This technology is a method for generating single-cell profiles from smaller input volumes, capable of producing multiple readouts, including transcriptomics, T-cell repertoires, spatial sequencing, CNV-sequencing, DNAsequencing, and more. Enables multimodal analysis: single-cell transcriptomics, T-cell repertoires, spatial sequencing, DNA, SNP, and CNV sequencing. Unmet Need: Improved single-cell sequencing efficiency and compatibility with frozen tissue.