Enhanced CMOS amplifier nanopore sensor for ion channel analysisCU12278Enhanced CMOS nanopore amplifier boosts high-throughput, high-resolution ion channel sensing for drug discovery and diagnostics. (136 characters)TagsAmplifierCMOSDNA sequencingInventorsKenneth ShepardJacob RosensteinSiddharth Ramakrishnan PhDManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-11-21
Efficient and scalable bio-integrated AI system using brain organoidsCU24020Bio-integrated AI uses brain organoids and CMOS interfaces for scalable, energy-efficient reservoir computing with enhanced AI performance.TagsArtificial intelligenceAutonomous system (Internet)Brain mappingInventorsKenneth ShepardKenneth KosikManagerGreg MaskelDepartmentsElectrical EngineeringNeuroscienceDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-05-27
Miniaturized multi-clamp CMOS amplifier for intracellular electrophysiology recordingCU19222Ultra-compact CMOS multi-clamp intracellular amplifier enabling high-SNR voltage/current recordings with low power.TagsAmplifierBrainCMOSInventorsKenneth ShepardKrishna JayantSiddharth ShekarManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-07-21CollectionsCNS/Neurology
Distributed differential oscillators for global clock networksM06-029Distributed differential oscillator network enables low-skew, low-jitter, low-power global clock distribution for high-frequency microprocessors.TagsAmplitudeClock signalDifferential signalingInventorsKenneth ShepardSteven ChanManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-10-20
Implantable ultrasound-powered microchipsCU15073Ultrasound-powered micron-scale IC chips wirelessly power and transmit real-time physiological data, enabling battery-free implants.TagsDrug deliveryElectric batteryElectrical energyInventorsKenneth ShepardChen ShiHongki KangManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-04-07
Optically-powered micron-scale chip for electrophysiological measurements and intracellular probesCU16181An optically powered, sub-10 micron CMOS chip for injectable electrophysiology and intracellular sensing via light-driven power and data.TagsBiologyCMOSElectrophysiologyInventorsKenneth ShepardGirish RamakrishnanManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-02-27
Wireless implantable device for optical brain imaging in freely moving animalsCU19385Wireless implantable, fully wireless optical brain imaging probe enables high-resolution, optogenetic interrogation in freely moving animals.TagsAction potentialBrain mappingCMOSInventorsKenneth ShepardEric PollmannSajjad MoazeniManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-07-21CollectionsCNS/Neurology
Flexible implantable probe for large-scale wireless neural stimulation and recordingCU15023A flexible, wireless, battery-free CMOS neural probe enabling large-scale, high-density brain stimulation and recording with minimal tissue disturbance.TagsBrainCMOSElectrophysiologyInventorsKenneth ShepardDavid TsaiHongki KangManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-04-07
CMOS imaging arrays for high-speed fluorescence lifetime imagingCU12003CMOS-SPAD FLIM array enables 200 fps wide-field imaging with on-chip timing, compact, cost-effective for live-cell and high-throughput assays.TagsCMOSDNA sequencingData acquisitionInventorsKenneth ShepardRyan M. FieldManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-10-09
Nanotechnology designed platform for DNA microarray applications using carbon nanotubesCU12289CNT-based smFET microarrays enable label-free, multiplexed DNA/RNA detection with high-sensitivity on a portable LOC platform.TagsAcidBiomoleculeCMOSInventorsKenneth ShepardSteven WarrenManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2013-09-06
Protein sequencing with a cavity-separated multi-nanopore deviceCU22073Cavity-separated multi-nanopore sequencing enables high-throughput, library-free, single-molecule protein sequencing with improved accuracy.TagsDrug developmentGene expressionIonInventorsKenneth ShepardJakob BuchheimManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-01-31
Integrated nanopore sensors for high-bandwidth DNA analysisM11-069Integrated solid-state nanopore with on-chip low-noise preamplifier enables high-bandwidth, low-noise, real-time DNA analysis.TagsAmplifierBiosensorCMOSInventorsKenneth ShepardJacob RosensteinManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)School of Engineering and Applied Science (SEAS)Release Date2012-01-10
Surface-based nucleic acid assays using morpholinosM07-104Morpholino probes enable low-ionic-strength, label-free, cost-effective surface nucleic acid assays with rapid, specific hybridization.TagsAssayBiosensorDNA microarrayInventorsKenneth ShepardNapoleon TerceroPing GongManagerGreg MaskelDepartmentsChemical & Biological EngineeringChemical Engineering/Applied ChemistryElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-10-20
High-density bioelectric sensor using CMOS-integrated Junctional Field Effect Transistors (JFETs)CU13098High-density CMOS JFET bioelectric sensors reduce flicker noise, enabling dense, high-resolution neural and bioassay interfaces.TagsBrain–computer interfaceCMOSElectrochemistryInventorsKenneth ShepardDan FleischerJacob RosensteinManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2013-09-06
Integrated voltage regulator for next-generation microprocessorsCU12053Integrated four-phase buck regulator embedded in microprocessors enables near-instantaneous, efficient power conversion across multiple rails.TagsHigh voltageIntegrated circuitVoltageInventorsKenneth ShepardNoah Andrew SturckenManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2016-03-11
Fabrication of flexible 2D ultrasound phased arrays for clinical imaging applicationsCU19259Flexible, wearable 2D ultrasound phased array patch enables conformal, long-term imaging and patient comfort with adjustable beamforming.TagsAblationCMOSExcimer laserInventorsKenneth ShepardJeffrey ElloianTiago CostaManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-07-21CollectionsMedical Device
Implantable, flexible, wireless chip for in vivo recording and stimulation of the brainCU17269A fully implanted, flexible, wireless brain chip delivering high-density, long-term surface recording and stimulation with no wires.TagsCMOSDevelopment of the nervous systemElectrophysiologyInventorsKenneth ShepardDavid TsaiJonathan David TerryManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-07-10CollectionsCNS/Neurology
Resonant Clock Distribution for Large Scale Integrated CircuitsM01-062Resonant clock distribution boosts high-speed timing in large-scale ICs with lower power, reduced skew, and improved jitter.TagsClock signalElectrical conductorInductorInventorsKenneth ShepardManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2001-06-08
Wireless ultrasound-based stimulation of the nervous systemCU21309Non-invasive, wireless ultrasound stimulates brain and vagus nerve via flexible microelectrode arrays, enabling multi-region neural interfaces.TagsArteryBaroreceptorBrainInventorsKenneth ShepardEdward Boyden PhDGiovanni FranzesiManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2021-05-05CollectionsCNS/NeurologyMedical Device
Mass sensor for label-free biomolecular and chemical detectionM09-083Label-free, high-sensitivity mass sensing with FBAR-CMOS arrays enabling multiplexed biomolecular/chemical detection beyond QCMs.TagsAcousticsAnalyteBiomarkerInventorsKenneth ShepardJohn Ioannis KymissisMatthew JohnstonManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2009-10-20
DNA-based high spatial resolution thermometer based on temperature dependent fluorescenceM11-123DNA-based high-resolution thermometer uses fluorescence in DNA strands for real-time, spatial temperature mapping with 0.1°C precision.TagsDNA sequencingFluorescenceIntegrated circuitInventorsKenneth ShepardHaig NorianJohn Ioannis KymissisManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering andFu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-10-14
Noninvasive near-infrared brain imaging systemCU19286ToFF-DOT: wearable, noninvasive near-infrared brain imaging achieving single-cell resolution of neural activity for mapping and research.TagsAction potentialBrain mappingGene expressionInventorsKenneth ShepardKevin RenehanSajjad MoazeniManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2021-01-15CollectionsCNS/NeurologyMedical Device
