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Pathology
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Conditional knockout mouse model for the Phf6 gene
CU22370
A tissue-specific Phf6 conditional knockout mouse model for studying Börjeson-Forssman-Lehmann syndrome and hematologic cancers.
Tags
Acute myeloid leukemia
Gene
High-throughput screening
Inventors
Adolfo A. Ferrando M.D., Ph.D.
Teresa Palomero Vasquez
Manager
Joan Martinez
Departments
Pathology
Institute for Cancer Genetics
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2022-08-20
SUMO2 conjugation therapy for restoring cognitive function in Alzheimer's disease
CU23265
SUMO2-based biologic restores synaptic function and memory in Alzheimer's without reducing amyloid, enabling late-stage cognitive recovery.
Tags
Adjuvant therapy
Amyloid beta
Blood–brain barrier
Inventors
Luana Fioriti Ph.D.
Ottavio Arancio
Paul Edward Fraser
Manager
Jerry Kokoshka
Departments
Pathology
Mortimer B. Zuckerman Mind Brain Behavior Institute
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-06-26
Treatment for Alzheimer's Disease-related memory loss
CU13335
Selective PDE4D inhibitors improve AD memory with fewer side effects, offering low-dose, targeted cognitive benefits.
Tags
Amyloid beta
Brain
Cerebral cortex
Inventors
Ernesto Fedele
Jos Prickaerts
Mauro Fa
Manager
Jerry Kokoshka
Departments
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2018-05-11
Use of intratracheally administered hyaluronic acid to ameliorate emphysema
428
Intratracheal hyaluronic acid protects elastic fibers, slowing lung disease progression and offering a prophylactic, elasticity-preserving therapy.
Tags
Aorta
Arthritis
Asthma
Inventors
Jerome Cantor
Manager
Sara Gusik
Departments
Pathology
Divisions
Columbia University Medical Center (CUMC)
Restoration of retromer complex in neurodegenerative diseases via transcriptional regulator
CU18398
Target CREB3L2-ATF4 complex to restore retromer function, slowing neurodegenerative progression in AD/PD.
Tags
Drug development
Endosome
Gene
Inventors
Claudio Andre Gouveia Martins Roque
Jimena Baleriola
Ulrich Hengst
Manager
Jerry Kokoshka
Departments
Pathology
Taub Institute
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-03-03
Collections
Small Molecule
CNS/Neurology
Preclinical models of angioimmunoblastic T-cell lymphoma for therapeutic investigation
CU23322
RhoA G17V-driven mouse model of angioimmunoblastic T-cell lymphoma enables translational drug screening and pathogenesis study.
Tags
Cancer cell
Chemotherapy
Gene expression
Inventors
Adolfo A. Ferrando M.D., Ph.D.
Teresa Palomero Vasquez
Manager
Joan Martinez
Departments
Pathology
Institute for Cancer Genetics
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2023-06-15
Collections
Oncology
Small molecule inhibitor of cognitive impairment associated with neurodegenerative disease
CU23096
Small molecule minaprine analog targets 5-HT2B to curb cognitive/behavioral deficits in neurodegenerative diseases, including Alzheimer's.
Tags
5-HT receptor
5-HT2B receptor
Amyloid beta
Inventors
Daniel M. Watterson
Erica Acquarone
Ottavio Arancio
Manager
Jerry Kokoshka
Departments
Pathology
Pharmacology
Taub Institute
Divisions
Columbia University Medical Center (CUMC)
Feinberg School of Medicine
Release Date
2025-04-10
BCL6 knockout mouse models of lymphoma development
CU21195
BCL6 knockout mice model lymphoma development and germinal center immunity, enabling in vivo studies of BCL6 function.
Tags
Allele
Antibody
Coding region
Inventors
Riccardo Dalla-Favera
Manager
Joan Martinez
Departments
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2021-02-10
Collections
Oncology
Modified cell-penetrating ATF5 protein to inhibit cancer cell growth
CU18385
Modified ATF5 peptide blocks cancer survival proteins (CEBPB/CEBPD/CCDC6), inducing cancer cell death; potential targeted therapy.
Tags
Breast cancer
Cancer
Cell growth
Inventors
James M. Angelastro
Lloyd Greene PhD
Xiaotian Sun
Manager
Jerry Kokoshka
Departments
Pathology
Molecular Biosciences
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2019-08-02
Collections
Oncology
High-affinity RAGE fusion proteins for treating RAGE-mediated pathologies
Proxy35
RAGE fusion proteins selectively block RAGE-ligand interactions, potentially reducing oxidative stress and inflammation in multiple diseases.
Tags
Arteriosclerosis
Biological half-life
Cardiovascular disease
Inventors
Adnan Mjalli
Ann Marie Schmidt M.D.
David Mark Stern M.D.
Manager
Jerry Kokoshka
Departments
Pathology
Dean's Office
Surgery
Divisions
Columbia University Medical Center (CUMC)
Release Date
2018-10-20
Specific inhibition of caspase-2 activation for the treatment of neurodegenerative diseases
CU12019
Membrane-penetrable hexapeptide selectively blocks caspase-2-RAIDD, halting neuron death for neurodegenerative therapies.
Tags
Amyotrophic lateral sclerosis
Caspase
Cell membrane
Inventors
Carol M. Troy MD, PhD
Manager
Jerry Kokoshka
Departments
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2015-12-09
Natural extracts to treat or prevent neurological and neurodegenerative disorders
1630
High-concentration ginseng dammaranes inhibit amyloid-beta production, enabling synthetic, natural-derived treatments for neurodegenerative diseases.
Tags
Amyloid beta
Amyotrophic lateral sclerosis
Apoptosis
Inventors
Donald William Landry
Shi-xian Deng
Tae-Wan Kim Ph.D.
Manager
Jerry Kokoshka
Departments
Pathology
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2010-10-26
Protein fragment to promote neurogenesis
CU13345
Dominant-negative ATF5 fragment drives differentiation of neuroprogenitors into mature neurons and glial cells, enabling brain regeneration research.
Tags
Astrocyte
Cellular differentiation
Central nervous system
Inventors
James M. Angelastro
Lloyd Greene PhD
Manager
Jerry Kokoshka
Departments
Pathology
Molecular Biosciences
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-01-13
TLX1 mouse model recapitulates clinical symptoms of T cell acute lymphoblastic leukemia
CU23147
TLX1 transgenic mouse models human T-ALL, mirroring clinical progression to study pathogenesis, microenvironment, and drug responses.
Tags
Acute lymphoblastic leukemia
Aneuploidy
Aortic dissection
Inventors
Adolfo A. Ferrando M.D., Ph.D.
Teresa Palomero Vasquez
Manager
Joan Martinez
Departments
Pathology
Institute for Cancer Genetics
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2023-04-15
Collections
Oncology
Therapeutic phosphodiesterase type 5 (PDE5) inhibitors
CU12089
PDE5 inhibitors with a novel benzonaphthyridine scaffold cross the blood-brain barrier to enhance memory, aiding Alzheimer’s therapy.
Tags
Amyloid beta
Apoptosis
Blood–brain barrier
Inventors
Donald William Landry MD, Ph.D.
Jole Fiorito
Ottavio Arancio MD, PhD
Manager
Jerry Kokoshka
Departments
Pathology
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-01-04
Collections
Small Molecule
CNS/Neurology
Lecithin cholesterol acyltransferase (LCAT) lipid activators for prevention and treatment of neurodegeneration
CU20145
LCAT-activating lipids aim to restore brain lipid metabolism, potentially slowing neurodegeneration and offering broad neurological disease applications.
Tags
Acyltransferase
Amyloid
Apolipoprotein E
Inventors
Laura Beth Johnson McIntire
Manager
Jerry Kokoshka
Departments
Pathology
Divisions
College of Physicians and Surgeons (CUMC
Release Date
2023-08-04
Collections
Small Molecule
CNS/Neurology
Conditional knockout mouse model to study genomic instability of BRCA1 mutations
CU23027
Inducible BRCA1 exon 2 knockout mouse model to study BRCA1-related genomic instability, tumorigenesis, and therapy screening.
Tags
Ablation
Allele
BRCA1
Inventors
Foon Wu-baer
Richard Baer Ph.D.
Manager
Joan Martinez
Departments
Pathology
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Release Date
2022-10-10
Collections
Oncology
Women's Health
Unique human phenotype to define novel gene function for OCRL1
CU22138
Neuron-specific OCRL1 variant model reveals brain-focused mechanisms in Lowe syndrome; enables targeted therapies, diagnostics, drug screening.
Tags
Cataract
Cell membrane
Cilium
Inventors
Barbara Corneo
Cecilia Sena
Charles LeDuc
Manager
Cynthia Lang
Departments
Pathology
Pediatrics
Rehabilitation & Regenerative Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-03-03
Collections
Rare Disease
CNS/Neurology
Conditional mouse model for the BARD1 gene
CU23026
A conditional Bard1 mouse model enables tissue-specific gene knockout to study BRCA1/BARD1 cancer risk and therapy.
Tags
Allele
BRCA1
Breast cancer
Inventors
Foon Wu-baer
Richard Baer Ph.D.
Manager
Joan Martinez
Departments
Pathology
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Release Date
2022-10-10
Collections
Oncology
Women's Health
Spatial sequencing platform for studying microbiome community structure
CU16351
A spatial metagenomics platform preserving microbial community structure for high-resolution sequencing and mapping microbe interactions.
Tags
Antibody
DNA sequencing
Fluorescence in situ hybridization
Inventors
Harris Wang
Ravi Sheth
Manager
Cynthia Lang
Departments
Pathology
Systems Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2022-07-22
Collections
Platform/Research Tool
Monoclonal Antibody Enhancing T Cell Reactivity in AIDS Treatments
2842
Monoclonal antibody boosts T cell reactivity, enhancing HIV/AIDS immunotherapy and broader immune responses.
Tags
AIDS
Antibody
Antigen
Inventors
Nicole Suciu-Foca
Manager
Sara Gusik
Departments
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-04-15
Diagnostic Testing of MUM-1, MUM-2 Chromosomal Abnormalities for Multiple Myleloma
611
Prognostic diagnostic method detects MUM-1/MUM-2 chromosomal rearrangements in multiple myeloma via DNA hybridization probes.
Tags
Antibody
Chromosomal translocation
Chromosome 14
Inventors
Riccardo Dalla-favera M.D.
Manager
Joan Martinez
Departments
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2010-05-18
Caspase-2 inhibitors for treating neurodegenerative diseases
CU23390
Non-invasive, selective caspase-2 inhibitors block neurodegeneration, preventing synapse loss and cognitive decline in Alzheimer's models.
Tags
Active site
Amyloid beta
Axon
Inventors
Carol M. Troy MD, PhD
Claire W. Chen
Etienne Jacotot
Manager
Jerry Kokoshka
Departments
Pathology
Pathology & Cell Biology
Taub Institute
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Release Date
2023-11-17
Collections
CNS/Neurology
Treatment for obesity and obesity-related diseases
CU13074
Notch1 decoy therapy lowers liver glucose, fat, and insulin resistance, offering obesity, T2D, NAFLD, and cancer protection.
Tags
Blood sugar level
Cancer
Cardiovascular disease
Inventors
Domenico Accili M.D.
Jan Kitajewski
Utpal Pajvani
Manager
Cynthia Lang
Departments
Pathology
Medicine
Divisions
Columbia University Medical Center (CUMC)
Naomi Berrie Diabetes Center
Release Date
2016-04-22
In vitro establishment of AIDS-related lymphoma cell lines
2953
In vitro AIDS-NHL cell lines (HBL-1, HBL-2, HBL-3) enable study of HIV-related lymphomagenesis and drug/antiviral responses.
Tags
B cell
Bone marrow
Disease
Inventors
Riccardo Dalla-Favera
Manager
Joan Martinez
Departments
Pathology
Release Date
2011-08-12
Mouse Model to Study Gene Cluster in Chronic Lymphocytic Leukemia and Cell Cycle Progression
2807
Conditional knockout mouse model deleting DLEU2/miR-15a/16-1 cluster recapitulates full human CLL pathogenesis for research and therapy testing.
Tags
Apoptosis
B cell
Cancer cell
Inventors
Riccardo Dalla-Favera
Ulf Klein
Manager
Joan Martinez
Departments
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-06-24
Specialized diet for enhanced cancer treatment
CU21118
Amino acid-restricted diet enhances chemotherapy/radiation efficacy by selectively targeting cancer cells while maintaining energy needs.
Tags
Amino acid
Chemotherapy
Glioma
Inventors
Brent Stockwell
Dominique Higgins
Jeffrey Bruce
Manager
Jerry Kokoshka
Departments
Pathology
Biological Sciences
Neurological Surgery
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2020-11-05
Collections
Oncology
Automated pathological imaging and detection of cancer
CU20175
High-speed OCT with AI enables automated, high-resolution breast tissue analysis for rapid cancer detection and margin assessment.
Tags
Anatomy
Artificial intelligence
Breast cancer
Inventors
Christine P. Hendon
Diana Mojahed
Hanina Hibshoosh
Manager
Dovina Qu
Departments
Pathology
Biomedical Engineering
Electrical Engineering
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2020-09-22
Collections
Oncology
Medical Device
Women's Health
Overcoming drug resistance in relapsed T-ALL patients
CU13051
Mutated NT5C2 inhibitors counteract nucleoside-analog resistance in relapsed T-ALL, enabling first-line therapies and broader applicability.
Tags
Acute lymphoblastic leukemia
Acute myeloid leukemia
Cancer cell
Inventors
Adolfo A. Ferrando M.D., Ph.D.
Raul Rabadan
Teresa Palomero Vasquez
Manager
Joan Martinez
Departments
Pathology
Biomedical Informatics
Institute for Cancer Genetics
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2013-09-03
A preclinical Gba p.E326K mouse model for precision-medicine research
CU23198
CRISPR-generated Gba p.E326K mouse model for Gaucher, PD, and DLB research; enables biomarker discovery and preclinical drug testing.
Tags
Biomarker
Cognitive deficit
Dementia
Inventors
Lorraine Clark
Manager
Kristin Neuman
Departments
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-03-17
Collections
CNS/Neurology
Platform/Research Tool
Mouse line as a model for Peripheral T-cell Lymphoma with GATA3+ features
CU23321
Mouse model for Vav1-Myof1-driven Peripheral T-cell Lymphoma (GATA3+) enabling targeted therapy screening and pathogenesis study.
Tags
CD4
Carcinogenesis
Genetic testing
Inventors
Adolfo A. Ferrando M.D., Ph.D.
Teresa Palomero Vasquez
Manager
Joan Martinez
Departments
Pathology
Institute for Cancer Genetics
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2023-06-15
Collections
Oncology
Phosphoinositide modulation for treatment of neurodegenerative diseases
2240
Modulating phosphoinositide lipids to reduce amyloid-β toxicity; potential therapeutics for Alzheimer's and other neurodegenerative diseases.
Tags
Amyloid beta
Down syndrome
High-throughput screening
Inventors
Diego Berman
Gilbert Di Paolo
Laura Beth Johnson McIntire
Manager
Jerry Kokoshka
Departments
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2018-10-20
Inhibition of circadian regulation or mTOR complex increases immunity against bacterial infection
CU16116
Inhibiting mTORC2 and adjusting circadian rhythm enhances immunity, offering host-targeted therapy against multidrug-resistant bacterial infections.
Tags
Antimicrobial resistance
Apoptosis
Cancer
Inventors
Julie Canman
Matthew Ulgherait
Michele M. Shirasu-Hiza
Manager
Kristin Neuman
Departments
Pathology
Genetics & Development
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2017-05-05
AVPR1A blockade for the treatment of social isolation-induced anxiety in females
CU21294
AVPR1A-targeted therapy reduces social isolation-induced anxiety in females by modulating AVP signaling in the amygdala.
Tags
Amygdala
Estrogen receptor
Genetically modified mouse
Inventors
Lori M. Zeltser
Marie Louise Pascale Jocelyna Francois
Manager
Kristin Neuman
Departments
Pathology
Pediatrics
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Release Date
2024-08-22
Conditional Ctip-co mouse strain for studying DNA resection
CU23028
A conditional CtIP knockout mouse model enables full inactivation studies of DNA resection, cancer development, and therapy screening.
Tags
Allele
Cancer
Carcinogenesis
Inventors
Foon Wu-baer
Richard Baer Ph.D.
Manager
Joan Martinez
Departments
Pathology
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Release Date
2022-10-10
Collections
Oncology
Transgenic T cells for Lymphoblastic Leukemia
1894
Transgenic CUTLL1 T-ALL model enables testing NOTCH1-targeted therapies and gamma-secretase inhibitors for pediatric leukemia.
Tags
Cancer
Chromosomal translocation
Drug development
Inventors
Adolfo A. Ferrando
Julia L. Glade Bender
Teresa Palomero Vasquez
Manager
Joan Martinez
Departments
Pathology
Institute for Cancer Genetics
Pediatrics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-05-12
Cancer Treatment with Notch-based Fusion Proteins
1530
Notch-receptor fusion biologics inhibit tumor angiogenesis and differentiation, offering standalone or combination cancer therapy with novel delivery.
Tags
Angiogenesis
Bevacizumab
Blood vessel
Inventors
Carrie Shawber
Jan Kitajewski
Yasuhiro Funahashi
Manager
Sara Gusik
Departments
Pathology
Obstetrics & Gynecol
Divisions
Columbia University Medical Center (CUMC)
Release Date
2009-05-20
Cysteine protease inhibitors to treat traumatic brain injury and Alzheimer's disease
CU12222
Potent, selective epoxide-based calpain-1 inhibitors ( NYC438/ NYC488 ) restore memory and synaptic function in AD and TBI models.
Tags
Cysteine protease
Enzyme inhibitor
Epoxide
Inventors
Gregory R.J. Thatcher
Isaac Schiefer
Mauro Fa
Manager
Jerry Kokoshka
Departments
Pathology
Medicinal Chemistry & Pharmacognosy
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2019-04-29
Collections
Small Molecule
CNS/Neurology
Method to target valproic acid treatment for the negative symptoms of psychiatric disorders using pharmacogenomics
CU15242
Personalized valproic acid therapy: predict response via circulating proline and COMT genotype to target treatment and reduce negative symptoms.
Tags
Bipolar disorder
Catechol-O-methyltransferase
Enzyme
Inventors
Catherine Clelland
Manager
Kristin Neuman
Departments
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2016-09-09
Stem cells and stem cell-derived neurons as a model for studying Alzheimer's Disease
2917
Renewable mouse embryonic stem cell–derived neurons model Alzheimer's pathology for high-throughput drug screening and target discovery.
Tags
Amyloid beta
Assay
Drug discovery
Inventors
Laura Beth Johnson McIntire
Natalie Landman
Tae-Wan Kim Ph.D.
Manager
Jerry Kokoshka
Departments
Pathology
Neurobiology
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Release Date
2016-04-22
BCL-6 gene and antibody for lymphoma diagnosis
381
Targeted BCL-6 biomarker-based lymphoma diagnostics and companion immunotherapies to improve accuracy and reduce treatment side effects.
Tags
Antibody
Assay
B cell
Inventors
Raju S. K. Chaganti
Riccardo Dalla-favera M.D.
Manager
Joan Martinez
Departments
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2010-11-18
Thiazolide treatment for Alzheimer's and other neurodegenerative diseases
CU18297
FDA-approved antivirals crossing blood-brain barrier may lower tau protein, offering potential Alzheimer's and tauopathy therapy.
Tags
Ablation
Antiviral drug
Blood–brain barrier
Inventors
Gina Finan
Tae-Wan Kim Ph.D.
Manager
Jerry Kokoshka
Departments
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2019-08-01
Collections
Small Molecule
CNS/Neurology
Methods for diagnosis and treatment of neuropsychiatric disorders
2789
Genetic GCH1 assay guides diagnosis and personalized treatment for schizophrenia and related neuropsychiatric disorders.
Tags
Allele
Assay
Bipolar disorder
Inventors
Catherine Clelland
Manager
Kristin Neuman
Departments
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2018-09-28
Truncated ATF5, CEBPB, and CEBPD inhibitors for effective cancer treatment
CU21274
Short cell-penetrating truncated inhibitors target ATF5/CEBPB/CEBPD, suppressing cancer survival across tumor types.
Tags
Breast cancer
Cancer
Cancer cell
Inventors
James M. Angelastro
Lloyd Greene PhD
Qing Zhou
Manager
Jerry Kokoshka
Departments
Pathology
Molecular Biosciences
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-10-31
Collections
Oncology
Osteocalcin as a treatment to enhance male fertility
2685
Osteocalcin from bone boosts male fertility by increasing testosterone, testis size, sperm motility, offering cheaper infertility therapy.
Tags
Assisted reproductive technology
Biomarker
Erectile dysfunction
Inventors
Gerard Karsenty
Patricia Ducy
Manager
Jerry Kokoshka
Departments
Pathology
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2016-05-27
Therapeutic activation of circadian-regulated autophagy to increase lifespan and healthspan
CU21009
Therapeutically activates circadian-regulated autophagy to extend lifespan and healthspan without dieting, via ULK1/LC3/AMPK/S6K targets.
Tags
Atherosclerosis
Autophagy
Calorie restriction
Inventors
Julie Canman
Matthew Ulgherait
Michele M. Shirasu-Hiza
Manager
Kristin Neuman
Departments
Pathology
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2020-07-17
Collections
CNS/Neurology
Recombinant ILT3 protein-produced antibodies for immunotherapy treatment of cancer
CU15207
Engineered anti-ILT3 antibodies enable targeted cancer immunotherapy, modulating myeloid signals and enhancing immune blockade.
Tags
Acute myeloid leukemia
Allotransplantation
Antibody
Inventors
George Vlad Ph.D.
Nicole Suciu-Foca
Zheng Xu
Manager
Sara Gusik
Departments
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2023-03-08
Collections
Oncology
Restoring synaptic function to prevent and treat neurodegenerative diseases
CU18018
Tech targets UBE3A to restore synaptic function, offering disease-modifying treatment for AD and other neurodegenerative disorders.
Tags
Amyloid beta
Enzyme
Gene expression
Inventors
Roger Lefort PhD
Manager
Kristin Neuman
Departments
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2019-01-25
Collections
CNS/Neurology
PDE5 inhibitor for Alzheimer's treatment
2439
A brain-penetrant PDE5 inhibitor enhances cGMP signaling, reduces amyloid, and supports synaptic plasticity in Alzheimer’s models.
Tags
Amyloid beta
Amyloid plaques
Blood–brain barrier
Inventors
Donald William Landry MD, Ph.D.
Ottavio Arancio MD, PhD
Shi-xian Deng
Manager
Jerry Kokoshka
Departments
Pathology
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-12-18
Antibody for probing the guanine biosynthesis pathway
CU14353
Monoclonal anti-IMPDH2 antibody labels and studies guanine biosynthesis, enabling cancer cell phenotyping and potential diagnostics/therapy.
Tags
Antibody
Antibody-drug conjugate
Biosynthesis
Inventors
George Vlad
Muyang Li
Nicole Suciu-Foca
Manager
Sara Gusik
Departments
Pathology
Institute for Cancer Genetics
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2014-12-31
