Targeting NTPDase8 for treating liver ischemiaCU25127NTPDase8 modulation protects the liver from ischemia-reperfusion injury, offering a potential first-in-class therapy.TagsAllotransplantationBleedingEpistasisInventorsGeorge HaskoTaha KelestemurManagerKristin NeumanDepartmentsAnesthesiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-10-16CollectionsImmunology & Inflammation
Real-time in situ measurement of electrical impedance of lung tissueCU22293Real-time in situ airway impedance device assesses epithelial health, enabling rapid COPD, asthma, and lung disease monitoring.TagsAsthmaBiomarkerCystic fibrosisInventorsGordana Vunjak-NovakovicJiawen ChenJinho KimManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-05-29
Lung regeneration method for treatment of lung diseasesCU23015Selective de-epithelialization with targeted stem cell engraftment regenerates lung tissue, preserving vasculature for disease treatment and modeling.TagsEx vivoLungMathematical optimizationInventorsCamilla PredellaJing WangNicolino Valerio DorrelloManagerJoan MartinezDepartmentsBiomedical EngineeringPediatricsDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-11-10
Dietary factors for the treatment of lymphomaCU24111Dietary iron and PUFA phospholipids induce ferroptosis to suppress DLBCL tumors, offering non-invasive, low-cost lymphoma therapy options.TagsAcyl groupChemotherapyDietary supplementInventorsBrent StockwellEman Riaz AhmedManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2024-11-08
Exogenous Rac1 analogs to treat acute lung injuryCU23206Exogenous activated Rac1 (V12Rac1) protects lungs from ALI/ARDS by stabilizing actin and blocking proinflammatory signaling.TagsActinAcute respiratory distress syndromeEpitheliumInventorsFrancine KatzGalina GusarovaJahar BhattacharyaManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-26
Machine learning tool for diagnosis of cutaneous T-cell lymphoma (CTCL)CU24366AI-powered CTCL diagnosis tool links genetic markers with EHR data to improve accuracy, staging, and prognosis.TagsAssayCancerCutaneous T cell lymphomaInventorsLarisa GeskinManagerCynthia LangDepartmentsDermatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-30
Lung organoid cells for therapeutic interventionCU23361Therapeutic lung regeneration via patient-specific stem cell–derived distal lung organoids with graftable basal and secretory cells.TagsCell therapyChronic obstructive pulmonary diseaseCoatingInventorsHans-Willem SnoeckManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-09-08
Therapy for EGFR-mutant lung cancerCU22193Targeting RA signaling to suppress brain relapse in EGFR-mutant lung cancer, boosting TKIs and preventing metastasis.TagsBlood–brain barrierEpidermal growth factor receptorEstrogen receptorInventorsAnup BiswasSwarnali AcharyyaManagerKristin NeumanDepartmentsInstitute for Cancer GeneticsDivisionsColumbia University Medical Center (CUMC)Release Date2023-01-04CollectionsOncology
Microvasculature-targeted therapeutic AAV vectors for selective brain deliveryCU24146Brain-endothelium-targeted AAV gene therapy enables non-invasive, selective CNS delivery, treating Glut1DS and neurovascular diseases.TagsAdeno-associated virusBlood–brain barrierCentral nervous systemInventorsShashi KumarUmrao R. Monani Ph.D.ManagerKristin NeumanDepartmentsNeurologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-03-17
Targeted delivery of anti-microRNA for the treatment of liver fibrosisCU21066Liver-targeted exosomes deliver anti-miR-132 to curb fibrosis, reducing collagen and pro-fibrotic signals with tissue specificity.TagsCell membraneCollagenFibrosisInventorsAkiva MintzFatemeh Momen-HeraviManagerJoan MartinezDepartmentsCollege of Dental MedicineRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-02
Preclinical models of angioimmunoblastic T-cell lymphoma for therapeutic investigationCU23322RhoA G17V-driven mouse model of angioimmunoblastic T-cell lymphoma enables translational drug screening and pathogenesis study.TagsCancer cellChemotherapyGene expressionInventorsAdolfo A. Ferrando M.D., Ph.D.Teresa Palomero VasquezManagerJoan MartinezDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-06-15CollectionsOncology
Functional recovery of human donor lungs for transplantationCU13138Localized regional lung regeneration preserves vasculature to revive rejected donor lungs for transplantation.TagsDrug discoveryEx vivoExtracellular matrixInventorsDonald FreytesGopal SinghGordana Vunjak-NovakovicManagerCynthia LangDepartmentsBiomedical EngineeringBiomedical InformaticsSurgeryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-11-20
Host proteases necessary for human parainfluenza virus spread in human lungCU22326Identifies HPIV spread proteases; shows serine protease inhibitors (nafamostat) hinder lung infection, offering targeted antiviral strategy.TagsAntiviral drugEnzyme inhibitorEvolutionInventorsAnne MosconaKyle StearnsMatteo PorottoManagerKristin NeumanDepartmentsAnesthesiologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2024-02-15
Efficient and scalable bio-integrated AI system using brain organoidsCU24020Bio-integrated AI uses brain organoids and CMOS interfaces for scalable, energy-efficient reservoir computing with enhanced AI performance.TagsArtificial intelligenceAutonomous system (Internet)Brain mappingInventorsKenneth KosikKenneth ShepardManagerGreg MaskelDepartmentsElectrical EngineeringNeuroscienceDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-05-27
Mouse line as a model for Peripheral T-cell Lymphoma with GATA3+ featuresCU23321Mouse model for Vav1-Myof1-driven Peripheral T-cell Lymphoma (GATA3+) enabling targeted therapy screening and pathogenesis study.TagsCD4CarcinogenesisGenetic testingInventorsAdolfo A. Ferrando M.D., Ph.D.Teresa Palomero VasquezManagerJoan MartinezDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-06-15CollectionsOncology
Targeted pharmacological agents for the prevention of multiple organ failure in hemorrhagic shock patientsCU23263Localized anti-inflammatory CD39/CD73 therapy to prevent multi-organ failure in hemorrhagic shock by targeted adenosine production.TagsAdenosineAdenosine receptorAgent-based modelInventorsGeorge HaskoTaha KelestemurManagerKristin NeumanDepartmentsAnesthesiologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-04-25CollectionsOncologyImmunology & Inflammation
Improved organ transplant preservation solution with modified albuminCU25173Modified albumin-based solution prevents glycation, extending organ preservation by maintaining structure and function.TagsAmino acidAnti-aging movementGlycationInventorsGiovanni FerrariManagerJerry KokoshkaDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2026-03-13
Quantitative measurement of eye and head movements for the diagnosis of traumatic brain injury and neurodegenerationCU21135Quantitative eye-head movement tracking diagnoses concussion and neurodegeneration, enabling rapid, objective tremor-based brain injury assessment.TagsBiomarkerCase–control studyCognitive deficitInventorsChristopher DriscollLinus SunThomas BottiglieriManagerJoan MartinezDepartmentsInstitute of Human NutritionOphthalmologyOrthopedic SurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-21CollectionsCNS/Neurology
Small scale screening bioreactor with airway tissues and mucosa for the progression and treatment of lung diseaseCU23307Bioreactor recreating mucus-lined airways ex vivo for real-time, high-throughput modeling and therapeutic screening.TagsBiomimeticsBioreactorCell cultureInventorsGordana Vunjak-NovakovicJinho KimKeith YeagerManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-04-08
Computational method for brain tumor classification and improved prognosisCU21156Integrates multi-omics to subtype glioblastoma, revealing four functional states and subtype-specific treatment targets.TagsBreast cancerGlioblastomaGliomaInventorsAnna LasorellaAntonio IavaroneManagerKristin NeumanDepartmentsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-01CollectionsOncology
Therapeutic target for blood-retinal barrier defect in glaucomaCU23351Targeting BRB leakage via Mfsd2a to predict, prevent, and treat glaucoma onset in high-IOP patients.TagsAgonistBlood vesselCell membraneInventorsChi ZhangSimon JohnManagerKristin NeumanDepartmentsOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-03-07
Fusion protein as target for brain cancer therapyCU12240Targeting FGFR-TACC gene fusions in glioblastoma with kinase inhibitors; precision therapy and diagnostic tools.TagsAssayChemotherapyGlioblastomaInventorsAnna LasorellaAntonio IavaroneRaul RabadanManagerKristin NeumanDepartmentsBiomedical InformaticsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2022-09-15CollectionsSmall MoleculeOncology
Plasma-based, biopsy-free cancer detection assayCU23111Plasma-based, blood biopsy-free cancer detection using deep learning on cfDNA methylation to diagnose multiple cancers non-invasively.TagsAssayCancerDNA methylationInventorsXu HuaZhiguo Zhang Ph.D.ManagerJoan MartinezDepartmentsGenetics & DevelopmentInstitute for Cancer GeneticsDivisionsColumbia University Medical Center (CUMC)Release Date2023-03-03CollectionsOncology
MoNNet platform for modeling mammalian brain function and diseaseCU18176MoNNet enables modular, high-fidelity in vitro brain networks modeling mammalian organization and disease for drug discovery.TagsBrainDrug discoveryHigh-throughput screeningInventorsMaria de los Angeles Rabadan LozanoRaju TomerManagerKristin NeumanDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2022-06-27CollectionsCNS/Neurology
Rapid, point-of-care assessment of radiation exposure in human bloodCU24211ELISA-based biodosimeter profiles blood biomarkers and uses ML to triage ionizing-radiation exposure-assessment at point-of-care.TagsAssayBioassayBiomarkerInventorsHelen TurnerIgor ShuryakKarthik KanagarajManagerJoan MartinezDepartmentsCenter for Radiological ResearchRadiation OncologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-05-05
Pharmacological inhibitors and mouse models of mitochondrial DNA depletion-deletion syndromes (MDDS)CU23197Therapeutic mouse models and deoxynucleoside-based treatment restore mtDNA balance in GUK1-related MDDS, enabling mtDNA repair.TagsAcute respiratory distress syndromeBiomarkerBiopharmaceuticalInventorsAgustin Hidalgo GutierrezJonathan ShintakuMichio Hirano M.D.ManagerKristin NeumanDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08CollectionsRare Disease
BCL6 knockout mouse models of lymphoma developmentCU21195BCL6 knockout mice model lymphoma development and germinal center immunity, enabling in vivo studies of BCL6 function.TagsAlleleAntibodyCoding regionInventorsRiccardo Dalla-FaveraManagerJoan MartinezDepartmentsPathologyDivisionsColumbia University Medical Center (CUMC)Release Date2021-02-10CollectionsOncology
Gene silencing for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)CU23021Silencing CASP8-METRN halts progression from steatosis to MASH, offering non-invasive therapy and diagnostic biomarkers.TagsBiomarkerBlood plasmaCaspase 8InventorsDanish SaleheenIra Tabas MD, PhDShareef KhalidManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08
Rapid-deployment stapling system for aortic graft connectionCU25342A circular stapler rapidly connects vascular grafts to the aorta in seconds, reducing time, trauma, and bleeding risk.TagsAnastomosisAortaAortic aneurysmInventorsSyed Tasnim RazaManagerJoan MartinezDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2025-09-16
Knock-in mouse lines to target striatal projection neurons and dopaminergic neuronsCU26031Knock-in Cre/FlpO mice precisely target striatal projection and dopaminergic neurons for cell-type specific neuroscience research.TagsAdenosineAdenosine A2A receptorBasal gangliaInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-07
Endogenous generation of insulin-producing cells for diabetes treatmentCU19065Gut-epithelium reprogramming yields autologous, glucose-responsive insulin-producing cells, potentially reducing injections and immune suppression.TagsBlood sugar levelEpitheliumHyperglycemiaInventorsDomenico Accili M.D.Hua V. LinTakumi KitamotoManagerCynthia LangDepartmentsEndocrinologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-11-13
Hormone therapy for age-related frailty and muscle degenerationCU15011Osteocalcin-based hormone therapy aims to reverse age-related frailty, muscle loss, and linked metabolic, reproductive, and cognitive disorders.TagsAnxietyApoptosisAsthmaInventorsGerard Karsenty M.D., Ph.D.Paula MeraManagerJerry KokoshkaDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-29
Precision-engineered biomaterial scaffold for periodontal ligament regenerationCU25075A customizable templated scaffold guides periodontal ligament regeneration, closely mimicking native structure for full periodontium recovery.TagsBiomaterialCollagenDental implantInventorsHelen Lu Ph.D.Philip Andrew Patrick BrudnickiThomas BinaManagerJoan MartinezDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-05-08
Serum Amyloid A1 antibody to treat leukemiasCU22360SAA1-targeting antibody blocks bone marrow–driven leukemia progression, aiming to prevent AML/MDS relapse and broaden hematologic cancer treatment.TagsAcute lymphoblastic leukemiaAcute myeloid leukemiaBreast cancerInventorsMarta Galan-DiezStavroula KousteniManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-10
Dual targeting of epigenetically amplified lymphomas via epigenetic modifiers and immune checkpoint inhibitionCU24177Dual-targeted PMBCL therapy: epigenetic reprogramming plus anti-PD-1 immune blockade enhances immunogenicity and overcomes resistance.TagsCancerCancer immunotherapyChromosomeInventorsJennifer AmengualSeda Serra ToluManagerKristin NeumanDepartmentsMedicineMedicine - Hematology/OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-17CollectionsOncology
Cell therapy methods for improved transplant acceptanceCU22264Hematopoietic stem cell therapy induces immune tolerance to transplanted organs, reducing rejection and long-term immunosuppression needs.TagsAllotransplantationCD34Cell therapyInventorsAubrey Marie SherryBrian H. JohnstoneDongsheng GuManagerJerry KokoshkaDepartmentsMedicineSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2024-09-05
Machine learning pipeline for neoantigen prioritization in personalized immunotherapiesCU25375ImmuneMirror: integrative ML pipeline predicting immunogenic neoantigens by combining processing, transport, binding, and recognition factors.TagsAntigenBiomarkerCancer immunotherapyInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Cross-platform radiomics toolkit for predictive cancer imagingProxy116Cross-platform radiomics toolkit automates standardized 2D/3D cancer imaging analysis for reproducible, scalable biomarker discovery.TagsBatch processingCross-platform softwareFeature extractionInventorsChristos DavatzikosDespina KontosManagerJoan MartinezDepartmentsRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-04
Microneedle for eye injection surgeryCU24034Minimally invasive ophthalmic microneedle enables precise subretinal/intravascular injections, improving retinal safety and targeting.TagsArteryBirth defectBleedingInventorsAhmet HondurAnil LalwaniAykut AksitManagerDovina QuDepartmentsMechanical EngineeringOphthalmologyOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-12-12
Allele-specific prime editing strategies for rhodopsin-mediated retinitis pigmentosaCU24356Allele-specific prime editing silences mutant RHO in retinal disease, preserving normal gene function without DNA breaks. 15 words, 139 chars.TagsAlleleGene therapyGenetic disorderInventorsPeter M.J. QuinnSalvatore M. CarusoStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-02-14
Gene therapy for metabolic dysfunction-associated steatohepatitis (MASH)CU25230Gene therapy restoring retromer activity to treat MASH by normalizing lipid metabolism and reducing fibrosis risk.TagsCirrhosisDrug discoveryFibrosisInventorsGregory A. PetskoScott A. Small M.D.ManagerJerry KokoshkaDepartmentsAnn Romney Center for Neurologic DiseasesNeurologyDivisionsColumbia University Medical Center (CUMC)Harvard Medical School and Brigham & Women’s HospitalRelease Date2025-07-31
D1-Cre knock-in mouse for genetic targeting of basal ganglia circuitsCU26035CRISPR knock-in D1-Cre mouse ensures precise, endogenous D1 neuron targeting in basal ganglia for targeted circuit studies.TagsBasal gangliaCre recombinaseDopamineInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-13
A mouse model expressing recombinase in dopamine transporter-positive neuronsCU26033Precise FlpO recombination in dopamine transporter neurons via CRISPR knock-in, enabling targeted dopaminergic research.TagsBasal gangliaDopamineDopamine transporterInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-07
Endoscopic imaging device for precise real-time detection of olfactory tissueCU25003Real-time spectral endoscopic detection of olfactory epithelium to preserve smell during head/neck surgeries.TagsBiopsyEndoscopyEpitheliumInventorsDavid A. GudisIan F. CaplanJames P. SchuckManagerSara GusikDepartmentsMechanical EngineeringOtolaryngologyOtolaryngology--Head & Neck SurgeryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-11-08
Small molecule activators for preventing vision loss in Best vitelliform macular dystrophyCU25176Small molecule activators restore Best1 function to slow BVMD vision loss; targeted, potentially non-invasive retinal therapy.Tags4-Aminobenzoic acidDrug developmentGene therapyInventorsBingchen YuTingting YangYu ZhangManagerJoan MartinezDepartmentsChemistryOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-05-01CollectionsOphthalmology
Programmable bacteria for targeted delivery of cancer therapeuticsCU18339Engineered tumor-targeting bacteria deliver immunotherapies locally, boosting efficacy and reducing systemic toxicity in cancer treatment.TagsAntigenCancer immunotherapyChemotherapyInventorsCandice GurbatriNicholas ArpaiaSreyan ChowdhuryManagerCynthia LangDepartmentsBiomedical EngineeringMicrobiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-04-07
Coherent factor-based passive cavitation mapping for monitoring of focused ultrasound treatmentCU22079Coherent factor-based passive acoustic mapping enables real-time, high-resolution, low-cost monitoring of transcranial focused ultrasound treatment.TagsAblationAcousticsAttenuationInventorsElisa KonofagouSua BaeManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-11-07
Non-invasive method for detection of cancer methylomesCU21185Non-invasive methylation profiling of tumor cfDNA enables early cancer detection, tumor origin, and targeted treatment insights.Tags5-MethylcytosineAntibodyAssayInventorsHui ZhouRegina Santella Ph.D.Zhiguo ZhangManagerJoan MartinezDepartmentsEnvironmental Health ScienceGenetics & DevelopmentInstitute for Cancer GeneticsDivisionsColumbia University Medical Center (CUMC)Mailman School Of Public Health (MSPH)Release Date2023-08-04CollectionsOncology
Focused ultrasound nanoparticles for targeted imaging and neuroregenerationCU21224Ultrasound-activated nanocup theranostics cross BBB for targeted Alzheimer’s imaging and neuroregenerative therapy.TagsAmyloid betaAntibodyBlood–brain barrierInventorsAntonios PoulipoulosElisa KonofagouManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-07-29
Gene editing for treatment of retinitis pigmentosaCU23293CRISPR-based retinal metabolism reprogramming targets PHD2 to slow retinitis pigmentosa progression, offering broad RP treatment potential.TagsAdeno-associated virusCRISPRCRISPR gene editingInventorsStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCRelease Date2024-11-26CollectionsOphthalmology
