Hybrid nanoporous membrane for enhanced filtration and fluid flowCU22071Hybrid nanoporous membrane blends polymer layers with nanospikes for efficient nanoscale filtration, flow, and biofunctional manipulation.TagsCatalysisCell cultureFiltrationInventorsKam LeongLetao YangManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-07-09
Manganese oxide nanoparticles for cell-free nucleic acid scavengingCU22060Anionic manganese oxide nanoparticles scavenge cell-free nucleic acids to reduce inflammation with low toxicity and biodegradability.TagsApoptosisBiodegradationInflammationInventorsKam LeongYiling ZhongManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-08-14
PAMAM nanoparticle for chemotherapy delivery to reduce metastasis and cognitive impairmentCU22225PAMAM nanoparticles deliver chemotherapy while scavenging cell-free nucleic acids to reduce metastasis and cognitive impairment.TagsBreast cancerChemotherapyCognitive deficitInventorsKam LeongDivya BhansaliHongxia WangManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-04-24
Orally administered drug with extended release for obesity treatmentCU23375Oral, extended-release nanoparticle drug LIGNOCAL delivers lipocalin-2 to suppress appetite, boost metabolism, and aid obesity/diabetes treatment.TagsAnorecticBioavailabilityBiological half-lifeInventorsKam LeongJessica DeAngelisStavroula KousteniManagerJerry KokoshkaDepartmentsBiomedical EngineeringHerbert and Florence Irving Center for Clinical ResearchPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-11-26
Programmable nanoencapsulation for probiotic deliveryCU21284Programmable nanoencapsulated probiotics boost cancer therapy safety and efficacy by tunable, immune-evasive bacterial delivery.TagsBacteriaBacterial capsuleBiomaterialInventorsKam LeongJaeseung HahnTal DaninoManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-01-30CollectionsOncology
Enhanced lipid nanoparticles with improved RNA deliveryCU26135PBA-conjugated lipid nanoparticles boost RNA delivery by enhanced endosomal escape and cytosolic release, enabling targeted therapies.TagsAcidCytosolEndosomeInventorsKam LeongVeronica FaragManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-05-07
PEG-SSRI conjugate for localized treatment of inflammatory bowel diseaseCU25441PEG-FLX conjugate enables oral, localized anti-IBD therapy with prolonged intestinal retention and reduced systemic exposure.TagsAnti-inflammatoryBioavailabilityDiseaseInventorsKam LeongChuanxu ChengHanyao HuangManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-04-21
Scalable, high-throughput drug delivery platform using cell-membrane coating technology for nanoparticlesCU20253Rapid, scalable membrane-coated nanoparticle production via flash nanocomplexation enables uniform biomimetic drug/gene delivery carriers.TagsBiomaterialBiomimeticsCell membraneInventorsKam LeongHanze HuManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-07-16CollectionsPlatform/Research Tool
Nucleic acid scavengers to reduce inflammationCU17078Nucleic acid scavengers bind extracellular nucleic acids to dampen pathogenic inflammation while preserving normal immune function.TagsAcidAssayAutoimmune diseaseInventorsKam LeongBo PengWei LeongManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-02-23
Multifunctional nanoparticles as an anti-inflammatory agent for sepsis and inflammatory diseasesCU22285Multifunctional tannic acid–Zn2+–gentamicin nanoparticles target multiple sepsis mediators to reduce inflammation and mortality.TagsAcidAntibioticCirrhosisInventorsKam LeongDan ShaoFeng LiuManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-04-12
Nanoparticle system for targeted cancer treatmentCU21031Targeted scavenging nanoparticles deliver non-opioid cancer therapy and pain relief, reducing inflammation and metastasis.TagsCancerChemotherapyDrug resistanceInventorsKam LeongDivya BhansaliTianyu LiManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-05-01CollectionsOncology
DNA-templated micelle system for delivery of therapeutic agentsCU18276DNA-templated PEG micelles enable co-delivery of diverse cargos (siRNA, gRNA, mRNA, drugs) to tumors with improved control and consistency.TagsAngiogenesisAutoimmune diseaseCRISPRInventorsKam LeongSmruthi SuryaprakashTzu-Chieh HoManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2019-10-25CollectionsOncology
DNA-templated micelle system for delivery of therapeutic agentsCU17119DNA-templated micelles enable co-delivery of diverse therapeutics (drugs, RNAs) with improved batch consistency and targeting.TagsAngiogenesisChemotherapyCurcuminInventorsKam LeongTzu-Chieh HoYeh-Hsing LaoManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-07-10
Serotonin targeting in the gut to treat anxiety and depressionCU21281Gut-targeted serotonin modulation offers safer, pregnancy-safe mood disorder treatment with fewer systemic side effects.TagsAttention deficit hyperactivity disorderBreastfeedingCentral nervous systemInventorsKam LeongKara MargolisMark AnsorgeManagerDovina QuDepartmentsBiomedical EngineeringPediatricsPsychiatryDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2021-04-16CollectionsCNS/NeurologyWomen's Health
