

CU26133

Restores CF-PC synapse function to normalize cerebellar rhythm, alleviating ataxia by repairing circuit defects.

Tags: Alpha wave
Ataxia
Biomarker
Inventors: Sheng-Han Kuo
Manager: Jerry Kokoshka
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2026-01-08