Therapeutic prime editing for gene therapy against ocular dystrophyCU22243Prime-editing therapy targets PRPH2 splice mutations (c.828+) for retinal dystrophies, enabling precise in-eye gene corrections.TagsAnimal husbandryCas9GenomeInventorsBruna Lopes da CostaPeter M.J. QuinnSalvatore M. CarusoManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-04-25CollectionsOphthalmologyGene Therapy
3D organoids for modeling squamous epithelial pathology and personalized medicineCU223013D squamous epithelial organoids enable patient-specific disease modeling and rapid, predictive drug testing for ESCC/EAC.TagsAdenocarcinomaCarcinomaEpitheliumInventorsAnil K. Rustgi M.D.Hiroshi NakagawaManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-01-04CollectionsOncology
Enhanced hematopoietic stem cell regenerationCU25234Partial inhibition of fatty acid metabolism boosts hematopoietic stem cell self-renewal, enhancing bone marrow transplants and regeneration.TagsBone marrowFatty acidGene therapyInventorsLei DingYue ZhangManagerKristin NeumanDepartmentsMicrobiologyRehabilitation & Regenerative MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-26
Universal gene therapy for retinal degenerationCU18340Broad, gene-agnostic retinal therapy using AAV-delivered PGC1α/NRF2 or inhibitors to rebalance metabolism, reduce oxidative stress, slow degeneration.TagsAntioxidantGene therapyGenetic disorderInventorsStephen H. Tsang M.D., Ph.D.Xuan CuiManagerKristin NeumanDepartmentsOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Release Date2023-05-15CollectionsOphthalmologyGene TherapyCNS/Neurology
Targeted gene therapy for retinopathiesCU21122CRB1-targeted gene therapy delivers isoform-specific CRB1 to Müller glia and photoreceptors, treating CRB1-retinopathies.TagsGene expressionGene therapyGenetic disorderInventorsPeter M.J. QuinnStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Release Date2023-07-06CollectionsOphthalmologyGene Therapy
Modified prime editor for gene therapy optimizationCU22084AAV-compatible, compact prime editor enables single-delivery gene therapy and research tools by packaging smaller genome-editing payloads.TagsAchromatopsiaAcidAdeno-associated virusInventorsBruna Lopes da CostaPeter M.J. QuinnStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2022-09-23CollectionsGene Therapy
Conformational DNA aptamers enabling small-molecule lateral flow assaysCU26117Conformational DNA aptamers enable rapid, cost-effective small-molecule detection in lateral flow assays via structure-switching binding.TagsAnalyteAntibodyAptamerInventorsKyungae YangManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-01
Topical gene therapy for the treatment of AP-1-associated genetic skin disordersCU26038Topical gene therapy restores AP-1 function in skin, enabling localized, repeatable treatment for monogenic ichthyosis and keratoderma.TagsAP-1 transcription factorCarcinogenesisCombination therapyInventorsStephen KalerTarun KanigantiManagerKristin NeumanDepartmentsPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-26
Small molecule activators for preventing vision loss in Best vitelliform macular dystrophyCU25176Small molecule activators restore Best1 function to slow BVMD vision loss; targeted, potentially non-invasive retinal therapy.Tags4-Aminobenzoic acidDrug developmentGene therapyInventorsBingchen YuTingting YangYu ZhangManagerJoan MartinezDepartmentsChemistryOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-05-01CollectionsOphthalmology
Nanofibrous scaffold for controlled release of small molecule immunomodulatorsCU24040Nanofibrous scaffold locally releases ACHP to inhibit NF-kB, enabling targeted immunomodulation with reduced systemic effects.TagsAutoimmune diseaseBiomaterialDrug deliveryInventorsFereshteh ZandkarimiHannah ChildsHelen Lu Ph.D.ManagerJoan MartinezDepartmentsBiological SciencesBiomedical EngineeringDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-12-18CollectionsSmall Molecule
Small molecule inhibitor of cognitive impairment associated with neurodegenerative diseaseCU23096Small molecule minaprine analog targets 5-HT2B to curb cognitive/behavioral deficits in neurodegenerative diseases, including Alzheimer's.Tags5-HT receptor5-HT2B receptorAmyloid betaInventorsDaniel M. WattersonErica AcquaroneOttavio ArancioManagerJerry KokoshkaDepartmentsPathologyPharmacologyTaub InstituteDivisionsColumbia University Medical Center (CUMC)Feinberg School of MedicineRelease Date2025-04-10
Combined small molecule treatment as a synergistic epigenetic therapy for pancreatic cancerCU23218Combined HDAC and eIF4A inhibition reprograms pancreatic cancer epigenetically, boosting efficacy and tumor suppression in vivo.TagsAdenocarcinomaApoptosisChemotherapyInventorsAntonio FojoMaryam SafariSusan BatesManagerJerry KokoshkaDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-08-22
High-throughput method for gene insertionCU19411A high-throughput, vector-based CRISPR system enabling parallel, precise DNA insertions in human cells for scalable genome editing.TagsBacteriaCas9Gene therapyInventorsAlejandro ChavezBrijesh Kumar SinghManagerCynthia LangDepartmentsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-17
Gene therapy for thymidine kinase 2 (TK2) deficiencyCU18199Engineered AAV9 gene therapy replaces TK2 to treat TK2 deficiency mitochondrial diseases, potentially correcting DNA depletion and symptoms.TagsComorbidityEnzymeGene therapyInventorsCarlos Lopez-GomezHasan Orhan AkmanMichio Hirano M.D.ManagerKristin NeumanDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-01-17CollectionsGene Therapy
Adeno-associated virus Glut1 gene therapy for rescuing glucose transport in Glut1 deficiency syndromeCU15054AAV-based Glut1 gene therapy restores brain glucose transport in Glut1 deficiency, offering a one-time, long-term treatment.TagsAdeno-associated virusBlood–brain barrierCognitive deficitInventorsDarryl C. De VivoGuangping GaoKristin EngelstadManagerKristin NeumanDepartmentsNeurologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Office of Technology ManagementRelease Date2025-08-19
Computational tool to predict RNA binding protein targets for gene therapy and agricultural bioengineeringCU23342PPRDecoder: a genome-wide, unbiased algorithm predicting RNA targets of PPR proteins, accelerating gene regulation research.TagsAlgorithmBiological engineeringBiotechnologyInventorsChaolin Zhang PhDManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2023-08-04CollectionsGene Therapy
Chop-Stick gene therapy for retinitis pigmentosa and other autosomal dominant ocular diseasesCU15206Chop-Stick CRISPR therapy edits dominant ocular genes to disable mutations and replace with wild-type function for RP and related diseases.TagsAlleleCRISPRComplementary DNAInventorsLawrence ChanStephen H. Tsang M.D., Ph.D.Wen-Hsuan WuManagerKristin NeumanDepartmentsNutritional and Metabolic BiologyOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2022-09-23CollectionsOphthalmologyGene Therapy
Gene therapy for Bestrophin-1 (BEST1) mutations in retinal degenerative diseasesCU21279AAV BEST1 gene therapy targets dominant BEST1 retinal mutations to restore function and potentially cure associated degeneration.TagsAdeno-associated virusGene therapyGenetic disorderInventorsStephen H. Tsang M.D., Ph.D.Tingting YangYu ZhangManagerKristin NeumanDepartmentsOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Release Date2023-09-08CollectionsOphthalmologyGene Therapy
Small molecule inhibitors of the ID2/VHL interactionCU17182Four small molecules block ID2/VHL, promote HIF degradation, potentially slowing tumor growth and angiogenesis in cancers.TagsAngiogenesisCell growthChemotherapyInventorsAnna LasorellaAntonio IavaroneDan ShermanManagerKristin NeumanDepartmentsInstitute for Cancer GeneticsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-19CollectionsSmall MoleculeOncology
Small molecule treatment for MAPK-regulated cancersCU20013MAP4K2-targeted small molecule inhibits MAPK signaling to curb multiple myeloma growth, offering therapy for resistant hematologic cancers.TagsApoptosisB cellCell proliferationInventorsDonald William Landry MD, Ph.D.Jing Fu Ph.D.Shi-xian DengManagerJerry KokoshkaDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2022-08-05CollectionsSmall MoleculeOncology
Parameters to maximize nebulized drug delivery to larynxCU24050Patient-specific CT-based nebulization parameters optimize aerosol size and velocity to maximize laryngeal drug deposition.TagsAerosolDrug deliveryHypersensitivityInventorsMichael Pitman MDManagerCynthia LangDepartmentsOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05
Robotic system to efficiently handle cell culture plates in embryology laboratoriesCU22015Robotic platform automates high-throughput, contamination-free preparation of embryology cell culture plates, boosting consistency and efficiency.TagsCell cultureEmbryoEmbryologyInventorsSamuel Z. "Zev" WilliamsManagerCynthia LangDepartmentsObstetrics & GynecologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-01-13
Multi-lumen microneedle for intracochlear drug delivery and samplingCU21117Ultra-sharp multi-lumen microneedles enable simultaneous intracochlear drug delivery and perilymph sampling with zero net volume change.TagsCochleaDiffusionDrug deliveryInventorsAnil LalwaniAykut AksitJeffrey W. KysarManagerDovina QuDepartmentsMechanical EngineeringOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-09-26
Targeting ID2 to impair hypoxic cancer stem cell proliferationCU16166Targeting ID2–DYRK1A/B axis degrades HIF2a in hypoxic cancer stem cells, offering glioblastoma–focused, broad oncologic potential.TagsAngiogenesisCancer stem cellCell proliferationInventorsAnna LasorellaAntonio IavaroneManagerKristin NeumanDepartmentsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-19CollectionsOncology
Universal gene editing strategy for cardiac arrhythmiaCU24243Universal gene-editing of Rad phosphorylation sites to curb adrenergic CaV1.2 signaling, offering targeted, long-term arrhythmia therapy.TagsArrhythmiaBeta blockerFight-or-flight responseInventorsGregory NewbyGuoxia LiuSteven MarxManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-14
Gene editing for treatment of retinitis pigmentosaCU23293CRISPR-based retinal metabolism reprogramming targets PHD2 to slow retinitis pigmentosa progression, offering broad RP treatment potential.TagsAdeno-associated virusCRISPRCRISPR gene editingInventorsStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCRelease Date2024-11-26CollectionsOphthalmology
Multimodal single-cell and whole-genome sequencing from small amounts of frozen tissueCU21047Ultra-efficient multimodal single-cell profiling from tiny, frozen tissue, enabling transcriptomics, CNV, T-cell repertoires, and more.TagsCancer immunotherapyDNA sequencingData qualityInventorsBenjamin Izar MD, PhDJohannes MelmsManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-02-24
Ultrasound-responsive microcapsules for localized and on-demand drug deliveryCU22072Ultrasound-triggered, biphasic microcapsules enable on-demand, localized drug release with reduced systemic toxicity and long-term payload stability.TagsChemotherapyDextranDrug deliveryInventorsMargaret JakusRachel D. FieldSamuel Sia Ph.D.ManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-07-20
Gene editing to treat retinal dystrophiesCU22019Prime editing corrects CRB1 mutations in retinal dystrophy, offering isoform-independent gene therapy and research tool potential.TagsCell therapyGene expressionGene therapyInventorsBruna Lopes da CostaPeter M.J. QuinnStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2022-10-31CollectionsOphthalmologyGene Therapy
Gene editing system for the treatment of autosomal dominant disease-related genesCU18283Mutation-independent CRISPR pair replaces dominant alleles with a functional gene to treat autosomal dominant diseases.TagsCRISPRGene therapyGenetic disorderInventorsStephen H. Tsang M.D., Ph.D.Wen-Hsuan WuYi-Ting TsaiManagerKristin NeumanDepartmentsNutritional and Metabolic BiologyOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2023-12-28CollectionsOphthalmologyGene Therapy
Combination therapy to increase the efficacy of antibody-drug conjugates in bladder cancerCU24095Small molecule reprograms bladder cancer cells to upregulate antigens, boosting antibody-drug conjugate efficacy. 14 words.TagsAntibody-drug conjugateAntigenBiopharmaceuticalInventorsJohn Robert ChristinMichael Shen Ph.D.ManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-09
Highly efficient T cell base editing for enhanced immunotherapiesCU24092Ultra-efficient base editing in human T cells using adenine/cytosine editors; enhances CAR-T, autoimmune therapies with lower toxicity.TagsAdenineCancerChimeric antigen receptor T cellInventorsBenjamin Izar MD, PhDZachary WalshManagerJoan MartinezDepartmentsMedicineMedicine - Hematology/OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08
Microneedle array for cross-barrier drug delivery in the eye, ear and central nervous systemCU18171Biodegradable microneedle arrays enable precise, cross-barrier drug delivery to the eye, ear, and CNS with controlled release.Tags3D printingBiodegradationCentral nervous systemInventorsAnil LalwaniAykut AksitDaniel N. ArteagaManagerDovina QuDepartmentsMechanical EngineeringOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-01-24
ARP-154 (HeLa T4+) human cancer cell line generated by gene transfer for AIDS researchCU24290CD4-expressing HeLa-derived cell line enables AIDS research; facilitates HIV binding studies, drug screening, and therapeutic development.TagsAIDSAntigenAutoimmune diseaseInventorsPaul J. MaddonRichard Axel M.D.ManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2024-05-29
Peptide nucleic acid conjugates for altering gene expression in cancerCU16241Selective peptide nucleic acid polymers block cancer gene expression, targeting mutations like BRAFV600E with improved delivery and specificity.TagsBioavailabilityBiosensorCell cultureInventorsGary Schwartz M.D.Jeffrey Rothman M.D.ManagerJoan MartinezDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-03CollectionsGene TherapyOncology
High-throughput approach for base editing the kinomeCU24051High-throughput base editing to selectively inhibit kinases endogenously, enabling scalable kinase function studies and drug target discovery.TagsChemical libraryEndogenous retrovirusEnzymeInventorsNeil Vasan MD, PhDManagerJerry KokoshkaDepartmentsOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-12
Small molecule therapeutics to treat treatment-resistant ALL and T-ALLCU19220NT5C2 inhibitors (e.g., HTP-2) boost chemotherapy efficacy in relapsed ALL/T-ALL, enabling combo treatments against resistance.TagsAcute lymphoblastic leukemiaAssayCancer cellInventorsAdolfo A. Ferrando M.D., Ph.D.Arie ZaskBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesInstitute for Cancer GeneticsProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2021-02-03CollectionsSmall MoleculeOncology
Microfluidic platform for large-scale single-cell sequencing and imagingCU16248Scalable, low-cost microfluidic platform linking live-cell imaging with single-cell RNA sequencing via optical barcodes.TagsBrain mappingCell cultureDrug discoveryInventorsJinzhou YuanPeter A. SimsSayantan BoseManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-02CollectionsGenomics & Multi-Omics
High-throughput single-cell multi-omics platform for integrated RNA, DNA, and protein analysisCU21072Integrated single-cell platform enabling high-throughput RNA, DNA, and protein profiling for holistic cellular insights and scalable studies.TagsBiomarkerCell nucleusDrug discoveryInventorsPeter A. SimsTimothy R. OlsenManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-02CollectionsGenomics & Multi-Omics
Stem cell-based gene delivery for biological pacemakers1352Biological pacemaker using engineered human mesenchymal stem cells to autonomously regulate heart rhythm without batteries.TagsArtificial cardiac pacemakerCardiac muscle cellDrug deliveryInventorsIra S. CohenMichael Rosen M.D.Peter BrinkManagerJerry KokoshkaDepartmentsAnesthesiologyPharmacologyPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2018-11-30
Small molecule inhibitors of ferroptosis for therapeutic applicationsCU17132Small-molecule ferroptosis inhibitors with improved drug-like properties for neurodegenerative, excitotoxic, and organ-protective therapies.TagsCell deathDrug developmentEpilepsyInventorsBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2020-07-09CollectionsSmall MoleculeCNS/Neurology
Evolved CRISPR-associated transposase systems for genome engineeringCU19096RNA-guided CRISPR-transposase enables kilobase-scale, precise DNA insertions in human cells without double-strand breaks or homologous repair.TagsCRISPRFibroblastGenetically modified animalInventorsSamuel H. SternbergSanne KlompeManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsChemistryDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2025-12-18CollectionsGenomics & Multi-Omics
Nucleic acid-guided DNA synthesis with reverse transcriptasesCU24147Reverse-transcriptase guided DNA synthesis enables precise, large-template genome edits with high efficiency and fewer byproducts.TagsAntiviral drugGenomeGenome editingInventorsSamuel H. SternbergStephen TangManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-09CollectionsGenomics & Multi-Omics
CRISPR-transposon platform for programmable DNA integrationCU22373Programmable CRISPR-transposon system enables precise, large-dna integrations and endogenous tagging without double-strand breaks.TagsDNA repairEndogenous retrovirusGeneInventorsSamuel H. SternbergManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-09CollectionsGenomics & Multi-Omics
Engineered CAST systems for RNA-guided DNA integrationCU24123Programmable, break-free RNA-guided DNA integration in mammalian cells using engineered CAST with Cas8 mutations for broader genomic targeting.TagsCell therapyGenetic engineeringGenome editingInventorsAshley LiangGeorge Davis LampeSamuel H. SternbergManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsBiological SciencesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2026-02-17
Integrated AI platform for causal discovery and drug validationCU25378Cloud-based AI suite enabling causal discovery, multimodal data integration, and translational drug validation for personalized medicine.TagsAntigenArtificial intelligenceBias (statistics)InventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Scalable, reproducible, immune-intact tumor organoid co-culture platformCU24328Patient-derived immune-intact tumor organoids enable scalable, reproducible co-culture for personalized immunotherapy and drug screening.TagsBiomarkerBiotechnologyCancer immunotherapyInventorsDavid CohenJoel T. Gabre MDManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Chimeric CRISPR-associated transposon system for RNA-mediated DNA integrationCU24119Chimeric CAST enables efficient, RNA-guided DNA insertion without breaks, combining components for larger cargo in cells.TagsCoevolutionDNA repairEnzymeInventorsGeorge Davis LampeSamuel H. SternbergManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-09CollectionsGenomics & Multi-Omics
Generation of mature neurons differentiated from differentiated stem cells by manipulating RNA splicingCU24262Accelerates maturation of iPSC-derived neurons by boosting Mbnl2 splicing, enabling adult-like models for neurodegenerative diseases.TagsAlternative splicingBrainDevelopment of the nervous systemInventorsBrian Jude JosephChaolin Zhang PhDHynek WichterleManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-16
Programmed bacteria for intracellular delivery of viral RNACU23238Engineered Salmonella delivers viral RNA inside tumor cells to initialize oncolytic virus therapy and enhanced cancer targeting.TagsBacteriaCytoplasmDisease vectorInventorsCharles M. Rice Ph.D.Jonathan PabonTal DaninoManagerCynthia LangDepartmentsBiomedical EngineeringLaboratory of Virology and Infectious DiseaseProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-12-17
