Inventors
Qiao Lin
View all technologies
Low-cost microfluidic chip for time-resolved cryo-electron microscopy
CU22182
Low-cost PDMS microfluidic TR cryo-EM chip enables affordable, modular time-resolved protein studies with rapid spray-plunge vitrification.
Tags
Adsorption
Biosensor
Cryogenic electron microscopy
Inventors
Qiao Lin
Joachim Frank
Xiangsong Feng
Manager
Kristin Neuman
Departments
Biochemistry
Biochemistry & Molecular Biophysics
Mechanical Engineering
Divisions
Columbia University Medical Center ( CUM
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-02-16
Graphene field effect transistors for the determination of pH in aqueous environments
CU15155
GFET pH sensor in water uses embedded high-dielectric gate, no external electrodes, low-voltage, photolithography.
Tags
Acid
Biosensor
Dielectric
Inventors
Qiao Lin
Yibo Zhu
Manager
Dovina Qu
Departments
Mechanical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2016-01-06
Microfluidic based system for purification and extraction of target molecules
M08-036
Microfluidic device uses biotin-avidin with RNA aptamers for selective capture, heat or competitive release of target molecules.
Tags
Analyte
Aptamer
Biotin
Inventors
Qiao Lin
Chenmui Qiu
Jingyue Ju
Manager
Dovina Qu
Departments
Chemical Engineering/Applied Chemistry
Mechanical Engineering
Medicine
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2009-12-23
Calibration-free affinity biosensors for rapid, accurate biomarker detection
CU22223
Calibration-free graphene FET biosensor uses aptamer kinetics for rapid, device-wide reproducible biomarker detection without per-sensor calibration.
Tags
Aptamer
Biomarker
Biosensor
Inventors
Qiao Lin
Milan N. Stojanovic M.D.
Wenting Dai
Manager
Dovina Qu
Departments
Mechanical Engineering
Medicine
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2025-08-21
Patient-specific aptamer generation for sensitive and noninvasive diagnosis of minimal residual disease
CU15020
Patient-specific microfluidic aptamers enable noninvasive, frequent MRD detection in blood for personalized multiple myeloma monitoring.
Tags
Chemotherapy
High-throughput screening
Medical diagnosis
Inventors
Qiao Lin
Manager
Dovina Qu
Departments
Mechanical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2017-03-02
Microfluidic based system for purification and extraction of target molecules
M07-079
Microfluidic device uses biotin-avidin and RNA aptamers for selective capture/release of targets, enabling gentle purification and preconcentration.
Tags
Analyte
Aptamer
Biotin
Inventors
Qiao Lin
Thai-Huu Nguyen
Manager
Dovina Qu
Departments
Mechanical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2009-12-23
Real-time label-free measurement of vasopressin
CU22222
Graphene aptamer nanosensor enables real-time, label-free, highly sensitive vasopressin monitoring with rapid results.
Tags
Aptamer
Assay
Biosensor
Inventors
Qiao Lin
Chao Su
Milan N. Stojanovic M.D.
Manager
Dovina Qu
Departments
Mechanical Engineering
Medicine
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2025-08-21
PDMS microfluidic chip for rapid time-resolved cryo-EM
CU19167
PDMS microfluidic chip automates rapid sample prep and loading for time-resolved cryo-EM, enabling intermediate-structure capture.
Tags
Cryogenic electron microscopy
Drug metabolism
Embryonic development
Inventors
Qiao Lin
Joachim Frank
Sandip Kaledhonkar
Manager
Kristin Neuman
Departments
Biochemistry
Biochemistry & Molecular Biophysics
Mechanical Engineering
Divisions
Columbia University Medical Center ( CUM
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-02-17
Graphene aptameric nanosensor for real-time insulin monitoring
CU17297
Graphene aptameric nanosensor enables real-time insulin monitoring via highly sensitive graphene FET, improving detection to 1 nM.
Tags
Acid
Analyte
Electronic music
Inventors
Qiao Lin
Zhuang Hao
Manager
Dovina Qu
Departments
Mechanical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2018-07-10
Aptamer-based graphene nanosensor for monitoring biomolecular interactions
CU17296
Aptamer-functionalized graphene nanosensor provides real-time, label-free detection of biomolecular interactions via a microfluidic FET.
Tags
Analyte
Antibody
Aptamer
Inventors
Qiao Lin
Xuejun Wang
Zhuang Hao
Manager
Dovina Qu
Departments
Mechanical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2018-02-15
A membrane-free system for continuous glucose monitoring
CU15153
Graphene-polymer membrane-free glucose sensor enables rapid, continuous, highly sensitive monitoring; potential non-invasive, real-time devices.
Tags
Glucose
Graphene
Insulin
Inventors
Qiao Lin
Yibo Zhu
Manager
Dovina Qu
Departments
Mechanical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2016-01-06
Microfluidic System for Purification and Extraction of Target Molecules
M07-078
Microfluidic device uses biotin-avidin and RNA aptamers for selective, thermally controlled capture and release of target molecules.
Tags
Analyte
Aptamer
Biotin
Inventors
Qiao Lin
Milan N. Stojanovic M.D.
Renjun Pei
Manager
Dovina Qu
Departments
Mechanical Engineering
Medicine
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2009-12-23
A MEMS Based Implantable Glucose Sensor
M09-071
A MEMS implantable glucose sensor uses a reversible glucose-binding polymer to electronically monitor real-time glucose for insulin dosing.
Tags
Biocompatibility
Compact space
Glucose
Inventors
Qiao Lin
Jerome Schultz
Qian Wang
Manager
Dovina Qu
Departments
Industrial Engineering & Operations Research
Mechanical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2009-09-28
Disposable micro-electromechanical system (MEMS) differential scanning calorimeter (DSC) for thermodynamic characterization of biomolecules
CU13356
A disposable MEMS DSC using Kapton microfluidics and Sb-Bi thermopile for high-throughput biomolecule thermodynamics.
Tags
Calorimeter
Disposable product
Microelectromechanical systems
Inventors
Qiao Lin
Yuan Jia
Manager
Dovina Qu
Departments
Mechanical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2013-06-13
Microdevice for small-scale calorimetric measurement
CU15102
MEMS microcalorimeter for microliter reactions using AC heating, delivering rapid, high-accuracy thermodynamic data with high throughput.
Tags
Alternating current
Calorimeter
Calorimetry
Inventors
Qiao Lin
Bin Wang
Yuan Jia
Manager
Dovina Qu
Departments
Mechanical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2017-05-04
Temperature-mediated catch-and-release cell sorting
M11-113
Portable microfluidic aptamer device isolates a target cell type with high specificity and temperature-triggered release for viable, rapid sorting.
Tags
Aptamer
Cell culture
Medication
Inventors
Qiao Lin
Jing Zhu
Renjun Pei
Manager
Dovina Qu
Departments
Mechanical Engineering
Medicine
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2016-01-06
Graphene-based nanosensors for customizable analyte detection
CU14370
Graphene nanosensors enable customizable, high-sensitivity analyte detection in aqueous samples, enabling compact, flexible monitoring devices.
Tags
Analyte
Contact lens
Dielectric
Inventors
Qiao Lin
Manager
Dovina Qu
Departments
Mechanical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2017-12-05
MEMS Based Implantable Glucose Sensor for Diabetes
M09-072
Implantable MEMS glucose sensor enables continuous, real-time monitoring with an electronic readout and insulin-pump integration.
Tags
Biocompatibility
Compact space
Glucose
Inventors
Qiao Lin
Jerome Schultz
Qian Wang
Manager
Dovina Qu
Departments
IEOR - Industrial Engineering & Operations Research
Mechanical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2009-09-28
