Mechanobiological assay for glaucoma drug screeningCU23377In vitro mechanobiological assay using patient Schlemm’s canal cells; high-throughput pore formation tests to screen glaucoma drugs.TagsAssayAqueous humourBiomechanicsInventorsDarryl OverbyJoseph van Batenburg-SherwoodKrishnakumar KizhatilManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of EngineeringColumbia University Medical Center (CUMC)Release Date2025-01-13
Sensitive, non-invasive diagnostic assay for detecting prostate cancerCU22152Noninvasive urine RAD9 methylation test detects aggressive prostate cancer, boosting accuracy and enabling point-of-care prognosis.TagsAssayBladder cancerBlood testInventorsCatherine Spina MD, PhDHoward Brett Lieberman Ph.D.Kevin HopkinsManagerKristin NeumanDepartmentsCenter for Radiological ResearchRadiation OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-08-23
Clinical management of Interstitial Lung Disease using a multiplex real-time PCR assay to quantify leukocyte telomere lengthCU24245Multiplex real-time PCR quantifies average leukocyte telomere length to guide ILD treatment decisions and outcomes.TagsAssayBiomarkerImmunosuppressionInventorsChad NewtonChristine K. GarciaDavid ZhangManagerKristin NeumanDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-13
Assay for neurotransmitter leakage detection using fluorescent analoguesCU22294Real-time, non-radioactive fluorescent assay tracks vesicular neurotransmitter leakage in cells for high-throughput neurological research.TagsAssayHigh-throughput screeningIsotopic labelingInventorsGary MillerMeghan L. BucherManagerJoan MartinezDepartmentsEnvironmental Health ScienceDivisionsMailman School Of Public Health (MSPH)Release Date2023-09-08CollectionsCNS/NeurologyPlatform/Research Tool
Extracellular vesicle-based assay for detecting head and neck cancerCU21332Noninvasive chip assay detects tumor-enriched proteins on patient extracellular vesicles to screen and monitor head-and-neck cancer.TagsAssayBody fluidCancer stagingInventorsAkiva MintzFatemeh Momen-HeraviGordana Vunjak-NovakovicManagerJoan MartinezDepartmentsBiomedical EngineeringCollege of Dental MedicineRadiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-06-28CollectionsOncology
Plasma-based, biopsy-free cancer detection assayCU23111Plasma-based, blood biopsy-free cancer detection using deep learning on cfDNA methylation to diagnose multiple cancers non-invasively.TagsAssayCancerDNA methylationInventorsXu HuaZhiguo Zhang Ph.D.ManagerJoan MartinezDepartmentsGenetics & DevelopmentInstitute for Cancer GeneticsDivisionsColumbia University Medical Center (CUMC)Release Date2023-03-03CollectionsOncology
CRISPR-modified microorganisms for rare-earth element recoveryCU22215CRISPR-Cas12a engineering of Acidithiobacillus ferrooxidans to boost iron oxidation and rare-earth biomining in acidic environments.TagsAssayBacteriaCRISPRInventorsHeejung JungScott A. BantaYuta InabaManagerDovina QuDepartmentsChemical Engineering/Applied ChemistryDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-12-17
Serochip for the diagnosis of tick-borne diseasesCU19325A programmable peptide microarray enables rapid, high-throughput, single-step serologic diagnosis of multiple tick-borne diseases.TagsAssayAntibodyEpidemiologyInventorsAdrian CaciulaNischay MishraRafal TokarzManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2025-09-04
Neutralizing monoclonal antibodies targeting SARS-CoV-2 variants and related coronavirusesCU22012Broadly neutralizing monoclonal antibodies block diverse SARS-CoV-2 variants, enabling prophylaxis, treatment, and multi-epitope cocktail strategies.TagsAssayAntiviral drugB cellInventorsDavid Da-i Ho M.D.Jian YuLihong LiuManagerKristin NeumanDepartmentsMedicineMicrobiologyPhysicians & SurgeonsDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-21
Real-time label-free measurement of vasopressinCU22222Graphene aptamer nanosensor enables real-time, label-free, highly sensitive vasopressin monitoring with rapid results.TagsAssayAptamerBiosensorInventorsChao SuMilan N. Stojanovic M.D.Nenad MilosavicManagerDovina QuDepartmentsMechanical EngineeringMedicineDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-08-21
Multi-knockoff filter for high-dimensional survival -omics with controlled false discovery rateCU25376CoxMKF: a multi-knockoff survival mediation method that guarantees finite-sample FDR control with stable, data-driven thresholds.TagsAssayBioinformaticsBiomarkerInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Platform to identify causal proteins in Alzheimer's for drug discoveryCU25371Integrated Mendelian-randomization and AlphaFold3 pipeline identifies causal Alzheimer's proteins to guide drug targets and diagnostics.TagsAssayCausalityDrug developmentInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-07-31
Novel prognostic marker for survival in myeloid malignanciesCU18296Multi-gene transcriptomic classifier using TED markers to predict MDS progression to AML, enabling earlier, accurate prognosis.TagsAssayAcute myeloid leukemiaGene expressionInventorsAbdullah Ali Ph.D.Azra Raza M.D.Etienne De ClaraManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedical OncologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-05-28
Rapid, point-of-care assessment of radiation exposure in human bloodCU24211ELISA-based biodosimeter profiles blood biomarkers and uses ML to triage ionizing-radiation exposure-assessment at point-of-care.TagsAssayBioassayBiomarkerInventorsHelen TurnerIgor ShuryakKarthik KanagarajManagerJoan MartinezDepartmentsCenter for Radiological ResearchRadiation OncologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-05-05
Live yeast biosensors for pathogen detectionCU21127Engineered live yeast biosensors emit color/fluorescent signals for rapid, sensitive pathogen detection, including fungi, viruses, and variants.TagsAssayAntifungalAntiviral drugInventorsVirginia W. CornishManagerJoan MartinezDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-03-07
Machine learning tool for diagnosis of cutaneous T-cell lymphoma (CTCL)CU24366AI-powered CTCL diagnosis tool links genetic markers with EHR data to improve accuracy, staging, and prognosis.TagsAssayCancerCutaneous T cell lymphomaInventorsLarisa GeskinManagerCynthia LangDepartmentsDermatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-30
Rapid assessment of T cell health for enhanced cancer immunotherapyCU24313A rapid platform uses biomaterials, imaging, and deep learning to assess T cell functionality and predict proliferation for immunotherapy.TagsAssayAlgorithmBiomaterialInventorsJia GuoLance KamNicole LamannaManagerDovina QuDepartmentsBiomedical EngineeringMedicinePsychiatryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-12-18
Engineered model of human bone marrow for diagnosis and prediction of cancer metastasisCU23273Engineered patient-specific bone marrow model predicts cancer metastasis, metastasis progression, and treatment response non-invasively.TagsAssayAutoimmune diseaseBone marrowInventorsDaniel Naveed TavakolGordana Vunjak-NovakovicPamela GraneyManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-04-08CollectionsOncologyPlatform/Research ToolMedical Device
Sensitive SARS-CoV-2 antigen testCU21002Ultra-sensitive SARS-CoV-2 antigen sandwich ELISA using dual nucleocapsid antibodies for rapid, low-viral-load detection.TagsAssayAntibodyAntigenInventorsDavid Da-i Ho M.D.Lihong LiuManagerKristin NeumanDepartmentsMedicinePhysicians & SurgeonsDivisionsColumbia University Medical Center (CUMC)Release Date2024-04-25
Multiplexing approach and associated image splitter for high-speed characterizationCU23161Combinatorial, beam-splitting multiplex immunofluorescence boosts cell-type detection, enabling high-throughput, cross-talk minimized tissue profiling.TagsAssayAlgorithmAntibodyInventorsCitlali Perez-Campos MSElizabeth HillmanMalte CasperManagerKristin NeumanDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-12-28CollectionsPlatform/Research Tool
In-situ wound healing modelCU24060In-situ wound healing model using 2D-3D skinoids mimics four skin healing stages for high-throughput research, safety, and therapeutics.TagsAssayBiological processCell adhesionInventorsDreyton AmadorYvon WoappiManagerDovina QuDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2024-01-04CollectionsPlatform/Research Tool
Method to characterize lithium-ion battery degradationCU23073Pulse-based method with neural networks rapidly and accurately assesses Li-ion degradation, SOC, health, life, and material loss.TagsAssayElectric vehicleEnergyInventorsAlan Gen LiAlan WestMatthias Preindl PhDManagerGreg MaskelDepartmentsChemical Engineering/Applied ChemistryElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-08-23
Genomic stabilization therapy for enhanced in vitro human embryo fertilization and survivalCU18389Synthetic mRNA–based genome stabilization enhances human embryo viability in IVF, aiming higher success, reduced mosaicism, and lower costs.TagsAssayAneuploidyDNA repairInventorsDietrich EgliManagerKristin NeumanDepartmentsPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-08-24CollectionsWomen's Health
Rapid, highly sensitive multiplexed viral detection with nanoporesCU21160Ultrafast, amplification-free nanopore-based single-molecule assay for multiplexed viral detection (SARS-CoV-2) and antibodies.TagsAssayAntibodyAntigenInventorsChuanjuan TaoJames J. RussoJingyue JuManagerCynthia LangDepartmentsChemical Engineering/Applied ChemistryChemistryGenome CenterDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering andFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-07-20
Non-invasive method for detection of cancer methylomesCU21185Non-invasive methylation profiling of tumor cfDNA enables early cancer detection, tumor origin, and targeted treatment insights.TagsAssay5-MethylcytosineAntibodyInventorsHui ZhouRegina Santella Ph.D.Zhiguo ZhangManagerJoan MartinezDepartmentsEnvironmental Health ScienceGenetics & DevelopmentInstitute for Cancer GeneticsDivisionsColumbia University Medical Center (CUMC)Mailman School Of Public Health (MSPH)Release Date2023-08-04CollectionsOncology
Metabolic modulation of cells for neurodegenerative disorder treatmentCU17362Metabolic reprogramming to boost cellular anabolism, slowing neurodegeneration by targeted glycolytic pathway manipulation.TagsAssayAnabolismCatabolismInventorsChristine XuKaren Sophia ParkStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Release Date2023-04-15CollectionsOphthalmologySmall MoleculeGene Therapy
Speech analysis software for diagnosis of dementiasCU23077Automated, noninvasive speech-analysis tool to screen for early cognitive impairment and Alzheimer’s-related dementias.TagsAssayAcousticsArtificial intelligenceInventorsMaryam ZolnooriManagerKristin NeumanDepartmentsSchool of NursingDivisionsSchool of Nursing (CUMC)Release Date2023-03-08CollectionsCNS/NeurologyPlatform/Research ToolMedical Device
Nanobodies for diagnosis, treatment and prevention of infection and disease caused by SARS-CoV-2 and variantsCU21304Broad-spectrum SARS-CoV-2 nanobodies enable diagnosis, treatment, and prevention across variants with easier delivery and stability.TagsAssayAngiotensinEnzymeInventorsThomas BrieseW. Ian Lipkin M.D.ManagerKristin NeumanDepartmentsEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2023-02-17CollectionsPlatform/Research Tool
Fusion protein as target for brain cancer therapyCU12240Targeting FGFR-TACC gene fusions in glioblastoma with kinase inhibitors; precision therapy and diagnostic tools.TagsAssayChemotherapyGlioblastomaInventorsAnna LasorellaAntonio IavaroneRaul RabadanManagerKristin NeumanDepartmentsBiomedical InformaticsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2022-09-15CollectionsSmall MoleculeOncology
Rapid Molecular Differential Detection of SARS-CoV-2CU20260Rapid, multi-virus PCR assay enables differential, rapid detection of SARS-CoV-2, influenza A/B, improving diagnostic accuracy.TagsAssayBlood plasmaEpidemiologyInventorsNischay MishraSimon H. WilliamsThomas BrieseManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2022-08-20
Cell-type specific covalent modifications of proteins in vivoCU22274Cell-type specific in vivo covalent linking of SpyTag/SpyCatcher proteins enables targeted tagging, visualization, and functional protein studies.TagsAssayAntibodyAntigenInventorsRichard S. MannSiqian FengManagerJerry KokoshkaDepartmentsBiochemistry & Molecular BiophysicsBiochemistry & Molecular Biophysics, Zuckerman InstituteDivisionsColumbia University Medical Center (CUMC)Release Date2022-06-19CollectionsPlatform/Research Tool
High-throughput in vivo mRNA-based proteomics via next-generation sequencingCU20206In vivo mRNA display enables high-throughput, sequencing-based proteomics in cells, linking proteins to mRNA with UMIs.TagsAssayAntigenDNA sequencingInventorsPanagiotis OikonomouSaeed TavazoieManagerJoan MartinezDepartmentsBiochemistrySystems BiologyDivisionsColumbia University Medical CenterColumbia University Medical Center (CUMC)Release Date2021-01-29CollectionsPlatform/Research Tool
Selective T cell repopulation for enhanced immunotherapyCU20336Selective T cell repopulation boosts immunotherapy by expanding progenitor T cells in blood/tumor to predict and enhance response.TagsAssayAutoimmune diseaseBiomarkerInventorsBrian HenickSteven ReinerManagerKristin NeumanDepartmentsMedicineMicrobiologyDivisionsColumbia University Medical Center (CUMC)Release Date2021-01-29CollectionsOncology
Small molecule therapeutics to treat treatment-resistant ALL and T-ALLCU19220NT5C2 inhibitors (e.g., HTP-2) boost chemotherapy efficacy in relapsed ALL/T-ALL, enabling combo treatments against resistance.TagsAssayAcute lymphoblastic leukemiaCancer cellInventorsAdolfo A. Ferrando M.D., Ph.D.Arie ZaskBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesInstitute for Cancer GeneticsProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2021-02-03CollectionsSmall MoleculeOncology
Non-invasive imaging analysis for predicting lung adenocarcinoma subtypesCU20338Noninvasive CT-based AI platform quantifying tumor imaging biomarkers to predict lung adenocarcinoma subtypes and prognosis.TagsAssayAdenocarcinomaBiomarkerInventorsBinsheng ZhaoLarry SchwartzLin LuManagerJoan MartinezDepartmentsRadiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2020-10-15CollectionsOncologyPlatform/Research Tool
Sorting of extracellular vesicles for precise, cell-specific diagnosticsCU19242Sorting extracellular vesicles by parent cell type enables precise, non-invasive, multi-organ diagnostics from a single blood sample.TagsAssayCardiac muscleCellular differentiationInventorsBohao LiuBryan WangGordana Vunjak-NovakovicManagerCynthia LangDepartmentsBiomedical EngineeringProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-01-13CollectionsPlatform/Research ToolMedical Device
Hyaluronidase for prevention, treatment, reduction and/or abolishment of cerebral edema and intracranial pressureCU18154Hyaluronidase-based therapy to reduce traumatic brain edema and intracranial pressure, complementing standard TBI treatments.TagsAssayAcidBarbiturateInventorsBarclay Morrison IIIPatricia WashingtonSteven Kernie M.D.ManagerKristin NeumanDepartmentsBiomedical EngineeringPediatrics and Pathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2019-12-30
Detection of CRISPR-mediated precision genome editing by a simple-to-use, rapid, and inexpensive detection methodCU18348Marker-free, rapid, programmable assay quantifies CRISPR-guided precise edits across loci, enabling same-day detection of base changes and indels.TagsAssayCRISPR gene editingCancerInventorsAlberto CicciaPierre BillonManagerCynthia LangDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2019-12-03
Pharmacological treatment for right ventricular failureCU18328Pharmacological approach targets genes to prevent, diagnose, and treat right ventricular failure using gene modulation and biomarkers.TagsAssayCancerCarcinogenesisInventorsChristos TzimasEmily TsaiManagerJerry KokoshkaDepartmentsCardiologyDivisionsColumbia University Medical Center (CUMC)Release Date2019-10-25CollectionsCardiovascular
Antibody for specific detection of ferroptosisCU20038Ferroptosis-specific antibody (3F3-FMA) detects ferroptotic cells via TfR1 for immunofluorescence, flow cytometry, and tissue assays.TagsAssayAntibodyApoptosisInventorsAngie Huizhong FengBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2019-08-07CollectionsCNS/Neurology
Assay for determining the health of CD8+ T cells1779-bAssay validates CD8+ T cell health by comparing antigen-specific proliferation to control targets, aiding autoimmunity risk assessment.TagsAssayAntigenAutoimmune diseaseInventorsHong JiangLeonard Chess MDManagerOfra WeinbergerDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2018-09-28
Serologic test to monitor and treat low turnover renal osteodystrophyCU18256Non-invasive serum miRNA panel to assess bone turnover in renal osteodystrophy, guiding therapy and monitoring response.TagsAssayBoneBone remodelingInventorsThomas NickolasManagerKristin NeumanDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2019-01-08
Scalable SNP assay with single molecule sensitivityCU14223Cost-effective, high-throughput SNP assay enabling single-molecule detection via nanopore tagging for scalable personalized medicine.TagsAssayCombinatoricsDNA profilingInventorsChuanjuan TaoJingyue JuMing-Cheng ChienManagerCynthia LangDepartmentsChemical Engineering/Applied ChemistryDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-04-13
Fluorescent substrates for imaging neurotransmissionM06-109-aFluorescent false neurotransmitters visualize dopamine vesicle content and release at single-synapse resolution for imaging and drug discovery.TagsAssayAttention deficit hyperactivity disorderBipolar disorderInventorsDalibor SamesDavid Sulzer Ph.D.Niko GubernatorManagerJerry KokoshkaDepartmentsChemistryPsychiatryDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2018-11-13
Surface-based nucleic acid assays using morpholinosM07-104Morpholino probes enable low-ionic-strength, label-free, cost-effective surface nucleic acid assays with rapid, specific hybridization.TagsAssayBiosensorDNA microarrayInventorsKenneth ShepardNapoleon TerceroPing GongManagerGreg MaskelDepartmentsChemical & Biological EngineeringChemical Engineering/Applied ChemistryElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-10-20
Methods for diagnosis and treatment of neuropsychiatric disorders2789Genetic GCH1 assay guides diagnosis and personalized treatment for schizophrenia and related neuropsychiatric disorders.TagsAssayAlleleBipolar disorderInventorsCatherine ClellandManagerKristin NeumanDepartmentsPathologyDivisionsColumbia University Medical Center (CUMC)Release Date2018-09-28
High-throughput assay for detection of Zika exposureCU17122High-throughput Zika serology using epitope signatures enables rapid, differential exposure detection, distinguishing past from acute infections.TagsAssayChikungunyaDifferential diagnosisInventorsAdrian CaciulaNischay MishraThomas BrieseManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2018-02-15
Biomarker-based assay for diagnosing non-celiac wheat/gluten sensitivityCU16173Biomarker panel diagnosing non-celiac gluten/wheat sensitivity and monitoring treatment via serologic markers.TagsAssayAntibodyAutoimmune diseaseInventorsArmin AlaediniManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2018-03-01
Characterizing and enhancing the efficacy of therapeutic CD8+ T cells2856Assay-driven enhancement and characterization of ex vivo CD8+ T cells to predict and boost therapeutic efficacy across cancers and infections.TagsAssayAutoimmune diseaseCognateInventorsJohn LoikePeter LeeRalph SteinmanManagerSara GusikDepartmentsBiomedical InformaticsMedicinePhysiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)HematologyRelease Date2018-08-29
Method for determining antigen-specific CD8+ T cell efficacy2830Assay-based method quantifies active CD8+ T cells to predict immunotherapy efficacy across cancers, infections, and autoimmune contexts.TagsAssayAntigenCell biologyInventorsArthur KarlinJohn LoikePeter LeeManagerSara GusikDepartmentsBiochemistry & Molecular BiophysicsBiomedical InformaticsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2018-08-27
