Immature myeloid cell activation pathway in inflammation-linked cancerCU26121IL-8–driven immature myeloid cell mobilization fuels inflammation-linked GI cancer; targets IMCs for therapy and biomarkers.TagsInflammationAngiogenesisBiomarkerInventorsTimothy Wang M.D.ManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Non-invasive laser therapy for cytokine modulation and corneal inflammation managementCU18315Femtosecond laser therapy non-invasively modulates corneal cytokines to reduce inflammation and keratocyte apoptosis, preserving tissue.TagsInflammationAnalgesicAntibioticInventorsSinisa VukelicManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-08-17CollectionsOphthalmology
Recombinant protein to treat inflammationCU23248Recombinant FSTL-1 protein targets and reduces cardiac inflammation, aiding Kawasaki disease research and myocarditis treatment.TagsInflammationAnti-inflammatoryAtherosclerosisInventorsMark GorelikManagerSara GusikDepartmentsPediatrics/RheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-10CollectionsCardiovascular
Modulating inflammation by altering 3’ Untranslated Region (3’ UTR) lengthCU23300Modulates inflammation by lengthening 3’ UTRs to control immunogenic dsRNA, enabling tunable neuroinflammation therapies and cancer immunotherapy.TagsInflammationCancer immunotherapyHomeostasisInventorsHachung ChungHeegwon ShinTyler DorrityManagerJerry KokoshkaDepartmentsMicrobiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-07-01CollectionsOncologyCNS/Neurology
Selective COX-2 radioligands for PET imaging of neuroinflammationCU19254Fluorine-18 COX-2 PET radioligands enable noninvasive imaging of neuroinflammation with higher affinity and broad clinical reach.TagsInflammationAgonistCOX-2 inhibitorInventorsAkiva MintzJ. John MannJ.S. Dileep KumarManagerJerry KokoshkaDepartmentsPsychiatryRadiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-12-17
Purine receptor blockade for treating hemorrhagic shockCU25052Purine receptor blockers (P2X4/P2X7) target shock-induced organ injury, reducing inflammation and preventing multi-organ failure.TagsInflammationChronic painHypovolemiaInventorsGeorge HaskoTaha KelestemurManagerKristin NeumanDepartmentsAnesthesiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-19CollectionsImmunology & Inflammation
Conditional depletion of WDFY3 in murine models of diseaseCU26144Engineered mouse with conditional WDFY3 knockout to study autophagy, mitophagy, efferocytosis, and neurodegenerative disease mechanisms.TagsInflammationAmino acidAutism spectrumInventorsAi YamamotoManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08CollectionsCNS/Neurology
Convection-enhanced delivery of topotecan and dexamethasone for malignant gliomasCU25031Implantable pump enables chronic, targeted brain delivery of topotecan plus dexamethasone via convection-enhanced delivery for glioma.TagsInflammationAdjuvant therapyAnimal disease modelInventorsJeffrey BrucePeter CanollManagerJerry KokoshkaDepartmentsNeurological SurgeryPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-29
IL-6 Inhibitor for acute inflammatory disordersCU24063Synthetic peptide suppressing IL-6 production to treat acute inflammatory conditions like sepsis, endotoxin shock, and cytokine storms.TagsInflammationAntibioticBiopharmaceuticalInventorsKazuya MasudaMoriya TsujiZizhang ShengManagerKristin NeumanDepartmentsAaron Diamond AIDS Research Center (ADARC)MedicineNeuroscienceDivisionsColumbia University Medical Center (CUMC)Zuckerman Mind Brain Behavior InstRelease Date2025-08-21
Targeting EGFR and IL-6 for the treatment of liver fibrosis and insulin resistanceCU23130Targeting Treg-derived amphiregulin–EGFR axis and IL-6 to treat liver fibrosis and insulin resistance in MASH.TagsInflammationBiomarkerCrosstalkInventorsNicholas ArpaiaThomas SavageManagerCynthia LangDepartmentsMicrobiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-24
Botanical formulation for rapid and natural acne treatmentCU19343A natural botanical topical gel rapidly treats acne, targets bacteria, reduces side effects, and works across cleansers and lotions.TagsInflammationAcidAcneInventorsChathuranga C. De SilvaShanta M. Modak Ph.D.ManagerCynthia LangDepartmentsChemical Engineering/Applied ChemistrySurgeryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-01-02
Multiplexed T cell profiling for generating engineered regulatory T cell therapiesCU23310High-throughput platform maps patient TCR–antigen pairs to create CRISPR‑engineered, autologous Tregs for precise local immune suppression.TagsInflammationAmyotrophic lateral sclerosisAntigenInventorsElizabeth M. BradshawNeil ShneiderRyan HobsonManagerJoan MartinezDepartmentsMolecular MedicineNeurologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-01-02
Screwless, patient-specific cranial implant for neural accessCU22306Screwless, patient-specific 3D-printed titanium cranial implants provide broad neural access, improve stability, and reduce invasiveness.TagsInflammation3D printingBiomechanicsInventorsAlexander KellElias IssaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2024-12-30
Exogenous Rac1 analogs to treat acute lung injuryCU23206Exogenous activated Rac1 (V12Rac1) protects lungs from ALI/ARDS by stabilizing actin and blocking proinflammatory signaling.TagsInflammationActinAcute respiratory distress syndromeInventorsFrancine KatzGalina GusarovaJahar BhattacharyaManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-26
Microneedle for eye injection surgeryCU24034Minimally invasive ophthalmic microneedle enables precise subretinal/intravascular injections, improving retinal safety and targeting.TagsInflammationArteryBirth defectInventorsAhmet HondurAnil LalwaniAykut AksitManagerDovina QuDepartmentsMechanical EngineeringOphthalmologyOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-12-12
Engineered probiotic for treating inflammatory conditionsCU24105Engineered probiotic delivers gut-targeted anti-inflammatory peptides, promoting barrier repair and tissue regeneration for IBD and related conditions.TagsInflammationAbdominal painCircadian rhythmInventorsCarlotta RondaHarris WangLeonie BrockmannManagerCynthia LangDepartmentsPathology & Cell BiologySystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08
cGAS inhibitor for robust anti-tumor immunity activationCU23316Bioavailable, chemically modified cGAS inhibitors enhance oral bioavailability to boost anti-tumor immunity via the cGAS–STING pathway.TagsInflammationAminopeptidaseAutoimmune diseaseInventorsBenjamin Izar MD, PhDDonald William Landry MD, Ph.D.Lindsay CaprioManagerJoan MartinezDepartmentsMedicineProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2024-09-26
Method to augment efferocytosis for treatment of autoimmune diseasesCU23287Augments macrophage efferocytosis by activating WDFY3 to reduce autoimmune inflammation across multiple diseases.TagsInflammationApoptosisAsthmaInventorsAi YamamotoHanrui ZhangKatherine R. CroceManagerKristin NeumanDepartmentsCardiologyMedicinePathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05
Inhalation device for targeted therapeutic delivery to the throatCU23297A portable, disposable inhaler delivering nebulized natural therapeutics to the larynx with precise 10–35 micron particles.TagsInflammationDisposable productDrug deliveryInventorsMichael Pitman MDManagerCynthia LangDepartmentsOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05
Targeted pharmacological agents for the prevention of multiple organ failure in hemorrhagic shock patientsCU23263Localized anti-inflammatory CD39/CD73 therapy to prevent multi-organ failure in hemorrhagic shock by targeted adenosine production.TagsInflammationAdenosineAdenosine receptorInventorsGeorge HaskoTaha KelestemurManagerKristin NeumanDepartmentsAnesthesiologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-04-25CollectionsOncologyImmunology & Inflammation
Small scale screening bioreactor with airway tissues and mucosa for the progression and treatment of lung diseaseCU23307Bioreactor recreating mucus-lined airways ex vivo for real-time, high-throughput modeling and therapeutic screening.TagsInflammationBiomimeticsBioreactorInventorsGordana Vunjak-NovakovicJinho KimKeith YeagerManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-04-08
Bioengineered human bone marrow model for drug discoveryCU22388Engineered 3D human bone marrow from iPSCs enables personalized, in vitro drug screening for hematologic diseases and toxicity.TagsInflammationAnemiaBone marrowInventorsAdolfo A. Ferrando M.D., Ph.D.Daniel Naveed TavakolGordana Vunjak-NovakovicManagerCynthia LangDepartmentsBiomedical EngineeringInstitute for Cancer GeneticsPediatricsDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-02-27CollectionsOncology
Hip implant for securement to the femur of a subject with applications to other jointsCU23044Patient-specific, minimally invasive reversible hip implant that anchors without bone penetration; applicable to other joints.TagsInflammationBoneBone remodelingInventorsAlexander KellElias IssaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2024-01-02CollectionsMedical Device
Nanofibrous scaffold for controlled release of small molecule immunomodulatorsCU24040Nanofibrous scaffold locally releases ACHP to inhibit NF-kB, enabling targeted immunomodulation with reduced systemic effects.TagsInflammationAutoimmune diseaseBiomaterialInventorsFereshteh ZandkarimiHannah ChildsHelen Lu Ph.D.ManagerJoan MartinezDepartmentsBiological SciencesBiomedical EngineeringDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-12-18CollectionsSmall Molecule
Selective serotonin reuptake inhibitors (SSRIs) for treatment of COPDCU21249SSRI-based MMP-1 inhibition slows COPD progression; oral/inhaled delivery reduces cigarette-smoke–driven lung damage and inflammation.TagsInflammationBronchodilatorChronic obstructive pulmonary diseaseInventorsJeanine D'ArmientoManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-07-14CollectionsSmall Molecule
Truncated ATF5, CEBPB, and CEBPD inhibitors for effective cancer treatmentCU21274Short cell-penetrating truncated inhibitors target ATF5/CEBPB/CEBPD, suppressing cancer survival across tumor types.TagsInflammationBreast cancerCancerInventorsJames M. AngelastroLloyd Greene PhDQing ZhouManagerJerry KokoshkaDepartmentsMolecular BiosciencesPathologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-10-31CollectionsOncology
Probiotic scaffolds for COPD prevention and treatmentCU23062Probiotic-infused electrospun scaffolds deliver targeted oral therapy to prevent COPD progression by combating respiratory pathogens.TagsInflammationAdjuvantBronchodilatorInventorsAaron J. MomentHelen Lu Ph.D.Ming Chau ChanManagerJoan MartinezDepartmentsBiomedical EngineeringChemical Engineering/Applied ChemistryDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-05-02
Multifunctional nanoparticles as an anti-inflammatory agent for sepsis and inflammatory diseasesCU22285Multifunctional tannic acid–Zn2+–gentamicin nanoparticles target multiple sepsis mediators to reduce inflammation and mortality.TagsInflammationAcidAntibioticInventorsDan ShaoFeng LiuHuayu TianManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-04-12
Targeted delivery of anti-microRNA for the treatment of liver fibrosisCU21066Liver-targeted exosomes deliver anti-miR-132 to curb fibrosis, reducing collagen and pro-fibrotic signals with tissue specificity.TagsInflammationCell membraneCollagenInventorsAkiva MintzFatemeh Momen-HeraviManagerJoan MartinezDepartmentsCollege of Dental MedicineRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-02
Immunosuppressant for treating inflammatory and autoimmune diseasesCU21025A novel immunosuppressant blocks T cell expansion to treat organ transplant rejection and autoimmune/inflammatory diseases.TagsInflammationEnzymeImmunosuppressive drugInventorsHuihui MaJing Fu Ph.D.Markus MaparaManagerJerry KokoshkaDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-03-23CollectionsSmall Molecule
Ultrafast laser method for tissue crosslinkingCU15164Ultrafast femtosecond laser induces collagen crosslinking non-invasively, improving corneal and cartilage biomechanics for vision and OA.TagsInflammationApoptosisBiomechanicsInventorsSinisa VukelicManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2022-11-14CollectionsOphthalmology
Probiotic-guided CAR-T cell system for targeted cancer immunotherapyCU22211Engineered probiotic-guided CAR-T therapy targets solid tumors, recruiting immune cells and enhancing immunotherapy with tumor-colonizing bacteria.TagsInflammationAutoimmune diseaseCancer immunotherapyInventorsCandice GurbatriJongwon ImNicholas ArpaiaManagerCynthia LangDepartmentsBiomedical EngineeringMicrobiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2022-02-04CollectionsOncology
BCL6 knockout mouse models of lymphoma developmentCU21195BCL6 knockout mice model lymphoma development and germinal center immunity, enabling in vivo studies of BCL6 function.TagsInflammationAlleleAntibodyInventorsRiccardo Dalla-FaveraManagerJoan MartinezDepartmentsPathologyDivisionsColumbia University Medical Center (CUMC)Release Date2021-02-10CollectionsOncology
Master regulators of regulatory T cell tumor infiltrationCU21189Target 17 tumor-regulatory T cell master regulators to selectively modulate infiltration, boosting anti-tumor immunity with CRISPR-validated precision.TagsInflammationCRISPRCancer immunotherapyInventorsAleksandar ObradovicAndrea CalifanoCasey Roy AgerManagerJoan MartinezDepartmentsBiomedical InformaticsMedicineSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2021-02-03CollectionsOncology
Biocompatible polymer to prevent degeneration of bioprosthetic heart valvesCU20085Biocompatible polymer-coated bioprosthetic heart valves reduce serum protein uptake and AGE accumulation, slowing degeneration.TagsInflammationAdsorptionBiomaterialInventorsAntonio FrascaGiovanni FerrariYingfei XueManagerJerry KokoshkaDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2020-12-24CollectionsMedical DeviceCardiovascular
Treatment and prevention of intestinal graft-versus-host disease following HPSC transplantationCU19098GLP-2 analogs strengthen intestinal barriers to prevent/treat GVHD after allogeneic stem cell transplantation, with low toxicity.TagsInflammationAllotransplantationAutoimmune diseaseInventorsRan ReshefManagerJerry KokoshkaDepartmentsOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2020-12-10
Mouse line for inducible tissue specific expression of peroxisome proliferator-activated receptor gammaCU20098Inducible, tissue-specific PPARG expression mouse model with Cre; cross-compatible with any Cre line for diverse disease studies.TagsInflammationFluorescence microscopeGamma rayInventorsCathy L. MendelsohnChyuan-Sheng (Victor) LinTiffany TateManagerJoan MartinezDepartmentsOpthamologyUrologyDivisionsColumbia University Medical Center (CUMC)Release Date2020-02-14CollectionsCNS/Neurology
All-natural mosquito repellent and anti-itch creamCU20052Botanical, non-DEET mosquito repellent and anti-itch cream; all-natural, non-steroidal, skin-friendly, safe for extended use.TagsInflammationCeramideCorticosteroidInventorsChathuranga C. De SilvaShanta M. Modak Ph.D.ManagerCynthia LangDepartmentsChemical Engineering/Applied ChemistrySurgeryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2019-08-19
Imaging tool for early detection of chronic obstructive pulmonary diseasesCU17292Radiolabeled MMP-targeting probe enables CT-based, early COPD detection and monitoring, leveraging existing imaging and noninvasive strategy.TagsInflammationBiomarkerCT scanInventorsJeanine D'ArmientoLynne JohnsonMonica GoldklangManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2019-08-01
Exosomes for the targeted delivery of CRISPR/Cas9 in human gene editingCU20006Exosome-based CRISPR/Cas9 delivery targets gene editing safely in vivo, reducing off-target effects and improving therapy scalability.TagsInflammationAutoimmune diseaseBiologyInventorsFatemeh Momen-HeraviManagerJoan MartinezDepartmentsCollege of Dental MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2019-07-01CollectionsGene Therapy
Nucleic acid scavengers to reduce inflammationCU17078Nucleic acid scavengers bind extracellular nucleic acids to dampen pathogenic inflammation while preserving normal immune function.TagsInflammationAcidAssayInventorsBo PengKam LeongWei LeongManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-02-23
Stem cell-based gene delivery for biological pacemakers1352Biological pacemaker using engineered human mesenchymal stem cells to autonomously regulate heart rhythm without batteries.TagsInflammationArtificial cardiac pacemakerCardiac muscle cellInventorsIra S. CohenMichael Rosen M.D.Peter BrinkManagerJerry KokoshkaDepartmentsAnesthesiologyPharmacologyPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2018-11-30
Analysis of the oral microbiome to non-invasively diagnose and treat Barrett's esophagus and other esophageal disordersCU17016Non-invasive oral microbiome test and antiseptic rinse for diagnosing, preventing, and treating Barrett’s esophagus and related esophageal diseases.TagsInflammationAntisepticEsophageal cancerInventorsJulian AbramsManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2018-08-20
Small molecule therapeutics for the treatment of asthmaCU17169GABAAR alpha-4 targeted positive allosteric modulators relax airways with fewer CNS side effects for asthma.TagsInflammationAdrenergic receptorAsthmaInventorsAlexander E. ArnoldCharles W. Emala M.D.Gloria S. ForkuoManagerSara GusikDepartmentsAnesthesiologyDivisionsColumbia University Medical Center (CUMC)Release Date2018-07-10CollectionsSmall Molecule
Implantable, flexible, wireless chip for in vivo recording and stimulation of the brainCU17269A fully implanted, flexible, wireless brain chip delivering high-density, long-term surface recording and stimulation with no wires.TagsInflammationCMOSDevelopment of the nervous systemInventorsDavid TsaiJonathan David TerryKenneth ShepardManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-07-10CollectionsCNS/Neurology
Herbal tincture to relieve IBS symptomsCU18088Herbal tincture blends eight Chinese herbs to ease IBS symptoms—pain, bloating, and inflammation—FDA-studied, natural relief.TagsInflammationAbdominal painBloatingInventorsMarc BrodskyManagerMaria RahmanyDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2018-05-30
Nanoparticles for targeted delivery of anti-inflammatory agentsCU13129Biodegradable targeted nanoparticles deliver inflammation-resolving drugs to atherosclerotic plaques, reducing systemic side effects and boosting efficacy.TagsInflammationArthritisAsthmaInventorsGabrielle FredmanIra Tabas MD, PhDNazila KarmalyManagerJoan MartinezDepartmentsAnesthesiologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2018-05-11
Flexible implantable probe for large-scale wireless neural stimulation and recordingCU15023A flexible, wireless, battery-free CMOS neural probe enabling large-scale, high-density brain stimulation and recording with minimal tissue disturbance.TagsInflammationBrainCMOSInventorsDavid TsaiHongki KangKenneth ShepardManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-04-07
Prediction of post-heart transplant primary graft dysfunction using exosome proteinsCU18316Pre-transplant exosome protein panel predicts post-heart graft dysfunction risk, enabling better stratification and management.TagsInflammationAlgorithmAllotransplantationInventorsBarry FineNicholas P. TatonettiNicolas GiangrecoManagerKristin NeumanDepartmentsBiomedical InformaticsMedicineSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2018-04-02CollectionsPlatform/Research ToolMedical DeviceCardiovascular
Therapeutic targets for preventing non-alcoholic fatty liver diseaseCU16179Targeting hepatocyte TAZ to prevent or reverse early-stage NASH, reducing inflammation, death, and fibrosis.TagsInflammationCirrhosisFatty liver diseaseInventorsIra Tabas MD, PhDXiaobo WangManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2018-03-01
