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A spinal motor neuron-specific enhancer for cell-type specific gene expression control in the developing and adult central nervous system
CU22281
Spinal motor neuron–specific enhancer enables AAV-deliverable, cell-type–restricted gene overexpression/knockdown in adults and development.
Tags
Central nervous system
Cholinergic
Gene expression
Inventors
Hynek Wichterle
Tulsi Patel
Manager
Jerry Kokoshka
Departments
Center for Neurobiology & Behavior
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-05-02
Collections
Gene Therapy
CNS/Neurology
Method for disease
phenotype
prediction from genetic
mutation
CU21310
Phenotype dosage sensitivity: predicts disease phenotypes from LGD mutations via NMD, enabling personalized ASD outcomes and targeted therapeutics.
Tags
Autism spectrum
Exon
Gene
Inventors
Andrew Chiang
Dennis Vitkup
Jiayao Wang
Manager
Joan Martinez
Departments
Biomedical Informatics
Systems Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2022-09-11
Collections
CNS/Neurology
Platform/Research Tool
Microneedle array for cross-barrier drug delivery in the eye, ear and
central
nervous
system
CU18171
Biodegradable microneedle arrays enable precise, cross-barrier drug delivery to the eye, ear, and CNS with controlled release.
Tags
3D printing
Biodegradation
Central nervous system
Inventors
Anil Lalwani
Aykut Aksit
Daniel N. Arteaga
Manager
Dovina Qu
Departments
Mechanical Engineering
Otolaryngology
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-01-24
Predicting breast cancer treatment response through PIK3R1
mutation
profiling
CU26021
Predicts breast cancer drug response via endogenous kinase inhibition models using PIK3R1 mutations; rapid, high-throughput screening.
Tags
AKT1
Adenine
Breast cancer
Inventors
Neil Vasan MD, PhD
Manager
Jerry Kokoshka
Release Date
2025-10-09
Targeting NTPDase8 for treating
liver
ischemia
CU25127
NTPDase8 modulation protects the liver from ischemia-reperfusion injury, offering a potential first-in-class therapy.
Tags
Allotransplantation
Bleeding
Epistasis
Inventors
George Hasko
Taha Kelestemur
Manager
Kristin Neuman
Departments
Anesthesiology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-10-16
Collections
Immunology & Inflammation
Lung
regeneration method for treatment
of
lung
diseases
CU23015
Selective de-epithelialization with targeted stem cell engraftment regenerates lung tissue, preserving vasculature for disease treatment and modeling.
Tags
Ex vivo
Lung
Mathematical optimization
Inventors
Camilla Predella
Jing Wang
Nicolino Valerio Dorrello
Manager
Joan Martinez
Departments
Biomedical Engineering
Pediatrics
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-11-10
Targeting EGFR and IL-6 for the treatment
of
liver
fibrosis and insulin resistance
CU23130
Targeting Treg-derived amphiregulin–EGFR axis and IL-6 to treat liver fibrosis and insulin resistance in MASH.
Tags
Biomarker
Crosstalk
Cytokine
Inventors
Nicholas Arpaia
Thomas Savage
Manager
Cynthia Lang
Departments
Microbiology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-04-24
VRK2 kinase inhibitors for enhanced cancer
immunotherapy
CU21245
VRK2 inhibitors boost PD-1 therapy by targeting downstream signaling, enhancing T cell activation and tumor clearance.
Tags
Adenocarcinoma
Bladder cancer
Cancer immunotherapy
Inventors
Adam Mor
Manager
Cynthia Lang
Departments
Rheumatology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-12-17
Immature myeloid cell activation pathway in
inflammation
-linked cancer
CU26121
IL-8–driven immature myeloid cell mobilization fuels inflammation-linked GI cancer; targets IMCs for therapy and biomarkers.
Tags
Angiogenesis
Biomarker
Bone marrow
Inventors
Timothy Wang M.D.
Manager
Jerry Kokoshka
Departments
Herbert and Florence Irving Center for Clinical Research
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-01-08
Targeting PAG for cancer
immunotherapy
CU23123
PAG-targeting antibodies boost T cell activation, inhibit PD-1 signaling, and reduce tumor growth, enabling monotherapy or combo immunotherapy.
Tags
Animal disease model
Cancer immunotherapy
Combination therapy
Inventors
Adam Mor
Manager
Cynthia Lang
Departments
Rheumatology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-04-07
Modulating
inflammation
by altering 3’ Untranslated Region (3’ UTR) length
CU23300
Modulates inflammation by lengthening 3’ UTRs to control immunogenic dsRNA, enabling tunable neuroinflammation therapies and cancer immunotherapy.
Tags
Cancer immunotherapy
Homeostasis
Immunogenicity
Inventors
Hachung Chung
Heegwon Shin
Tyler Dorrity
Manager
Jerry Kokoshka
Departments
Microbiology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-07-01
Collections
Oncology
CNS/Neurology
Recombinant protein to treat
inflammation
CU23248
Recombinant FSTL-1 protein targets and reduces cardiac inflammation, aiding Kawasaki disease research and myocarditis treatment.
Tags
Anti-inflammatory
Atherosclerosis
Biomarker
Inventors
Mark Gorelik
Manager
Sara Gusik
Departments
Pediatrics/Rheumatology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-05-10
Collections
Cardiovascular
Unique human
phenotype
to define novel gene function for OCRL1
CU22138
Neuron-specific OCRL1 variant model reveals brain-focused mechanisms in Lowe syndrome; enables targeted therapies, diagnostics, drug screening.
Tags
Cataract
Cell membrane
Cilium
Inventors
Barbara Corneo
Cecilia Sena
Charles LeDuc
Manager
Cynthia Lang
Departments
Pathology
Pediatrics
Rehabilitation & Regenerative Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-03-03
Collections
Rare Disease
CNS/Neurology
Exogenous Rac1 analogs to treat acute
lung
injury
CU23206
Exogenous activated Rac1 (V12Rac1) protects lungs from ALI/ARDS by stabilizing actin and blocking proinflammatory signaling.
Tags
Actin
Acute respiratory distress syndrome
Epithelium
Inventors
Francine Katz
Galina Gusarova
Jahar Bhattacharya
Manager
Jerry Kokoshka
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-11-26
Preconditioning cell treatment for
immunotherapy
CU17038
Dual hypoxia and inflammatory cytokine preconditioning boosts mesenchymal stem cells’ immunosuppressive potency for more effective immunotherapies.
Tags
Autoimmune disease
Coronary artery disease
Cytokine
Inventors
Gordana Vunjak-Novakovic
Holly Wobma
Mariko Kanai
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-06-03
Transcriptional reprogramming platform for neuroprotection, rejuvenation, and treatment of motor neuron diseases
CU23208
AAV-delivered Islet1/Lhx3 re-expression reprograms motor neurons, restoring youthful resilience to prevent motor neuron degeneration.
Tags
Amyotrophic lateral sclerosis
Gene expression
Gene therapy
Inventors
Emily Rhodes Lowry
Hynek Wichterle
Tulsi Patel
Manager
Jerry Kokoshka
Departments
Center for Neurobiology & Behavior
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-01-18
Collections
Gene Therapy
Rapid assessment
of
T cell health for enhanced cancer
immunotherapy
CU24313
A rapid platform uses biomaterials, imaging, and deep learning to assess T cell functionality and predict proliferation for immunotherapy.
Tags
Algorithm
Assay
Biomaterial
Inventors
Jia Guo
Lance Kam
Nicole Lamanna
Manager
Dovina Qu
Departments
Biomedical Engineering
Medicine
Psychiatry
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-12-18
CD58 modulation for improved cancer
immunotherapy
outcomes
CU21046
CD58 modulation enhances antitumor immunity, overcoming resistance and informing biomarkers for optimized, combinational cancer immunotherapy.
Tags
Antigen presentation
Biomarker
Cancer cell
Inventors
Benjamin Izar MD, PhD
Johannes Melms
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-10-17
Non-invasive laser therapy for cytokine modulation and corneal
inflammation
management
CU18315
Femtosecond laser therapy non-invasively modulates corneal cytokines to reduce inflammation and keratocyte apoptosis, preserving tissue.
Tags
Analgesic
Antibiotic
Apoptosis
Inventors
Sinisa Vukelic
Manager
Dovina Qu
Departments
Mechanical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-08-17
Collections
Ophthalmology
Mechanosensitive regulatory T cell induction for improved adoptive
immunotherapy
CU23392
Mechanosensitive substrate stiffness boosts stable regulatory T cell induction, improving durability and effectiveness for adoptive immunotherapy.
Tags
Autoimmune disease
Coating
Immune system
Inventors
Lance Kam
Lingting Shi
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-12-12
Real-time in situ measurement
of
electrical impedance
of
lung
tissue
CU22293
Real-time in situ airway impedance device assesses epithelial health, enabling rapid COPD, asthma, and lung disease monitoring.
Tags
Asthma
Biomarker
Cystic fibrosis
Inventors
Gordana Vunjak-Novakovic
Jiawen Chen
Jinho Kim
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-05-29
Lung
organoid cells for therapeutic intervention
CU23361
Therapeutic lung regeneration via patient-specific stem cell–derived distal lung organoids with graftable basal and secretory cells.
Tags
Cell therapy
Chronic obstructive pulmonary disease
Coating
Inventors
Hans-Willem Snoeck
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-09-08
Targeted delivery
of
anti-microRNA for the treatment
of
liver
fibrosis
CU21066
Liver-targeted exosomes deliver anti-miR-132 to curb fibrosis, reducing collagen and pro-fibrotic signals with tissue specificity.
Tags
Cell membrane
Collagen
Fibrosis
Inventors
Akiva Mintz
Fatemeh Momen-Heravi
Manager
Joan Martinez
Departments
College of Dental Medicine
Radiology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-05-02
Therapy for EGFR-mutant
lung
cancer
CU22193
Targeting RA signaling to suppress brain relapse in EGFR-mutant lung cancer, boosting TKIs and preventing metastasis.
Tags
Blood–brain barrier
Epidermal growth factor receptor
Estrogen receptor
Inventors
Anup Biswas
Swarnali Acharyya
Manager
Kristin Neuman
Departments
Institute for Cancer Genetics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-01-04
Collections
Oncology
Generation
of
self-renewed CD4+ T cells for cancer and viral disease
immunotherapy
CU24385
Ex vivo culture method yields durable, polyfunctional cytotoxic CD4+ T cells for enhanced cancer and viral immunotherapies.
Tags
Antigen
Cell culture
Cell therapy
Inventors
Mithil Soni
Pawel Muranski
Prabesh Khatiwada
Manager
Jerry Kokoshka
Departments
Columbia Center for Translational Immunology
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-09-16
Host proteases necessary for human parainfluenza virus spread in human
lung
CU22326
Identifies HPIV spread proteases; shows serine protease inhibitors (nafamostat) hinder lung infection, offering targeted antiviral strategy.
Tags
Antiviral drug
Enzyme inhibitor
Evolution
Inventors
Anne Moscona
Kyle Stearns
Matteo Porotto
Manager
Kristin Neuman
Departments
Anesthesiology
Pediatrics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-02-15
Targeting the CD58:CD2 axis for cancer
immunotherapy
CU21140
Activates CD28-CD8+ T-cells via CD58:CD2 axis, offering an immunotherapy option for PD-1–unresponsive cancers.
Tags
Antibody
Antigen-presenting cell
CD28
Inventors
Benjamin Izar MD, PhD
Johannes Melms
Patricia Ho
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-06-23
Collections
Oncology
Recombinant ILT3 protein-produced antibodies for
immunotherapy
treatment
of
cancer
CU15207
Engineered anti-ILT3 antibodies enable targeted cancer immunotherapy, modulating myeloid signals and enhancing immune blockade.
Tags
Acute myeloid leukemia
Allotransplantation
Antibody
Inventors
George Vlad Ph.D.
Nicole Suciu-Foca
Zheng Xu
Manager
Sara Gusik
Departments
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2023-03-08
Collections
Oncology
Small scale screening bioreactor with airway tissues and mucosa for the progression and treatment of lung disease
CU23307
Bioreactor recreating mucus-lined airways ex vivo for real-time, high-throughput modeling and therapeutic screening.
Tags
Biomimetics
Bioreactor
Cell culture
Inventors
Gordana Vunjak-Novakovic
Jinho Kim
Keith Yeager
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-04-08
Tri-specific human immunodeficiency virus antibodies for
immunotherapy
CU22364
Tri-specific HIV antibody targets three epitopes, offering longer-acting, potent immunotherapy to treat and prevent HIV infection.
Tags
Antibody
Antiviral drug
Epitope
Inventors
David Da-i Ho M.D.
Manager
Kristin Neuman
Departments
Physicians & Surgeons
Divisions
Columbia University Medical Center (CUMC)
Release Date
2022-07-22
Pharmacological inhibitors and mouse models
of
mitochondrial DNA depletion-deletion syndromes (MDDS)
CU23197
Therapeutic mouse models and deoxynucleoside-based treatment restore mtDNA balance in GUK1-related MDDS, enabling mtDNA repair.
Tags
Acute respiratory distress syndrome
Biomarker
Biopharmaceutical
Inventors
Agustin Hidalgo Gutierrez
Jonathan Shintaku
Michio Hirano M.D.
Manager
Kristin Neuman
Departments
Neurology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-11-08
Collections
Rare Disease
Multiplexed T cell profiling for generating engineered regulatory T cell therapies
CU23310
High-throughput platform maps patient TCR–antigen pairs to create CRISPR‑engineered, autologous Tregs for precise local immune suppression.
Tags
Amyotrophic lateral sclerosis
Antigen
CRISPR
Inventors
Elizabeth M. Bradshaw
Neil Shneider
Ryan Hobson
Manager
Joan Martinez
Departments
Molecular Medicine
Neurology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2025-01-02
Radiolabeled microtubule ligands for
central
nervous
system
(CNS) imaging
CU17295
Brain-penetrant radiolabeled microtubule PET/SPECT tracers enable in vivo CNS imaging for tumors and neurodegenerative monitoring.
Tags
Blood–brain barrier
Brain
Central nervous system
Inventors
Dileep Kumar
J. John Mann
Manager
Jerry Kokoshka
Departments
Psychiatry
Divisions
Columbia University Medical Center (CUMC)
Release Date
2018-08-13
Collections
CNS/Neurology
Tumor-infiltrating lymphocyte and organoid co-culture for patient-specific
immunotherapy
CU22128
Ex vivo tumor-lymphocyte co-culture screens patient TILs for tumor killing, guiding pre-treatment immunotherapy choices and cost savings.
Tags
Cell culture
Cytotoxicity
Drug resistance
Inventors
Alana Nguyen
Michael Shen Ph.D.
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2022-08-22
Collections
Oncology
Platform/Research Tool
Targeted pharmacological agents for the prevention
of
multiple organ failure in hemorrhagic shock patients
CU23263
Localized anti-inflammatory CD39/CD73 therapy to prevent multi-organ failure in hemorrhagic shock by targeted adenosine production.
Tags
Adenosine
Adenosine receptor
Agent-based model
Inventors
George Hasko
Taha Kelestemur
Manager
Kristin Neuman
Departments
Anesthesiology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-04-25
Collections
Oncology
Immunology & Inflammation
Protein fragment to promote neurogenesis
CU13345
Dominant-negative ATF5 fragment drives differentiation of neuroprogenitors into mature neurons and glial cells, enabling brain regeneration research.
Tags
Astrocyte
Cellular differentiation
Central nervous system
Inventors
James M. Angelastro
Lloyd Greene PhD
Manager
Jerry Kokoshka
Departments
Molecular Biosciences
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-01-13
Convection-enhanced delivery
of
topotecan and dexamethasone for malignant gliomas
CU25031
Implantable pump enables chronic, targeted brain delivery of topotecan plus dexamethasone via convection-enhanced delivery for glioma.
Tags
Adjuvant therapy
Animal disease model
Blood–brain barrier
Inventors
Jeffrey Bruce
Peter Canoll
Manager
Jerry Kokoshka
Departments
Neurological Surgery
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-08-29
PDE5 inhibitor for Alzheimer's treatment
2439
A brain-penetrant PDE5 inhibitor enhances cGMP signaling, reduces amyloid, and supports synaptic plasticity in Alzheimer’s models.
Tags
Amyloid beta
Amyloid plaques
Blood–brain barrier
Inventors
Donald William Landry MD, Ph.D.
Ottavio Arancio MD, PhD
Shi-xian Deng
Manager
Jerry Kokoshka
Departments
Medicine
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-12-18
Focused ultrasound nanoparticles for targeted imaging and neuroregeneration
CU21224
Ultrasound-activated nanocup theranostics cross BBB for targeted Alzheimer’s imaging and neuroregenerative therapy.
Tags
Amyloid beta
Antibody
Blood–brain barrier
Inventors
Antonios Poulipoulos
Elisa Konofagou
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2025-07-29
Precision modulation
of
synaptic chaperones for neurodegeneration treatment
CU23056
Precise Hspa8 variant enhances synaptic SNARE function to treat SMA and other neurodegenerative diseases, via gene therapy.
Tags
Amyotrophic lateral sclerosis
Central nervous system
Chaperone (protein)
Inventors
Umrao R. Monani Ph.D.
Manager
Kristin Neuman
Departments
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-09-25
Collections
Gene Therapy
CNS/Neurology
Probiotic-guided CAR-T cell
system
for targeted cancer
immunotherapy
CU22211
Engineered probiotic-guided CAR-T therapy targets solid tumors, recruiting immune cells and enhancing immunotherapy with tumor-colonizing bacteria.
Tags
Autoimmune disease
Cancer immunotherapy
Chemokine
Inventors
Candice Gurbatri
Jongwon Im
Nicholas Arpaia
Manager
Cynthia Lang
Departments
Biomedical Engineering
Microbiology
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2022-02-04
Collections
Oncology
Serum Amyloid A1 antibody to treat leukemias
CU22360
SAA1-targeting antibody blocks bone marrow–driven leukemia progression, aiming to prevent AML/MDS relapse and broaden hematologic cancer treatment.
Tags
Acute lymphoblastic leukemia
Acute myeloid leukemia
Breast cancer
Inventors
Marta Galan-Diez
Stavroula Kousteni
Manager
Jerry Kokoshka
Departments
Herbert and Florence Irving Center for Clinical Research
Physiology and Cellular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-04-10
Targeting Delta-2 tubulin for the treatment
of
peripheral neuropathy
CU25119
Delta-2 tubulin as a therapeutic target to prevent or treat chemotherapy-induced peripheral neuropathy, addressing multiple drug classes.
Tags
Analgesic
Anticonvulsant
Antidepressant
Inventors
Francesca Bartolini Ph.D.
Maria Elena Pero
Manager
Kristin Neuman
Departments
Pathology & Cell Biology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2025-12-17
Collections
CNS/Neurology
Conditional knockout mouse model for studying autosomal-dominant optic atrophy
CU26140
A mammalian, cell-type–specific conditional Ssbp1 R107Q mouse model to dissect autosomal-dominant optic atrophy mechanisms.
Tags
Allele
Arginine
Cre recombinase
Inventors
Chyuan-Sheng (Victor) Lin
Nan-Kai Wang
Yunju Tseng
Manager
Kristin Neuman
Departments
Ophthalmology
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-01-08
Blood-brain barrier opening and cavitation imaging using a single diagnostic imaging array
CU21007
Single diagnostic ultrasound array opens the blood-brain barrier and images cavitation simultaneously for cost-effective, targeted brain therapy.
Tags
Beamforming
Blood–brain barrier
Cavitation
Inventors
Elisa Konofagou
Mark T. Burgess
Robin Ji
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2025-07-29
Functional recovery
of
human donor lungs for transplantation
CU13138
Localized regional lung regeneration preserves vasculature to revive rejected donor lungs for transplantation.
Tags
Drug discovery
Ex vivo
Extracellular matrix
Inventors
Donald Freytes
Gopal Singh
Gordana Vunjak-Novakovic
Manager
Cynthia Lang
Departments
Biomedical Engineering
Biomedical Informatics
Surgery
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2025-11-20
Combinatorial treatment for amyotrophic lateral sclerosis (ALS)
CU25447
Combinatorial ASO therapy targets 15 dysregulated genes in SOD1-ALS, mitigating neuron death and boosting motor function.
Tags
Amyotrophic lateral sclerosis
Biomarker
Combinatorics
Inventors
George Z. Mentis Ph.D.
JoonHyung Park
Manager
Jerry Kokoshka
Departments
Pathology & Cell Biology
Pathology and Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-07-29
Mouse model with impaired bipolar cell function for congenital stationary night blindness
CU26066
A Grm6-missense mouse model mimics human CSNB, enabling targeted gene editing studies and biomarker discovery for therapy.
Tags
Genetic disorder
Genome editing
Laboratory mouse
Inventors
Nan-Kai Wang
Yunju Tseng
Manager
Kristin Neuman
Departments
Ophthalmology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-11-07
Targeting senescent cells for the treatment
of
photoaging and melanoma
CU25349
Senescent-cell–targeting therapy reverses photoaging and slows melanoma, offering dual cosmetic and oncologic benefits.
Tags
Cellular senescence
Chemotherapy
Hyperpigmentation
Inventors
Danial Khayatan
Rolando Perez-Lorenzo
Manager
Jerry Kokoshka
Departments
Dermatology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-10-09
Human ALFY knock-in mice for studying neurodegenerative disease
CU26143
Human ALFY knock-in mice enable tissue-specific, controllable hALFY expression to study neurodegenerative protein aggregation.
Tags
Autophagy
Copy number variation
Cre recombinase
Inventors
Ai Yamamoto
Manager
Kristin Neuman
Departments
Physiology and Cellular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-01-08
Collections
CNS/Neurology
