Columbia Technology Ventures

Bioengineered human bone marrow model for drug discovery

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Compatible with monolayer culture of cancer cells and the 3D engineered model of human bone marrow.
“Bioengineered IPSC-Derived Models of Human Bone Marrow for Studies of Systemic Injury and Disease” Exp Hem.
The engineered bone marrow recapitulates the human immune stem cell niche, which drives peripheral blood and immune cell phenotypes.
This technology is a three-dimensional decellularized bone scaffold that replicates the tumor microenvironment for more accurate cell culture and drug screening for Ewing’s sarcoma.
Prostate cancer and Ewing's sarcoma are human diseases that are not accurately represented in an animal model.
This technology is a 3D decellularized bone scaffold that is seeded with cancer cells to accurately model various forms of cancer and the in vivo tumor phenotype and microenvironment.
Research tool for analysis of modeling of injury, genetic and acquired diseases.
The vascular perfusion linking the tissues mimics blood flow in the human circulatory system.
“Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety” Lab Chip.