Two-photon holographic microscope system for 3D neuronal circuit imaging and stimulationCU23132A holographic two-photon microscope enables simultaneous, high-resolution 3D neuronal imaging and optogenetic stimulation in vivo.TagsAdaptive opticsHolographyMicroscopyInventorsRafael YusteYuriy ShymkivManagerKristin NeumanDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2023-12-04CollectionsCNS/NeurologyPlatform/Research Tool
Virome-capture-sequencing (VirCapSeq) for viral infection diagnosisCU18221VirCapSeq-VERT: a high-throughput, cost-effective viral capture and sequencing platform enabling broad, sensitive vertebrate virus detection and discovery.TagsChain reactionDNA sequencingMassive parallel sequencingInventorsCheng GuoNischay MishraOrchid AllicockManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2025-09-04
Paramyxovirus fusion complex structure for antiviral and vaccine designCU23202A conserved paramyxovirus fusion complex structure enables targeted antivirals and vaccine design, stabilizing pre-fusion entry protein.TagsAntigenAntiviral drugFusion proteinInventorsAnne MosconaMatteo PorottoTara MarcinkManagerKristin NeumanDepartmentsPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2024-02-21
An improved virome-capture-sequencing method for viral diagnosis and virus discoveryCU24096Improved virome capture sequencing boosts vertebrate virus detection with fewer probes, lower costs, and broader viral coverage.TagsAcidCerebrospinal fluidChemical libraryInventorsThomas BrieseW. Ian Lipkin M.D.ManagerKristin NeumanDepartmentsEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2026-03-06
Therapeutic antibodies against amyloid aggregatesCU23354Antibody platform targets TMEM106B amyloid aggregates for diagnosis, therapeutics, and research across neurodegenerative diseases.TagsAmyloid betaAntibodyBiomarkerInventorsAnthony William Paul FitzpatrickCarolyn LeeJunqiang Ye Ph.D.ManagerKristin NeumanDepartmentsBiochemistryBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-26
WDFY3 variant mouse models for neurodegenerative studiesCU26145A clinically relevant WDFY3 knock-in mouse model to study autophagy’s role in neurodegenerative diseases and therapies.TagsAutophagyNeurodegenerative diseaseNeuronInventorsAi YamamotoManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Artificial intelligence tool for rapid, automated electronic health record reviewCU26003AI-powered OphthoACR automates rapid, accurate ophthalmology EHR data extraction from unstructured notes and imaging.TagsAbstraction (computer science)Artificial intelligenceCohort studyInventorsKaren ChenLeejee Han SuhVlad DiaconitaManagerKristin NeumanDepartmentsOphthalmologyPhysicians & SurgeonsDivisionsColumbia University Medical Center (CUMC)Release Date2025-10-23
Broadly neutralizing antibody against SARS-CoV-2 variants and related sarbecovirusesCU24218Broadly neutralizing antibody targets SARS-CoV-2 variants and related sarbecoviruses, enabling versatile, durable treatment and prophylaxis.TagsAntibodyAntiviral drugCladeInventorsDavid Da-i Ho M.D.Jian YuLawrence S. Shapiro Ph.D.ManagerKristin NeumanDepartmentsAaron Diamond AIDS Research Center (ADARC)Biochemistry and Molecular Biophysics / OphthalmologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-09-16
Sensitive SARS-CoV-2 antigen testCU21002Ultra-sensitive SARS-CoV-2 antigen sandwich ELISA using dual nucleocapsid antibodies for rapid, low-viral-load detection.TagsAntibodyAntigenAssayInventorsDavid Da-i Ho M.D.Lihong LiuManagerKristin NeumanDepartmentsMedicinePhysicians & SurgeonsDivisionsColumbia University Medical Center (CUMC)Release Date2024-04-25
Surgical imaging device for minimally invasive surgery2381An insertable, stereoscopic surgical imaging device enabling single-port, fully internal visualization with pan-tilt-zoom and lighting.TagsDepth perceptionLaparoscopyLensInventorsDennis FowlerPeter AllenManagerKristin NeumanDepartmentsComputer ScienceSurgeryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-03-06
Brain-informed speech separation (BISS) for auditory speech signal enhancementCU21093Brain-informed speech separation (BISS) uses neural signals and deep learning to isolate and enhance target speech in noisy environments.TagsActive noise controlElectroencephalographyHearing lossInventorsEnea CeoliniNima MesgaraniManagerKristin NeumanDepartmentsElectrical EngineeringMortimer B. Zuckerman Mind Brain Behavior InstituteDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-11-20
Knock-in mouse lines to target striatal projection neurons and dopaminergic neuronsCU26031Knock-in Cre/FlpO mice precisely target striatal projection and dopaminergic neurons for cell-type specific neuroscience research.TagsAdenosineAdenosine A2A receptorBasal gangliaInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-07
Diagnostic peptides for Lyme disease serodiagnosisCU25107Rapid, affordable Lyme diagnostic using two specific peptides; enables early, at-home, point-of-care serodiagnosis with higher accuracy.TagsAntibioticAntibodyBorrelia burgdorferiInventorsRafal TokarzW. Ian Lipkin M.D.ManagerKristin NeumanDepartmentsEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2025-04-04
Conditional 5-HT1A receptor knockout mouse model for studying antidepressant responseCU25138Inducible, cell-type specific 5HT1AR knockout mouse model reveals dentate gyrus roles in antidepressant response and mood regulation.Tags5-HT receptor5-HT1A receptorAntidepressantInventorsRene HenManagerKristin NeumanDepartmentsPharmacologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-02-28
Targeting glial cells for treating myelofibrosisCU23243Targeting Sox10+ and ErbB3+ glial cells in bone marrow to slow or halt myelofibrosis progression.TagsAortic dissectionBiomarkerCell therapyInventorsJunsong ZhouLei DingShawn SarkariaManagerKristin NeumanDepartmentsMicrobiologyOncologyRehabilitation & Regenerative MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-21CollectionsOncology
Clinical decision support system using artificial intelligenceCU24273AI-based CONCERN system converts nurse documentation into early warning predictions, reducing mortality, sepsis, and ICU transfers.TagsArtificial intelligenceClinical trialEHealthInventorsChristopher KnaplundKenrick CatoSarah RossettiManagerKristin NeumanDepartmentsBiomedical InformaticsEmergency MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05
Host proteases necessary for human parainfluenza virus spread in human lungCU22326Identifies HPIV spread proteases; shows serine protease inhibitors (nafamostat) hinder lung infection, offering targeted antiviral strategy.TagsAntiviral drugEnzyme inhibitorEvolutionInventorsAnne MosconaKyle StearnsMatteo PorottoManagerKristin NeumanDepartmentsAnesthesiologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2024-02-15
A peptide microarray for serodiagnosis of exposure to high-threat hemorrhagic fever virusesCU23088Peptide microarray identifies immunoreactive epitopes for high-specificity serodiagnosis of hemorrhagic fevers, distinguishing infection from vaccination.TagsAntibodyBlood plasmaBlood transfusionInventorsLisa HensleyNischay MishraSunil Kumar DubeyManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2024-01-10CollectionsPlatform/Research Tool
Gene editing system for the treatment of autosomal dominant disease-related genesCU18283Mutation-independent CRISPR pair replaces dominant alleles with a functional gene to treat autosomal dominant diseases.TagsCRISPRGene therapyGenetic disorderInventorsStephen H. Tsang M.D., Ph.D.Wen-Hsuan WuYi-Ting TsaiManagerKristin NeumanDepartmentsNutritional and Metabolic BiologyOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2023-12-28CollectionsOphthalmologyGene Therapy
Swept, Confocally-Aligned, Planar Excitation (SCAPE) Microscopy Using a Graded-Index (GRIN) lens for deep tissue imagingCU21327GRIN-SCAPE enables high-speed, 3D deep-brain imaging in awake animals using GRIN lenses for wide-field, multispectral activity mapping.TagsAnatomical terms of locationBrainBrainstemInventorsElizabeth HillmanGrace Sooyeon LeeWenxuan LiangManagerKristin NeumanDepartmentsBiomedical EngineeringMortimer B. Zuckerman Mind Brain Behavior InstituteDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-09-25CollectionsPlatform/Research ToolMedical Device
Computational pipeline for identifying kinase drug targets in cancerCU23037An integrative multi-omics pipeline uses ML to identify master kinases per cancer subtype, enabling precision targeted therapies.TagsDrug developmentGlioblastomaKinaseInventorsAnna LasorellaAntonio IavaroneManagerKristin NeumanDepartmentsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-07-20CollectionsOncology
Speech analysis software for diagnosis of dementiasCU23077Automated, noninvasive speech-analysis tool to screen for early cognitive impairment and Alzheimer’s-related dementias.TagsAcousticsArtificial intelligenceAssayInventorsMaryam ZolnooriManagerKristin NeumanDepartmentsSchool of NursingDivisionsSchool of Nursing (CUMC)Release Date2023-03-08CollectionsCNS/NeurologyPlatform/Research ToolMedical Device
System for detection and amplification of target speech in multi-talker environmentsCU17276Brainwave-guided real-time speech separation amplifies attended speaker in multi-talker scenes, aiding hearing-impaired listeners.TagsAttractorNoise reductionSpeech perceptionInventorsNima MesgaraniYi LuoZhuo ChenManagerKristin NeumanDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2017-06-08
Diagnosis of viral disease in tilapia populationsCU15044Identifies TiLV-specific nucleic acid and protein markers for rapid, high-throughput tilapia viral diagnostics and monitoring.TagsDNA sequencingFish farmingHigh-throughput screeningInventorsNischay MishraSandra Abel NielsenThomas BrieseManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2015-11-06
A2a-FlpO mouse model for neuroscience studiesCU26036Precise, cell-type specific A2a-FlpO knock-in mice enable orthogonal D1/D2 dopaminergic studies in basal ganglia circuits.TagsBasal gangliaBehavioral neuroscienceCombinatoricsInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-13
D1-Cre knock-in mouse for genetic targeting of basal ganglia circuitsCU26035CRISPR knock-in D1-Cre mouse ensures precise, endogenous D1 neuron targeting in basal ganglia for targeted circuit studies.TagsBasal gangliaCre recombinaseDopamineInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-13
Treating elevated intraocular pressure with nicotinamide and its analogsCU23299Nicotinamide-based oral therapy lowers elevated intraocular pressure to prevent glaucoma, offering easy, non-invasive prophylaxis.TagsAnti-aging movementAqueous humourGlaucomaInventorsNicholas TolmanSimon JohnStephen C. KneelandManagerKristin NeumanDepartmentsOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-09-12CollectionsOphthalmology
Prophylactic therapy for SARS-CoV-2 and MERSCU25029Lipopeptide fusion inhibitors with enhanced solubility to prophylactically block SARS-CoV-2 and MERS entry.TagsAntiviral drugCell membraneCholesterolInventorsAnne MosconaManagerKristin NeumanDepartmentsPediatricsRelease Date2025-08-29
Genetic sequence database for identifying bacteria, pathogenicity, and antibiotic resistanceCU23199Curated million-sequence database enabling rapid bacterial ID, virulence and antibiotic-resistance detection for diagnostics.TagsAntimicrobial resistanceBiological databaseDrug developmentInventorsAmit RanjanCheng GuoThomas BrieseManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-29
Efficient, generalizable brain-computer interface for neural feedback controlCU23225Generalizable, unsupervised brain-computer interface: invariant neural dynamics enable context-free motor control without per-task calibration.TagsBrain–computer interfaceCyborgMotor controlInventorsJose CarmenaRui CostaVivek AthalyeManagerKristin NeumanDepartmentsMortimer B. Zuckerman Mind Brain Behavior InstituteNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-07-06
Low-cost microfluidic chip for time-resolved cryo-electron microscopyCU22182Low-cost PDMS microfluidic TR cryo-EM chip enables affordable, modular time-resolved protein studies with rapid spray-plunge vitrification.TagsAdsorptionBiosensorCryogenic electron microscopyInventorsJoachim FrankQiao LinXiangsong FengManagerKristin NeumanDepartmentsBiochemistryBiochemistry & Molecular BiophysicsMechanical EngineeringDivisionsColumbia University Medical Center ( CUMColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-02-16
Glycolipids and analogues as antigens for natural killer T cellsCU22361Glycolipid analogues activate natural killer T cells via CD1d, boosting immune responses for vaccines and immunotherapy.TagsAdjuvant therapyAntigenCytokineInventorsDavid Da-i Ho M.D.Moriya TsujiManagerKristin NeumanDepartmentsMedicinePhysicians & SurgeonsDivisionsColumbia University Medical Center (CUMC)Release Date2022-07-21CollectionsImmunology & Inflammation
FixR: Late sodium current peptide inhibitor for treating cardiac arrhythmiasCU22077FixR uses a cell-targeted peptide to more selectively block late cardiac sodium currents, reducing arrhythmia risk.TagsAdeno-associated virusArrhythmiaAutism spectrumInventorsManu Ben-JohnyNourdine ChakouriManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2021-10-12CollectionsSmall MoleculeCardiovascular
Induced differentiation and maturation of stem cells via interruption of DNA replicationCU18295Induces stem cell terminal differentiation by blocking DNA replication, yielding mature, functional cells for therapy, research, and transplantation.TagsBeta cellCardiac muscle cellCell cycleInventorsDietrich EgliLina SuiManagerKristin NeumanDepartmentsPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2020-08-09
Digitized analysis and scoring of spiral drawing testCU20146Digitized spiral analysis automates recording and scoring of hand-drawn spirals for objective motor dysfunction diagnosis and monitoring.TagsAlgorithmAtaxiaBiomarkerInventorsSeth PullmanManagerKristin NeumanDepartmentsNeurologyRelease Date2020-06-04CollectionsMedical DeviceDigital Health (Software, AI, bioinformatics, etc)
One step assay for rapid and selective diagnosis of arbovirusesCU16221Multiplex one-step qPCR quickly differentiates Zika, Dengue, Chikungunya, and West Nile from serum or urine samples.TagsArbovirusAssayChikungunyaInventorsNischay MishraRafal TokarzW. Ian Lipkin M.D.ManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2017-08-18
Algorithm for detecting potential structural interactions among proteinsCU12266PrePPI uses structure-informed sequence alignments to predict genome-wide protein interactions, reducing experimental effort and false positives.TagsAffinity chromatographyAlgorithmDrug developmentInventorsBarry HonigDonald PetreyQiangfeng "Cliff" ZhangManagerKristin NeumanDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2015-10-13
Inhibition of RAR/RXR signaling for adenoid cystic carcinoma treatmentCU23276Targeted ACC therapy modulates RAR/RXR signaling to reclassify tumor cells and selectively kill ductal-like populations.TagsAdenocarcinomaAdenoidAdjuvant therapyInventorsPierangela PalmeriniPiero D. DalerbaSara ViragovaManagerKristin NeumanDepartmentsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-03-13
Human ALFY knock-in mice for studying neurodegenerative diseaseCU26143Human ALFY knock-in mice enable tissue-specific, controllable hALFY expression to study neurodegenerative protein aggregation.TagsAutophagyCopy number variationCre recombinaseInventorsAi YamamotoManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08CollectionsCNS/Neurology
Conditional knockout mouse model for studying autosomal-dominant optic atrophyCU26140A mammalian, cell-type–specific conditional Ssbp1 R107Q mouse model to dissect autosomal-dominant optic atrophy mechanisms.TagsAlleleArginineCre recombinaseInventorsChyuan-Sheng (Victor) LinNan-Kai WangYunju TsengManagerKristin NeumanDepartmentsOphthalmologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Targeted knock-in mouse line for studying neuropsychiatric diseaseCU26034A knock-in mouse line enabling precise A2a-expressing neuron targeting in basal ganglia for neuropsychiatric research and drug validation.TagsAdenosine A2A receptorBasal gangliaCre recombinaseInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-13
Neutralizing monoclonal antibodies targeting SARS-CoV-2 variants and related coronavirusesCU22012Broadly neutralizing monoclonal antibodies block diverse SARS-CoV-2 variants, enabling prophylaxis, treatment, and multi-epitope cocktail strategies.TagsAntiviral drugAssayB cellInventorsDavid Da-i Ho M.D.Jian YuLihong LiuManagerKristin NeumanDepartmentsMedicineMicrobiologyPhysicians & SurgeonsDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-21
Human protective antibodies for use against H7N9 influenza virusCU23380Human-derived monoclonal antibodies neutralize H7N9, blocking entry and enabling post-exposure prevention and diagnostics.TagsAntiviral drugAvian influenzaB cellInventorsDavid Da-i Ho M.D.Kelvin Kai-Wang ToKwok-Yung YuenManagerKristin NeumanDepartmentsAaron Diamond AIDS Research Center (ADARC)Dept. of Biochemistry and Molecular Biophysics / OphthalmologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-18CollectionsImmunology & Inflammation
Therapeutic prime editing for gene therapy against ocular dystrophyCU22243Prime-editing therapy targets PRPH2 splice mutations (c.828+) for retinal dystrophies, enabling precise in-eye gene corrections.TagsAnimal husbandryCas9GenomeInventorsBruna Lopes da CostaPeter M.J. QuinnSalvatore M. CarusoManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-04-25CollectionsOphthalmologyGene Therapy
Microvasculature-targeted therapeutic AAV vectors for selective brain deliveryCU24146Brain-endothelium-targeted AAV gene therapy enables non-invasive, selective CNS delivery, treating Glut1DS and neurovascular diseases.TagsAdeno-associated virusBlood–brain barrierCentral nervous systemInventorsShashi KumarUmrao R. Monani Ph.D.ManagerKristin NeumanDepartmentsNeurologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-03-17
Digital twin for cardiovascular surgery planningCU25246AI-driven patient-specific virtual heart surgery tool predicts post-operative blood flow to guide BLV treatment decisions.TagsAlgorithmCardiac surgeryCongenital heart defectInventorsDavid KalfaVijay VedulaYurui ChenManagerKristin NeumanDepartmentsMechanical EngineeringSurgeryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-03-06
Clinical management of Interstitial Lung Disease using a multiplex real-time PCR assay to quantify leukocyte telomere lengthCU24245Multiplex real-time PCR quantifies average leukocyte telomere length to guide ILD treatment decisions and outcomes.TagsAssayBiomarkerImmunosuppressionInventorsChad NewtonChristine K. GarciaDavid ZhangManagerKristin NeumanDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-13
Hip implant for securement to the femur of a subject with applications to other jointsCU23044Patient-specific, minimally invasive reversible hip implant that anchors without bone penetration; applicable to other joints.TagsBoneBone remodelingFemurInventorsAlexander KellElias IssaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2024-01-02CollectionsMedical Device
Targeting ID2 to impair hypoxic cancer stem cell proliferationCU16166Targeting ID2–DYRK1A/B axis degrades HIF2a in hypoxic cancer stem cells, offering glioblastoma–focused, broad oncologic potential.TagsAngiogenesisCancer stem cellCell proliferationInventorsAnna LasorellaAntonio IavaroneManagerKristin NeumanDepartmentsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-19CollectionsOncology
Tri-specific human immunodeficiency virus antibodies for immunotherapyCU22364Tri-specific HIV antibody targets three epitopes, offering longer-acting, potent immunotherapy to treat and prevent HIV infection.TagsAntibodyAntiviral drugEpitopeInventorsDavid Da-i Ho M.D.ManagerKristin NeumanDepartmentsPhysicians & SurgeonsDivisionsColumbia University Medical Center (CUMC)Release Date2022-07-22
