Targeting PAG for cancer immunotherapyCU23123PAG-targeting antibodies boost T cell activation, inhibit PD-1 signaling, and reduce tumor growth, enabling monotherapy or combo immunotherapy.TagsAnimal disease modelCancer immunotherapyCombination therapyInventorsAdam MorManagerCynthia LangDepartmentsRheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-07
VRK2 kinase inhibitors for enhanced cancer immunotherapyCU21245VRK2 inhibitors boost PD-1 therapy by targeting downstream signaling, enhancing T cell activation and tumor clearance.TagsAdenocarcinomaBladder cancerCancer immunotherapyInventorsAdam MorManagerCynthia LangDepartmentsRheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-17
CD58 modulation for improved cancer immunotherapy outcomesCU21046CD58 modulation enhances antitumor immunity, overcoming resistance and informing biomarkers for optimized, combinational cancer immunotherapy.TagsAntigen presentationBiomarkerCancer cellInventorsBenjamin Izar MD, PhDJohannes MelmsManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-10-17
Rapid assessment of T cell health for enhanced cancer immunotherapyCU24313A rapid platform uses biomaterials, imaging, and deep learning to assess T cell functionality and predict proliferation for immunotherapy.TagsAlgorithmAssayBiomaterialInventorsJia GuoLance KamNicole LamannaManagerDovina QuDepartmentsBiomedical EngineeringMedicinePsychiatryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-12-18
Method for disease phenotype prediction from genetic mutationCU21310Phenotype dosage sensitivity: predicts disease phenotypes from LGD mutations via NMD, enabling personalized ASD outcomes and targeted therapeutics.TagsAutism spectrumExonGeneInventorsAndrew ChiangDennis VitkupJiayao WangManagerJoan MartinezDepartmentsBiomedical InformaticsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2022-09-11CollectionsCNS/NeurologyPlatform/Research Tool
Targeting the CD58:CD2 axis for cancer immunotherapyCU21140Activates CD28-CD8+ T-cells via CD58:CD2 axis, offering an immunotherapy option for PD-1–unresponsive cancers.TagsAntibodyAntigen-presenting cellCD28InventorsBenjamin Izar MD, PhDJohannes MelmsPatricia HoManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-06-23CollectionsOncology
Predicting breast cancer treatment response through PIK3R1 mutation profilingCU26021Predicts breast cancer drug response via endogenous kinase inhibition models using PIK3R1 mutations; rapid, high-throughput screening.TagsAKT1AdenineBreast cancerInventorsNeil Vasan MD, PhDManagerJerry KokoshkaRelease Date2025-10-09
Probiotic-guided CAR-T cell system for targeted cancer immunotherapyCU22211Engineered probiotic-guided CAR-T therapy targets solid tumors, recruiting immune cells and enhancing immunotherapy with tumor-colonizing bacteria.TagsAutoimmune diseaseCancer immunotherapyChemokineInventorsCandice GurbatriJongwon ImNicholas ArpaiaManagerCynthia LangDepartmentsBiomedical EngineeringMicrobiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2022-02-04CollectionsOncology
Immature myeloid cell activation pathway in inflammation-linked cancerCU26121IL-8–driven immature myeloid cell mobilization fuels inflammation-linked GI cancer; targets IMCs for therapy and biomarkers.TagsAngiogenesisBiomarkerBone marrowInventorsTimothy Wang M.D.ManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Single-neuron resolution recordings across the brainCU25180Neuropixels Rail Drive System enables simultaneous single-neuron recordings across deep and superficial primate brain regions.TagsAmygdalaBrainBrain–computer interfaceInventorsC. Daniel SalzmanEric M. TrautmannMark ChurchlandManagerKristin NeumanDepartmentsBiological SciencesNeurosciencePsychiatryDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesZuckerman Mind Brain Behavior InstRelease Date2026-03-27
Targeting NTPDase8 for treating liver ischemiaCU25127NTPDase8 modulation protects the liver from ischemia-reperfusion injury, offering a potential first-in-class therapy.TagsAllotransplantationBleedingEpistasisInventorsGeorge HaskoTaha KelestemurManagerKristin NeumanDepartmentsAnesthesiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-10-16CollectionsImmunology & Inflammation
Modulating inflammation by altering 3’ Untranslated Region (3’ UTR) lengthCU23300Modulates inflammation by lengthening 3’ UTRs to control immunogenic dsRNA, enabling tunable neuroinflammation therapies and cancer immunotherapy.TagsCancer immunotherapyHomeostasisImmunogenicityInventorsHachung ChungHeegwon ShinTyler DorrityManagerJerry KokoshkaDepartmentsMicrobiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-07-01CollectionsOncologyCNS/Neurology
Lung regeneration method for treatment of lung diseasesCU23015Selective de-epithelialization with targeted stem cell engraftment regenerates lung tissue, preserving vasculature for disease treatment and modeling.TagsEx vivoLungMathematical optimizationInventorsCamilla PredellaJing WangNicolino Valerio DorrelloManagerJoan MartinezDepartmentsBiomedical EngineeringPediatricsDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-11-10
Targeting EGFR and IL-6 for the treatment of liver fibrosis and insulin resistanceCU23130Targeting Treg-derived amphiregulin–EGFR axis and IL-6 to treat liver fibrosis and insulin resistance in MASH.TagsBiomarkerCrosstalkCytokineInventorsNicholas ArpaiaThomas SavageManagerCynthia LangDepartmentsMicrobiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-24
Self-assembly of multi-specific antibodies for efficient cancer immunotherapyCU21275Self-assembling multi-specific antibodies target cancer cells with high specificity, reducing side effects and enabling personalized immunotherapy.TagsAntibodyAntigenCancer immunotherapyInventorsHuihui MaMarkus MaparaMilan N. Stojanovic M.D.ManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2021-04-12CollectionsOncology
Recombinant protein to treat inflammationCU23248Recombinant FSTL-1 protein targets and reduces cardiac inflammation, aiding Kawasaki disease research and myocarditis treatment.TagsAnti-inflammatoryAtherosclerosisBiomarkerInventorsMark GorelikManagerSara GusikDepartmentsPediatrics/RheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-10CollectionsCardiovascular
Therapy for EGFR-mutant lung cancerCU22193Targeting RA signaling to suppress brain relapse in EGFR-mutant lung cancer, boosting TKIs and preventing metastasis.TagsBlood–brain barrierEpidermal growth factor receptorEstrogen receptorInventorsAnup BiswasSwarnali AcharyyaManagerKristin NeumanDepartmentsInstitute for Cancer GeneticsDivisionsColumbia University Medical Center (CUMC)Release Date2023-01-04CollectionsOncology
Exogenous Rac1 analogs to treat acute lung injuryCU23206Exogenous activated Rac1 (V12Rac1) protects lungs from ALI/ARDS by stabilizing actin and blocking proinflammatory signaling.TagsActinAcute respiratory distress syndromeEpitheliumInventorsFrancine KatzGalina GusarovaJahar BhattacharyaManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-26
Unique human phenotype to define novel gene function for OCRL1CU22138Neuron-specific OCRL1 variant model reveals brain-focused mechanisms in Lowe syndrome; enables targeted therapies, diagnostics, drug screening.TagsCataractCell membraneCiliumInventorsBarbara CorneoCecilia SenaCharles LeDucManagerCynthia LangDepartmentsPathologyPediatricsRehabilitation & Regenerative MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-03-03CollectionsRare DiseaseCNS/Neurology
Recombinant ILT3 protein-produced antibodies for immunotherapy treatment of cancerCU15207Engineered anti-ILT3 antibodies enable targeted cancer immunotherapy, modulating myeloid signals and enhancing immune blockade.TagsAcute myeloid leukemiaAllotransplantationAntibodyInventorsGeorge Vlad Ph.D.Nicole Suciu-FocaZheng XuManagerSara GusikDepartmentsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-03-08CollectionsOncology
Generation of self-renewed CD4+ T cells for cancer and viral disease immunotherapyCU24385Ex vivo culture method yields durable, polyfunctional cytotoxic CD4+ T cells for enhanced cancer and viral immunotherapies.TagsAntigenCell cultureCell therapyInventorsMithil SoniPawel MuranskiPrabesh KhatiwadaManagerJerry KokoshkaDepartmentsColumbia Center for Translational ImmunologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-09-16
Preconditioning cell treatment for immunotherapyCU17038Dual hypoxia and inflammatory cytokine preconditioning boosts mesenchymal stem cells’ immunosuppressive potency for more effective immunotherapies.TagsAutoimmune diseaseCoronary artery diseaseCytokineInventorsGordana Vunjak-NovakovicHolly WobmaMariko KanaiManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-06-03
Non-invasive laser therapy for cytokine modulation and corneal inflammation managementCU18315Femtosecond laser therapy non-invasively modulates corneal cytokines to reduce inflammation and keratocyte apoptosis, preserving tissue.TagsAnalgesicAntibioticApoptosisInventorsSinisa VukelicManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-08-17CollectionsOphthalmology
Transcriptional reprogramming platform for neuroprotection, rejuvenation, and treatment of motor neuron diseasesCU23208AAV-delivered Islet1/Lhx3 re-expression reprograms motor neurons, restoring youthful resilience to prevent motor neuron degeneration.TagsAmyotrophic lateral sclerosisGene expressionGene therapyInventorsEmily Rhodes LowryHynek WichterleTulsi PatelManagerJerry KokoshkaDepartmentsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-01-18CollectionsGene Therapy
Real-time in situ measurement of electrical impedance of lung tissueCU22293Real-time in situ airway impedance device assesses epithelial health, enabling rapid COPD, asthma, and lung disease monitoring.TagsAsthmaBiomarkerCystic fibrosisInventorsGordana Vunjak-NovakovicJiawen ChenJinho KimManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-05-29
Mechanosensitive regulatory T cell induction for improved adoptive immunotherapyCU23392Mechanosensitive substrate stiffness boosts stable regulatory T cell induction, improving durability and effectiveness for adoptive immunotherapy.TagsAutoimmune diseaseCoatingImmune systemInventorsLance KamLingting ShiManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-12-12
Lung organoid cells for therapeutic interventionCU23361Therapeutic lung regeneration via patient-specific stem cell–derived distal lung organoids with graftable basal and secretory cells.TagsCell therapyChronic obstructive pulmonary diseaseCoatingInventorsHans-Willem SnoeckManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-09-08
Targeted delivery of anti-microRNA for the treatment of liver fibrosisCU21066Liver-targeted exosomes deliver anti-miR-132 to curb fibrosis, reducing collagen and pro-fibrotic signals with tissue specificity.TagsCell membraneCollagenFibrosisInventorsAkiva MintzFatemeh Momen-HeraviManagerJoan MartinezDepartmentsCollege of Dental MedicineRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-02
Host proteases necessary for human parainfluenza virus spread in human lungCU22326Identifies HPIV spread proteases; shows serine protease inhibitors (nafamostat) hinder lung infection, offering targeted antiviral strategy.TagsAntiviral drugEnzyme inhibitorEvolutionInventorsAnne MosconaKyle StearnsMatteo PorottoManagerKristin NeumanDepartmentsAnesthesiologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2024-02-15
Small scale screening bioreactor with airway tissues and mucosa for the progression and treatment of lung diseaseCU23307Bioreactor recreating mucus-lined airways ex vivo for real-time, high-throughput modeling and therapeutic screening.TagsBiomimeticsBioreactorCell cultureInventorsGordana Vunjak-NovakovicJinho KimKeith YeagerManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-04-08
Tri-specific human immunodeficiency virus antibodies for immunotherapyCU22364Tri-specific HIV antibody targets three epitopes, offering longer-acting, potent immunotherapy to treat and prevent HIV infection.TagsAntibodyAntiviral drugEpitopeInventorsDavid Da-i Ho M.D.ManagerKristin NeumanDepartmentsPhysicians & SurgeonsDivisionsColumbia University Medical Center (CUMC)Release Date2022-07-22
Programmable bacteria for targeted delivery of cancer therapeuticsCU18339Engineered tumor-targeting bacteria deliver immunotherapies locally, boosting efficacy and reducing systemic toxicity in cancer treatment.TagsAntigenCancer immunotherapyChemotherapyInventorsCandice GurbatriNicholas ArpaiaSreyan ChowdhuryManagerCynthia LangDepartmentsBiomedical EngineeringMicrobiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-04-07
Targeted pharmacological agents for the prevention of multiple organ failure in hemorrhagic shock patientsCU23263Localized anti-inflammatory CD39/CD73 therapy to prevent multi-organ failure in hemorrhagic shock by targeted adenosine production.TagsAdenosineAdenosine receptorAgent-based modelInventorsGeorge HaskoTaha KelestemurManagerKristin NeumanDepartmentsAnesthesiologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-04-25CollectionsOncologyImmunology & Inflammation
A spinal motor neuron-specific enhancer for cell-type specific gene expression control in the developing and adult central nervous systemCU22281Spinal motor neuron–specific enhancer enables AAV-deliverable, cell-type–restricted gene overexpression/knockdown in adults and development.TagsCentral nervous systemCholinergicGene expressionInventorsHynek WichterleTulsi PatelManagerJerry KokoshkaDepartmentsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-02CollectionsGene TherapyCNS/Neurology
Engineered probiotics for safe and targeted cancer vaccinesCU25192Engineered bacteria deliver tumor neoantigens to solid tumors, boosting targeted, durable immunotherapy with minimal dosing.TagsAntigenBacteriaCancer immunotherapyInventorsJongwon ImTal DaninoManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-03-27
Cross-platform radiomics toolkit for predictive cancer imagingProxy116Cross-platform radiomics toolkit automates standardized 2D/3D cancer imaging analysis for reproducible, scalable biomarker discovery.TagsBatch processingCross-platform softwareFeature extractionInventorsChristos DavatzikosDespina KontosManagerJoan MartinezDepartmentsRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-04
Tumor-infiltrating lymphocyte and organoid co-culture for patient-specific immunotherapyCU22128Ex vivo tumor-lymphocyte co-culture screens patient TILs for tumor killing, guiding pre-treatment immunotherapy choices and cost savings.TagsCell cultureCytotoxicityDrug resistanceInventorsAlana NguyenMichael Shen Ph.D.ManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2022-08-22CollectionsOncologyPlatform/Research Tool
Peptide nucleic acid conjugates for altering gene expression in cancerCU16241Selective peptide nucleic acid polymers block cancer gene expression, targeting mutations like BRAFV600E with improved delivery and specificity.TagsBioavailabilityBiosensorCell cultureInventorsGary Schwartz M.D.Jeffrey Rothman M.D.ManagerJoan MartinezDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-03CollectionsGene TherapyOncology
Convection-enhanced delivery of topotecan and dexamethasone for malignant gliomasCU25031Implantable pump enables chronic, targeted brain delivery of topotecan plus dexamethasone via convection-enhanced delivery for glioma.TagsAdjuvant therapyAnimal disease modelBlood–brain barrierInventorsJeffrey BrucePeter CanollManagerJerry KokoshkaDepartmentsNeurological SurgeryPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-29
Serum Amyloid A1 antibody to treat leukemiasCU22360SAA1-targeting antibody blocks bone marrow–driven leukemia progression, aiming to prevent AML/MDS relapse and broaden hematologic cancer treatment.TagsAcute lymphoblastic leukemiaAcute myeloid leukemiaBreast cancerInventorsMarta Galan-DiezStavroula KousteniManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-10
Pharmacological inhibitors and mouse models of mitochondrial DNA depletion-deletion syndromes (MDDS)CU23197Therapeutic mouse models and deoxynucleoside-based treatment restore mtDNA balance in GUK1-related MDDS, enabling mtDNA repair.TagsAcute respiratory distress syndromeBiomarkerBiopharmaceuticalInventorsAgustin Hidalgo GutierrezJonathan ShintakuMichio Hirano M.D.ManagerKristin NeumanDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08CollectionsRare Disease
Targeting Delta-2 tubulin for the treatment of peripheral neuropathyCU25119Delta-2 tubulin as a therapeutic target to prevent or treat chemotherapy-induced peripheral neuropathy, addressing multiple drug classes.TagsAnalgesicAnticonvulsantAntidepressantInventorsFrancesca Bartolini Ph.D.Maria Elena PeroManagerKristin NeumanDepartmentsPathology & Cell BiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-12-17CollectionsCNS/Neurology
Conditional knockout mouse model for studying autosomal-dominant optic atrophyCU26140A mammalian, cell-type–specific conditional Ssbp1 R107Q mouse model to dissect autosomal-dominant optic atrophy mechanisms.TagsAlleleArginineCre recombinaseInventorsChyuan-Sheng (Victor) LinNan-Kai WangYunju TsengManagerKristin NeumanDepartmentsOphthalmologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Multiplexed T cell profiling for generating engineered regulatory T cell therapiesCU23310High-throughput platform maps patient TCR–antigen pairs to create CRISPR‑engineered, autologous Tregs for precise local immune suppression.TagsAmyotrophic lateral sclerosisAntigenCRISPRInventorsElizabeth M. BradshawNeil ShneiderRyan HobsonManagerJoan MartinezDepartmentsMolecular MedicineNeurologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-01-02
Targeting senescent cells for the treatment of photoaging and melanomaCU25349Senescent-cell–targeting therapy reverses photoaging and slows melanoma, offering dual cosmetic and oncologic benefits.TagsCellular senescenceChemotherapyHyperpigmentationInventorsDanial KhayatanRolando Perez-LorenzoManagerJerry KokoshkaDepartmentsDermatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-10-09
Integrated AI platform for causal discovery and drug validationCU25378Cloud-based AI suite enabling causal discovery, multimodal data integration, and translational drug validation for personalized medicine.TagsAntigenArtificial intelligenceBias (statistics)InventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Scalable, reproducible, immune-intact tumor organoid co-culture platformCU24328Patient-derived immune-intact tumor organoids enable scalable, reproducible co-culture for personalized immunotherapy and drug screening.TagsBiomarkerBiotechnologyCancer immunotherapyInventorsDavid CohenJoel T. Gabre MDManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Functional recovery of human donor lungs for transplantationCU13138Localized regional lung regeneration preserves vasculature to revive rejected donor lungs for transplantation.TagsDrug discoveryEx vivoExtracellular matrixInventorsDonald FreytesGopal SinghGordana Vunjak-NovakovicManagerCynthia LangDepartmentsBiomedical EngineeringBiomedical InformaticsSurgeryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-11-20
T cell co-receptor clustering for cancer treatmentCU22398Bispecific SLAMF6 antibodies compartmentalize T cells to enhance activation, enabling targeted cancer immunotherapy with fewer off-target effects.TagsCancer immunotherapyCo-receptorImmunotherapyInventorsAdam MorManagerCynthia LangDepartmentsRheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-09-05CollectionsOncology
Combined small molecule treatment as a synergistic epigenetic therapy for pancreatic cancerCU23218Combined HDAC and eIF4A inhibition reprograms pancreatic cancer epigenetically, boosting efficacy and tumor suppression in vivo.TagsAdenocarcinomaApoptosisChemotherapyInventorsAntonio FojoMaryam SafariSusan BatesManagerJerry KokoshkaDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-08-22
