Endoscopic imaging device for precise real-time detection of olfactory tissueCU25003Real-time spectral endoscopic detection of olfactory epithelium to preserve smell during head/neck surgeries.TagsBiopsyEndoscopyEpitheliumInventorsDavid A. GudisIan F. CaplanJames P. SchuckManagerSara GusikDepartmentsMechanical EngineeringOtolaryngologyOtolaryngology--Head & Neck SurgeryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-11-08
Prevention and reversal of polymyxin drug resistance in gram negative bacteriaCU16040ArnT inhibitors block polymyxin resistance in Gram-negative bacteria, enabling combination therapies and resistance reversal.TagsAntibioticAntimicrobial resistanceBacteriaInventorsFilippo ManciaJeremie VendomeOliver ClarkeManagerSara GusikDepartmentsBiochemistry & Molecular BiophysicsDepartment of Physiology/Cell BiophysicsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2018-03-09
Use of intratracheally administered hyaluronic acid to ameliorate emphysema428Intratracheal hyaluronic acid protects elastic fibers, slowing lung disease progression and offering a prophylactic, elasticity-preserving therapy.TagsAortaArthritisAsthmaInventorsJerome CantorManagerSara GusikDepartmentsPathologyDivisionsColumbia University Medical Center (CUMC)
Targeting IL-17A for treating neuroinflammation from Group A Streptococcus infectionsCU19125IL-17A neutralization targets GAS-induced neuroinflammation, offering PANDAS/Sydenhams treatment potential and Th17 pathway insights.TagsAntibioticAntibodyAutoantibodyInventorsAndrew Sproul Ph.D.Dritan AgalliuIlir AgalliuManagerSara GusikDepartmentsEpidemiology & Population Health, UrologyNeurologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Yeshiva UniversityRelease Date2024-04-12CollectionsCNS/Neurology
Mouse line with T cell-specific deletion of Blimp-1CU19236Mouse line deletes Blimp-1 specifically in T cells, enabling in vivo study of Blimp-1 function in myeloid lineage.TagsB cellCombinatoricsGeneInventorsKathryn L. Calame Ph.D.Miriam ShelefManagerSara GusikDepartmentsMicrobiologyDivisionsColumbia University Medical Center (CUMC)Release Date2019-04-02
Transgenic Mouse for Studying Embryogenetic Significance of RGS Domain on Axin2991A mutant mouse lacking Axin’s RGS domain reveals its essential role in normal embryogenesis via Wnt signaling disruption.TagsEmbryonic developmentGeneIntravenous therapyInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-26
ATP7B knockout mouse model for Wilson diseaseCU18413ATP7B knockout mouse models Wilson disease, enabling in vivo study of copper accumulation, liver cirrhosis-like pathology, and therapy screening.TagsCopperDrug developmentExonInventorsDominik HusterOlesia BuiakovaSvetlana LutsenkoManagerSara GusikDepartmentsDepartment of Human GeneticsDivisionsMolecular and Medical GeneticsRelease Date2023-06-28CollectionsRare Disease
Transgenic mouse strain allows inducible genetic expression in kidney cells and nervous systemCU14313Inducible kidney and nervous system-specific gene edits in mice via GDNF-driven CreERT2, enabling precise temporal control.TagsComplementary DNACre recombinaseEnteric nervous systemInventorsCristina CebriaFranklin David Costantini Ph.D.Naoya AsaiManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2014-08-25
Video-guided bedside thoracoscopy systemCU24084Video-guided bedside thoracoscopy enables safer, faster chest tube placement with real-time feedback and bedside diagnostics.TagsBiopsyCT scanChest tubeInventorsJosh SonnetMorgan MoroiRobert CrumManagerSara GusikDepartmentsSurgeryDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2024-07-18
Lysosomal phospholipase A2 to study and treat bis(monoacylglycero)phosphate-related disordersCU23186Lysosomal phospholipase A2 enables BMP biosynthesis modulation to study and treat BMP-related disorders, including Niemann-Pick disease.TagsBiosynthesisCholesterolEndosomeInventorsCatherine MarquerManagerSara GusikDepartmentsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-30CollectionsRare DiseaseCNS/Neurology
Optimizing multiplex decisions using machine learning for cancer screeningCU23231Bayesian optimization reduces calculations for multiplex cancer screening without assumptions, updating predictions with real-world data.TagsAlgorithmBayesian inferenceBiomarkerInventorsYing Kuen (Ken) CheungManagerSara GusikDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2023-07-14CollectionsOncologyMedical DeviceDigital Health (Software, AI, bioinformatics, etc)
Therapeutic method to overcome basal cell carcinoma resistanceCU17185BRD7/BRD9 inhibitors restore SMO inhibitor sensitivity in drug-resistant basal cell carcinomas, enabling combo therapies.TagsBasal-cell carcinomaCancerCarcinomaInventorsArianna Kim Ph.D.David Bickers M.D.ManagerSara GusikDepartmentsDermatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-05-08
Organoid fertility preservation system to differentiate testicular stem cells into mature spermCU232623D testicular organoids differentiate spermatogonial stem cells into functional haploid spermatids for safe fertility preservation.TagsAzoospermiaBiopsyCancerInventorsBangjin KimJill GinsbergSandra RyeomManagerSara GusikDepartmentsPediatricsSurgical SciencesDivisionsColumbia University Medical Center (CUMC)Release Date2023-06-23
Intra-arterial administration of peptide-drug conjugates for tumor-selective drug deliveryCU17144Intra-arterial, flow-arrest delivery preserves cationic peptide-drug charge, enhancing tumor and brain tumor targeting.TagsApoptosisBlood–brain barrierCardiac arrestInventorsShailendra JoshiManagerSara GusikDepartmentsAnesthesiologyRelease Date2019-08-21
Functional hand orthosis for stroke patientsCU15139A wearable, self-contained glove using motors and tendons restores dexterous hand movement for daily activities in stroke recovery.TagsAlgorithmLightweightMotor cortexInventorsJoel Stein M.D.Matei CiocarlieManagerSara GusikDepartmentsMechanical EngineeringRehabilitation and Regenerative MedicineDivisionsCollege of Physicians and Surgeons (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2019-04-08
Immunohistochemical test for determining the role of Aflatoxin B1 in liver cancer957Immunohistochemical AFB1-DNA adduct antibody links aflatoxin exposure to human liver cancer risk and research tools.TagsAntibodyAntigenCarcinogenInventorsI. Bernard Weinstein M.D.Ling Ling HsiehRegina SantellaManagerSara GusikDepartmentsAnesthesiologyMailman School Of Public Health (MSPH)MedicineDivisionsColumbia University Medical Center (CUMC)Mailman School Of Public Health (MSPH)Release Date2016-04-07
Monoclonal Antibody Enhancing T Cell Reactivity in AIDS Treatments2842Monoclonal antibody boosts T cell reactivity, enhancing HIV/AIDS immunotherapy and broader immune responses.TagsAIDSAntibodyAntigenInventorsNicole Suciu-FocaManagerSara GusikDepartmentsPathologyDivisionsColumbia University Medical Center (CUMC)Release Date2011-04-15
Use of an omega-3 lipid-based emulsion following ischemic injury to provide protection and recovery in human organs1926Intravenous omega-3 lipid emulsions post-ischemia protect and aid recovery across organs, enabling rapid EPA/DHA delivery.TagsAcute respiratory distress syndromeAngiographyBrain ischemiaInventorsRichard J. DeckelbaumYvon CarpentierManagerSara GusikDepartmentsPediatricsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2010-04-16
Enhanced hemostatic dressing enables stabilization of traumatic hemorrhage2950Enhanced hemostatic dressing combines multiple factors to amplify coagulation, stabilize traumatic bleeding, and extend shelf-life.TagsBandageBleedingBody cavityInventorsGopal SinghMatthew BacchettaManagerSara GusikDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2015-10-09
A user-friendly, microwell-based multi-tissue culture platformCU22271A microwell multi-tissue culture platform enabling automated, standardized, high-throughput modeling of native tissue environments.TagsBiologyCell cultureHigh-throughput screeningInventorsKeith YeagerManagerSara GusikDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-07-09
Healthcare process modeling framework to phenotype clinician behaviors and harness clinical expertiseCU20380Predicts clinician concerns and high-risk patients from EHR data using NLP, enabling prioritized care and improved outcomes.TagsElectronic health recordMachine learningNatural language processingInventorsChristopher KnaplundKenrick CatoSarah RossettiManagerSara GusikDepartmentsBiomedical InformaticsEmergency MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2020-10-28CollectionsDigital Health (Software, AI, bioinformatics, etc)
Method for determining antigen-specific CD8+ T cell efficacy2830Assay-based method quantifies active CD8+ T cells to predict immunotherapy efficacy across cancers, infections, and autoimmune contexts.TagsAntigenAssayCell biologyInventorsArthur KarlinJohn LoikePeter LeeManagerSara GusikDepartmentsBiochemistry & Molecular BiophysicsBiomedical InformaticsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2018-08-27
Functional hand orthosis for stroke patientsCU15275A lightweight, self-contained wearable hand orthosis using artificial tendons and motors to restore daily-hand movements for stroke patients.TagsLightweightMotor systemOrthoticsInventorsJoel Stein M.D.Matei CiocarlieManagerSara GusikDepartmentsMechanical EngineeringRehabilitation and Regenerative MedicineDivisionsCollege of Physicians and Surgeons (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2016-03-25
Form 1 Axin Knockin Mouse for Studying Functional Equivalence of Axin and Axin22988A genetically engineered mouse tests functional equivalence of Axin and Axin2, revealing non-redundant roles and isoform-specific insights.TagsAlleleBirth weightComplementary DNAInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
Use of an omega-3 lipid-based emulsion following ischemic injury to provide protection and recovery in human organs1895Omega-3 fish oil emulsion administered post-ischemia protects organs, reduces injury, and improves recovery in stroke and related conditions.TagsAcute respiratory distress syndromeAngiographyBrain ischemiaInventorsRichard J. DeckelbaumSusan J. VannucciYvon CarpentierManagerSara GusikDepartmentsPediatricsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2010-04-16
Characterizing and enhancing the efficacy of therapeutic CD8+ T cells2856Assay-driven enhancement and characterization of ex vivo CD8+ T cells to predict and boost therapeutic efficacy across cancers and infections.TagsAssayAutoimmune diseaseCognateInventorsJohn LoikePeter LeeRalph SteinmanManagerSara GusikDepartmentsBiomedical InformaticsMedicinePhysiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)HematologyRelease Date2018-08-29
Topical treatment for progressively stabilizing collagenous eye tissuesProxy62Topical nitrite/nitroalcohol eye treatment stabilizes corneal/scleral collagen, enabling noninvasive cross-linking without UV or epithelium removal.TagsBoneCartilageCollagenInventorsDavid PaikStephen L. TrokelManagerSara GusikDepartmentsOphthalmologyDivisionsColumbia University Medical Center (CUMC)Eye InstituteRelease Date2018-04-20
Hemostatic wound dressing with reduced clotting timeCU13372Flexible, biocompatible hemostatic dressing rapidly stops severe bleeding (under a minute), reducing clotting time and mortality.TagsAnalgesicAntihemorrhagicBiocompatibilityInventorsGopal SinghHarold CoonsJames M. SinclairManagerSara GusikDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2017-03-03
Mutant Mouse with Modified Axin Gene for Studying Embryogenetic Significance of Protein-Binding Domains2995Mutant mouse lacking Axin’s six C-terminal amino acids reveals indispensable domain for normal embryogenesis; aids Wnt research.TagsAmino acidC-terminusEmbryonic developmentInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
Ret-Men2B Mouse Model for Investigation of Pheochromocytoma Linked Endocrine Tumors2994Transgenic Ret M918T mouse model reveals MEN2B mechanisms, enabling rapid study of pheochromocytoma development and Ret signaling.TagsEndocrine systemEnteric nervous systemGeneInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
Axin and Axin2 Studied in Mutant Mouse for Functional Equivalence2989Axin and Axin2 show largely equivalent in vivo function; mutant mice reveal shared Wnt pathway roles and cancer relevance.TagsAlleleBirth weightComplementary DNAInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
Cancer Treatment with Notch-based Fusion Proteins1530Notch-receptor fusion biologics inhibit tumor angiogenesis and differentiation, offering standalone or combination cancer therapy with novel delivery.TagsAngiogenesisBevacizumabBlood vesselInventorsCarrie ShawberJan KitajewskiYasuhiro FunahashiManagerSara GusikDepartmentsObstetrics & GynecolPathologyDivisionsColumbia University Medical Center (CUMC)Release Date2009-05-20
Motion-tracking rehabilitation bracelet for movement disordersCU19289A wearable, child-friendly motion-tracking bracelet delivers real-time biofeedback for at-home upper-limb rehabilitation.TagsBiofeedbackCerebral palsyHaptic technologyInventorsBlynn ShidelerElizabeth ShroutKatherine CavanaughManagerSara GusikDepartmentsBiobehavioral SciencesBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-01-07CollectionsMedical Device
Perfusion solutions for improved organ transplantationCU13217Lipid-containing perfusion buffers with omega-3 glycerides extend organ viability and reduce reperfusion injury during transplantation.TagsInflammationLipidOmega-3 fatty acidInventorsRavichandran RamasamyRichard J. DeckelbaumManagerSara GusikDepartmentsPediatricsRelease Date2015-10-09
Biventricular pacemaker for post-surgery heart pacing1372Adaptive perioperative biventricular pacemaker with real-time multiparameter optimization for personalized post-surgical cardiac pacing.TagsAlgorithmArtificial cardiac pacemakerBlood pressureInventorsHenry M. Spotnitz MDManagerSara GusikDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2018-12-07
VPS26aTg (Hbeta58) Cos Mouse Model for the Investigation of Alzheimer's Disease2997Transgenic mice with Hbeta58 mutation model retromer-related amyloid trafficking to study Alzheimer’s disease mechanisms.TagsAmyloidBrainDementiaInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-10-31
Mouse Model as a Tool for Spatiotemporal and Lineage-Specific Gene Expression2998Transgenic mice enabling tissue-, time-, and lineage-specific gene expression via Cre-loxP and rtTA/tet systems for precise studies.TagsCre recombinaseDoxycyclineGeneInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-26
Mouse Model, Ret-S697A for Enteric Nervous System Function and Development Investigation2993Transgenic Ret S697A mice reveal Ret signaling's crucial role in enteric nervous system development and ENCC migration.TagsChemotaxisEnteric nervous systemGastrointestinal tractInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
Tetracycline-Controlled System for Targeted Gene Expression in Axin2-Expressing Cells2987Targeted, tetracycline-controlled gene expression in Axin2-expressing cells enables temporal-spatial studies of Wnt signaling in neural development.TagsDevelopment of the nervous systemEmbryonic developmentGeneInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
Transgenic Mouse Strain for Visualization of Epithelial Cells during Renal Development2986Transgenic mouse reveals epithelial cell membrane shapes during ureteric bud morphogenesis using myr-Venus fluorescence.TagsConfocal microscopyCytoplasmEmbryonic developmentInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
Optical CT scanner for fast, accurate 3D dosimetryCU20058Optical fiber-taper-based parallel-beam CT enables fast, high-resolution 3D dosimetry for radiotherapy with improved accuracy.TagsCT scanDosimeterDosimetryInventorsCheng-Shie WuuXin QianManagerSara GusikDepartmentsRadiation OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2021-01-28CollectionsMedical Device
Recombinant protein to treat inflammationCU23248Recombinant FSTL-1 protein targets and reduces cardiac inflammation, aiding Kawasaki disease research and myocarditis treatment.TagsAnti-inflammatoryAtherosclerosisBiomarkerInventorsMark GorelikManagerSara GusikDepartmentsPediatrics/RheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-10CollectionsCardiovascular
Digital health enabled hybrid cardiac rehabilitationCU23057Hybrid digital health platform shifts cardiac rehab home-based with telehealth, remote monitoring, and real-time EHR integration.TagsData integrationTelehealthInventorsAndrea T. DuranManagerSara GusikDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-02-17CollectionsCardiovascularDigital Health (Software, AI, bioinformatics, etc)
Mouse Model for Investigation of the Function of the Potentially Cancer Causing Ret Proto-Oncogene2996Engineered mice explore Ret9 proto-oncogene signaling; dissects PDZ motif roles, aiding cancer research and targeted therapies.TagsC-terminusEnteric nervous systemGeneInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
Stabilization of eye tissue with nitro compounds2206Non-invasive eye drops using nitroalcohols to crosslink corneal collagen, delaying keratoconus without UV or surgery.TagsAliphatic compoundCell membraneCollagenInventorsDavid PaikJeffrey HolmesStephen L. TrokelManagerSara GusikDepartmentsBiomedical EngineeringOphthalmologyOpthalmologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-11-12
Mouse for cell lineage tracing in living tissue2711Cre-reporter mouse enables real-time, inducible cell lineage tracing in living tissue via YFP at ROSA26 locus.TagsCre recombinaseGene expressionGenetic recombinationInventorsFranklin David Costantini Ph.D.Shankar SrinivasManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-05-09
Recombinant ILT3 protein-produced antibodies for immunotherapy treatment of cancerCU15207Engineered anti-ILT3 antibodies enable targeted cancer immunotherapy, modulating myeloid signals and enhancing immune blockade.TagsAcute myeloid leukemiaAllotransplantationAntibodyInventorsGeorge Vlad Ph.D.Nicole Suciu-FocaZheng XuManagerSara GusikDepartmentsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-03-08CollectionsOncology
Cosmetic preservatives for stabilizing human eye tissue2073Noninvasive eyedrop cross-links corneal collagen with formaldehyde-releasing compounds, avoiding UV and epithelial removal for keratoconus.TagsAliphatic compoundCell membraneCollagenInventorsDavid PaikJeffrey HolmesStephen L. TrokelManagerSara GusikDepartmentsBiomedical EngineeringOphthalmologyOpthalmologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2016-11-18
Device for delivering therapeutic agents and medical devices to the coronary sinusCU15217Custom curved coronary sinus introducer via right parasternal access, enabling easier, multi-channel delivery for CRT and imaging.TagsAngiographyArtificial cardiac pacemakerCannulaInventorsHenry M. Spotnitz MDManagerSara GusikDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2018-04-13
Antibody for probing the guanine biosynthesis pathwayCU14353Monoclonal anti-IMPDH2 antibody labels and studies guanine biosynthesis, enabling cancer cell phenotyping and potential diagnostics/therapy.TagsAntibodyAntibody-drug conjugateBiosynthesisInventorsGeorge VladMuyang LiNicole Suciu-FocaManagerSara GusikDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2014-12-31
