Two-photon holographic microscope system for 3D neuronal circuit imaging and stimulationCU23132A holographic two-photon microscope enables simultaneous, high-resolution 3D neuronal imaging and optogenetic stimulation in vivo.TagsAdaptive opticsHolographyMicroscopyInventorsRafael YusteYuriy ShymkivManagerKristin NeumanDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2023-12-04CollectionsCNS/NeurologyPlatform/Research Tool
Optical in situ nucleotide sequence detection using combinatorial hybridizationCU24118High-throughput optical CRISPR screening with combinatorial hybridization enables scalable, cost-efficient, multi-omic readouts in situ.TagsBreast cancerCRISPRCohort studyInventorsJellert GaublommeManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2026-01-29CollectionsGenomics & Multi-Omics
Humidity-responsive textiles for adaptive moisture managementCU22375Humidity-responsive textiles dynamically adjust breathability via reversible hygromorphing, passively regulating moisture and comfort without power.TagsElastic modulusHumidityLipid bilayerInventorsOzgur SahinYocheved UngarManagerDovina QuDepartmentsBiological SciencesApplied Physics & Applied Math (APAM)DivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-02-14
Erastin analogs for genotype-selective ferroptosis inductionCU14068ERS: Genotype-selective ferroptosis induction using enhanced erastin analogs targeting RAS V12+ tumors for potent, soluble, stable anticancer activity.TagsApoptosisFunctional groupGenotypeInventorsBrent StockwellMarie-Helene LarraufieWan Seok YangManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2025-05-22
Targeting a neural fat-sensing pathway for the treatment of obesityCU22137Target fat-sensing gut-brain pathway to curb high-fat eating; potential obesity, diabetes, and heart-disease therapeutics.TagsCardiovascular diseaseChronic kidney diseaseDrug developmentInventorsCharles S. ZukerMengtong LiZhengyuan LuManagerJoan MartinezDepartmentsBiological SciencesBiochemistry & Molecular BiophysicsMortimer B. Zuckerman Mind Brain Behavior InstituteDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2024-08-01
Light Guided Patterning of Stimuli-Responsive ActuatorsCU17117Photolithography-patterned water-responsive bacterial spores power humidity-driven actuators in polymer sheets, enabling energy-free adaptive architecture.TagsBacillusEndosporeHumidityInventorsOnur CakmakOzgur SahinXi ChenManagerDovina QuDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2023-03-08
Inducible genetic knockdown library for Saccharomyces cerevisiaeCU21052Inducible CRISPRi library for yeast enables tetracycline-controlled, genome-wide gene knockdown with high coverage and precision.TagsCRISPREpistasisEukaryoteInventorsAmir Momen-RoknabadiPanagiotis OikonomouSaeed TavazoieManagerJoan MartinezDepartmentsBiological SciencesBiochemistrySystems BiologyDivisionsColumbia University Medical CenterColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2020-10-23
DSSR: an integrated software tool for dissecting the spatial structure of RNACU20391Integrated DSSR software automates RNA/DNA 3D structure analysis, annotation, and in silico mutations, streamlining bioinformatics workflows.TagsAcidBioinformaticsIn silicoInventorsHarmen J. BussemakerXiang-Jun LuManagerDovina QuDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2020-06-15CollectionsPlatform/Research ToolDigital Health (Software, AI, bioinformatics, etc)
High-pressure injector device for comfortable and rapid drug deliveryCU18187High-pressure, spring-free injector enables rapid, quiet delivery of viscous drugs for self-administration and higher concentration dosing.TagsAdrenalineBiopharmaceuticalDrug deliveryInventorsOzgur SahinManagerDovina QuDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2019-12-03
FIN56, a well-characterized small molecule for modeling ferroptosis-mediated cell deathCU17131FIN56 triggers ferroptosis by GPX4 suppression and lipid oxidation, enabling research tools and drug discovery for neurodegenerative and cancer therapies.TagsBiosynthesisCancerCancer cellInventorsBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2018-05-25CollectionsSmall MoleculeOncologyCNS/Neurology
Production method of the essential metabolic enzyme Propionyl-CoA carboxylase (PCC)CU16014Method to produce and purify human/bacterial Propionyl-CoA carboxylase in E. coli for PA therapeutics and research.TagsAcidosisAmino acidCarboxylationInventorsLiang TongManagerBeth KaudererDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2015-09-23
Engineered CAST systems for RNA-guided DNA integrationCU24123Programmable, break-free RNA-guided DNA integration in mammalian cells using engineered CAST with Cas8 mutations for broader genomic targeting.TagsCell therapyGenetic engineeringGenome editingInventorsAshley LiangGeorge Davis LampeSamuel H. SternbergManagerCynthia LangDepartmentsBiological SciencesBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2026-02-17
Fluorescent labeling of cell surface proteins in vivo with spatiotemporal controlCU25172Fluorescently label cell-surface proteins in vivo using DogTag-DogCatcher for spatiotemporal, loop-targeted GFP tagging.TagsBiopsyCell membraneCovalent bondInventorsKevin RostamRichard S. MannManagerJerry KokoshkaDepartmentsBiological SciencesBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2025-03-21
Computational Method to Identify Bacterial Genes and Strains for Enhanced GI Tract ColonizationCU24221Computationally identifies bacterial genes driving GI tract colonization to guide engineered strains and therapeutic microbiome tools.TagsBacteriaEscherichia coliGastrointestinal tractInventorsMenghan LiuSaeed TavazoieManagerJoan MartinezDepartmentsBiological SciencesBiochemistryDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2025-09-18
GPX4 inhibitors for cancer therapyCU20261Potent, selective GPX4 inhibitors induce ferroptosis to target EMT-driven, drug-resistant cancers and enable GPX4 research.TagsActive siteAllosteric regulationApoptosisInventorsBrent StockwellHengrui LiuManagerJoan MartinezDepartmentsBiological SciencesChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-05-01
Dietary factors for the treatment of lymphomaCU24111Dietary iron and PUFA phospholipids induce ferroptosis to suppress DLBCL tumors, offering non-invasive, low-cost lymphoma therapy options.TagsAcyl groupChemotherapyDietary supplementInventorsBrent StockwellEman Riaz AhmedManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2024-11-08
High-resolution method for determining the molecular structure of biomoleculesCU13086AFM-based molecular sequencing maps biomolecules at Ångstrom resolution using DNA-labeled probes and cantilever twist.TagsAmino acidAtomic force microscopyBiomoleculeInventorsOzgur SahinManagerDovina QuDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2019-01-19
Evaporation-driven engines for renewable energy generationCU14162Evaporation-powered bio-hybrid actuators harvest humidity differences to generate robust, high-density mechanical energy for renewables.TagsBacillusElectricityEndosporeInventorsOzgur SahinXi ChenManagerDovina QuDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2015-06-12
Lipid targets and biomarkers for ferroptosisCU24174Lipid biomarkers (PC-PUFA2s) drive ferroptosis; enables diagnostics and targeted therapies by regulating iron-dependent cell death.TagsAcyl groupApoptosisBiomarkerInventorsBaiyu QiuBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2024-12-20
Method for identifying vertebrate viruses using multiplexed, high-throughput genome sequencingCU16058Virome-Capture-Sequencing (VirCapSeq-VERT) enables high-throughput, cost-effective vertebrate virus detection and discovery.TagsChemical libraryGlobal healthUlcerative colitisInventorsAmit KapoorOmar JabadoThomas BrieseManagerKristin NeumanDepartmentsBiological SciencesEpidemiologyMailman School Of Public Health (MSPH)DivisionsFaculty of the Arts & SciencesMailman School Of Public Health (MSPH)Release Date2025-09-04
Small molecule inhibitors of ferroptosis for therapeutic applicationsCU17132Small-molecule ferroptosis inhibitors with improved drug-like properties for neurodegenerative, excitotoxic, and organ-protective therapies.TagsCell deathDrug developmentEpilepsyInventorsBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2020-07-09CollectionsSmall MoleculeCNS/Neurology
Cancer treatment for Tumor Cells Using RSL3M10-018RAS-selective-lethal compound RSL3 induces rapid, nonapoptotic death in HRAS-mutant tumor cells; promising targeted cancer therapy.TagsCarcinogenesisDrug discoveryMutationInventorsBrent StockwellRohitha SriRamaratnamManagerJoan MartinezDepartmentsBiological SciencesChemistryDivisionsFaculty of the Arts & SciencesRelease Date2009-12-22
Cysview and blue light irradiation for effective and non-invasive bladder cancer therapyCU24375Cysview-based blue-light therapy non-invasively kills bladder cancer cells via rapid ROS, enabling broad, targeted treatment.TagsBladder cancerCancerChemotherapyInventorsJustin MatulayMichael Shen Ph.D.Talal Ahsan SyedManagerJoan MartinezDepartmentsBiological SciencesMedicineUrologyDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2025-01-02
Bacterial genetic engineering system to treat infectionsCU24061Efficient CAST-based bacterial genome editing enables targeted cargo insertion to treat infections and reprogram microbiomes.TagsAntibioticBacteriaCRISPRInventorsCarlotta RondaDiego GelsingerHarris WangManagerCynthia LangDepartmentsBiological SciencesBiochemistry & Molecular BiophysicsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2024-08-29
Biomaterial matrix with tunable hygroscopic propertiesCU19050Biodegradable spore–nanofiber composite that harvests humidity-driven strain for sensing, heating, antimicrobial, and sealing uses.TagsAntimicrobialBiodegradationBiomaterialInventorsEran SchenkerOnur CakmakOzgur SahinManagerDovina QuDepartmentsBiological SciencesApplied Physics & Applied Math (APAM)DivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-11-21
Micro-scale pillared surfaces with variable rigidity to monitor cellular responsesM08-073Patterned elastomeric pillar surfaces with tunable rigidity via electron-beam exposure to study and steer cellular responses.TagsCellular differentiationCoatingElectron-beam lithographyInventorsMichael SheetzShalom WindTeresa A. FazioManagerBeth KaudererDepartmentsBiological SciencesApplied Physics & Applied Math (APAM)DivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2009-06-09
Ferroptosis inducers as radiosensitizers for improved cancer treatmentCU19410Ferroptosis-inducing radiosensitizers boost radiation therapy by non-apoptotic cancer cell death, overcoming resistance.TagsApoptosisDNA repairEnzyme inducerInventorsBrent StockwellLing YeSimon Cheng M.D., Ph.D.ManagerJoan MartinezDepartmentsBiological SciencesRadiation OncologyDivisionsCollege of Physicians and Surgeons (CUMC)Faculty of the Arts & SciencesRelease Date2022-08-05CollectionsSmall MoleculeOncology
MoNNet platform for modeling mammalian brain function and diseaseCU18176MoNNet enables modular, high-fidelity in vitro brain networks modeling mammalian organization and disease for drug discovery.TagsBrainDrug discoveryHigh-throughput screeningInventorsMaria de los Angeles Rabadan LozanoRaju TomerManagerKristin NeumanDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2022-06-27CollectionsCNS/Neurology
Lipid-peroxidation-resistant cell line for studying ferroptosisCU20193Engineered GPX4-overexpressing cells resist lipid peroxidation and ferroptosis, enabling high-throughput ferroptosis mechanism and drug screening.TagsCancerDrug developmentEnzymeInventorsBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2020-07-21CollectionsPlatform/Research Tool
Compounds for modulating ferroptosis and treating excitotoxic disordersCU12192Ferroptosis-inhibiting small molecules—novel therapy to prevent excitotoxic cell death in neurodegenerative diseases and cancer.TagsApoptosisBlood transfusionCarcinogenesisInventorsBrent StockwellRachid SkoutaScott DixonManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2016-01-06
Optical delivery of biomoleculesM04-031Visible/IR light uncaging releases biomolecules rapidly via ruthenium cages, enabling targeted, non-damaging photorelease for therapies.TagsBiomoleculeCardiovascular diseaseCovalent bondInventorsLuis BaraldoRafael YusteRoberto EtcheniqueManagerKristin NeumanDepartmentsBiological SciencesQuimica InorganicaDivisionsFaculty of the Arts & SciencesRelease Date2014-06-23
MatrixREDUCE: Software for quantifying sequence specificity of nucleotide-binding factors using genomic dataM06-084MatrixREDUCE predicts transcription factor binding affinities from genome data, enabling motif discovery without prior empirical data.TagsAlgorithmBioinformaticsBiological systemInventorsBarrett FoatHarmen J. BussemakerManagerDovina QuDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2009-08-10
Mouse model for studying cholecystokinin type A receptorCU22214Engineered mouse with Cre under CCKAR control for precise CCKAR biology, disease modeling, and targeted drug discovery.TagsAnimal disease modelCholecystokininCre recombinaseInventorsCharles S. ZukerHwei-Ee TanMengtong LiManagerJoan MartinezDepartmentsBiological SciencesBiochemistry & Molecular BiophysicsMortimer B. Zuckerman Mind Brain Behavior InstituteDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2022-02-07
Antibody for specific detection of ferroptosisCU20038Ferroptosis-specific antibody (3F3-FMA) detects ferroptotic cells via TfR1 for immunofluorescence, flow cytometry, and tissue assays.TagsAntibodyApoptosisAssayInventorsAngie Huizhong FengBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2019-08-07CollectionsCNS/Neurology
Computational methods for assessing and optimizing the protein expression potential of gene sequences in vivoCU12083Computationally optimize gene mRNA folding to boost in vivo protein expression, reducing costs via improved translation efficiency.TagsBiochemistryBiotechnologyData setInventorsDaniel AalbertsGregory BoelGuy MontelioneManagerOfra WeinbergerDepartmentsBiological SciencesNortheast Structural Genomics ConsortiumPhysicsDivisionsAdministrative Services Bldg.Faculty of the Arts & SciencesRelease Date2015-03-10
Targeted Mutagenesis and Codon Selection Techniques to Improve Protein Expression and SolubilityM10-014Codon-optimization algorithm boosts protein expression and solubility without altering sequence, enabling cost-effective industrial production.TagsAlgorithmAmino acidBig dataInventorsGregory BoelGuy MontelioneHelen NeelyManagerOfra WeinbergerDepartmentsBiological SciencesNortheast Structural Genomics ConsortiumDivisionsAdministrative Services Bldg.Faculty of the Arts & SciencesRelease Date2014-07-08
Engineering surface epitopes for improving protein crystallizationM08-082Engineers protein surfaces with epitopes via mutations to boost crystallization success for high-resolution structure determination.TagsAlgorithmDatabaseEpitopeInventorsJohn F. HuntWilliam Nicholson Price IIManagerOfra WeinbergerDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2008-04-07
Nucleic acid modification with tools from OxytrichaCU19015A ciliate enzyme enables fast, site-specific N6-methyladenine DNA methylation (m6dA) for diverse substrates and cancer research.TagsAdenineCarcinogenesisCiliateInventorsLaura Landweber PhDLeslie BehManagerJerry KokoshkaDepartmentsBiological SciencesBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2019-04-29
Small molecule therapeutics to treat treatment-resistant ALL and T-ALLCU19220NT5C2 inhibitors (e.g., HTP-2) boost chemotherapy efficacy in relapsed ALL/T-ALL, enabling combo treatments against resistance.TagsAcute lymphoblastic leukemiaAssayCancer cellInventorsAdolfo A. Ferrando M.D., Ph.D.Arie ZaskBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesInstitute for Cancer GeneticsProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2021-02-03CollectionsSmall MoleculeOncology
Specialized diet for enhanced cancer treatmentCU21118Amino acid-restricted diet enhances chemotherapy/radiation efficacy by selectively targeting cancer cells while maintaining energy needs.TagsAmino acidChemotherapyGliomaInventorsBrent StockwellDominique HigginsJeffrey BruceManagerJerry KokoshkaDepartmentsBiological SciencesNeurological SurgeryPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2020-11-05CollectionsOncology
BulkArg: computational pipeline for improving protein crystallization propensityCU23101A computational pipeline suggesting lysine-to-arginine substitutions to boost crystallization propensity and speed structure determination.TagsArginineBiological targetCrystallizationInventorsBlaine L. LoughlinJohn F. HuntNooriel E. BanayanManagerOfra WeinbergerDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2023-09-13
Heme oxygenase-2 inhibition to increase lentiviral production efficiencyCU16034Inhibiting heme oxygenase-2 boosts lentiviral production, enabling faster, cheaper, scalable gene therapy and editing tools.TagsCell membraneGene expressionGene therapyInventorsLiang TongShukun LuoStephen P. GoffManagerKristin NeumanDepartmentsBiological SciencesBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2016-07-15
Nanofibrous scaffold for controlled release of small molecule immunomodulatorsCU24040Nanofibrous scaffold locally releases ACHP to inhibit NF-kB, enabling targeted immunomodulation with reduced systemic effects.TagsAutoimmune diseaseBiomaterialDrug deliveryInventorsFereshteh ZandkarimiHannah ChildsHelen Lu Ph.D.ManagerJoan MartinezDepartmentsBiological SciencesBiomedical EngineeringDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-12-18CollectionsSmall Molecule
Discovery of RAS-selective drugs to treat cancerM06-044RAS-selective small molecules kill tumor cells with oncogenic RAS, enabling targeted, potent cancer therapies with reduced toxicity.TagsCarcinogenesisCytotoxicityDrug resistanceInventorsBrent StockwellWan Seok YangManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2005-12-06
Method for Predicting Gene Expression by Modeling Transcription Factor ActivityM09-020Predicts gene expression by modeling transcription factor activity; maps regulatory networks to identify therapeutic targets and phenotypes.TagsAlgorithmGene expressionLocus (genetics)InventorsHarmen J. BussemakerManagerDovina QuDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2012-11-29
Holographic 3D imaging and photostimulation for enhanced functional assays of neuroactive compoundsM08-107Holographic 3D two-photon imaging and photostimulation enables rapid, high-resolution neural circuit mapping and compound assays.Tags3D reconstructionAdaptive opticsAssayInventorsBrendon O. WatsonDarcy PeterkaRafael YusteManagerKristin NeumanDepartmentsBiological SciencesNeurobiologyScience & Technology Ventures (STV)DivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesMorningsideRelease Date2015-05-04
Antisera to Myocyte Enhancer Factor 2 (MEF2) ProteinsM06-094Rabbit antisera detect MEF2A/B/D across human/mouse; suitable for EMSA, IP, WB; highly specific, public domain licensing.TagsAmino acidAntibodyAntigenInventorsRonald Michael PrywesManagerBeth KaudererDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2011-05-12
Photoactivated, localized drug delivery utilizing visible and infrared lightM09-102Visible/IR light-triggered, ruthenium-tethered drug release enables localized, single-cell precision delivery with biocompatibility and depth.TagsChemotherapyDrug deliveryGamma-Aminobutyric acidInventorsLuis BaraldoRafael YusteRoberto EtcheniqueManagerKristin NeumanDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2009-11-10
Targeting oncogenic lipids for cancer therapyCU20221Targeting cancer's oncogenic lipids to disrupt rewired metabolism, aiming for higher therapeutic index and lower resistance risk.TagsCancerMetabolismInventorsBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2020-01-16CollectionsOncology
Small-molecule drugs for targeted cancer therapyM10-018-aSmall-molecule, RAS-selective cancer therapeutics inducing nonapoptotic death in RAS-driven tumors; improves precision, reduces toxicity.TagsApoptosisCarcinogenesisDrug discoveryInventorsBrent StockwellRohitha SriRamaratnamWan Seok YangManagerJoan MartinezDepartmentsBiological SciencesChemistryDivisionsFaculty of the Arts & SciencesRelease Date2018-08-30
