Low-cost microfluidic chip for time-resolved cryo-electron microscopyCU22182Low-cost PDMS microfluidic TR cryo-EM chip enables affordable, modular time-resolved protein studies with rapid spray-plunge vitrification.TagsAdsorptionBiosensorCryogenic electron microscopyInventorsQiao LinJoachim FrankXiangsong FengManagerKristin NeumanDepartmentsBiochemistryBiochemistry & Molecular BiophysicsMechanical EngineeringDivisionsColumbia University Medical Center ( CUMColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-02-16
Graphene field effect transistors for the determination of pH in aqueous environmentsCU15155GFET pH sensor in water uses embedded high-dielectric gate, no external electrodes, low-voltage, photolithography.TagsAcidBiosensorDielectricInventorsQiao LinYibo ZhuManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2016-01-06
Microfluidic based system for purification and extraction of target moleculesM08-036Microfluidic device uses biotin-avidin with RNA aptamers for selective capture, heat or competitive release of target molecules.TagsAnalyteAptamerBiotinInventorsQiao LinChenmui QiuJingyue JuManagerDovina QuDepartmentsChemical Engineering/Applied ChemistryMechanical EngineeringMedicineDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2009-12-23
Calibration-free affinity biosensors for rapid, accurate biomarker detectionCU22223Calibration-free graphene FET biosensor uses aptamer kinetics for rapid, device-wide reproducible biomarker detection without per-sensor calibration.TagsAptamerBiomarkerBiosensorInventorsQiao LinMilan N. Stojanovic M.D.Wenting DaiManagerDovina QuDepartmentsMechanical EngineeringMedicineDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-08-21
Patient-specific aptamer generation for sensitive and noninvasive diagnosis of minimal residual diseaseCU15020Patient-specific microfluidic aptamers enable noninvasive, frequent MRD detection in blood for personalized multiple myeloma monitoring.TagsChemotherapyHigh-throughput screeningMedical diagnosisInventorsQiao LinManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2017-03-02
Microfluidic based system for purification and extraction of target moleculesM07-079Microfluidic device uses biotin-avidin and RNA aptamers for selective capture/release of targets, enabling gentle purification and preconcentration.TagsAnalyteAptamerBiotinInventorsQiao LinThai-Huu NguyenManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2009-12-23
Real-time label-free measurement of vasopressinCU22222Graphene aptamer nanosensor enables real-time, label-free, highly sensitive vasopressin monitoring with rapid results.TagsAptamerAssayBiosensorInventorsQiao LinChao SuMilan N. Stojanovic M.D.ManagerDovina QuDepartmentsMechanical EngineeringMedicineDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-08-21
PDMS microfluidic chip for rapid time-resolved cryo-EMCU19167PDMS microfluidic chip automates rapid sample prep and loading for time-resolved cryo-EM, enabling intermediate-structure capture.TagsCryogenic electron microscopyDrug metabolismEmbryonic developmentInventorsQiao LinJoachim FrankSandip KaledhonkarManagerKristin NeumanDepartmentsBiochemistryBiochemistry & Molecular BiophysicsMechanical EngineeringDivisionsColumbia University Medical Center ( CUMColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-02-17
Graphene aptameric nanosensor for real-time insulin monitoringCU17297Graphene aptameric nanosensor enables real-time insulin monitoring via highly sensitive graphene FET, improving detection to 1 nM.TagsAcidAnalyteElectronic musicInventorsQiao LinZhuang HaoManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-07-10
Aptamer-based graphene nanosensor for monitoring biomolecular interactionsCU17296Aptamer-functionalized graphene nanosensor provides real-time, label-free detection of biomolecular interactions via a microfluidic FET.TagsAnalyteAntibodyAptamerInventorsQiao LinXuejun WangZhuang HaoManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-02-15
A membrane-free system for continuous glucose monitoringCU15153Graphene-polymer membrane-free glucose sensor enables rapid, continuous, highly sensitive monitoring; potential non-invasive, real-time devices.TagsGlucoseGrapheneInsulinInventorsQiao LinYibo ZhuManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2016-01-06
Microfluidic System for Purification and Extraction of Target MoleculesM07-078Microfluidic device uses biotin-avidin and RNA aptamers for selective, thermally controlled capture and release of target molecules.TagsAnalyteAptamerBiotinInventorsQiao LinMilan N. Stojanovic M.D.Renjun PeiManagerDovina QuDepartmentsMechanical EngineeringMedicineDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2009-12-23
A MEMS Based Implantable Glucose SensorM09-071A MEMS implantable glucose sensor uses a reversible glucose-binding polymer to electronically monitor real-time glucose for insulin dosing.TagsBiocompatibilityCompact spaceGlucoseInventorsQiao LinJerome SchultzQian WangManagerDovina QuDepartmentsIndustrial Engineering & Operations ResearchMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2009-09-28
Disposable micro-electromechanical system (MEMS) differential scanning calorimeter (DSC) for thermodynamic characterization of biomoleculesCU13356A disposable MEMS DSC using Kapton microfluidics and Sb-Bi thermopile for high-throughput biomolecule thermodynamics.TagsCalorimeterDisposable productMicroelectromechanical systemsInventorsQiao LinYuan JiaManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2013-06-13
Microdevice for small-scale calorimetric measurementCU15102MEMS microcalorimeter for microliter reactions using AC heating, delivering rapid, high-accuracy thermodynamic data with high throughput.TagsAlternating currentCalorimeterCalorimetryInventorsQiao LinBin WangYuan JiaManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2017-05-04
Temperature-mediated catch-and-release cell sortingM11-113Portable microfluidic aptamer device isolates a target cell type with high specificity and temperature-triggered release for viable, rapid sorting.TagsAptamerCell cultureMedicationInventorsQiao LinJing ZhuRenjun PeiManagerDovina QuDepartmentsMechanical EngineeringMedicineDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2016-01-06
Graphene-based nanosensors for customizable analyte detectionCU14370Graphene nanosensors enable customizable, high-sensitivity analyte detection in aqueous samples, enabling compact, flexible monitoring devices.TagsAnalyteContact lensDielectricInventorsQiao LinManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2017-12-05
MEMS Based Implantable Glucose Sensor for DiabetesM09-072Implantable MEMS glucose sensor enables continuous, real-time monitoring with an electronic readout and insulin-pump integration.TagsBiocompatibilityCompact spaceGlucoseInventorsQiao LinJerome SchultzQian WangManagerDovina QuDepartmentsIEOR - Industrial Engineering & Operations ResearchMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2009-09-28
