PAMAM nanoparticle for chemotherapy delivery to reduce metastasis and cognitive impairmentCU22225PAMAM nanoparticles deliver chemotherapy while scavenging cell-free nucleic acids to reduce metastasis and cognitive impairment.TagsBreast cancerChemotherapyCognitive deficitInventorsDivya BhansaliHongxia WangKam LeongManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-04-24
A spinal motor neuron-specific enhancer for cell-type specific gene expression control in the developing and adult central nervous systemCU22281Spinal motor neuron–specific enhancer enables AAV-deliverable, cell-type–restricted gene overexpression/knockdown in adults and development.TagsCentral nervous systemCholinergicGene expressionInventorsHynek WichterleTulsi PatelManagerJerry KokoshkaDepartmentsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-02CollectionsGene TherapyCNS/Neurology
Method for disease phenotype prediction from genetic mutationCU21310Phenotype dosage sensitivity: predicts disease phenotypes from LGD mutations via NMD, enabling personalized ASD outcomes and targeted therapeutics.TagsAutism spectrumExonGeneInventorsAndrew ChiangDennis VitkupJiayao WangManagerJoan MartinezDepartmentsBiomedical InformaticsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2022-09-11CollectionsCNS/NeurologyPlatform/Research Tool
Microneedle array for cross-barrier drug delivery in the eye, ear and central nervous systemCU18171Biodegradable microneedle arrays enable precise, cross-barrier drug delivery to the eye, ear, and CNS with controlled release.Tags3D printingBiodegradationCentral nervous systemInventorsAnil LalwaniAykut AksitDaniel N. ArteagaManagerDovina QuDepartmentsMechanical EngineeringOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-01-24
Predicting breast cancer treatment response through PIK3R1 mutation profilingCU26021Predicts breast cancer drug response via endogenous kinase inhibition models using PIK3R1 mutations; rapid, high-throughput screening.TagsAKT1AdenineBreast cancerInventorsNeil Vasan MD, PhDManagerJerry KokoshkaRelease Date2025-10-09
Peptide for sensitizing cancers to immunotherapyCU21100iRGD peptide sensitizes resistant cancers to immunotherapy by tumor-specific Treg depletion, boosting CD8+ T cell activity and survival.TagsBreast cancerCentral nervous systemChemotherapyInventorsAndrew M. LowyKazuki N. SugaharaManagerJerry KokoshkaDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2026-06-26
Single-neuron resolution recordings across the brainCU25180Neuropixels Rail Drive System enables simultaneous single-neuron recordings across deep and superficial primate brain regions.TagsAmygdalaBrainBrain–computer interfaceInventorsC. Daniel SalzmanEric M. TrautmannMark ChurchlandManagerKristin NeumanDepartmentsBiological SciencesNeurosciencePsychiatryDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesZuckerman Mind Brain Behavior InstRelease Date2026-03-27
Immature myeloid cell activation pathway in inflammation-linked cancerCU26121IL-8–driven immature myeloid cell mobilization fuels inflammation-linked GI cancer; targets IMCs for therapy and biomarkers.TagsAngiogenesisBiomarkerBone marrowInventorsTimothy Wang M.D.ManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
VRK2 kinase inhibitors for enhanced cancer immunotherapyCU21245VRK2 inhibitors boost PD-1 therapy by targeting downstream signaling, enhancing T cell activation and tumor clearance.TagsAdenocarcinomaBladder cancerCancer immunotherapyInventorsAdam MorManagerCynthia LangDepartmentsRheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-17
Lung regeneration method for treatment of lung diseasesCU23015Selective de-epithelialization with targeted stem cell engraftment regenerates lung tissue, preserving vasculature for disease treatment and modeling.TagsEx vivoLungMathematical optimizationInventorsCamilla PredellaJing WangNicolino Valerio DorrelloManagerJoan MartinezDepartmentsBiomedical EngineeringPediatricsDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-11-10
Targeting PAG for cancer immunotherapyCU23123PAG-targeting antibodies boost T cell activation, inhibit PD-1 signaling, and reduce tumor growth, enabling monotherapy or combo immunotherapy.TagsAnimal disease modelCancer immunotherapyCombination therapyInventorsAdam MorManagerCynthia LangDepartmentsRheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-07
Recombinant protein to treat inflammationCU23248Recombinant FSTL-1 protein targets and reduces cardiac inflammation, aiding Kawasaki disease research and myocarditis treatment.TagsAnti-inflammatoryAtherosclerosisBiomarkerInventorsMark GorelikManagerSara GusikDepartmentsPediatrics/RheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-10CollectionsCardiovascular
Exogenous Rac1 analogs to treat acute lung injuryCU23206Exogenous activated Rac1 (V12Rac1) protects lungs from ALI/ARDS by stabilizing actin and blocking proinflammatory signaling.TagsActinAcute respiratory distress syndromeEpitheliumInventorsFrancine KatzGalina GusarovaJahar BhattacharyaManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-26
Unique human phenotype to define novel gene function for OCRL1CU22138Neuron-specific OCRL1 variant model reveals brain-focused mechanisms in Lowe syndrome; enables targeted therapies, diagnostics, drug screening.TagsCataractCell membraneCiliumInventorsBarbara CorneoCecilia SenaCharles LeDucManagerCynthia LangDepartmentsPathologyPediatricsRehabilitation & Regenerative MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-03-03CollectionsRare DiseaseCNS/Neurology
Extracellular vesicles isolation for lung and liver disease biomarkersCU25187Minimally invasive blood test isolates lung/liver–specific extracellular vesicles for tissue biomarkers and disease monitoring.TagsAssayBiomarkerBiopsyInventorsAndrea Baccarelli MD, PhDBiancamaria PierriGabriela L. JacksonManagerJoan MartinezDepartmentsEnvironmental Health ScienceMailman School Of Public Health (MSPH)DivisionsMailman School Of Public Health (MSPH)Release Date2026-05-21
Non-invasive laser therapy for cytokine modulation and corneal inflammation managementCU18315Femtosecond laser therapy non-invasively modulates corneal cytokines to reduce inflammation and keratocyte apoptosis, preserving tissue.TagsAnalgesicAntibioticApoptosisInventorsSinisa VukelicManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-08-17CollectionsOphthalmology
Engineered model of human bone marrow for diagnosis and prediction of cancer metastasisCU23273Engineered patient-specific bone marrow model predicts cancer metastasis, metastasis progression, and treatment response non-invasively.TagsAssayAutoimmune diseaseBone marrowInventorsDaniel Naveed TavakolGordana Vunjak-NovakovicPamela GraneyManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-04-08CollectionsOncologyPlatform/Research ToolMedical Device
Tumor-penetrating peptide for enhancing immunotherapy in solid tumorsCU26104Tumor-penetrating peptide remodels desmoplastic tumors to boost immunotherapy, enabling T-cell infiltration with targeted, local TME modulation.TagsCancer cellCytotoxic T cellImmunosuppressionInventorsAndrew M. LowyKazuki N. SugaharaManagerJerry KokoshkaDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2026-07-06
Therapy for EGFR-mutant lung cancerCU22193Targeting RA signaling and S100A9-ALDH1A1 axis to suppress brain metastasis relapse in EGFR-mutant lung cancer.TagsBlood–brain barrierEpidermal growth factor receptorEstrogen receptorInventorsAnup BiswasSwarnali AcharyyaManagerKristin NeumanDepartmentsInstitute for Cancer GeneticsDivisionsColumbia University Medical Center (CUMC)Release Date2023-01-04CollectionsOncology
Preconditioning cell treatment for immunotherapyCU17038Dual hypoxia and inflammatory cytokine preconditioning boosts mesenchymal stem cells’ immunosuppressive potency for more effective immunotherapies.TagsAutoimmune diseaseCoronary artery diseaseCytokineInventorsGordana Vunjak-NovakovicHolly WobmaMariko KanaiManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-06-03
Rapid assessment of T cell health for enhanced cancer immunotherapyCU24313A rapid platform uses biomaterials, imaging, and deep learning to assess T cell functionality and predict proliferation for immunotherapy.TagsAlgorithmAssayBiomaterialInventorsJia GuoLance KamNicole LamannaManagerDovina QuDepartmentsBiomedical EngineeringMedicinePsychiatryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-12-18CollectionsArtificial Intelligence (AI)
CD58 modulation for improved cancer immunotherapy outcomesCU21046CD58 modulation enhances antitumor immunity, overcoming resistance and informing biomarkers for optimized, combinational cancer immunotherapy.TagsAntigen presentationBiomarkerCancer cellInventorsBenjamin Izar MD, PhDJohannes MelmsManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-10-17
Transcriptional reprogramming platform for neuroprotection, rejuvenation, and treatment of motor neuron diseasesCU23208AAV-delivered Islet1/Lhx3 re-expression reprograms motor neurons, restoring youthful resilience to prevent motor neuron degeneration.TagsAmyotrophic lateral sclerosisGene expressionGene therapyInventorsEmily Rhodes LowryHynek WichterleTulsi PatelManagerJerry KokoshkaDepartmentsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-01-18CollectionsGene Therapy
Mechanosensitive regulatory T cell induction for improved adoptive immunotherapyCU23392Mechanosensitive substrate stiffness boosts stable regulatory T cell induction, improving durability and effectiveness for adoptive immunotherapy.TagsAutoimmune diseaseCoatingImmune systemInventorsLance KamLingting ShiManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-12-12
Lung organoid cells for therapeutic interventionCU23361Therapeutic lung regeneration via patient-specific stem cell–derived distal lung organoids with graftable basal and secretory cells.TagsCell therapyChronic obstructive pulmonary diseaseCoatingInventorsHans-Willem SnoeckManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-09-08
Generation of self-renewed CD4+ T cells for cancer and viral disease immunotherapyCU24385Ex vivo culture method yields durable, polyfunctional cytotoxic CD4+ T cells for enhanced cancer and viral immunotherapies.TagsAntigenCell cultureCell therapyInventorsMithil SoniPawel MuranskiPrabesh KhatiwadaManagerJerry KokoshkaDepartmentsColumbia Center for Translational ImmunologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-09-16
Real-time in situ measurement of electrical impedance of lung tissueCU22293Real-time in situ airway impedance device assesses epithelial health, enabling rapid COPD, asthma, and lung disease monitoring.TagsAsthmaBiomarkerCystic fibrosisInventorsGordana Vunjak-NovakovicJiawen ChenJinho KimManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-05-29
Host proteases necessary for human parainfluenza virus spread in human lungCU22326Identifies HPIV spread proteases; shows serine protease inhibitors (nafamostat) hinder lung infection, offering targeted antiviral strategy.TagsAntiviral drugEnzyme inhibitorEvolutionInventorsAnne MosconaKyle StearnsMatteo PorottoManagerKristin NeumanDepartmentsAnesthesiologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2024-02-15
Small scale screening bioreactor with airway tissues and mucosa for the progression and treatment of lung diseaseCU23307Bioreactor recreating mucus-lined airways ex vivo for real-time, high-throughput modeling and therapeutic screening.TagsBiomimeticsBioreactorCell cultureInventorsGordana Vunjak-NovakovicJinho KimKeith YeagerManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-04-08
Targeting the CD58:CD2 axis for cancer immunotherapyCU21140Activates CD28-CD8+ T-cells via CD58:CD2 axis, offering an immunotherapy option for PD-1–unresponsive cancers.TagsAntibodyAntigen-presenting cellCD28InventorsBenjamin Izar MD, PhDJohannes MelmsPatricia HoManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-06-23CollectionsOncology
Recombinant ILT3 protein-produced antibodies for immunotherapy treatment of cancerCU15207Engineered anti-ILT3 antibodies enable targeted cancer immunotherapy, modulating myeloid signals and enhancing immune blockade.TagsAcute myeloid leukemiaAllotransplantationAntibodyInventorsGeorge Vlad Ph.D.Nicole Suciu-FocaZheng XuManagerSara GusikDepartmentsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-03-08CollectionsOncology
Tissue-selective GABA(A) receptor modulators for asthma and bronchoconstrictive airway diseaseCU24261Airway-targeted GABA(A) modulators relax smooth muscle and reduce inflammation without CNS sedation, offering non-sedating asthma therapy.TagsAgonistAnticholinergicAsthmaInventorsCharles W. Emala M.D.ManagerSara GusikDepartmentsAnesthesiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-08-03
Multiplexed T cell profiling for generating engineered regulatory T cell therapiesCU23310High-throughput platform maps patient TCR–antigen pairs to create CRISPR‑engineered, autologous Tregs for precise local immune suppression.TagsAmyotrophic lateral sclerosisAntigenCRISPRInventorsElizabeth M. BradshawNeil ShneiderRyan HobsonManagerJoan MartinezDepartmentsMolecular MedicineNeurologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-01-02
Tri-specific human immunodeficiency virus antibodies for immunotherapyCU22364Tri-specific HIV antibody targets three epitopes, offering longer-acting, potent immunotherapy to treat and prevent HIV infection.TagsAntibodyAntiviral drugEpitopeInventorsDavid Da-i Ho M.D.ManagerKristin NeumanDepartmentsPhysicians & SurgeonsDivisionsColumbia University Medical Center (CUMC)Release Date2022-07-22
Microvasculature-targeted therapeutic AAV vectors for selective brain deliveryCU24146Brain-endothelium-targeted AAV gene therapy enables non-invasive, selective CNS delivery, treating Glut1DS and neurovascular diseases.TagsAdeno-associated virusBlood–brain barrierCentral nervous systemInventorsShashi KumarUmrao R. Monani Ph.D.ManagerKristin NeumanDepartmentsNeurologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-03-17
Nanoparticle system for targeted cancer treatmentCU21031Targeted scavenging nanoparticles deliver non-opioid cancer therapy and pain relief, reducing inflammation and metastasis.TagsCancerChemotherapyDrug resistanceInventorsDivya BhansaliKam LeongTianyu LiManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-05-01CollectionsOncology
Pharmacological inhibitors and mouse models of mitochondrial DNA depletion-deletion syndromes (MDDS)CU23197Therapeutic mouse models and deoxynucleoside-based treatment restore mtDNA balance in GUK1-related MDDS, enabling mtDNA repair.TagsAcute respiratory distress syndromeBiomarkerBiopharmaceuticalInventorsAgustin Hidalgo GutierrezJonathan ShintakuMichio Hirano M.D.ManagerKristin NeumanDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08CollectionsRare Disease
Inhibition of RAR/RXR signaling for adenoid cystic carcinoma treatmentCU23276Targeted ACC therapy modulates RAR/RXR signaling to reclassify tumor cells and selectively kill ductal-like populations.TagsAdenocarcinomaAdenoidAdjuvant therapyInventorsPierangela PalmeriniPiero D. DalerbaSara ViragovaManagerKristin NeumanDepartmentsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-03-13
In vivo internalizing RGD peptide production for enhanced treatment of solid tumorsCU25033In vivo iRGD plasmid drives tumor penetration, reducing immunosuppression; co-administers with CAR-T/ therapies for enhanced efficacy.TagsAngiogenesisCancer immunotherapyChemotherapyInventorsKazuki N. SugaharaNorio MiyamuraManagerJerry KokoshkaDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2025-11-20
PDE5 inhibitor for Alzheimer's treatment2439A brain-penetrant PDE5 inhibitor enhances cGMP signaling, reduces amyloid, and supports synaptic plasticity in Alzheimer’s models.TagsAmyloid betaAmyloid plaquesBlood–brain barrierInventorsDonald William Landry MD, Ph.D.Ottavio Arancio MD, PhDShi-xian DengManagerJerry KokoshkaDepartmentsMedicinePathologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-18
Convection-enhanced delivery of topotecan and dexamethasone for malignant gliomasCU25031Chronic convection-enhanced local delivery of topotecan plus dexamethasone via an implantable pump-catheter system for glioma therapy.TagsAdjuvant therapyAnimal disease modelBlood–brain barrierInventorsJeffrey BrucePeter CanollManagerJerry KokoshkaDepartmentsNeurological SurgeryPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-29
Focused ultrasound nanoparticles for targeted imaging and neuroregenerationCU21224Ultrasound-activated nanocup theranostics cross BBB for targeted Alzheimer’s imaging and neuroregenerative therapy.TagsAmyloid betaAntibodyBlood–brain barrierInventorsAntonios PoulipoulosElisa KonofagouManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-07-29
Protein fragment to promote neurogenesisCU13345Dominant-negative ATF5 fragment drives differentiation of neuroprogenitors into mature neurons and glial cells, enabling brain regeneration research.TagsAstrocyteCellular differentiationCentral nervous systemInventorsJames M. AngelastroLloyd Greene PhDManagerJerry KokoshkaDepartmentsMolecular BiosciencesPathologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-13
Manganese oxide nanoparticles for cell-free nucleic acid scavengingCU22060Anionic manganese oxide nanoparticles scavenge cell-free nucleic acids to reduce inflammation with low toxicity and biodegradability.TagsApoptosisBiodegradationInflammationInventorsKam LeongYiling ZhongManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-08-14
Targeting Delta-2 tubulin for the treatment of peripheral neuropathyCU25119Delta-2 tubulin as a therapeutic target to prevent or treat chemotherapy-induced peripheral neuropathy, addressing multiple drug classes.TagsAnalgesicAnticonvulsantAntidepressantInventorsFrancesca Bartolini Ph.D.Maria Elena PeroManagerKristin NeumanDepartmentsPathology & Cell BiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-12-17CollectionsCNS/Neurology
Tumor-infiltrating lymphocyte and organoid co-culture for patient-specific immunotherapyCU22128Ex vivo tumor-lymphocyte co-culture screens patient TILs for tumor killing, guiding pre-treatment immunotherapy choices and cost savings.TagsCell cultureCytotoxicityDrug resistanceInventorsAlana NguyenMichael Shen Ph.D.ManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2022-08-22CollectionsOncologyPlatform/Research Tool
Radiolabeled microtubule ligands for central nervous system (CNS) imagingCU17295Brain-penetrant radiolabeled microtubule PET/SPECT tracers enable in vivo CNS imaging for tumors and neurodegenerative monitoring.TagsBlood–brain barrierBrainCentral nervous systemInventorsDileep KumarJ. John MannManagerJerry KokoshkaDepartmentsPsychiatryDivisionsColumbia University Medical Center (CUMC)Release Date2018-08-13CollectionsCNS/Neurology
Conditional knockout mouse model for studying autosomal-dominant optic atrophyCU26140A mammalian, cell-type–specific conditional Ssbp1 R107Q mouse model to dissect autosomal-dominant optic atrophy mechanisms.TagsAlleleArginineCre recombinaseInventorsChyuan-Sheng (Victor) LinNan-Kai WangYunju TsengManagerKristin NeumanDepartmentsOphthalmologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Engineered bacterial platform for localized cancer therapyCU26042Engineered bacteria deliver localized chemoimmunotherapy to tumors, combining prodrug activation, IL-15 boosting, and PD-L1 blockade.TagsBacteriaBiopharmaceuticalChemotherapyInventorsJongwon ImNicholas ArpaiaTal DaninoManagerCynthia LangDepartmentsBiomedical EngineeringMicrobiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-05-15
Blood-brain barrier opening and cavitation imaging using a single diagnostic imaging arrayCU21007Single diagnostic ultrasound array opens the blood-brain barrier and images cavitation simultaneously for cost-effective, targeted brain therapy.TagsBeamformingBlood–brain barrierCavitationInventorsElisa KonofagouMark T. BurgessRobin JiManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-07-29
