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Method for improving ongoing workflows interested in studying DNA methylation. Methylated DNA immunoprecipitation sequencing (MeDIP-seq) has been used extensively to analyze DNA methylation in cells. The Technology: An efficient, simple, sensitive method to study DNA methylation. This technology isolates cell free DNA (cfDNA) from polynucleotides found in plasma, serum, urine, saliva, and other bodily excretions by mixing them with sequencing primers and DNA polymerase. The major advance of this method is that it can analyze both DNA methylation and hemi-methylation, the latter of which occurs in 10% CpG dinucleotides in human genome. Therefore, this method can be used to identify both the presence of tumors and the tumor cell-type-of-origin based on both DNA methylation and hemi-methylation patterns, which increase the sensitivity and accuracy of tumor detection. 
