Manager
Sara Gusik
View all technologies
Endoscopic imaging device for precise real-time detection of olfactory tissue
CU25003
Real-time spectral endoscopic detection of olfactory epithelium to preserve smell during head/neck surgeries.
Tags
Biopsy
Endoscopy
Epithelium
Inventors
David A. Gudis
Ian F. Caplan
James P. Schuck
Manager
Sara Gusik
Departments
Mechanical Engineering
Otolaryngology
Otolaryngology--Head & Neck Surgery
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-11-08
Prevention and reversal of polymyxin drug resistance in gram negative bacteria
CU16040
ArnT inhibitors block polymyxin resistance in Gram-negative bacteria, enabling combination therapies and resistance reversal.
Tags
Antibiotic
Antimicrobial resistance
Bacteria
Inventors
Filippo Mancia
Jeremie Vendome
Oliver Clarke
Manager
Sara Gusik
Departments
Biochemistry & Molecular Biophysics
Department of Physiology/Cell Biophysics
Physiology and Cellular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2018-03-09
Use of intratracheally administered hyaluronic acid to ameliorate emphysema
428
Intratracheal hyaluronic acid protects elastic fibers, slowing lung disease progression and offering a prophylactic, elasticity-preserving therapy.
Tags
Aorta
Arthritis
Asthma
Inventors
Jerome Cantor
Manager
Sara Gusik
Departments
Pathology
Divisions
Columbia University Medical Center (CUMC)
Targeting IL-17A for treating neuroinflammation from Group A Streptococcus infections
CU19125
IL-17A neutralization targets GAS-induced neuroinflammation, offering PANDAS/Sydenhams treatment potential and Th17 pathway insights.
Tags
Antibiotic
Antibody
Autoantibody
Inventors
Andrew Sproul Ph.D.
Dritan Agalliu
Ilir Agalliu
Manager
Sara Gusik
Departments
Epidemiology & Population Health, Urology
Neurology
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Yeshiva University
Release Date
2024-04-12
Collections
CNS/Neurology
Mouse line with T cell-specific deletion of Blimp-1
CU19236
Mouse line deletes Blimp-1 specifically in T cells, enabling in vivo study of Blimp-1 function in myeloid lineage.
Tags
B cell
Combinatorics
Gene
Inventors
Kathryn L. Calame Ph.D.
Miriam Shelef
Manager
Sara Gusik
Departments
Microbiology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2019-04-02
Transgenic Mouse for Studying Embryogenetic Significance of RGS Domain on Axin
2991
A mutant mouse lacking Axin’s RGS domain reveals its essential role in normal embryogenesis via Wnt signaling disruption.
Tags
Embryonic development
Gene
Intravenous therapy
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-26
ATP7B knockout mouse model for Wilson disease
CU18413
ATP7B knockout mouse models Wilson disease, enabling in vivo study of copper accumulation, liver cirrhosis-like pathology, and therapy screening.
Tags
Copper
Drug development
Exon
Inventors
Dominik Huster
Olesia Buiakova
Svetlana Lutsenko
Manager
Sara Gusik
Departments
Department of Human Genetics
Divisions
Molecular and Medical Genetics
Release Date
2023-06-28
Collections
Rare Disease
Transgenic mouse strain allows inducible genetic expression in kidney cells and nervous system
CU14313
Inducible kidney and nervous system-specific gene edits in mice via GDNF-driven CreERT2, enabling precise temporal control.
Tags
Complementary DNA
Cre recombinase
Enteric nervous system
Inventors
Cristina Cebria
Franklin David Costantini Ph.D.
Naoya Asai
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2014-08-25
Video-guided bedside thoracoscopy system
CU24084
Video-guided bedside thoracoscopy enables safer, faster chest tube placement with real-time feedback and bedside diagnostics.
Tags
Biopsy
CT scan
Chest tube
Inventors
Josh Sonnet
Morgan Moroi
Robert Crum
Manager
Sara Gusik
Departments
Surgery
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2024-07-18
Lysosomal phospholipase A2 to study and treat bis(monoacylglycero)phosphate-related disorders
CU23186
Lysosomal phospholipase A2 enables BMP biosynthesis modulation to study and treat BMP-related disorders, including Niemann-Pick disease.
Tags
Biosynthesis
Cholesterol
Endosome
Inventors
Catherine Marquer
Manager
Sara Gusik
Departments
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-11-30
Collections
Rare Disease
CNS/Neurology
Optimizing multiplex decisions using machine learning for cancer screening
CU23231
Bayesian optimization reduces calculations for multiplex cancer screening without assumptions, updating predictions with real-world data.
Tags
Algorithm
Bayesian inference
Biomarker
Inventors
Ying Kuen (Ken) Cheung
Manager
Sara Gusik
Departments
Biostatistics
Divisions
Mailman School Of Public Health (MSPH)
Release Date
2023-07-14
Collections
Oncology
Medical Device
Digital Health (Software, AI, bioinformatics, etc)
Therapeutic method to overcome basal cell carcinoma resistance
CU17185
BRD7/BRD9 inhibitors restore SMO inhibitor sensitivity in drug-resistant basal cell carcinomas, enabling combo therapies.
Tags
Basal-cell carcinoma
Cancer
Carcinoma
Inventors
Arianna Kim Ph.D.
David Bickers M.D.
Manager
Sara Gusik
Departments
Dermatology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-05-08
Organoid fertility preservation system to differentiate testicular stem cells into mature sperm
CU23262
3D testicular organoids differentiate spermatogonial stem cells into functional haploid spermatids for safe fertility preservation.
Tags
Azoospermia
Biopsy
Cancer
Inventors
Bangjin Kim
Jill Ginsberg
Sandra Ryeom
Manager
Sara Gusik
Departments
Pediatrics
Surgical Sciences
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-06-23
Intra-arterial administration of peptide-drug conjugates for tumor-selective drug delivery
CU17144
Intra-arterial, flow-arrest delivery preserves cationic peptide-drug charge, enhancing tumor and brain tumor targeting.
Tags
Apoptosis
Blood–brain barrier
Cardiac arrest
Inventors
Shailendra Joshi
Manager
Sara Gusik
Departments
Anesthesiology
Release Date
2019-08-21
Functional hand orthosis for stroke patients
CU15139
A wearable, self-contained glove using motors and tendons restores dexterous hand movement for daily activities in stroke recovery.
Tags
Algorithm
Lightweight
Motor cortex
Inventors
Joel Stein M.D.
Matei Ciocarlie
Manager
Sara Gusik
Departments
Mechanical Engineering
Rehabilitation and Regenerative Medicine
Divisions
College of Physicians and Surgeons (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2019-04-08
Immunohistochemical test for determining the role of Aflatoxin B1 in liver cancer
957
Immunohistochemical AFB1-DNA adduct antibody links aflatoxin exposure to human liver cancer risk and research tools.
Tags
Antibody
Antigen
Carcinogen
Inventors
I. Bernard Weinstein M.D.
Ling Ling Hsieh
Regina Santella
Manager
Sara Gusik
Departments
Anesthesiology
Mailman School Of Public Health (MSPH)
Medicine
Divisions
Columbia University Medical Center (CUMC)
Mailman School Of Public Health (MSPH)
Release Date
2016-04-07
Monoclonal Antibody Enhancing T Cell Reactivity in AIDS Treatments
2842
Monoclonal antibody boosts T cell reactivity, enhancing HIV/AIDS immunotherapy and broader immune responses.
Tags
AIDS
Antibody
Antigen
Inventors
Nicole Suciu-Foca
Manager
Sara Gusik
Departments
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-04-15
Use of an omega-3 lipid-based emulsion following ischemic injury to provide protection and recovery in human organs
1926
Intravenous omega-3 lipid emulsions post-ischemia protect and aid recovery across organs, enabling rapid EPA/DHA delivery.
Tags
Acute respiratory distress syndrome
Angiography
Brain ischemia
Inventors
Richard J. Deckelbaum
Yvon Carpentier
Manager
Sara Gusik
Departments
Pediatrics
Surgery
Divisions
Columbia University Medical Center (CUMC)
Release Date
2010-04-16
Enhanced hemostatic dressing enables stabilization of traumatic hemorrhage
2950
Enhanced hemostatic dressing combines multiple factors to amplify coagulation, stabilize traumatic bleeding, and extend shelf-life.
Tags
Bandage
Bleeding
Body cavity
Inventors
Gopal Singh
Matthew Bacchetta
Manager
Sara Gusik
Departments
Surgery
Divisions
Columbia University Medical Center (CUMC)
Release Date
2015-10-09
A user-friendly, microwell-based multi-tissue culture platform
CU22271
A microwell multi-tissue culture platform enabling automated, standardized, high-throughput modeling of native tissue environments.
Tags
Biology
Cell culture
High-throughput screening
Inventors
Keith Yeager
Manager
Sara Gusik
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-07-09
Healthcare process modeling framework to phenotype clinician behaviors and harness clinical expertise
CU20380
Predicts clinician concerns and high-risk patients from EHR data using NLP, enabling prioritized care and improved outcomes.
Tags
Electronic health record
Machine learning
Natural language processing
Inventors
Christopher Knaplund
Kenrick Cato
Sarah Rossetti
Manager
Sara Gusik
Departments
Biomedical Informatics
Emergency Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2020-10-28
Collections
Digital Health (Software, AI, bioinformatics, etc)
Method for determining antigen-specific CD8+ T cell efficacy
2830
Assay-based method quantifies active CD8+ T cells to predict immunotherapy efficacy across cancers, infections, and autoimmune contexts.
Tags
Antigen
Assay
Cell biology
Inventors
Arthur Karlin
John Loike
Peter Lee
Manager
Sara Gusik
Departments
Biochemistry & Molecular Biophysics
Biomedical Informatics
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2018-08-27
Functional hand orthosis for stroke patients
CU15275
A lightweight, self-contained wearable hand orthosis using artificial tendons and motors to restore daily-hand movements for stroke patients.
Tags
Lightweight
Motor system
Orthotics
Inventors
Joel Stein M.D.
Matei Ciocarlie
Manager
Sara Gusik
Departments
Mechanical Engineering
Rehabilitation and Regenerative Medicine
Divisions
College of Physicians and Surgeons (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2016-03-25
Form 1 Axin Knockin Mouse for Studying Functional Equivalence of Axin and Axin2
2988
A genetically engineered mouse tests functional equivalence of Axin and Axin2, revealing non-redundant roles and isoform-specific insights.
Tags
Allele
Birth weight
Complementary DNA
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
Use of an omega-3 lipid-based emulsion following ischemic injury to provide protection and recovery in human organs
1895
Omega-3 fish oil emulsion administered post-ischemia protects organs, reduces injury, and improves recovery in stroke and related conditions.
Tags
Acute respiratory distress syndrome
Angiography
Brain ischemia
Inventors
Richard J. Deckelbaum
Susan J. Vannucci
Yvon Carpentier
Manager
Sara Gusik
Departments
Pediatrics
Surgery
Divisions
Columbia University Medical Center (CUMC)
Release Date
2010-04-16
Characterizing and enhancing the efficacy of therapeutic CD8+ T cells
2856
Assay-driven enhancement and characterization of ex vivo CD8+ T cells to predict and boost therapeutic efficacy across cancers and infections.
Tags
Assay
Autoimmune disease
Cognate
Inventors
John Loike
Peter Lee
Ralph Steinman
Manager
Sara Gusik
Departments
Biomedical Informatics
Medicine
Physiology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Hematology
Release Date
2018-08-29
Topical treatment for progressively stabilizing collagenous eye tissues
Proxy62
Topical nitrite/nitroalcohol eye treatment stabilizes corneal/scleral collagen, enabling noninvasive cross-linking without UV or epithelium removal.
Tags
Bone
Cartilage
Collagen
Inventors
David Paik
Stephen L. Trokel
Manager
Sara Gusik
Departments
Ophthalmology
Divisions
Columbia University Medical Center (CUMC)
Eye Institute
Release Date
2018-04-20
Hemostatic wound dressing with reduced clotting time
CU13372
Flexible, biocompatible hemostatic dressing rapidly stops severe bleeding (under a minute), reducing clotting time and mortality.
Tags
Analgesic
Antihemorrhagic
Biocompatibility
Inventors
Gopal Singh
Harold Coons
James M. Sinclair
Manager
Sara Gusik
Departments
Surgery
Divisions
Columbia University Medical Center (CUMC)
Release Date
2017-03-03
Mutant Mouse with Modified Axin Gene for Studying Embryogenetic Significance of Protein-Binding Domains
2995
Mutant mouse lacking Axin’s six C-terminal amino acids reveals indispensable domain for normal embryogenesis; aids Wnt research.
Tags
Amino acid
C-terminus
Embryonic development
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
Ret-Men2B Mouse Model for Investigation of Pheochromocytoma Linked Endocrine Tumors
2994
Transgenic Ret M918T mouse model reveals MEN2B mechanisms, enabling rapid study of pheochromocytoma development and Ret signaling.
Tags
Endocrine system
Enteric nervous system
Gene
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
Axin and Axin2 Studied in Mutant Mouse for Functional Equivalence
2989
Axin and Axin2 show largely equivalent in vivo function; mutant mice reveal shared Wnt pathway roles and cancer relevance.
Tags
Allele
Birth weight
Complementary DNA
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
Cancer Treatment with Notch-based Fusion Proteins
1530
Notch-receptor fusion biologics inhibit tumor angiogenesis and differentiation, offering standalone or combination cancer therapy with novel delivery.
Tags
Angiogenesis
Bevacizumab
Blood vessel
Inventors
Carrie Shawber
Jan Kitajewski
Yasuhiro Funahashi
Manager
Sara Gusik
Departments
Obstetrics & Gynecol
Pathology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2009-05-20
Motion-tracking rehabilitation bracelet for movement disorders
CU19289
A wearable, child-friendly motion-tracking bracelet delivers real-time biofeedback for at-home upper-limb rehabilitation.
Tags
Biofeedback
Cerebral palsy
Haptic technology
Inventors
Blynn Shideler
Elizabeth Shrout
Katherine Cavanaugh
Manager
Sara Gusik
Departments
Biobehavioral Sciences
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2020-01-07
Collections
Medical Device
Perfusion solutions for improved organ transplantation
CU13217
Lipid-containing perfusion buffers with omega-3 glycerides extend organ viability and reduce reperfusion injury during transplantation.
Tags
Inflammation
Lipid
Omega-3 fatty acid
Inventors
Ravichandran Ramasamy
Richard J. Deckelbaum
Manager
Sara Gusik
Departments
Pediatrics
Release Date
2015-10-09
Biventricular pacemaker for post-surgery heart pacing
1372
Adaptive perioperative biventricular pacemaker with real-time multiparameter optimization for personalized post-surgical cardiac pacing.
Tags
Algorithm
Artificial cardiac pacemaker
Blood pressure
Inventors
Henry M. Spotnitz MD
Manager
Sara Gusik
Departments
Surgery
Divisions
Columbia University Medical Center (CUMC)
Release Date
2018-12-07
VPS26aTg (Hbeta58) Cos Mouse Model for the Investigation of Alzheimer's Disease
2997
Transgenic mice with Hbeta58 mutation model retromer-related amyloid trafficking to study Alzheimer’s disease mechanisms.
Tags
Amyloid
Brain
Dementia
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-10-31
Mouse Model as a Tool for Spatiotemporal and Lineage-Specific Gene Expression
2998
Transgenic mice enabling tissue-, time-, and lineage-specific gene expression via Cre-loxP and rtTA/tet systems for precise studies.
Tags
Cre recombinase
Doxycycline
Gene
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-26
Mouse Model, Ret-S697A for Enteric Nervous System Function and Development Investigation
2993
Transgenic Ret S697A mice reveal Ret signaling's crucial role in enteric nervous system development and ENCC migration.
Tags
Chemotaxis
Enteric nervous system
Gastrointestinal tract
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
Tetracycline-Controlled System for Targeted Gene Expression in Axin2-Expressing Cells
2987
Targeted, tetracycline-controlled gene expression in Axin2-expressing cells enables temporal-spatial studies of Wnt signaling in neural development.
Tags
Development of the nervous system
Embryonic development
Gene
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
Transgenic Mouse Strain for Visualization of Epithelial Cells during Renal Development
2986
Transgenic mouse reveals epithelial cell membrane shapes during ureteric bud morphogenesis using myr-Venus fluorescence.
Tags
Confocal microscopy
Cytoplasm
Embryonic development
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
Optical CT scanner for fast, accurate 3D dosimetry
CU20058
Optical fiber-taper-based parallel-beam CT enables fast, high-resolution 3D dosimetry for radiotherapy with improved accuracy.
Tags
CT scan
Dosimeter
Dosimetry
Inventors
Cheng-Shie Wuu
Xin Qian
Manager
Sara Gusik
Departments
Radiation Oncology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2021-01-28
Collections
Medical Device
Recombinant protein to treat inflammation
CU23248
Recombinant FSTL-1 protein targets and reduces cardiac inflammation, aiding Kawasaki disease research and myocarditis treatment.
Tags
Anti-inflammatory
Atherosclerosis
Biomarker
Inventors
Mark Gorelik
Manager
Sara Gusik
Departments
Pediatrics/Rheumatology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-05-10
Collections
Cardiovascular
Digital health enabled hybrid cardiac rehabilitation
CU23057
Hybrid digital health platform shifts cardiac rehab home-based with telehealth, remote monitoring, and real-time EHR integration.
Tags
Data integration
Telehealth
Inventors
Andrea T. Duran
Manager
Sara Gusik
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-02-17
Collections
Cardiovascular
Digital Health (Software, AI, bioinformatics, etc)
Mouse Model for Investigation of the Function of the Potentially Cancer Causing Ret Proto-Oncogene
2996
Engineered mice explore Ret9 proto-oncogene signaling; dissects PDZ motif roles, aiding cancer research and targeted therapies.
Tags
C-terminus
Enteric nervous system
Gene
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
Stabilization of eye tissue with nitro compounds
2206
Non-invasive eye drops using nitroalcohols to crosslink corneal collagen, delaying keratoconus without UV or surgery.
Tags
Aliphatic compound
Cell membrane
Collagen
Inventors
David Paik
Jeffrey Holmes
Stephen L. Trokel
Manager
Sara Gusik
Departments
Biomedical Engineering
Ophthalmology
Opthalmology
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2018-11-12
Mouse for cell lineage tracing in living tissue
2711
Cre-reporter mouse enables real-time, inducible cell lineage tracing in living tissue via YFP at ROSA26 locus.
Tags
Cre recombinase
Gene expression
Genetic recombination
Inventors
Franklin David Costantini Ph.D.
Shankar Srinivas
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-05-09
Recombinant ILT3 protein-produced antibodies for immunotherapy treatment of cancer
CU15207
Engineered anti-ILT3 antibodies enable targeted cancer immunotherapy, modulating myeloid signals and enhancing immune blockade.
Tags
Acute myeloid leukemia
Allotransplantation
Antibody
Inventors
George Vlad Ph.D.
Nicole Suciu-Foca
Zheng Xu
Manager
Sara Gusik
Departments
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2023-03-08
Collections
Oncology
Cosmetic preservatives for stabilizing human eye tissue
2073
Noninvasive eyedrop cross-links corneal collagen with formaldehyde-releasing compounds, avoiding UV and epithelial removal for keratoconus.
Tags
Aliphatic compound
Cell membrane
Collagen
Inventors
David Paik
Jeffrey Holmes
Stephen L. Trokel
Manager
Sara Gusik
Departments
Biomedical Engineering
Ophthalmology
Opthalmology
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2016-11-18
Device for delivering therapeutic agents and medical devices to the coronary sinus
CU15217
Custom curved coronary sinus introducer via right parasternal access, enabling easier, multi-channel delivery for CRT and imaging.
Tags
Angiography
Artificial cardiac pacemaker
Cannula
Inventors
Henry M. Spotnitz MD
Manager
Sara Gusik
Departments
Surgery
Divisions
Columbia University Medical Center (CUMC)
Release Date
2018-04-13
Antibody for probing the guanine biosynthesis pathway
CU14353
Monoclonal anti-IMPDH2 antibody labels and studies guanine biosynthesis, enabling cancer cell phenotyping and potential diagnostics/therapy.
Tags
Antibody
Antibody-drug conjugate
Biosynthesis
Inventors
George Vlad
Muyang Li
Nicole Suciu-Foca
Manager
Sara Gusik
Departments
Institute for Cancer Genetics
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2014-12-31
