A universal method to interrogate genome-wide methylation patterns
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The Technology: An efficient, simple, sensitive method to study DNA methylation. This technology is a tagmentation-based method for global DNA methylation and sequencing that uses a fusion protein without DNA-targeting antibodies, enabling efficient and convenient analysis of methylation patterns in normal and disease conditions, including early cancer detection. Reduces the cost of DNA methylation analysis.
This technology is a direct-tag method for rapid nanopore sequencing that enables rapid DNA extraction and high-yield sequencing of DNA fragments within a fraction of the time of current sequencing technologies. This underscores the urgent need for faster and more affordable DNA sequencing technologies. This technology is a direct-tag method for rapid nanopore sequencing that enables rapid DNA extraction and high-yield sequencing of DNA fragments within a fraction of the time of current sequencing technologies.
This technology is two methods, called ssg-MeDIP-Seq and sscf-MeDIP-Seq, for improved tumor detection using detection of DNA methylation density in genomic DNA, and of hemi-methylated regions in plasma cell-free DNA. The Technology: Tumor detection via DNA methylation and hemi-methylation biomarkers. This technology detects sDNA methylation density as well as hemi-methylated regions of genomic DNA and plasma cell free (cf) DNA to detect tumors.
- 8DNA sequencing
- 6Genotyping
- 6DNA methylation
- 6Assay
- 5Genome
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- 24Biology
- 20Biotechnology
- 20Branches of biology
- 11Genetics
- 6Genomics
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- 6Jingyue Ju
- 4James J. Russo
- 3Hui Zhou
- 3Shiv Kumar
- 3Xiaoxu Li
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- 10Cynthia Lang
- 9Joan Martinez
- 2Greg Maskel
- 1Dovina Qu
- 1Jerry Kokoshka
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- 8Genetics & Development
- 7Chemical Engineering/Applied Chemistry
- 5Institute for Cancer Genetics
- 4Biomedical Informatics
- 4Genome Center
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- 18Columbia University Medical Center (CUMC)
- 8Fu Foundation School of Engineering and Applied Science (SEAS)
- 5Faculty of the Arts & Sciences
- 3Fu Foundation School of Engineering and
- 2Mailman School Of Public Health (MSPH)
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