Rapid DNA extraction and direct-barcoding for efficient nanopore-based DNA sequencing

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Johannes Melms
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This technology is a method for generating single-cell profiles from smaller input volumes, capable of producing multiple readouts, including transcriptomics, T-cell repertoires, spatial sequencing, CNV-sequencing, DNA sequencing, and more.
Enables multimodal analysis: single-cell transcriptomics, T-cell repertoires, spatial sequencing, DNA, SNP, and CNV sequencing.
Unmet Need: Improved single-cell sequencing efficiency and compatibility with frozen tissue.
    • Tags
      • 1
        Cancer immunotherapy
      • 1
        DNA sequencing
      • 1
        Data quality
      • 1
        Mathematical optimization
      • 1
        Pancreatic cancer
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    • Categories
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        Biology
      • 1
        Biological systems
      • 1
        Biotechnology
      • 1
        Branches of biology
      • 1
        Branches of immunology
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    • Inventors
      • 7
        Jingyue Ju
      • 6
        James J. Russo
      • 5
        Shiv Kumar
      • 4
        Kenneth Shepard
      • 3
        Chuanjuan Tao
      • 1
        Johannes Melms
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    • Manager
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        Joan Martinez
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    • Departments
      • 1
        Medicine
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    • Divisions
      • 1
        Columbia University Medical Center (CUMC)
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