Inhibition of RAR/RXR signaling for adenoid cystic carcinoma treatmentCU23276Targeted ACC therapy modulates RAR/RXR signaling to reclassify tumor cells and selectively kill ductal-like populations.TagsNeoplasmAdenocarcinomaAdenoidInventorsPierangela PalmeriniPiero D. DalerbaSara ViragovaManagerKristin NeumanDepartmentsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-03-13
Scalable, reproducible, immune-intact tumor organoid co-culture platformCU24328Patient-derived immune-intact tumor organoids enable scalable, reproducible co-culture for personalized immunotherapy and drug screening.TagsNeoplasmBiomarkerBiotechnologyInventorsDavid CohenJoel T. Gabre MDManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Selective COX-2 radioligands for PET imaging of neuroinflammationCU19254Fluorine-18 COX-2 PET radioligands enable noninvasive imaging of neuroinflammation with higher affinity and broad clinical reach.TagsNeoplasmAgonistCOX-2 inhibitorInventorsAkiva MintzJ. John MannJ.S. Dileep KumarManagerJerry KokoshkaDepartmentsPsychiatryRadiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-12-17
VRK2 kinase inhibitors for enhanced cancer immunotherapyCU21245VRK2 inhibitors boost PD-1 therapy by targeting downstream signaling, enhancing T cell activation and tumor clearance.TagsNeoplasmAdenocarcinomaBladder cancerInventorsAdam MorManagerCynthia LangDepartmentsRheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-17
Cross-platform radiomics toolkit for predictive cancer imagingProxy116Cross-platform radiomics toolkit automates standardized 2D/3D cancer imaging analysis for reproducible, scalable biomarker discovery.TagsNeoplasmBatch processingCross-platform softwareInventorsChristos DavatzikosDespina KontosManagerJoan MartinezDepartmentsRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-04
Dynein inhibition for enhanced anti-tumor cytotoxicity in solid tumorsCU24341Dynein inhibition boosts natural killer cell cytotoxicity against solid tumors, enhancing immunotherapy efficacy across diverse microenvironments.TagsNeoplasmAdjuvantCytotoxic T cellInventorsJordan S. Orange MD, PhDManagerJerry KokoshkaDepartmentsPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2025-11-20
In vivo internalizing RGD peptide production for enhanced treatment of solid tumorsCU25033In vivo iRGD plasmid drives tumor penetration, reducing immunosuppression; co-administers with CAR-T/ therapies for enhanced efficacy.TagsNeoplasmAngiogenesisCancer immunotherapyInventorsKazuki N. SugaharaNorio MiyamuraManagerJerry KokoshkaDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2025-11-20
Coherent factor-based passive cavitation mapping for monitoring of focused ultrasound treatmentCU22079Coherent factor-based passive acoustic mapping enables real-time, high-resolution, low-cost monitoring of transcranial focused ultrasound treatment.TagsNeoplasmAblationAcousticsInventorsElisa KonofagouSua BaeManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-11-07
Targeting senescent cells for the treatment of photoaging and melanomaCU25349Senescent-cell–targeting therapy reverses photoaging and slows melanoma, offering dual cosmetic and oncologic benefits.TagsNeoplasmCellular senescenceChemotherapyInventorsDanial KhayatanRolando Perez-LorenzoManagerJerry KokoshkaDepartmentsDermatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-10-09
Dual targeting of epigenetically amplified lymphomas via epigenetic modifiers and immune checkpoint inhibitionCU24177Dual-targeted PMBCL therapy: epigenetic reprogramming plus anti-PD-1 immune blockade enhances immunogenicity and overcomes resistance.TagsNeoplasmCancerCancer immunotherapyInventorsJennifer AmengualSeda Serra ToluManagerKristin NeumanDepartmentsMedicineMedicine - Hematology/OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-17CollectionsOncology
GPX4 inhibitors for cancer therapyCU20261Potent, selective GPX4 inhibitors induce ferroptosis to target EMT-driven, drug-resistant cancers and enable GPX4 research.TagsNeoplasmActive siteAllosteric regulationInventorsBrent StockwellHengrui LiuManagerJoan MartinezDepartmentsBiological SciencesChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-05-01
Programmable bacteria for targeted delivery of cancer therapeuticsCU18339Engineered tumor-targeting bacteria deliver immunotherapies locally, boosting efficacy and reducing systemic toxicity in cancer treatment.TagsNeoplasmAntigenCancer immunotherapyInventorsCandice GurbatriNicholas ArpaiaSreyan ChowdhuryManagerCynthia LangDepartmentsBiomedical EngineeringMicrobiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-04-07
Targeting PAG for cancer immunotherapyCU23123PAG-targeting antibodies boost T cell activation, inhibit PD-1 signaling, and reduce tumor growth, enabling monotherapy or combo immunotherapy.TagsNeoplasmAnimal disease modelCancer immunotherapyInventorsAdam MorManagerCynthia LangDepartmentsRheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-07
cGAS inhibitor for robust anti-tumor immunity activationCU23316Bioavailable, chemically modified cGAS inhibitors enhance oral bioavailability to boost anti-tumor immunity via the cGAS–STING pathway.TagsNeoplasmAminopeptidaseAutoimmune diseaseInventorsBenjamin Izar MD, PhDDonald William Landry MD, Ph.D.Lindsay CaprioManagerJoan MartinezDepartmentsMedicineProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2024-09-26
Generation of self-renewed CD4+ T cells for cancer and viral disease immunotherapyCU24385Ex vivo culture method yields durable, polyfunctional cytotoxic CD4+ T cells for enhanced cancer and viral immunotherapies.TagsNeoplasmAntigenCell cultureInventorsMithil SoniPawel MuranskiPrabesh KhatiwadaManagerJerry KokoshkaDepartmentsColumbia Center for Translational ImmunologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-09-16
Combination therapy to increase the efficacy of antibody-drug conjugates in bladder cancerCU24095Small molecule reprograms bladder cancer cells to upregulate antigens, boosting antibody-drug conjugate efficacy. 14 words.TagsNeoplasmAntibody-drug conjugateAntigenInventorsJohn Robert ChristinMichael Shen Ph.D.ManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-09
Combinatorial treatment LZTR1 mutant tumors by inhibiting oncogenic substratesCU23141Combinatorial inhibitors target LZTR1-mutant cancers by suppressing EGFR, AXL, and RIT1 to reduce tumor growth.TagsNeoplasmBreast cancerColorectal cancerInventorsAnna LasorellaAntonio IavaroneAram KoManagerKristin NeumanDepartmentsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2024-06-06
Combination therapy for the treatment of melanomaCU16039Selective NF-kB c-Rel inhibitor plus immune checkpoint blockade boosts therapy for drug-resistant metastatic melanoma.TagsNeoplasmCancer immunotherapyChemotherapyInventorsSankar GhoshYenkel Grinberg-BleyerManagerCynthia LangDepartmentsMicrobiologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-05-24
Engineered model of human bone marrow for diagnosis and prediction of cancer metastasisCU23273Engineered patient-specific bone marrow model predicts cancer metastasis, metastasis progression, and treatment response non-invasively.TagsNeoplasmAssayAutoimmune diseaseInventorsDaniel Naveed TavakolGordana Vunjak-NovakovicPamela GraneyManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-04-08CollectionsOncologyPlatform/Research ToolMedical Device
Patient-specific organoid system for pancreatic ductal adenocarcinoma (PDAC) drug screeningCU24025Patient-specific pancreatic cancer organoids with patient immune cells enable high-throughput drug screening and personalized therapy insights.TagsNeoplasmCell therapyHigh-throughput screeningInventorsGulam ManjiIlenia PellicciottaManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-30CollectionsOncology
Modular, multi-tissue system for in vitro modeling of systemic diseaseCU19102Multi-tissue organ-on-a-chip platform enables vascular-coupled, patient-specific modeling of systemic disease and cancer metastasis.TagsNeoplasmCirculatory systemCrosstalkInventorsAlan ChramiecAndrea Califano Ph.D.Ece OzturkManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsBiomedical EngineeringBiomedical InformaticsDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-10-31CollectionsOncologyPlatform/Research Tool
T cell co-receptor clustering for cancer treatmentCU22398Bispecific SLAMF6 antibodies compartmentalize T cells to enhance activation, enabling targeted cancer immunotherapy with fewer off-target effects.TagsNeoplasmCancer immunotherapyCo-receptorInventorsAdam MorManagerCynthia LangDepartmentsRheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-09-05CollectionsOncology
Non-invasive method for detection of cancer methylomesCU21185Non-invasive methylation profiling of tumor cfDNA enables early cancer detection, tumor origin, and targeted treatment insights.TagsNeoplasm5-MethylcytosineAntibodyInventorsHui ZhouRegina Santella Ph.D.Zhiguo ZhangManagerJoan MartinezDepartmentsEnvironmental Health ScienceGenetics & DevelopmentInstitute for Cancer GeneticsDivisionsColumbia University Medical Center (CUMC)Mailman School Of Public Health (MSPH)Release Date2023-08-04CollectionsOncology
Targeting the CD58:CD2 axis for cancer immunotherapyCU21140Activates CD28-CD8+ T-cells via CD58:CD2 axis, offering an immunotherapy option for PD-1–unresponsive cancers.TagsNeoplasmAntibodyAntigen-presenting cellInventorsBenjamin Izar MD, PhDJohannes MelmsPatricia HoManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-06-23CollectionsOncology
Tumor irradiation role in adenosine signalingCU22323Examines how tumor irradiation modulates adenosine signaling to enhance immunotherapy and tumor microenvironment targeting.TagsNeoplasmAdenosineCancer immunotherapyInventorsCatherine Spina MD, PhDShruti BansalManagerJoan MartinezDepartmentsRadiation OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-06-02CollectionsOncology
Targeting ID2 to impair hypoxic cancer stem cell proliferationCU16166Targeting ID2–DYRK1A/B axis degrades HIF2a in hypoxic cancer stem cells, offering glioblastoma–focused, broad oncologic potential.TagsNeoplasmAngiogenesisCancer stem cellInventorsAnna LasorellaAntonio IavaroneManagerKristin NeumanDepartmentsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-19CollectionsOncology
Small molecule inhibitors of the ID2/VHL interactionCU17182Four small molecules block ID2/VHL, promote HIF degradation, potentially slowing tumor growth and angiogenesis in cancers.TagsNeoplasmAngiogenesisCell growthInventorsAnna LasorellaAntonio IavaroneDan ShermanManagerKristin NeumanDepartmentsInstitute for Cancer GeneticsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-19CollectionsSmall MoleculeOncology
Co-delivery platform for enhanced nucleic acid therapeuticsCU21087Co-delivery platform stabilizes nucleic acid therapeutics with exosome carriers and RISC associations, boosting efficacy while reducing off-targets.TagsNeoplasmGene expressionHead and neck cancerInventorsAkiva MintzFatemeh Momen-HeraviManagerJoan MartinezDepartmentsCollege of Dental MedicineRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-19CollectionsGene TherapyOncologyPlatform/Research Tool
Computational method for brain tumor classification and improved prognosisCU21156Integrates multi-omics to subtype glioblastoma, revealing four functional states and subtype-specific treatment targets.TagsNeoplasmBreast cancerGlioblastomaInventorsAnna LasorellaAntonio IavaroneManagerKristin NeumanDepartmentsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-01CollectionsOncology
Recombinant ILT3 protein-produced antibodies for immunotherapy treatment of cancerCU15207Engineered anti-ILT3 antibodies enable targeted cancer immunotherapy, modulating myeloid signals and enhancing immune blockade.TagsNeoplasmAcute myeloid leukemiaAllotransplantationInventorsGeorge Vlad Ph.D.Nicole Suciu-FocaZheng XuManagerSara GusikDepartmentsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-03-08CollectionsOncology
Programmable nanoencapsulation for probiotic deliveryCU21284Programmable nanoencapsulated probiotics boost cancer therapy safety and efficacy by tunable, immune-evasive bacterial delivery.TagsNeoplasmBacteriaBacterial capsuleInventorsJaeseung HahnKam LeongTal DaninoManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-01-30CollectionsOncology
Inhibition of osteoblast activity to treat acute myeloid leukemia (AML) and myelodysplasia (MD)CU21283Inhibits osteoblast–AML crosstalk via kynurenine/SAA axis, reducing leukemia progression; therapeutic and biomarker potential.TagsNeoplasm5-HT receptorAcute myeloid leukemiaInventorsMarta Galan-DiezStavroula KousteniManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2023-01-24CollectionsOncology
Conditional knockout mouse model for the Phf6 geneCU22370A tissue-specific Phf6 conditional knockout mouse model for studying Börjeson-Forssman-Lehmann syndrome and hematologic cancers.TagsNeoplasmAcute myeloid leukemiaGeneInventorsAdolfo A. Ferrando M.D., Ph.D.Teresa Palomero VasquezManagerJoan MartinezDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2022-08-20
Conditional knockout mouse model to study genomic instability of BRCA1 mutationsCU23027Inducible BRCA1 exon 2 knockout mouse model to study BRCA1-related genomic instability, tumorigenesis, and therapy screening.TagsNeoplasmAblationAlleleInventorsFoon Wu-baerRichard Baer Ph.D.ManagerJoan MartinezDepartmentsPathologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Release Date2022-10-10CollectionsOncologyWomen's Health
Fusion protein as target for brain cancer therapyCU12240Targeting FGFR-TACC gene fusions in glioblastoma with kinase inhibitors; precision therapy and diagnostic tools.TagsNeoplasmAssayChemotherapyInventorsAnna LasorellaAntonio IavaroneRaul RabadanManagerKristin NeumanDepartmentsBiomedical InformaticsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2022-09-15CollectionsSmall MoleculeOncology
Tumor-infiltrating lymphocyte and organoid co-culture for patient-specific immunotherapyCU22128Ex vivo tumor-lymphocyte co-culture screens patient TILs for tumor killing, guiding pre-treatment immunotherapy choices and cost savings.TagsNeoplasmCell cultureCytotoxicityInventorsAlana NguyenMichael Shen Ph.D.ManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2022-08-22CollectionsOncologyPlatform/Research Tool
Probiotic-guided CAR-T cell system for targeted cancer immunotherapyCU22211Engineered probiotic-guided CAR-T therapy targets solid tumors, recruiting immune cells and enhancing immunotherapy with tumor-colonizing bacteria.TagsNeoplasmAutoimmune diseaseCancer immunotherapyInventorsCandice GurbatriJongwon ImNicholas ArpaiaManagerCynthia LangDepartmentsBiomedical EngineeringMicrobiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2022-02-04CollectionsOncology
Master regulators of regulatory T cell tumor infiltrationCU21189Target 17 tumor-regulatory T cell master regulators to selectively modulate infiltration, boosting anti-tumor immunity with CRISPR-validated precision.TagsNeoplasmCRISPRCancer immunotherapyInventorsAleksandar ObradovicAndrea CalifanoCasey Roy AgerManagerJoan MartinezDepartmentsBiomedical InformaticsMedicineSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2021-02-03CollectionsOncology
Automated 3D modeling of diseased livers using artificial intelligenceCU19417Automated, AI-guided 3D liver modeling from CT: segmenting heterogeneous diseased tissue for safer interventions.TagsNeoplasm3D modelingArthroscopyInventorsBinsheng ZhaoLarry SchwartzXiaotao GuoManagerJoan MartinezDepartmentsRadiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2020-06-12CollectionsOncologyDigital Health (Software, AI, bioinformatics, etc)
Catheter-based optical method for improving treatment of cardiac arrhythmiasCU17035A catheter-based optical method ensures accurate heart tissue contact before radiofrequency ablation, improving arrhythmia treatment outcomes.TagsNeoplasmAtrial fibrillationCardiac muscleInventorsChristine P. HendonMohammad ZaryabRajinder Singh-MoonManagerDovina QuDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-02-14CollectionsCardiovascular
Sorting of extracellular vesicles for precise, cell-specific diagnosticsCU19242Sorting extracellular vesicles by parent cell type enables precise, non-invasive, multi-organ diagnostics from a single blood sample.TagsNeoplasmAssayCardiac muscleInventorsBohao LiuBryan WangGordana Vunjak-NovakovicManagerCynthia LangDepartmentsBiomedical EngineeringProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-01-13CollectionsPlatform/Research ToolMedical Device
Harmonic motion elastography for noninvasive tumor imaging in vivoCU19055Noninvasive harmonic motion elastography images tumor stiffness in real time, improving margins, monitoring therapy, and guiding surgery.TagsNeoplasmBreastBreast cancerInventorsAlireza NabavizadehrafsanjaniElisa KonofagouManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2019-12-16CollectionsOncologyWomen's Health
Vibrational probes for metabolic imaging in live cells and organismsCU19023Vibrational IR probes enable non-destructive, real-time metabolic imaging in live cells and whole organisms at subcellular resolution.TagsNeoplasmAmino acidBrainInventorsLingyan ShiWei MinManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2019-11-15CollectionsOncologyPlatform/Research ToolCardiovascular
Automated medical imaging method for optimized portal venous phase acquisitionCU18342Automated CNN-based portal venous phase tuning improves tumor vascular density and volume assessment, enabling unbiased treatment response monitoring.TagsNeoplasmAlgorithmAngiogenesisInventorsBinsheng ZhaoJingchen MaLarry SchwartzManagerJoan MartinezDepartmentsRadiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2019-10-17CollectionsOncology
Intra-arterial administration of peptide-drug conjugates for tumor-selective drug deliveryCU17144Intra-arterial, flow-arrest delivery preserves cationic peptide-drug charge, enhancing tumor and brain tumor targeting.TagsNeoplasmApoptosisBlood–brain barrierInventorsShailendra JoshiManagerSara GusikDepartmentsAnesthesiologyRelease Date2019-08-21
Characterizing and enhancing the efficacy of therapeutic CD8+ T cells2856Assay-driven enhancement and characterization of ex vivo CD8+ T cells to predict and boost therapeutic efficacy across cancers and infections.TagsNeoplasmAssayAutoimmune diseaseInventorsJohn LoikePeter LeeRalph SteinmanManagerSara GusikDepartmentsBiomedical InformaticsMedicinePhysiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)HematologyRelease Date2018-08-29
Method for determining antigen-specific CD8+ T cell efficacy2830Assay-based method quantifies active CD8+ T cells to predict immunotherapy efficacy across cancers, infections, and autoimmune contexts.TagsNeoplasmAntigenAssayInventorsArthur KarlinJohn LoikePeter LeeManagerSara GusikDepartmentsBiochemistry & Molecular BiophysicsBiomedical InformaticsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2018-08-27
Cell-penetrating TAT oligomers for drug deliveryCU17314Cell-penetrating TAT oligomers enable targeted drug delivery across membranes, including blood-brain barriers, for tumors and CNS.TagsNeoplasmApoptosisBiopharmaceuticalInventorsShailendra JoshiManagerSara GusikDepartmentsAnesthesiologyRelease Date2018-07-16CollectionsOncology
Cholinergic agonists for treating pancreatic cancerCU17111Cholinergic agonists (bethanechol) suppress pancreatic cancer growth and stemness via M3 receptor, improving outcomes in models.TagsNeoplasmAdjuvantAgonistInventorsChandan GuhaTimothy Wang M.D.ManagerJerry KokoshkaDepartmentsMedicineRadiation OncologyRelease Date2018-02-15
Human hybridoma cell lines that produce functional human monoclonal antibodies1820Karyochi-based human hybridomas enable fast, scalable production of fully human monoclonal antibodies for cancer therapy and diagnostics.TagsNeoplasmAntibodyAntigenInventorsGavreel KalantarovIlya TrakhtManagerJerry KokoshkaDepartmentsAnesthesiologyHerbert and Florence Irving Center for Clinical ResearchDivisionsColumbia University Medical Center (CUMC)Release Date2017-08-23
