Peptide nucleic acid conjugates for altering gene expression in cancerCU16241Selective peptide nucleic acid polymers block cancer gene expression, targeting mutations like BRAFV600E with improved delivery and specificity.TagsBioavailabilityBiosensorCell cultureInventorsGary Schwartz M.D.Jeffrey Rothman M.D.ManagerJoan MartinezDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-03CollectionsGene TherapyOncology
Nucleic acid-guided DNA synthesis with reverse transcriptasesCU24147Reverse-transcriptase guided DNA synthesis enables precise, large-template genome edits with high efficiency and fewer byproducts.TagsAntiviral drugGenomeGenome editingInventorsSamuel H. SternbergStephen TangManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-09CollectionsGenomics & Multi-Omics
Nucleic acid biosensor system for point-of-care diagnosticsCU20204A CRISPR-transposase nucleic acid biosensor enables rapid, sensitive, point-of-care detection of RNA and DNA pathogens.TagsAcidAdenoviridaeBiosafetyInventorsHarris WangKenneth ShepardSamuel H. SternbergManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsBiomedical EngineeringElectrical EngineeringDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-06-26
Manganese oxide nanoparticles for cell-free nucleic acid scavengingCU22060Anionic manganese oxide nanoparticles scavenge cell-free nucleic acids to reduce inflammation with low toxicity and biodegradability.TagsApoptosisBiodegradationInflammationInventorsKam LeongYiling ZhongManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-08-14
Co-delivery platform for enhanced nucleic acid therapeuticsCU21087Co-delivery platform stabilizes nucleic acid therapeutics with exosome carriers and RISC associations, boosting efficacy while reducing off-targets.TagsGene expressionHead and neck cancerLiverInventorsAkiva MintzFatemeh Momen-HeraviManagerJoan MartinezDepartmentsCollege of Dental MedicineRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-19CollectionsGene TherapyOncologyPlatform/Research Tool
Engineered anti-Cre antibody for detection of CreCU23045Engineered monoclonal anti-Cre antibody enables precise, tissue-specific Cre detection, improving reliability over current reagents.TagsAntibodyCre recombinaseDNA sequencingInventorsDavid NgSusan Brenner-MortonManagerJerry KokoshkaDepartmentsBiochemistryMortimer B. Zuckerman Mind Brain Behavior InstituteRelease Date2022-10-31
Sensitive SARS-CoV-2 antigen testCU21002Ultra-sensitive SARS-CoV-2 antigen sandwich ELISA using dual nucleocapsid antibodies for rapid, low-viral-load detection.TagsAntibodyAntigenAssayInventorsDavid Da-i Ho M.D.Lihong LiuManagerKristin NeumanDepartmentsMedicinePhysicians & SurgeonsDivisionsColumbia University Medical Center (CUMC)Release Date2024-04-25
Noninvasive focused ultrasound for neuromodulation and targeted brain stimulationCU15132Noninvasive focused ultrasound enables precise deep-brain stimulation with real-time monitoring for mapping, therapy, and personalized neuromodulation.TagsAcousticsBlood–brain barrierBrain mappingInventorsElisa KonofagouHermes Arytto Salles KamimuraManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-06-05
CMOS imaging arrays for high-speed fluorescence lifetime imagingCU12003CMOS-SPAD FLIM array enables 200 fps wide-field imaging with on-chip timing, compact, cost-effective for live-cell and high-throughput assays.TagsCMOSDNA sequencingData acquisitionInventorsKenneth ShepardRyan M. FieldManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-10-09
Tet-a-TET: a silencing-resistant, doxycycline-inducible gene expression system for differentiated neuronsCU26148Silencing-resistant, doxycycline-inducible gene system for mature neurons; enables robust, tunable, uniform transgene expression.TagsDoxycyclineEpigeneticsFunctional genomicsInventorsHynek WichterleJonathon CostaManagerJerry KokoshkaDepartmentsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-07-24
Computational model for predicting gene expression profiles across human cell typesCU23168A multi-omics, foundation-model predicts cross-cell-type gene expression, enabling regulatory module discovery and in silico perturbation.TagsChromatinCis-regulatory elementGeneInventorsRaul RabadanXi FuManagerJoan MartinezDepartmentsBiomedical InformaticsDivisionsColumbia University Medical Center (CUMC)Release Date2024-10-10CollectionsArtificial Intelligence (AI)
NAPA-ID: a proximity-based system to decode protein-protein interactionsCU26166NAPA-ID enables antibody-guided, proximity labeling of protein interactions without genetic editing, compatible with standard proteomics workflows.TagsAntibodyBiological engineeringBiomarkerInventorsJeremy CartalasSara ZaccaraManagerJerry KokoshkaDepartmentsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-17
Non-invasive laser therapy for cytokine modulation and corneal inflammation managementCU18315Femtosecond laser therapy non-invasively modulates corneal cytokines to reduce inflammation and keratocyte apoptosis, preserving tissue.TagsAnalgesicAntibioticApoptosisInventorsSinisa VukelicManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-08-17CollectionsOphthalmology
Chimeric antigen receptor regulatory T cells (CAR Tregs) for immune tolerance in xenotransplantationCU25017CAR Tregs engineered to target SLA induce selective immune tolerance for pig-to-human xenotransplants, reducing rejection.TagsAntigenChimeric antigen receptor T cellDrug deliveryInventorsMegan Sykes M.D.Mohsen Khosravi MaharlooeiRemi CreusotManagerJerry KokoshkaDepartmentsImmunologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-05-08
Mechanobiological assay for glaucoma drug screeningCU23377In vitro mechanobiological assay using patient Schlemm’s canal cells; high-throughput pore formation tests to screen glaucoma drugs.TagsAqueous humourAssayBiomechanicsInventorsDarryl OverbyJoseph van Batenburg-SherwoodKrishnakumar KizhatilManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of EngineeringColumbia University Medical Center (CUMC)Release Date2025-01-13
Serum Amyloid A1 antibody to treat leukemiasCU22360SAA1-targeting antibody blocks bone marrow–driven leukemia progression, aiming to prevent AML/MDS relapse and broaden hematologic cancer treatment.TagsAcute lymphoblastic leukemiaAcute myeloid leukemiaBreast cancerInventorsMarta Galan-DiezStavroula KousteniManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-10
Sensitive, non-invasive diagnostic assay for detecting prostate cancerCU22152Noninvasive urine RAD9 methylation test detects aggressive prostate cancer, boosting accuracy and enabling point-of-care prognosis.TagsAssayBladder cancerBlood testInventorsCatherine Spina MD, PhDHoward Brett Lieberman Ph.D.Kevin HopkinsManagerKristin NeumanDepartmentsCenter for Radiological ResearchRadiation OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-08-23
Engineered cell line for inducible protein expression for single-molecule imagingCU24352Inducible CHO cell line enables single-molecule GPCR interaction tracking in live cells with high-resolution smFRET.TagsCell membraneCell signalingCell surface receptorInventorsJonathan JavitchWesley AsherManagerJerry KokoshkaDepartmentsPsychiatryDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05
Protein fragment to promote neurogenesisCU13345Dominant-negative ATF5 fragment drives differentiation of neuroprogenitors into mature neurons and glial cells, enabling brain regeneration research.TagsAstrocyteCellular differentiationCentral nervous systemInventorsJames M. AngelastroLloyd Greene PhDManagerJerry KokoshkaDepartmentsMolecular BiosciencesPathologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-13
Monoclonal antibody for isolation of LRP1 for treatment of neurodegenerative diseasesCU25221Monoclonal antibody enables native LRP1 purification across species, boosting neurodegenerative therapy research and production.TagsAffinity chromatographyChromatographyEpitopeInventorsGabriele CeruttiLawrence S. Shapiro Ph.D.Susan Brenner-MortonManagerKristin NeumanDepartmentsBiochemistryBiochemistry and Molecular Biophysics / OphthalmologyMortimer B. Zuckerman Mind Brain Behavior InstituteRelease Date2025-04-24
Assay for neurotransmitter leakage detection using fluorescent analoguesCU22294Real-time, non-radioactive fluorescent assay tracks vesicular neurotransmitter leakage in cells for high-throughput neurological research.TagsAssayHigh-throughput screeningIsotopic labelingInventorsGary MillerMeghan L. BucherManagerJoan MartinezDepartmentsEnvironmental Health ScienceDivisionsMailman School Of Public Health (MSPH)Release Date2023-09-08CollectionsCNS/NeurologyPlatform/Research Tool
Broadly neutralizing antibody against SARS-CoV-2 variants and related sarbecovirusesCU24218Broadly neutralizing antibody targets SARS-CoV-2 variants and related sarbecoviruses, enabling versatile, durable treatment and prophylaxis.TagsAntibodyAntiviral drugCladeInventorsDavid Da-i Ho M.D.Jian YuLawrence S. Shapiro Ph.D.ManagerKristin NeumanDepartmentsAaron Diamond AIDS Research Center (ADARC)Biochemistry and Molecular Biophysics / OphthalmologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-09-16
KDM1A inhibitor combination therapy to enhance antibody-drug conjugate efficacy in carcinomasCU24095KDM1A inhibitors epigenetically upregulate NECTIN4/TROP2, boosting ADC efficacy in carcinomas and overcoming antigen-low resistance.TagsAntibody-drug conjugateAntigenBiopharmaceuticalInventorsJohn Robert ChristinMichael Shen Ph.D.ManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-09
Chimeric T cell receptors for preventing antibody-mediated rejection of transplantsCU24372Engineered CAR T cells selectively deplete donor-specific antibody–producing B cells to prevent transplant antibody-mediated rejection.TagsAntibodyB cellCancerInventorsMarkus MaparaMichel SadelainManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-03-20
Clinical management of Interstitial Lung Disease using a multiplex real-time PCR assay to quantify leukocyte telomere lengthCU24245Multiplex real-time PCR quantifies average leukocyte telomere length to guide ILD treatment decisions and outcomes.TagsAssayBiomarkerImmunosuppressionInventorsChad NewtonChristine K. GarciaDavid ZhangManagerKristin NeumanDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-13
BulkArg: computational pipeline for improving protein crystallization propensityCU23101A computational pipeline suggesting lysine-to-arginine substitutions to boost crystallization propensity and speed structure determination.TagsArginineBiological targetCrystallizationInventorsBlaine L. LoughlinJohn F. HuntNooriel E. BanayanManagerOfra WeinbergerDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2023-09-13
Antibody therapeutic targeting Funsobacterium nucleatum-mediated diseasesCU21261Monoclonal antibody against Annexin A1 blocks Fusobacterium nucleatum invasion, offering targeted prevention and treatment of Fn-related cancers.TagsAntibioticAntibodyBacteriaInventorsYiping HanManagerJerry KokoshkaDepartmentsPeriodonticsDivisionsColumbia University Medical Campus (CUMC)Release Date2024-02-09CollectionsRare DiseaseOncology
Combinatorial protein design platform for safe, high-potency CRISPR activatorsCU24283A high-throughput combinatorial protein design platform identifies potent, low-toxicity CRISPR activators across targets and cell types.TagsCRISPRCombinatoricsDNA barcodingInventorsAlejandro ChavezMarla GiddinsManagerCynthia LangDepartmentsMicrobiologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-04-10
High-throughput single-cell multi-omics platform for integrated RNA, DNA, and protein analysisCU21072Integrated single-cell platform enabling high-throughput RNA, DNA, and protein profiling for holistic cellular insights and scalable studies.TagsBiomarkerCell nucleusDrug discoveryInventorsPeter A. SimsTimothy R. OlsenManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-02CollectionsGenomics & Multi-Omics
Chaperone-enhanced platform for rescuing protein misfolding in neurodegenerative diseasesCU22082Chaperone-based gene therapy stabilizes RNA-binding proteins, reducing misfolding and aggregation in ALS/FTD. 120-150 chars.TagsAmyotrophic lateral sclerosisBiomarkerChaperone (protein)InventorsAlejandro ChavezSamuel J. ResnickManagerCynthia LangDepartmentsPathology & Cell BiologyProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2025-07-17
Inhibitory peptides targeting SARS-CoV-2 envelope proteinCU21015Inhibitory peptides block SARS-CoV-2 envelope protein, aiming for broad coronavirus protection by disrupting viral assembly and replication.TagsCombination therapyGene therapyProteinInventorsKazushige YoshidaMasayuki Yazawa Ph.D.Ramsey BekdashManagerKristin NeumanDepartmentsRehabilitation & Regenerative MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-10-03
D1-Cre knock-in mouse for genetic targeting of basal ganglia circuitsCU26035CRISPR knock-in D1-Cre mouse ensures precise, endogenous D1 neuron targeting in basal ganglia for targeted circuit studies.TagsBasal gangliaCre recombinaseDopamineInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-13
Extracellular vesicle-based assay for detecting head and neck cancerCU21332Noninvasive chip assay detects tumor-enriched proteins on patient extracellular vesicles to screen and monitor head-and-neck cancer.TagsAssayBody fluidCancer stagingInventorsAkiva MintzFatemeh Momen-HeraviGordana Vunjak-NovakovicManagerJoan MartinezDepartmentsBiomedical EngineeringCollege of Dental MedicineRadiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-06-28CollectionsOncology
Bacterial strain for improved protein productionCU15280Engineered BL21(DE3) E. coli strain boosts protein yield, enabling reliable production of unstable proteins for faster biotech development.TagsCell cultureEscherichia coliGene expressionInventorsMaxwell E. GottesmanManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-17
A spinal motor neuron-specific enhancer for cell-type specific gene expression control in the developing and adult central nervous systemCU22281Spinal motor neuron–specific enhancer enables AAV-deliverable, cell-type–restricted gene overexpression/knockdown in adults and development.TagsCentral nervous systemCholinergicGene expressionInventorsHynek WichterleTulsi PatelManagerJerry KokoshkaDepartmentsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-02CollectionsGene TherapyCNS/Neurology
Plasma-based, biopsy-free cancer detection assayCU23111Plasma-based, blood biopsy-free cancer detection using deep learning on cfDNA methylation to diagnose multiple cancers non-invasively.TagsAssayCancerDNA methylationInventorsXu HuaZhiguo Zhang Ph.D.ManagerJoan MartinezDepartmentsGenetics & DevelopmentInstitute for Cancer GeneticsDivisionsColumbia University Medical Center (CUMC)Release Date2023-03-03CollectionsOncologyArtificial Intelligence (AI)
Computational tool to predict RNA binding protein targets for gene therapy and agricultural bioengineeringCU23342PPRDecoder: a genome-wide, unbiased algorithm predicting RNA targets of PPR proteins, accelerating gene regulation research.TagsAlgorithmBiological engineeringBiotechnologyInventorsChaolin Zhang PhDManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2023-08-04CollectionsGene Therapy
Chimeric protein for directly modulating calcium ion channel activityCU23388Genetically encoded enhancer boosts L-type Ca2+ currents with tissue targeting, rescuing dysfunctional calcium channels.TagsActuatorAntiarrhythmic agentArrhythmiaInventorsManu Ben-JohnyPedro Javier del Rivero MorfinManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05CollectionsCardiovascular
Recombinant ILT3 protein-produced antibodies for immunotherapy treatment of cancerCU15207Engineered anti-ILT3 antibodies enable targeted cancer immunotherapy, modulating myeloid signals and enhancing immune blockade.TagsAcute myeloid leukemiaAllotransplantationAntibodyInventorsGeorge Vlad Ph.D.Nicole Suciu-FocaZheng XuManagerSara GusikDepartmentsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-03-08CollectionsOncology
Anxa1-Cre mouse for selective modeling of dopaminergic neurons in Parkinson's diseaseCU26032Anxa1-Cre mouse enables precise manipulation of a vulnerable dopaminergic neuron subtype to study early Parkinson’s motor deficits.TagsBiomarkerCausalityCre recombinaseInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-07
Recombinant protein to treat inflammationCU23248Recombinant FSTL-1 protein targets and reduces cardiac inflammation, aiding Kawasaki disease research and myocarditis treatment.TagsAnti-inflammatoryAtherosclerosisBiomarkerInventorsMark GorelikManagerSara GusikDepartmentsPediatrics/RheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-10CollectionsCardiovascular
A mouse model expressing recombinase in dopamine transporter-positive neuronsCU26033Precise FlpO recombination in dopamine transporter neurons via CRISPR knock-in, enabling targeted dopaminergic research.TagsBasal gangliaDopamineDopamine transporterInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-07
Protein sequencing with a cavity-separated multi-nanopore deviceCU22073Cavity-separated multi-nanopore sequencing enables high-throughput, library-free, single-molecule protein sequencing with improved accuracy.TagsDrug developmentGene expressionIonInventorsJakob BuchheimKenneth ShepardManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-01-31
Conditional 5-HT1A receptor knockout mouse model for studying antidepressant responseCU25138Inducible, cell-type specific 5HT1AR knockout mouse model reveals dentate gyrus roles in antidepressant response and mood regulation.Tags5-HT receptor5-HT1A receptorAntidepressantInventorsRene HenManagerKristin NeumanDepartmentsPharmacologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-02-28
Fusion protein as target for brain cancer therapyCU12240Targeting FGFR-TACC gene fusions in glioblastoma with kinase inhibitors; precision therapy and diagnostic tools.TagsAssayChemotherapyGlioblastomaInventorsAnna LasorellaAntonio IavaroneRaul RabadanManagerKristin NeumanDepartmentsBiomedical InformaticsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2022-09-15CollectionsSmall MoleculeOncology
Human ALFY knock-in mice for studying neurodegenerative diseaseCU26143Human ALFY knock-in mice enable tissue-specific, controllable hALFY expression to study neurodegenerative protein aggregation.TagsAutophagyCopy number variationCre recombinaseInventorsAi YamamotoManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08CollectionsCNS/Neurology
Modified peptide nucleic acids for highly specific suppression of oncogene transcriptionCU19272Modified peptide nucleic acids deliver tumor-specific transcription suppression with reduced off-target toxicity for KRAS-driven cancers.TagsChemotherapyCytotoxicityKRASInventorsJeffrey RothmanManagerJoan MartinezDepartmentsOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-06-18
Gene therapy for metabolic dysfunction-associated steatohepatitis (MASH)CU25230Gene therapy restoring retromer activity to treat MASH by normalizing lipid metabolism and reducing fibrosis risk.TagsCirrhosisDrug discoveryFibrosisInventorsGregory A. PetskoScott A. Small M.D.ManagerJerry KokoshkaDepartmentsAnn Romney Center for Neurologic DiseasesNeurologyDivisionsColumbia University Medical Center (CUMC)Harvard Medical School and Brigham & Women’s HospitalRelease Date2025-07-31
Adeno-associated virus Glut1 gene therapy for rescuing glucose transport in Glut1 deficiency syndromeCU15054AAV-based Glut1 gene therapy restores brain glucose transport in Glut1 deficiency, offering a one-time, long-term treatment.TagsAdeno-associated virusBlood–brain barrierCognitive deficitInventorsDarryl C. De VivoGuangping GaoKristin EngelstadManagerKristin NeumanDepartmentsNeurologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Office of Technology ManagementRelease Date2025-08-19
Genome-wide qPCR with increased primer multiplexity for diagnostics and drug screeningCU23284A qPCR platform using optically barcoded beads enables genome-wide multiplex expression analysis (100–10,000 targets) faster and cheaper.TagsAcidChain reactionHigh-throughput screeningInventorsNaixin QianWei MinZhilun ZhaoManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-10-16
