Nucleic acid modification with tools from Oxytricha
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Method for improving ongoing workflows interested in studying DNA methylation. Methylated DNA immunoprecipitation sequencing (MeDIP-seq) has been used extensively to analyze DNA methylation in cells. The Technology: An efficient, simple, sensitive method to study DNA methylation.
This technology is two methods, called ssg-MeDIP-Seq and sscf-MeDIP-Seq, for improved tumor detection using detection of DNA methylation density in genomic DNA, and of hemi-methylated regions in plasma cell-free DNA. The Technology: Tumor detection via DNA methylation and hemi-methylation biomarkers. This technology detects sDNA methylation density as well as hemi-methylated regions of genomic DNA and plasma cell free (cf) DNA to detect tumors.
Whole Genome Methylation Profiling
In the effort to gain insight into whole genome methylation patterns, their biological functions and their abnormality in human disease, various methylation profiling technologies have been developed. Traditional bisulfite conversion suffers from variability due to incomplete conversion, over-conversion, DNA degradation, and low yield. Previous studies have shown that DNA methyltransferases can efficiently transfer a wide variety of functional groups to the 5 position of cytosines in DNA by means of synthetic S-Adenosyl L-methionine (AdoMet) analogs in which the methyl group has been replaced.
- 8Mutation
- 7Gene expression
- 6DNA methylation
- 5DNA repair
- 5Genome
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- 24Biology
- 23Branches of biology
- 12Genetics
- 6Genomics
- 3Nucleobases
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- 4Jingyue Ju
- 4Xiaoxu Li
- 3Hui Zhou
- 3Timothy Bestor
- 3Zhiguo Zhang Ph.D.
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- 12Joan Martinez
- 4Cynthia Lang
- 4Kristin Neuman
- 2Jerry Kokoshka
- 1Greg Maskel
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- 9Genetics & Development
- 8Institute for Cancer Genetics
- 5Chemical Engineering/Applied Chemistry
- 4Pathology
- 3Oncology
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- 21Columbia University Medical Center (CUMC)
- 5Fu Foundation School of Engineering and Applied Science (SEAS)
- 3College of Physicians and Surgeons (CUMC)
- 3Faculty of the Arts & Sciences
- 3Fu Foundation School of Engineering and
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