Peptide nucleic acid conjugates for altering gene expression in cancerCU16241Selective peptide nucleic acid polymers block cancer gene expression, targeting mutations like BRAFV600E with improved delivery and specificity.TagsGene expressionBioavailabilityBiosensorInventorsGary Schwartz M.D.Jeffrey Rothman M.D.ManagerJoan MartinezDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-03CollectionsGene TherapyOncology
A spinal motor neuron-specific enhancer for cell-type specific gene expression control in the developing and adult central nervous systemCU22281Spinal motor neuron–specific enhancer enables AAV-deliverable, cell-type–restricted gene overexpression/knockdown in adults and development.TagsGene expressionCentral nervous systemCholinergicInventorsHynek WichterleTulsi PatelManagerJerry KokoshkaDepartmentsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-02CollectionsGene TherapyCNS/Neurology
Humanoid-robot capable of facial co-expressionCU24301A soft-skinned humanoid robot predicts and synchronizes facial expressions in real time, enhancing natural human-robot interaction.TagsGene expressionAnimatronicsAnthropomorphismInventorsHod LipsonYuhang HuManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-02-03
Engineered cell line for inducible protein expression for single-molecule imagingCU24352Inducible CHO cell line enables single-molecule GPCR interaction tracking in live cells with high-resolution smFRET.TagsGene expressionCell membraneCell signalingInventorsJonathan JavitchWesley AsherManagerJerry KokoshkaDepartmentsPsychiatryDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05
ARP-154 (HeLa T4+) human cancer cell line generated by gene transfer for AIDS researchCU24290CD4-expressing HeLa-derived cell line enables AIDS research; facilitates HIV binding studies, drug screening, and therapeutic development.TagsGene expressionAIDSAntigenInventorsPaul J. MaddonRichard Axel M.D.ManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2024-05-29
Targeted gene therapy for retinopathiesCU21122CRB1-targeted gene therapy delivers isoform-specific CRB1 to Müller glia and photoreceptors, treating CRB1-retinopathies.TagsGene expressionGene therapyGenetic disorderInventorsPeter M.J. QuinnStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Release Date2023-07-06CollectionsOphthalmologyGene Therapy
Novel prognostic marker for survival in myeloid malignanciesCU18296Multi-gene transcriptomic classifier using TED markers to predict MDS progression to AML, enabling earlier, accurate prognosis.TagsGene expressionAcute myeloid leukemiaAssayInventorsAbdullah Ali Ph.D.Azra Raza M.D.Etienne De ClaraManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedical OncologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-05-28
Computational tool to predict RNA binding protein targets for gene therapy and agricultural bioengineeringCU23342PPRDecoder: a genome-wide, unbiased algorithm predicting RNA targets of PPR proteins, accelerating gene regulation research.TagsGene expressionAlgorithmBiological engineeringInventorsChaolin Zhang PhDManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2023-08-04CollectionsGene Therapy
Gene editing to treat retinal dystrophiesCU22019Prime editing corrects CRB1 mutations in retinal dystrophy, offering isoform-independent gene therapy and research tool potential.TagsGene expressionCell therapyGene therapyInventorsBruna Lopes da CostaPeter M.J. QuinnStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2022-10-31CollectionsOphthalmologyGene Therapy
Transcriptional reprogramming platform for neuroprotection, rejuvenation, and treatment of motor neuron diseasesCU23208AAV-delivered Islet1/Lhx3 re-expression reprograms motor neurons, restoring youthful resilience to prevent motor neuron degeneration.TagsGene expressionAmyotrophic lateral sclerosisGene therapyInventorsEmily Rhodes LowryHynek WichterleTulsi PatelManagerJerry KokoshkaDepartmentsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-01-18CollectionsGene Therapy
Conditional mouse model for the BARD1 geneCU23026A conditional Bard1 mouse model enables tissue-specific gene knockout to study BRCA1/BARD1 cancer risk and therapy.TagsGene expressionAlleleBRCA1InventorsFoon Wu-baerRichard Baer Ph.D.ManagerJoan MartinezDepartmentsPathologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Release Date2022-10-10CollectionsOncologyWomen's Health
Truncated ATF5, CEBPB, and CEBPD inhibitors for effective cancer treatmentCU21274Short cell-penetrating truncated inhibitors target ATF5/CEBPB/CEBPD, suppressing cancer survival across tumor types.TagsGene expressionBreast cancerCancerInventorsJames M. AngelastroLloyd Greene PhDQing ZhouManagerJerry KokoshkaDepartmentsMolecular BiosciencesPathologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-10-31CollectionsOncology
Lung organoid cells for therapeutic interventionCU23361Therapeutic lung regeneration via patient-specific stem cell–derived distal lung organoids with graftable basal and secretory cells.TagsGene expressionCell therapyChronic obstructive pulmonary diseaseInventorsHans-Willem SnoeckManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-09-08
Genomic stabilization therapy for enhanced in vitro human embryo fertilization and survivalCU18389Synthetic mRNA–based genome stabilization enhances human embryo viability in IVF, aiming higher success, reduced mosaicism, and lower costs.TagsGene expressionAneuploidyAssayInventorsDietrich EgliManagerKristin NeumanDepartmentsPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-08-24CollectionsWomen's Health
CRISPR-based system for detecting DNA transfer and recording biological signalsCU20160CRISPR-based platform detects exogenous DNA transfer and records temporal biological signals in engineered cells for rapid screening.TagsGene expressionBioinformaticsCRISPRInventorsHarris WangSung Sun YimManagerCynthia LangDepartmentsSystems BiologyRelease Date2023-12-06CollectionsPlatform/Research Tool
Host proteases necessary for human parainfluenza virus spread in human lungCU22326Identifies HPIV spread proteases; shows serine protease inhibitors (nafamostat) hinder lung infection, offering targeted antiviral strategy.TagsGene expressionAntiviral drugEnzyme inhibitorInventorsAnne MosconaKyle StearnsMatteo PorottoManagerKristin NeumanDepartmentsAnesthesiologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2024-02-15
Bacterial strain for improved protein productionCU15280Engineered BL21(DE3) E. coli strain boosts protein yield, enabling reliable production of unstable proteins for faster biotech development.TagsGene expressionCell cultureEscherichia coliInventorsMaxwell E. GottesmanManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-17
Targeted delivery of anti-microRNA for the treatment of liver fibrosisCU21066Liver-targeted exosomes deliver anti-miR-132 to curb fibrosis, reducing collagen and pro-fibrotic signals with tissue specificity.TagsGene expressionCell membraneCollagenInventorsAkiva MintzFatemeh Momen-HeraviManagerJoan MartinezDepartmentsCollege of Dental MedicineRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-02
ATP7B knockout mouse model for Wilson diseaseCU18413ATP7B knockout mouse models Wilson disease, enabling in vivo study of copper accumulation, liver cirrhosis-like pathology, and therapy screening.TagsGene expressionCopperDrug developmentInventorsDominik HusterOlesia BuiakovaSvetlana LutsenkoManagerSara GusikDepartmentsDepartment of Human GeneticsDivisionsMolecular and Medical GeneticsRelease Date2023-06-28CollectionsRare Disease
Selective serotonin reuptake inhibitors (SSRIs) for treatment of COPDCU21249SSRI-based MMP-1 inhibition slows COPD progression; oral/inhaled delivery reduces cigarette-smoke–driven lung damage and inflammation.TagsGene expressionBronchodilatorChronic obstructive pulmonary diseaseInventorsJeanine D'ArmientoManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-07-14CollectionsSmall Molecule
Preclinical models of angioimmunoblastic T-cell lymphoma for therapeutic investigationCU23322RhoA G17V-driven mouse model of angioimmunoblastic T-cell lymphoma enables translational drug screening and pathogenesis study.TagsGene expressionCancer cellChemotherapyInventorsAdolfo A. Ferrando M.D., Ph.D.Teresa Palomero VasquezManagerJoan MartinezDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-06-15CollectionsOncology
Co-delivery platform for enhanced nucleic acid therapeuticsCU21087Co-delivery platform stabilizes nucleic acid therapeutics with exosome carriers and RISC associations, boosting efficacy while reducing off-targets.TagsGene expressionHead and neck cancerLiverInventorsAkiva MintzFatemeh Momen-HeraviManagerJoan MartinezDepartmentsCollege of Dental MedicineRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-19CollectionsGene TherapyOncologyPlatform/Research Tool
Mouse model for ion channel disruption via TRIP8b disruptionCU23232Inducible mouse model to disrupt TRIP8b, altering HCN ion channel localization in heart/brain cells for in vivo study and drug screening.TagsGene expressionDendriteExonInventorsBina SantoroSteven A. Siegelbaum PhDManagerJerry KokoshkaDepartmentsCENTER OF NEUROBIOLOGY AND BEHAVIORPharmacologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-02CollectionsCNS/NeurologyPlatform/Research ToolCardiovascular
Engineered anti-Cre antibody for detection of CreCU23045Engineered monoclonal anti-Cre antibody enables precise, tissue-specific Cre detection, improving reliability over current reagents.TagsGene expressionAntibodyCre recombinaseInventorsDavid NgSusan Brenner-MortonManagerJerry KokoshkaDepartmentsBiochemistryMortimer B. Zuckerman Mind Brain Behavior InstituteRelease Date2022-10-31
Mouse model for studying immune system lineagesCU23013T-bet (Tbx21) floxed mouse model enables tissue-specific T cell knockout to study immune lineages and diseases.TagsGene expressionAlleleArthritisInventorsNezih CerebSoo Young YangSteven ReinerManagerKristin NeumanDepartmentsMicrobiologyDivisionsColumbia University Medical Center (CUMC)Release Date2022-10-14
Recombinant ILT3 protein-produced antibodies for immunotherapy treatment of cancerCU15207Engineered anti-ILT3 antibodies enable targeted cancer immunotherapy, modulating myeloid signals and enhancing immune blockade.TagsGene expressionAcute myeloid leukemiaAllotransplantationInventorsGeorge Vlad Ph.D.Nicole Suciu-FocaZheng XuManagerSara GusikDepartmentsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-03-08CollectionsOncology
Peptide targeting CD33 to treat cognitive decline in Alzheimer's Disease patientsCU21001A cost-effective peptide disrupts CD33-CD45, activates microglia, reduces amyloid, potentially slowing cognitive decline in Alzheimer's.TagsGene expressionAcetylcholinesteraseAcute myeloid leukemiaInventorsElizabeth M. BradshawWassim ElyamanManagerJoan MartinezDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-02-02CollectionsCNS/Neurology
Protein sequencing with a cavity-separated multi-nanopore deviceCU22073Cavity-separated multi-nanopore sequencing enables high-throughput, library-free, single-molecule protein sequencing with improved accuracy.TagsGene expressionDrug developmentIonInventorsJakob BuchheimKenneth ShepardManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-01-31
Conditional knockout mouse model to study genomic instability of BRCA1 mutationsCU23027Inducible BRCA1 exon 2 knockout mouse model to study BRCA1-related genomic instability, tumorigenesis, and therapy screening.TagsGene expressionAblationAlleleInventorsFoon Wu-baerRichard Baer Ph.D.ManagerJoan MartinezDepartmentsPathologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Release Date2022-10-10CollectionsOncologyWomen's Health
Method for disease phenotype prediction from genetic mutationCU21310Phenotype dosage sensitivity: predicts disease phenotypes from LGD mutations via NMD, enabling personalized ASD outcomes and targeted therapeutics.TagsGene expressionAutism spectrumExonInventorsAndrew ChiangDennis VitkupJiayao WangManagerJoan MartinezDepartmentsBiomedical InformaticsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2022-09-11CollectionsCNS/NeurologyPlatform/Research Tool
High Resolution 3D Imaging of Purkinje NeuronsCU22200High-resolution 3D Purkinje neuron reconstruction across cerebellar layers using dual immunofluorescence, enabling single-cell visualization.TagsGene expression3D reconstructionAntibodyInventorsAlexei ChemiakineSalvatore BottaVincenzo Alessandro GennarinoManagerJerry KokoshkaDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2022-08-05CollectionsCNS/Neurology
Inducible mouse line for cardiac NOX2 inhibitionCU22219Inducible cardiac NRROS-based NOX2 inhibition in mice; tissue-specific ROS control to protect against diet-induced arrhythmias.TagsGene expressionAntioxidantAtherosclerosisInventorsJohn MorrowManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2022-02-16CollectionsCardiovascular
Regulation of cholesterol efflux for treating macular degenerationCU21299Promotes retinal cholesterol efflux via CES1 upregulation or EGFR signaling modulation to slow or prevent macular degeneration.TagsGene expressionCholesterolEnzymeInventorsStephen H. Tsang M.D., Ph.D.Yi-Ting TsaiManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCFu Foundation School of Engineering and Applied Science (SEAS)Release Date2021-04-27CollectionsOphthalmologyGene Therapy
Cross-bred mouse lines for biomedical researchCU21129Cross-bred, Cre-driver mouse cancer models enable conditional gene activation for efficient, cost-saving tumor research and drug testing.TagsGene expressionBRCA1CarcinogenesisInventorsCory Abate-Shen Ph.D.ManagerJoan MartinezDepartmentsUrologyDivisionsColumbia University Medical Center (CUMC)Release Date2021-01-29CollectionsOncology
High-throughput in vivo mRNA-based proteomics via next-generation sequencingCU20206In vivo mRNA display enables high-throughput, sequencing-based proteomics in cells, linking proteins to mRNA with UMIs.TagsGene expressionAntigenAssayInventorsPanagiotis OikonomouSaeed TavazoieManagerJoan MartinezDepartmentsBiochemistrySystems BiologyDivisionsColumbia University Medical CenterColumbia University Medical Center (CUMC)Release Date2021-01-29CollectionsPlatform/Research Tool
Noninvasive near-infrared brain imaging systemCU19286ToFF-DOT: wearable, noninvasive near-infrared brain imaging achieving single-cell resolution of neural activity for mapping and research.TagsGene expressionAction potentialBrain mappingInventorsKenneth ShepardKevin RenehanSajjad MoazeniManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2021-01-15CollectionsCNS/NeurologyMedical Device
Patient-derived organoids to study and treat oral cancerCU20232Patient-derived 3D oral cancer organoids enable personalized disease modeling, drug screening, and in vivo xenograft validation.TagsGene expressionBiopsyCarcinomaInventorsAnil K. Rustgi M.D.Hiroshi NakagawaManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2020-10-15CollectionsOncology
Whole methylome sequencing at the single molecule levelCU16353Single-molecule, targeted methylome sequencing detects methylation types with high sensitivity, enabling precise epigenetic profiling and diagnostics.TagsGene expressionChemistryDNA methylationInventorsJames J. RussoJingyue JuSteffen JockuschManagerCynthia LangDepartmentsChemical Engineering/Applied ChemistryChemistryGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesFu Foundation School of Engineering andRelease Date2020-12-24
Mouse line for inducible tissue specific expression of peroxisome proliferator-activated receptor gammaCU20098Inducible, tissue-specific PPARG expression mouse model with Cre; cross-compatible with any Cre line for diverse disease studies.TagsGene expressionFluorescence microscopeGamma rayInventorsCathy L. MendelsohnChyuan-Sheng (Victor) LinTiffany TateManagerJoan MartinezDepartmentsOpthamologyUrologyDivisionsColumbia University Medical Center (CUMC)Release Date2020-02-14CollectionsCNS/Neurology
Inhibiting chemokine interactions to improve treatment outcomes for prostate cancerCU19210Blocking IL-8 and receptors to reduce immunosuppressive tumor infiltration, boosting prostate cancer treatment efficacy.TagsGene expressionChemokineChemotherapyInventorsCharles G. DrakeZoila Areli Lopez-BujandaManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2020-10-02CollectionsOncology
RNA regulation of the SLC2A1 gene for treatment of Glut1 deficiencyCU17177RNA-based therapy using antisense long non-coding RNA to modulate SLC2A1/Glut1 expression for Glut1 deficiency treatment.TagsGene expressionAnticonvulsantBiomarkerInventorsMaoxue TangUmrao R. Monani Ph.D.ManagerKristin NeumanDepartmentsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2019-05-20CollectionsRare DiseaseOphthalmologyGene Therapy
Peptide therapy for alcohol abuse disorderCU16253Spexin peptide treats alcohol use disorder by reducing craving, offering a novel pathway alongside existing therapies.TagsGene expressionAdipocyteDisulfiramInventorsJose Leonardo WalewskiPaul Berk M.D.ManagerCynthia LangDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2019-07-22
Modified cell-penetrating ATF5 protein to inhibit cancer cell growthCU18385Modified ATF5 peptide blocks cancer survival proteins (CEBPB/CEBPD/CCDC6), inducing cancer cell death; potential targeted therapy.TagsGene expressionBreast cancerCancerInventorsJames M. AngelastroLloyd Greene PhDXiaotian SunManagerJerry KokoshkaDepartmentsMolecular BiosciencesPathologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2019-08-02CollectionsOncology
Prevention and modulation of chemotherapy resistance in glioblastomasCU18203MGMT enhancer targeting with BETi/HATi restores temozolomide sensitivity in glioblastoma, delaying resistance and improving GBM treatment.TagsGene expressionCRISPRCell growthInventorsHaiyun GanJann SarkariaXiaoyue ChenManagerJoan MartinezDepartmentsGenetics & DevelopmentInstitute for Cancer GeneticsDivisionsColumbia University Medical Center (CUMC)Release Date2019-08-01CollectionsOncology
Imaging tool for early detection of chronic obstructive pulmonary diseasesCU17292Radiolabeled MMP-targeting probe enables CT-based, early COPD detection and monitoring, leveraging existing imaging and noninvasive strategy.TagsGene expressionBiomarkerCT scanInventorsJeanine D'ArmientoLynne JohnsonMonica GoldklangManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2019-08-01
Method for improving genomic stability and cell line reprogrammingCU20029Promotes homologous recombination during reprogramming to boost iPSC genomic stability and reprogramming efficiency.TagsGene expressionDNA replicationGenomeInventorsDaniela GeorgievaDietrich (Dieter) EgliManagerKristin NeumanDepartmentsMedicinePediatricsDivisionsColumbia University Medical Center (CUMC)Naomi Berrie Diabetes CenterRelease Date2019-07-22
Delta-2 tubulin for detection and treatment of peripheral neuropathyCU18162Delta-2 tubulin biomarker enables CIPN diagnosis and targeted prevention/treatment, plus drug screening for prophylactic therapies.TagsGene expressionAnticonvulsantBiomarkerInventorsFrancesca Bartolini Ph.D.Guido CavalettiMaria Elena PeroManagerKristin NeumanDepartmentsPathology & Cell BiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2019-07-15
Restoring synaptic function to prevent and treat neurodegenerative diseasesCU18018Tech targets UBE3A to restore synaptic function, offering disease-modifying treatment for AD and other neurodegenerative disorders.TagsGene expressionAmyloid betaEnzymeInventorsRoger Lefort PhDManagerKristin NeumanDepartmentsPathologyDivisionsColumbia University Medical Center (CUMC)Release Date2019-01-25CollectionsCNS/Neurology
High-affinity RAGE fusion proteins for treating RAGE-mediated pathologiesProxy35RAGE fusion proteins selectively block RAGE-ligand interactions, potentially reducing oxidative stress and inflammation in multiple diseases.TagsGene expressionArteriosclerosisBiological half-lifeInventorsAdnan MjalliAnn Marie Schmidt M.D.David Mark Stern M.D.ManagerJerry KokoshkaDepartmentsDean's OfficePathologySurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2018-10-20
Methods for diagnosis and treatment of neuropsychiatric disorders2789Genetic GCH1 assay guides diagnosis and personalized treatment for schizophrenia and related neuropsychiatric disorders.TagsGene expressionAlleleAssayInventorsCatherine ClellandManagerKristin NeumanDepartmentsPathologyDivisionsColumbia University Medical Center (CUMC)Release Date2018-09-28
