Bacterial genetic engineering system to treat infections

Development of new bacterial strains.

This technology is a modified bacterial model for improved expression and production of proteins.

This technology is a modified bacterial model for expression and production of protein.

CRISPR is a technology that enables researchers to edit parts of the genome by removing, adding, or mutating sections of DNA.

There is a need for tools and methods that can improve the efficiency and scalability of genetic research using CRISPR.

The ability to perform in silico CRISPR enables a more effective strategy for choosing how to edit the genome in both research and therapeutic applications.

The genetic basis of bacterial colonization in the GI tract remains poorly defined, limiting efforts to predictably control colonization efficiency.

The approach allows for the selection of candidate genetic factors that can be incorporated into plasmid-based reagents or engineered bacterial strains, which can overexpress or carry the identified genes.

Screening platforms to identify bacterial genes and colonization pathways.