Engineered anti-Cre antibody for detection of CreCU23045Engineered monoclonal anti-Cre antibody enables precise, tissue-specific Cre detection, improving reliability over current reagents.TagsAntibodyCre recombinaseDNA sequencingInventorsDavid NgSusan Brenner-MortonManagerJerry KokoshkaDepartmentsBiochemistryMortimer B. Zuckerman Mind Brain Behavior InstituteRelease Date2022-10-31
Sensitive SARS-CoV-2 antigen testCU21002Ultra-sensitive SARS-CoV-2 antigen sandwich ELISA using dual nucleocapsid antibodies for rapid, low-viral-load detection.TagsAntibodyAntigenAssayInventorsDavid Da-i Ho M.D.Lihong LiuManagerKristin NeumanDepartmentsMedicinePhysicians & SurgeonsDivisionsColumbia University Medical Center (CUMC)Release Date2024-04-25
CMOS imaging arrays for high-speed fluorescence lifetime imagingCU12003CMOS-SPAD FLIM array enables 200 fps wide-field imaging with on-chip timing, compact, cost-effective for live-cell and high-throughput assays.TagsCMOSDNA sequencingData acquisitionInventorsKenneth ShepardRyan M. FieldManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-10-09
Peptide nucleic acid conjugates for altering gene expression in cancerCU16241Selective peptide nucleic acid polymers block cancer gene expression, targeting mutations like BRAFV600E with improved delivery and specificity.TagsBioavailabilityBiosensorCell cultureInventorsGary Schwartz M.D.Jeffrey Rothman M.D.ManagerJoan MartinezDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-03CollectionsGene TherapyOncology
NAPA-ID: a proximity-based system to decode protein-protein interactionsCU26166NAPA-ID enables antibody-guided, proximity labeling of protein interactions without genetic editing, compatible with standard proteomics workflows.TagsAntibodyBiological engineeringBiomarkerInventorsJeremy CartalasSara ZaccaraManagerJerry KokoshkaDepartmentsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-17
Non-invasive laser therapy for cytokine modulation and corneal inflammation managementCU18315Femtosecond laser therapy non-invasively modulates corneal cytokines to reduce inflammation and keratocyte apoptosis, preserving tissue.TagsAnalgesicAntibioticApoptosisInventorsSinisa VukelicManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-08-17CollectionsOphthalmology
Mechanobiological assay for glaucoma drug screeningCU23377In vitro mechanobiological assay using patient Schlemm’s canal cells; high-throughput pore formation tests to screen glaucoma drugs.TagsAqueous humourAssayBiomechanicsInventorsDarryl OverbyJoseph van Batenburg-SherwoodKrishnakumar KizhatilManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of EngineeringColumbia University Medical Center (CUMC)Release Date2025-01-13
Engineered cell line for inducible protein expression for single-molecule imagingCU24352Inducible CHO cell line enables single-molecule GPCR interaction tracking in live cells with high-resolution smFRET.TagsCell membraneCell signalingCell surface receptorInventorsJonathan JavitchWesley AsherManagerJerry KokoshkaDepartmentsPsychiatryDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05
Sensitive, non-invasive diagnostic assay for detecting prostate cancerCU22152Noninvasive urine RAD9 methylation test detects aggressive prostate cancer, boosting accuracy and enabling point-of-care prognosis.TagsAssayBladder cancerBlood testInventorsCatherine Spina MD, PhDHoward Brett Lieberman Ph.D.Kevin HopkinsManagerKristin NeumanDepartmentsCenter for Radiological ResearchRadiation OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-08-23
Serum Amyloid A1 antibody to treat leukemiasCU22360SAA1-targeting antibody blocks bone marrow–driven leukemia progression, aiming to prevent AML/MDS relapse and broaden hematologic cancer treatment.TagsAcute lymphoblastic leukemiaAcute myeloid leukemiaBreast cancerInventorsMarta Galan-DiezStavroula KousteniManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-10
Assay for neurotransmitter leakage detection using fluorescent analoguesCU22294Real-time, non-radioactive fluorescent assay tracks vesicular neurotransmitter leakage in cells for high-throughput neurological research.TagsAssayHigh-throughput screeningIsotopic labelingInventorsGary MillerMeghan L. BucherManagerJoan MartinezDepartmentsEnvironmental Health ScienceDivisionsMailman School Of Public Health (MSPH)Release Date2023-09-08CollectionsCNS/NeurologyPlatform/Research Tool
Protein fragment to promote neurogenesisCU13345Dominant-negative ATF5 fragment drives differentiation of neuroprogenitors into mature neurons and glial cells, enabling brain regeneration research.TagsAstrocyteCellular differentiationCentral nervous systemInventorsJames M. AngelastroLloyd Greene PhDManagerJerry KokoshkaDepartmentsMolecular BiosciencesPathologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-13
Broadly neutralizing antibody against SARS-CoV-2 variants and related sarbecovirusesCU24218Broadly neutralizing antibody targets SARS-CoV-2 variants and related sarbecoviruses, enabling versatile, durable treatment and prophylaxis.TagsAntibodyAntiviral drugCladeInventorsDavid Da-i Ho M.D.Jian YuLawrence S. Shapiro Ph.D.ManagerKristin NeumanDepartmentsAaron Diamond AIDS Research Center (ADARC)Biochemistry and Molecular Biophysics / OphthalmologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-09-16
Monoclonal antibody for isolation of LRP1 for treatment of neurodegenerative diseasesCU25221Monoclonal antibody enables native LRP1 purification across species, boosting neurodegenerative therapy research and production.TagsAffinity chromatographyChromatographyEpitopeInventorsGabriele CeruttiLawrence S. Shapiro Ph.D.Susan Brenner-MortonManagerKristin NeumanDepartmentsBiochemistryBiochemistry and Molecular Biophysics / OphthalmologyMortimer B. Zuckerman Mind Brain Behavior InstituteRelease Date2025-04-24
Combination therapy to increase the efficacy of antibody-drug conjugates in bladder cancerCU24095Small molecule reprograms bladder cancer cells to upregulate antigens, boosting antibody-drug conjugate efficacy. 14 words.TagsAntibody-drug conjugateAntigenBiopharmaceuticalInventorsJohn Robert ChristinMichael Shen Ph.D.ManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-09
Clinical management of Interstitial Lung Disease using a multiplex real-time PCR assay to quantify leukocyte telomere lengthCU24245Multiplex real-time PCR quantifies average leukocyte telomere length to guide ILD treatment decisions and outcomes.TagsAssayBiomarkerImmunosuppressionInventorsChad NewtonChristine K. GarciaDavid ZhangManagerKristin NeumanDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-13
BulkArg: computational pipeline for improving protein crystallization propensityCU23101A computational pipeline suggesting lysine-to-arginine substitutions to boost crystallization propensity and speed structure determination.TagsArginineBiological targetCrystallizationInventorsBlaine L. LoughlinJohn F. HuntNooriel E. BanayanManagerOfra WeinbergerDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2023-09-13
Antibody therapeutic targeting Funsobacterium nucleatum-mediated diseasesCU21261Monoclonal antibody against Annexin A1 blocks Fusobacterium nucleatum invasion, offering targeted prevention and treatment of Fn-related cancers.TagsAntibioticAntibodyBacteriaInventorsYiping HanManagerJerry KokoshkaDepartmentsPeriodonticsDivisionsColumbia University Medical Campus (CUMC)Release Date2024-02-09CollectionsRare DiseaseOncology
Antibody-like molecule for specific and potent HIV latency reversalCU23253Bispecific antibody targets CD4+ T cells and IL-15 receptor to deliver potent latency reversal agents, reactivating HIV reservoirs.TagsAntiviral drugCD4Combination therapyInventorsDavid Da-i Ho M.D.Hiroshi MohriJian YuManagerKristin NeumanDepartmentsAaron Diamond AIDS Research Center (ADARC)MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-10-25CollectionsImmunology & Inflammation
A spinal motor neuron-specific enhancer for cell-type specific gene expression control in the developing and adult central nervous systemCU22281Spinal motor neuron–specific enhancer enables AAV-deliverable, cell-type–restricted gene overexpression/knockdown in adults and development.TagsCentral nervous systemCholinergicGene expressionInventorsHynek WichterleTulsi PatelManagerJerry KokoshkaDepartmentsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-02CollectionsGene TherapyCNS/Neurology
Extracellular vesicle-based assay for detecting head and neck cancerCU21332Noninvasive chip assay detects tumor-enriched proteins on patient extracellular vesicles to screen and monitor head-and-neck cancer.TagsAssayBody fluidCancer stagingInventorsAkiva MintzFatemeh Momen-HeraviGordana Vunjak-NovakovicManagerJoan MartinezDepartmentsBiomedical EngineeringCollege of Dental MedicineRadiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-06-28CollectionsOncology
Inhibitory peptides targeting SARS-CoV-2 envelope proteinCU21015Inhibitory peptides block SARS-CoV-2 envelope protein, aiming for broad coronavirus protection by disrupting viral assembly and replication.TagsCombination therapyGene therapyProteinInventorsKazushige YoshidaMasayuki Yazawa Ph.D.Ramsey BekdashManagerKristin NeumanDepartmentsRehabilitation & Regenerative MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-10-03
Chaperone-enhanced platform for rescuing protein misfolding in neurodegenerative diseasesCU22082Chaperone-based gene therapy stabilizes RNA-binding proteins, reducing misfolding and aggregation in ALS/FTD. 120-150 chars.TagsAmyotrophic lateral sclerosisBiomarkerChaperone (protein)InventorsAlejandro ChavezSamuel J. ResnickManagerCynthia LangDepartmentsPathology & Cell BiologyProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2025-07-17
Plasma-based, biopsy-free cancer detection assayCU23111Plasma-based, blood biopsy-free cancer detection using deep learning on cfDNA methylation to diagnose multiple cancers non-invasively.TagsAssayCancerDNA methylationInventorsXu HuaZhiguo Zhang Ph.D.ManagerJoan MartinezDepartmentsGenetics & DevelopmentInstitute for Cancer GeneticsDivisionsColumbia University Medical Center (CUMC)Release Date2023-03-03CollectionsOncology
Bacterial strain for improved protein productionCU15280Engineered BL21(DE3) E. coli strain boosts protein yield, enabling reliable production of unstable proteins for faster biotech development.TagsCell cultureEscherichia coliGene expressionInventorsMaxwell E. GottesmanManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-17
Computational tool to predict RNA binding protein targets for gene therapy and agricultural bioengineeringCU23342PPRDecoder: a genome-wide, unbiased algorithm predicting RNA targets of PPR proteins, accelerating gene regulation research.TagsAlgorithmBiological engineeringBiotechnologyInventorsChaolin Zhang PhDManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2023-08-04CollectionsGene Therapy
D1-Cre knock-in mouse for genetic targeting of basal ganglia circuitsCU26035CRISPR knock-in D1-Cre mouse ensures precise, endogenous D1 neuron targeting in basal ganglia for targeted circuit studies.TagsBasal gangliaCre recombinaseDopamineInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-13
Recombinant ILT3 protein-produced antibodies for immunotherapy treatment of cancerCU15207Engineered anti-ILT3 antibodies enable targeted cancer immunotherapy, modulating myeloid signals and enhancing immune blockade.TagsAcute myeloid leukemiaAllotransplantationAntibodyInventorsGeorge Vlad Ph.D.Nicole Suciu-FocaZheng XuManagerSara GusikDepartmentsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-03-08CollectionsOncology
Chimeric protein for directly modulating calcium ion channel activityCU23388Genetically encoded enhancer boosts L-type Ca2+ currents with tissue targeting, rescuing dysfunctional calcium channels.TagsActuatorAntiarrhythmic agentArrhythmiaInventorsManu Ben-JohnyPedro Javier del Rivero MorfinManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05CollectionsCardiovascular
Recombinant protein to treat inflammationCU23248Recombinant FSTL-1 protein targets and reduces cardiac inflammation, aiding Kawasaki disease research and myocarditis treatment.TagsAnti-inflammatoryAtherosclerosisBiomarkerInventorsMark GorelikManagerSara GusikDepartmentsPediatrics/RheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-10CollectionsCardiovascular
Anxa1-Cre mouse for selective modeling of dopaminergic neurons in Parkinson's diseaseCU26032Anxa1-Cre mouse enables precise manipulation of a vulnerable dopaminergic neuron subtype to study early Parkinson’s motor deficits.TagsBiomarkerCausalityCre recombinaseInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-07
Protein sequencing with a cavity-separated multi-nanopore deviceCU22073Cavity-separated multi-nanopore sequencing enables high-throughput, library-free, single-molecule protein sequencing with improved accuracy.TagsDrug developmentGene expressionIonInventorsJakob BuchheimKenneth ShepardManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-01-31
A mouse model expressing recombinase in dopamine transporter-positive neuronsCU26033Precise FlpO recombination in dopamine transporter neurons via CRISPR knock-in, enabling targeted dopaminergic research.TagsBasal gangliaDopamineDopamine transporterInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-07
High-throughput single-cell multi-omics platform for integrated RNA, DNA, and protein analysisCU21072Integrated single-cell platform enabling high-throughput RNA, DNA, and protein profiling for holistic cellular insights and scalable studies.TagsBiomarkerCell nucleusDrug discoveryInventorsPeter A. SimsTimothy R. OlsenManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-02CollectionsGenomics & Multi-Omics
Fusion protein as target for brain cancer therapyCU12240Targeting FGFR-TACC gene fusions in glioblastoma with kinase inhibitors; precision therapy and diagnostic tools.TagsAssayChemotherapyGlioblastomaInventorsAnna LasorellaAntonio IavaroneRaul RabadanManagerKristin NeumanDepartmentsBiomedical InformaticsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2022-09-15CollectionsSmall MoleculeOncology
Conditional 5-HT1A receptor knockout mouse model for studying antidepressant responseCU25138Inducible, cell-type specific 5HT1AR knockout mouse model reveals dentate gyrus roles in antidepressant response and mood regulation.Tags5-HT receptor5-HT1A receptorAntidepressantInventorsRene HenManagerKristin NeumanDepartmentsPharmacologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-02-28
Human ALFY knock-in mice for studying neurodegenerative diseaseCU26143Human ALFY knock-in mice enable tissue-specific, controllable hALFY expression to study neurodegenerative protein aggregation.TagsAutophagyCopy number variationCre recombinaseInventorsAi YamamotoManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08CollectionsCNS/Neurology
Gene therapy for metabolic dysfunction-associated steatohepatitis (MASH)CU25230Gene therapy restoring retromer activity to treat MASH by normalizing lipid metabolism and reducing fibrosis risk.TagsCirrhosisDrug discoveryFibrosisInventorsGregory A. PetskoScott A. Small M.D.ManagerJerry KokoshkaDepartmentsAnn Romney Center for Neurologic DiseasesNeurologyDivisionsColumbia University Medical Center (CUMC)Harvard Medical School and Brigham & Women’s HospitalRelease Date2025-07-31
Adeno-associated virus Glut1 gene therapy for rescuing glucose transport in Glut1 deficiency syndromeCU15054AAV-based Glut1 gene therapy restores brain glucose transport in Glut1 deficiency, offering a one-time, long-term treatment.TagsAdeno-associated virusBlood–brain barrierCognitive deficitInventorsDarryl C. De VivoGuangping GaoKristin EngelstadManagerKristin NeumanDepartmentsNeurologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Office of Technology ManagementRelease Date2025-08-19
Aldh3a1-Creert mouse lineCU25020Inducible Aldh3a1-CreERT mouse enables tamoxifen-controlled lineage tracing of Aldh3a1-positive pancreatic β-cells for diabetes research.TagsAldehydeAldehyde dehydrogenaseBeta cellInventorsDomenico Accili M.D.Jinsook Son PhDManagerCynthia LangDepartmentsEndocrinologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-09-26
Serochip for the diagnosis of tick-borne diseasesCU19325A programmable peptide microarray enables rapid, high-throughput, single-step serologic diagnosis of multiple tick-borne diseases.TagsAntibodyAssayEpidemiologyInventorsAdrian CaciulaNischay MishraRafal TokarzManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2025-09-04
Chemical painting for high-throughput single-cell drug response analysisCU23332Multiplexed infrared imaging enables high-throughput, single-cell drug profiling with ML-enabled mechanism-of-action predictions.TagsCombination therapyDNA sequencingDrug discoveryInventorsWei MinXinwen LiuManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-10-16
Gene silencing for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)CU23021Silencing CASP8-METRN halts progression from steatosis to MASH, offering non-invasive therapy and diagnostic biomarkers.TagsBiomarkerBlood plasmaCaspase 8InventorsDanish SaleheenIra Tabas MD, PhDShareef KhalidManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08
Gene editing for treatment of retinitis pigmentosaCU23293CRISPR-based retinal metabolism reprogramming targets PHD2 to slow retinitis pigmentosa progression, offering broad RP treatment potential.TagsAdeno-associated virusCRISPRCRISPR gene editingInventorsStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCRelease Date2024-11-26CollectionsOphthalmology
Functional tagging of neurons for further integrative analysisCU24343In vivo activity-tagging of activated neurons enables high-throughput collection for downstream transcriptomic analysis and function-genome mapping.TagsTranscriptomeInventorsAttila LosonczyBoaz NutkovichDahlia KushinskyManagerKristin NeumanDepartmentsBrain SciencesNeuroscienceDivisionsColumbia University Medical Center (CUMC)Zuckerman Mind Brain Behavior InstRelease Date2025-12-01
Conditional knockout mouse model for studying autosomal-dominant optic atrophyCU26140A mammalian, cell-type–specific conditional Ssbp1 R107Q mouse model to dissect autosomal-dominant optic atrophy mechanisms.TagsAlleleArginineCre recombinaseInventorsChyuan-Sheng (Victor) LinNan-Kai WangYunju TsengManagerKristin NeumanDepartmentsOphthalmologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
ARP-154 (HeLa T4+) human cancer cell line generated by gene transfer for AIDS researchCU24290CD4-expressing HeLa-derived cell line enables AIDS research; facilitates HIV binding studies, drug screening, and therapeutic development.TagsAIDSAntigenAutoimmune diseaseInventorsPaul J. MaddonRichard Axel M.D.ManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2024-05-29
Conditional mouse model for the BARD1 geneCU23026A conditional Bard1 mouse model enables tissue-specific gene knockout to study BRCA1/BARD1 cancer risk and therapy.TagsAlleleBRCA1Breast cancerInventorsFoon Wu-baerRichard Baer Ph.D.ManagerJoan MartinezDepartmentsPathologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Release Date2022-10-10CollectionsOncologyWomen's Health
VPS35 floxed mouse model for Alzheimer's drug discoveryCU25395Inducible, tissue-specific VPS35 knockout mouse enabling controlled adult-onset retromer disruption for Alzheimer’s research.TagsBiomarkerCerebrospinal fluidDrug discoveryInventorsScott A. Small M.D.ManagerJerry KokoshkaDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-31
Live yeast biosensors for pathogen detectionCU21127Engineered live yeast biosensors emit color/fluorescent signals for rapid, sensitive pathogen detection, including fungi, viruses, and variants.TagsAntifungalAntiviral drugAssayInventorsVirginia W. CornishManagerJoan MartinezDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-03-07
