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Biotechnology
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Therapeutic prime
editing
for
gene
therapy
against ocular dystrophy
CU22243
Prime-editing therapy targets PRPH2 splice mutations (c.828+) for retinal dystrophies, enabling precise in-eye gene corrections.
Tags
Animal husbandry
Cas9
Genome
Inventors
Bruna Lopes da Costa
Peter M.J. Quinn
Salvatore M. Caruso
Manager
Kristin Neuman
Departments
Biomedical Engineering
Ophthalmology
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-04-25
Collections
Ophthalmology
Gene Therapy
3D organoids for modeling squamous epithelial pathology and
personalized
medicine
CU22301
3D squamous epithelial organoids enable patient-specific disease modeling and rapid, predictive drug testing for ESCC/EAC.
Tags
Adenocarcinoma
Carcinoma
Epithelium
Inventors
Anil K. Rustgi M.D.
Hiroshi Nakagawa
Manager
Joan Martinez
Departments
Herbert Irving Comprehensive Cancer Center
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-01-04
Collections
Oncology
Enhanced hematopoietic
stem
cell
regeneration
CU25234
Partial inhibition of fatty acid metabolism boosts hematopoietic stem cell self-renewal, enhancing bone marrow transplants and regeneration.
Tags
Bone marrow
Fatty acid
Gene therapy
Inventors
Lei Ding
Yue Zhang
Manager
Kristin Neuman
Departments
Microbiology
Rehabilitation & Regenerative Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-02-26
Universal
gene
therapy
for retinal degeneration
CU18340
Broad, gene-agnostic retinal therapy using AAV-delivered PGC1α/NRF2 or inhibitors to rebalance metabolism, reduce oxidative stress, slow degeneration.
Tags
Antioxidant
Gene therapy
Genetic disorder
Inventors
Stephen H. Tsang M.D., Ph.D.
Xuan Cui
Manager
Kristin Neuman
Departments
Ophthalmology
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Release Date
2023-05-15
Collections
Ophthalmology
Gene Therapy
CNS/Neurology
Targeted
gene
therapy
for retinopathies
CU21122
CRB1-targeted gene therapy delivers isoform-specific CRB1 to Müller glia and photoreceptors, treating CRB1-retinopathies.
Tags
Gene expression
Gene therapy
Genetic disorder
Inventors
Peter M.J. Quinn
Stephen H. Tsang M.D., Ph.D.
Manager
Kristin Neuman
Departments
Ophthalmology
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Release Date
2023-07-06
Collections
Ophthalmology
Gene Therapy
Modified prime editor for
gene
therapy
optimization
CU22084
AAV-compatible, compact prime editor enables single-delivery gene therapy and research tools by packaging smaller genome-editing payloads.
Tags
Achromatopsia
Acid
Adeno-associated virus
Inventors
Bruna Lopes da Costa
Peter M.J. Quinn
Stephen H. Tsang M.D., Ph.D.
Manager
Kristin Neuman
Departments
Biomedical Engineering
Ophthalmology
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2022-09-23
Collections
Gene Therapy
Conformational
DNA
aptamers enabling
small
-
molecule
lateral flow assays
CU26117
Conformational DNA aptamers enable rapid, cost-effective small-molecule detection in lateral flow assays via structure-switching binding.
Tags
Analyte
Antibody
Aptamer
Inventors
Kyungae Yang
Manager
Jerry Kokoshka
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-12-01
Small
molecule
activators for preventing vision loss in Best vitelliform macular dystrophy
CU25176
Small molecule activators restore Best1 function to slow BVMD vision loss; targeted, potentially non-invasive retinal therapy.
Tags
4-Aminobenzoic acid
Drug development
Gene therapy
Inventors
Bingchen Yu
Tingting Yang
Yu Zhang
Manager
Joan Martinez
Departments
Chemistry
Ophthalmology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-05-01
Collections
Ophthalmology
Topical
gene
therapy
for the treatment of AP-1-associated genetic skin disorders
CU26038
Topical gene therapy restores AP-1 function in skin, enabling localized, repeatable treatment for monogenic ichthyosis and keratoderma.
Tags
AP-1 transcription factor
Carcinogenesis
Combination therapy
Inventors
Stephen Kaler
Tarun Kaniganti
Manager
Kristin Neuman
Departments
Pediatrics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-02-26
Nanofibrous scaffold for controlled release of
small
molecule
immunomodulators
CU24040
Nanofibrous scaffold locally releases ACHP to inhibit NF-kB, enabling targeted immunomodulation with reduced systemic effects.
Tags
Autoimmune disease
Biomaterial
Drug delivery
Inventors
Fereshteh Zandkarimi
Hannah Childs
Helen Lu Ph.D.
Manager
Joan Martinez
Departments
Biological Sciences
Biomedical Engineering
Divisions
Faculty of the Arts & Sciences
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-12-18
Collections
Small Molecule
Small
molecule
inhibitor of cognitive impairment associated with neurodegenerative disease
CU23096
Small molecule minaprine analog targets 5-HT2B to curb cognitive/behavioral deficits in neurodegenerative diseases, including Alzheimer's.
Tags
5-HT receptor
5-HT2B receptor
Amyloid beta
Inventors
Daniel M. Watterson
Erica Acquarone
Ottavio Arancio
Manager
Jerry Kokoshka
Departments
Pathology
Pharmacology
Taub Institute
Divisions
Columbia University Medical Center (CUMC)
Feinberg School of Medicine
Release Date
2025-04-10
Combined
small
molecule
treatment as a synergistic epigenetic
therapy
for pancreatic cancer
CU23218
Combined HDAC and eIF4A inhibition reprograms pancreatic cancer epigenetically, boosting efficacy and tumor suppression in vivo.
Tags
Adenocarcinoma
Apoptosis
Chemotherapy
Inventors
Antonio Fojo
Maryam Safari
Susan Bates
Manager
Jerry Kokoshka
Departments
Medicine
Oncology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-08-22
Gene
therapy
for thymidine kinase 2 (TK2) deficiency
CU18199
Engineered AAV9 gene therapy replaces TK2 to treat TK2 deficiency mitochondrial diseases, potentially correcting DNA depletion and symptoms.
Tags
Comorbidity
Enzyme
Gene therapy
Inventors
Carlos Lopez-Gomez
Hasan Orhan Akman
Michio Hirano M.D.
Manager
Kristin Neuman
Departments
Neurology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-01-17
Collections
Gene Therapy
High-throughput method for
gene
insertion
CU19411
A high-throughput, vector-based CRISPR system enabling parallel, precise DNA insertions in human cells for scalable genome editing.
Tags
Bacteria
Cas9
Gene therapy
Inventors
Alejandro Chavez
Brijesh Kumar Singh
Manager
Cynthia Lang
Departments
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-07-17
Adeno-associated virus Glut1
gene
therapy
for rescuing glucose transport in Glut1 deficiency syndrome
CU15054
AAV-based Glut1 gene therapy restores brain glucose transport in Glut1 deficiency, offering a one-time, long-term treatment.
Tags
Adeno-associated virus
Blood–brain barrier
Cognitive deficit
Inventors
Darryl C. De Vivo
Guangping Gao
Kristin Engelstad
Manager
Kristin Neuman
Departments
Neurology
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Office of Technology Management
Release Date
2025-08-19
Computational tool to predict RNA binding protein targets for
gene
therapy
and agricultural bioengineering
CU23342
PPRDecoder: a genome-wide, unbiased algorithm predicting RNA targets of PPR proteins, accelerating gene regulation research.
Tags
Algorithm
Biological engineering
Biotechnology
Inventors
Chaolin Zhang PhD
Manager
Joan Martinez
Departments
Biochemistry & Molecular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-08-04
Collections
Gene Therapy
Chop-Stick
gene
therapy
for retinitis pigmentosa and other autosomal dominant ocular diseases
CU15206
Chop-Stick CRISPR therapy edits dominant ocular genes to disable mutations and replace with wild-type function for RP and related diseases.
Tags
Allele
CRISPR
Complementary DNA
Inventors
Lawrence Chan
Stephen H. Tsang M.D., Ph.D.
Wen-Hsuan Wu
Manager
Kristin Neuman
Departments
Nutritional and Metabolic Biology
Ophthalmology
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2022-09-23
Collections
Ophthalmology
Gene Therapy
Gene
therapy
for Bestrophin-1 (BEST1) mutations in retinal degenerative diseases
CU21279
AAV BEST1 gene therapy targets dominant BEST1 retinal mutations to restore function and potentially cure associated degeneration.
Tags
Adeno-associated virus
Gene therapy
Genetic disorder
Inventors
Stephen H. Tsang M.D., Ph.D.
Tingting Yang
Yu Zhang
Manager
Kristin Neuman
Departments
Ophthalmology
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Release Date
2023-09-08
Collections
Ophthalmology
Gene Therapy
Small
molecule
inhibitors of the ID2/VHL interaction
CU17182
Four small molecules block ID2/VHL, promote HIF degradation, potentially slowing tumor growth and angiogenesis in cancers.
Tags
Angiogenesis
Cell growth
Chemotherapy
Inventors
Anna Lasorella
Antonio Iavarone
Dan Sherman
Manager
Kristin Neuman
Departments
Institute for Cancer Genetics
Neurology
Pediatrics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-05-19
Collections
Small Molecule
Oncology
Small
molecule
treatment for MAPK-regulated cancers
CU20013
MAP4K2-targeted small molecule inhibits MAPK signaling to curb multiple myeloma growth, offering therapy for resistant hematologic cancers.
Tags
Apoptosis
B cell
Cell proliferation
Inventors
Donald William Landry MD, Ph.D.
Jing Fu Ph.D.
Shi-xian Deng
Manager
Jerry Kokoshka
Departments
Medicine
Oncology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2022-08-05
Collections
Small Molecule
Oncology
Parameters to maximize nebulized
drug
delivery
to larynx
CU24050
Patient-specific CT-based nebulization parameters optimize aerosol size and velocity to maximize laryngeal drug deposition.
Tags
Aerosol
Drug delivery
Hypersensitivity
Inventors
Michael Pitman MD
Manager
Cynthia Lang
Departments
Otolaryngology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-07-05
Robotic system to efficiently handle
cell
culture
plates in embryology laboratories
CU22015
Robotic platform automates high-throughput, contamination-free preparation of embryology cell culture plates, boosting consistency and efficiency.
Tags
Cell culture
Embryo
Embryology
Inventors
Samuel Z. "Zev" Williams
Manager
Cynthia Lang
Departments
Obstetrics & Gynecology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-01-13
Multi-lumen microneedle for intracochlear
drug
delivery
and sampling
CU21117
Ultra-sharp multi-lumen microneedles enable simultaneous intracochlear drug delivery and perilymph sampling with zero net volume change.
Tags
Cochlea
Diffusion
Drug delivery
Inventors
Anil Lalwani
Aykut Aksit
Jeffrey W. Kysar
Manager
Dovina Qu
Departments
Mechanical Engineering
Otolaryngology
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-09-26
Targeting ID2 to impair hypoxic cancer
stem
cell
proliferation
CU16166
Targeting ID2–DYRK1A/B axis degrades HIF2a in hypoxic cancer stem cells, offering glioblastoma–focused, broad oncologic potential.
Tags
Angiogenesis
Cancer stem cell
Cell proliferation
Inventors
Anna Lasorella
Antonio Iavarone
Manager
Kristin Neuman
Departments
Neurology
Pediatrics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-05-19
Collections
Oncology
Universal
gene
editing
strategy for cardiac arrhythmia
CU24243
Universal gene-editing of Rad phosphorylation sites to curb adrenergic CaV1.2 signaling, offering targeted, long-term arrhythmia therapy.
Tags
Arrhythmia
Beta blocker
Fight-or-flight response
Inventors
Gregory Newby
Guoxia Liu
Steven Marx
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-02-14
Gene
editing
for treatment of retinitis pigmentosa
CU23293
CRISPR-based retinal metabolism reprogramming targets PHD2 to slow retinitis pigmentosa progression, offering broad RP treatment potential.
Tags
Adeno-associated virus
CRISPR
CRISPR gene editing
Inventors
Stephen H. Tsang M.D., Ph.D.
Manager
Kristin Neuman
Departments
Ophthalmology
Divisions
College of Physicians and Surgeons (CUMC
Release Date
2024-11-26
Collections
Ophthalmology
Ultrasound-responsive microcapsules for localized and on-demand
drug
delivery
CU22072
Ultrasound-triggered, biphasic microcapsules enable on-demand, localized drug release with reduced systemic toxicity and long-term payload stability.
Tags
Chemotherapy
Dextran
Drug delivery
Inventors
Margaret Jakus
Rachel D. Field
Samuel Sia Ph.D.
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-07-20
Multimodal single-
cell
and whole-
genome
sequencing
from
small
amounts of frozen tissue
CU21047
Ultra-efficient multimodal single-cell profiling from tiny, frozen tissue, enabling transcriptomics, CNV, T-cell repertoires, and more.
Tags
Cancer immunotherapy
DNA sequencing
Data quality
Inventors
Benjamin Izar MD, PhD
Johannes Melms
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-02-24
Gene
editing
to treat retinal dystrophies
CU22019
Prime editing corrects CRB1 mutations in retinal dystrophy, offering isoform-independent gene therapy and research tool potential.
Tags
Cell therapy
Gene expression
Gene therapy
Inventors
Bruna Lopes da Costa
Peter M.J. Quinn
Stephen H. Tsang M.D., Ph.D.
Manager
Kristin Neuman
Departments
Biomedical Engineering
Ophthalmology
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2022-10-31
Collections
Ophthalmology
Gene Therapy
Gene
editing
system for the treatment of autosomal dominant disease-related genes
CU18283
Mutation-independent CRISPR pair replaces dominant alleles with a functional gene to treat autosomal dominant diseases.
Tags
CRISPR
Gene therapy
Genetic disorder
Inventors
Stephen H. Tsang M.D., Ph.D.
Wen-Hsuan Wu
Yi-Ting Tsai
Manager
Kristin Neuman
Departments
Nutritional and Metabolic Biology
Ophthalmology
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2023-12-28
Collections
Ophthalmology
Gene Therapy
Microneedle array for cross-barrier
drug
delivery
in the eye, ear and central nervous system
CU18171
Biodegradable microneedle arrays enable precise, cross-barrier drug delivery to the eye, ear, and CNS with controlled release.
Tags
3D printing
Biodegradation
Central nervous system
Inventors
Anil Lalwani
Aykut Aksit
Daniel N. Arteaga
Manager
Dovina Qu
Departments
Mechanical Engineering
Otolaryngology
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-01-24
Combination
therapy
to increase the efficacy of antibody-
drug
conjugates in bladder cancer
CU24095
Small molecule reprograms bladder cancer cells to upregulate antigens, boosting antibody-drug conjugate efficacy. 14 words.
Tags
Antibody-drug conjugate
Antigen
Biopharmaceutical
Inventors
John Robert Christin
Michael Shen Ph.D.
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-07-09
Highly efficient T
cell
base
editing
for enhanced immunotherapies
CU24092
Ultra-efficient base editing in human T cells using adenine/cytosine editors; enhances CAR-T, autoimmune therapies with lower toxicity.
Tags
Adenine
Cancer
Chimeric antigen receptor T cell
Inventors
Benjamin Izar MD, PhD
Zachary Walsh
Manager
Joan Martinez
Departments
Medicine
Medicine - Hematology/Oncology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-11-08
ARP-154 (HeLa T4+) human cancer
cell
line generated by
gene
transfer for AIDS research
CU24290
CD4-expressing HeLa-derived cell line enables AIDS research; facilitates HIV binding studies, drug screening, and therapeutic development.
Tags
AIDS
Antigen
Autoimmune disease
Inventors
Paul J. Maddon
Richard Axel M.D.
Manager
Joan Martinez
Departments
Biochemistry & Molecular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-05-29
Peptide nucleic acid conjugates for altering
gene
expression in cancer
CU16241
Selective peptide nucleic acid polymers block cancer gene expression, targeting mutations like BRAFV600E with improved delivery and specificity.
Tags
Bioavailability
Biosensor
Cell culture
Inventors
Gary Schwartz M.D.
Jeffrey Rothman M.D.
Manager
Joan Martinez
Departments
Medicine
Oncology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-11-03
Collections
Gene Therapy
Oncology
High-throughput approach for base
editing
the kinome
CU24051
High-throughput base editing to selectively inhibit kinases endogenously, enabling scalable kinase function studies and drug target discovery.
Tags
Chemical library
Endogenous retrovirus
Enzyme
Inventors
Neil Vasan MD, PhD
Manager
Jerry Kokoshka
Departments
Oncology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-07-12
Small
molecule
therapeutics to treat treatment-resistant ALL and T-ALL
CU19220
NT5C2 inhibitors (e.g., HTP-2) boost chemotherapy efficacy in relapsed ALL/T-ALL, enabling combo treatments against resistance.
Tags
Acute lymphoblastic leukemia
Assay
Cancer cell
Inventors
Adolfo A. Ferrando M.D., Ph.D.
Arie Zask
Brent Stockwell
Manager
Joan Martinez
Departments
Biological Sciences
Institute for Cancer Genetics
Program in Cellular, Molecular, Structural and Genetic Studies
Divisions
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2021-02-03
Collections
Small Molecule
Oncology
Microfluidic platform for large-scale single-
cell
sequencing
and imaging
CU16248
Scalable, low-cost microfluidic platform linking live-cell imaging with single-cell RNA sequencing via optical barcodes.
Tags
Brain mapping
Cell culture
Drug discovery
Inventors
Jinzhou Yuan
Peter A. Sims
Sayantan Bose
Manager
Cynthia Lang
Departments
Biochemistry & Molecular Biophysics
Systems Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-01-02
Collections
Genomics & Multi-Omics
Stem
cell
-based
gene
delivery
for biological pacemakers
1352
Biological pacemaker using engineered human mesenchymal stem cells to autonomously regulate heart rhythm without batteries.
Tags
Artificial cardiac pacemaker
Cardiac muscle cell
Drug delivery
Inventors
Ira S. Cohen
Michael Rosen M.D.
Peter Brink
Manager
Jerry Kokoshka
Departments
Anesthesiology
Pharmacology
Physiology and Cellular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2018-11-30
High-throughput single-
cell
multi-omics platform for integrated RNA,
DNA
, and protein analysis
CU21072
Integrated single-cell platform enabling high-throughput RNA, DNA, and protein profiling for holistic cellular insights and scalable studies.
Tags
Biomarker
Cell nucleus
Drug discovery
Inventors
Peter A. Sims
Timothy R. Olsen
Manager
Cynthia Lang
Departments
Biochemistry & Molecular Biophysics
Systems Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-01-02
Collections
Genomics & Multi-Omics
Small
molecule
inhibitors of ferroptosis for therapeutic applications
CU17132
Small-molecule ferroptosis inhibitors with improved drug-like properties for neurodegenerative, excitotoxic, and organ-protective therapies.
Tags
Cell death
Drug development
Epilepsy
Inventors
Brent Stockwell
Manager
Joan Martinez
Departments
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2020-07-09
Collections
Small Molecule
CNS/Neurology
Evolved CRISPR-associated transposase systems for
genome
engineering
CU19096
RNA-guided CRISPR-transposase enables kilobase-scale, precise DNA insertions in human cells without double-strand breaks or homologous repair.
Tags
CRISPR
Fibroblast
Genetically modified animal
Inventors
Samuel H. Sternberg
Sanne Klompe
Manager
Cynthia Lang
Departments
Biochemistry & Molecular Biophysics
Chemistry
Divisions
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2025-12-18
Collections
Genomics & Multi-Omics
Nucleic acid-guided
DNA
synthesis with reverse transcriptases
CU24147
Reverse-transcriptase guided DNA synthesis enables precise, large-template genome edits with high efficiency and fewer byproducts.
Tags
Antiviral drug
Genome
Genome editing
Inventors
Samuel H. Sternberg
Stephen Tang
Manager
Cynthia Lang
Departments
Biochemistry & Molecular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-01-09
Collections
Genomics & Multi-Omics
CRISPR-transposon platform for programmable
DNA
integration
CU22373
Programmable CRISPR-transposon system enables precise, large-dna integrations and endogenous tagging without double-strand breaks.
Tags
DNA repair
Endogenous retrovirus
Gene
Inventors
Samuel H. Sternberg
Manager
Cynthia Lang
Departments
Biochemistry & Molecular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-01-09
Collections
Genomics & Multi-Omics
Engineered CAST systems for RNA-guided
DNA
integration
CU24123
Programmable, break-free RNA-guided DNA integration in mammalian cells using engineered CAST with Cas8 mutations for broader genomic targeting.
Tags
Cell therapy
Genetic engineering
Genome editing
Inventors
Ashley Liang
George Davis Lampe
Samuel H. Sternberg
Manager
Cynthia Lang
Departments
Biochemistry & Molecular Biophysics
Biological Sciences
Divisions
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2026-02-17
Integrated AI platform for causal discovery and
drug
validation
CU25378
Cloud-based AI suite enabling causal discovery, multimodal data integration, and translational drug validation for personalized medicine.
Tags
Antigen
Artificial intelligence
Bias (statistics)
Inventors
Zhonghua Liu
Manager
Joan Martinez
Departments
Biostatistics
Divisions
Mailman School Of Public Health (MSPH)
Release Date
2025-08-07
Scalable, reproducible, immune-intact tumor organoid co-
culture
platform
CU24328
Patient-derived immune-intact tumor organoids enable scalable, reproducible co-culture for personalized immunotherapy and drug screening.
Tags
Biomarker
Biotechnology
Cancer immunotherapy
Inventors
David Cohen
Joel T. Gabre MD
Manager
Joan Martinez
Departments
Herbert Irving Comprehensive Cancer Center
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-01-08
Generation of mature neurons differentiated from differentiated
stem
cells by manipulating RNA splicing
CU24262
Accelerates maturation of iPSC-derived neurons by boosting Mbnl2 splicing, enabling adult-like models for neurodegenerative diseases.
Tags
Alternative splicing
Brain
Development of the nervous system
Inventors
Brian Jude Joseph
Chaolin Zhang PhD
Hynek Wichterle
Manager
Joan Martinez
Departments
Biochemistry & Molecular Biophysics
Center for Neurobiology & Behavior
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-01-16
Chimeric CRISPR-associated transposon system for RNA-mediated
DNA
integration
CU24119
Chimeric CAST enables efficient, RNA-guided DNA insertion without breaks, combining components for larger cargo in cells.
Tags
Coevolution
DNA repair
Enzyme
Inventors
George Davis Lampe
Samuel H. Sternberg
Manager
Cynthia Lang
Departments
Biochemistry & Molecular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-01-09
Collections
Genomics & Multi-Omics
Programmed bacteria for intracellular
delivery
of viral RNA
CU23238
Engineered Salmonella delivers viral RNA inside tumor cells to initialize oncolytic virus therapy and enhanced cancer targeting.
Tags
Bacteria
Cytoplasm
Disease vector
Inventors
Charles M. Rice Ph.D.
Jonathan Pabon
Tal Danino
Manager
Cynthia Lang
Departments
Biomedical Engineering
Laboratory of Virology and Infectious Disease
Program in Cellular, Molecular, Structural and Genetic Studies
Divisions
Faculty of the Arts & Sciences
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2025-12-17
