Safer ibogaine analogs for the treatment of substance use disordersCU24362Safer oxa-ibogaine analogs reduce cardiac risk while retaining ibogaine’s anti-addiction effects and therapeutic potential.TagsAlkaloidAnalgesicArrhythmiaInventorsDalibor SamesDavid LankriVaclav HavelManagerJerry KokoshkaDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-03-12CollectionsCNS/Neurology
Small molecule activators for preventing vision loss in Best vitelliform macular dystrophyCU25176Small molecule activators restore Best1 function to slow BVMD vision loss; targeted, potentially non-invasive retinal therapy.Tags4-Aminobenzoic acidDrug developmentGene therapyInventorsBingchen YuTingting YangYu ZhangManagerJoan MartinezDepartmentsChemistryOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-05-01CollectionsOphthalmology
Live yeast biosensors for pathogen detectionCU21127Engineered live yeast biosensors emit color/fluorescent signals for rapid, sensitive pathogen detection, including fungi, viruses, and variants.TagsAntifungalAntiviral drugAssayInventorsVirginia W. CornishManagerJoan MartinezDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-03-07
Synthesis of nitrogen isotopologues for pharmaceutical researchCU23020One-pot, cost-effective synthesis to replace nitrogen with heavy 15N isotopologue for tracking in pharma, agriculture, and environments.TagsBioavailabilityDrug developmentEnvironmental monitoringInventorsJulia DorsheimerTomislav RovisManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2023-08-04
Rapid, highly sensitive multiplexed viral detection with nanoporesCU21160Ultrafast, amplification-free nanopore-based single-molecule assay for multiplexed viral detection (SARS-CoV-2) and antibodies.TagsAntibodyAntigenAssayInventorsChuanjuan TaoJames J. RussoJingyue JuManagerCynthia LangDepartmentsChemistryChemical Engineering/Applied ChemistryGenome CenterDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering andFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-07-20
Fluorescent substrates for imaging neurotransmissionM06-109-aFluorescent false neurotransmitters visualize dopamine vesicle content and release at single-synapse resolution for imaging and drug discovery.TagsAssayAttention deficit hyperactivity disorderBipolar disorderInventorsDalibor SamesDavid Sulzer Ph.D.Niko GubernatorManagerJerry KokoshkaDepartmentsChemistryPsychiatryDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2018-11-13
Evolved CRISPR-associated transposase systems for genome engineeringCU19096RNA-guided CRISPR-transposase enables kilobase-scale, precise DNA insertions in human cells without double-strand breaks or homologous repair.TagsCRISPRFibroblastGenetically modified animalInventorsSamuel H. SternbergSanne KlompeManagerCynthia LangDepartmentsChemistryBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2025-12-18CollectionsGenomics & Multi-Omics
Solar-powered mechanical motion of crystalsCU22086Solar-energy–driven crystals autonomously roll under visible light; fatigue-free, customizable, scalable for microdevices and soft robots.TagsEnergy harvestingFatigue (material)Laser cuttingInventorsAmymarie K. BartholomewIlana B. StoneMichael SteigerwaldManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2022-10-14
High-yield production of macroscopic 2D materialsCU20156Ultra-flat gold tape enables scalable, high-yield production of macroscopic 2D materials for electronics and quantum tech.TagsGrapheneMetalMonolayerInventorsFang LiuJames HoneJue WangManagerDovina QuDepartmentsChemistryMechanical EngineeringDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering andFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-05-13
Psychedelic based treatment for Parkinson’s disease and other psychiatric disordersCU23079Non-hallucinogenic 5-HT2A agonist Ariadne targets Parkinson’s and psychiatric disorders, offering safer, broader therapeutic potential.Tags5-HT2A receptorAgonistBipolar disorderInventorsDalibor SamesMichael J. CunninghamManagerJerry KokoshkaDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2023-11-03CollectionsSmall MoleculeCNS/Neurology
Chemical painting for high-throughput single-cell drug response analysisCU23332Multiplexed infrared imaging enables high-throughput, single-cell drug profiling with ML-enabled mechanism-of-action predictions.TagsCombination therapyDNA sequencingDrug discoveryInventorsWei MinXinwen LiuManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-10-16
GPX4 inhibitors for cancer therapyCU20261Potent, selective GPX4 inhibitors induce ferroptosis to target EMT-driven, drug-resistant cancers and enable GPX4 research.TagsActive siteAllosteric regulationApoptosisInventorsBrent StockwellHengrui LiuManagerJoan MartinezDepartmentsChemistryBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2025-05-01
Photocatalysis method with low-energy lightCU18169Photon upconversion enables infrared-driven, safer photocatalysis with deeper penetration for pharma, biomedicine, and materials.TagsAntimicrobialBiomedicineCatalysisInventorsAndrew B. PunBenjamin RavetzDaniel N. CongreveManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesMassachusetts Eye and Ear InfirmaryRelease Date2024-12-06
First-in-class organic materials for efficient multiple exciton generationCU17103First-in-class organic polymers enable intramolecular singlet fission with 170–200% triplet yield, boosting solar efficiency and tunability.TagsAromaticityCarrier generation and recombinationCharge-transfer complexInventorsAndrew B. PunElango KumarasamyLuis CamposManagerGreg MaskelDepartmentsChemistryDivisionsCenter for Functional NanomaterialsFaculty of the Arts & SciencesRelease Date2019-03-18
Genome-wide qPCR with increased primer multiplexity for diagnostics and drug screeningCU23284A qPCR platform using optically barcoded beads enables genome-wide multiplex expression analysis (100–10,000 targets) faster and cheaper.TagsAcidChain reactionHigh-throughput screeningInventorsNaixin QianWei MinZhilun ZhaoManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-10-16
Optical super-multiplexing for molecule detection and live-cell imagingCU17371Optical materials enable super-multiplexed imaging and Raman-based barcoding for high-throughput, live-cell molecular detection.TagsChemical libraryDyeFluorescenceInventorsFanghao HuWei MinManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2023-10-20CollectionsMedical Device
Organic material for high-performance and rapidly-charging pseudocapacitorsCU20174Organic dye-based pseudocapacitor combines PDI and HATN for high-capacitance, fast-charging energy storage with low cost.TagsCapacitorComposite materialDyeInventorsColin NuckollsJake Carter RussellSamuel Robert PeurifoyManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2021-01-15
Stimulated Raman fluorescence for enhanced biological imagingCU19260Stimulated Raman coupled fluorescence enables all-field, single-molecule imaging with high chemical specificity and sensitivity.TagsBiophysicsConfocal microscopyFluorescence spectroscopyInventorsHanqing XiongLixue ShiLu WeiManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2020-10-29
Organic semiconductor materials for improving solar cell performanceCU14323Perylene diimide nanoribbons boost organic solar cell efficiency by precise fusion, enabling cheaper, flexible, scalable photovoltaic devices.TagsElectroluminescenceEnergyOLEDInventorsBharat KumarChang-Yong NamColin NuckollsManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2016-08-26
Fluorescent substrates for imaging neurotransmissionM06-109Fluorescent false neurotransmitters enable high-resolution, single-synapse imaging of monoamine release and VMAT2 activity.TagsAssayAttention deficit hyperactivity disorderBipolar disorderInventorsDalibor SamesDavid Sulzer Ph.D.Niko GubernatorManagerJerry KokoshkaDepartmentsChemistryPsychiatryDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2006-06-15
Scalable intercellular signaling language for yeastCU18278A scalable GPCR/peptide intercellular language enabling long-range, switchable, high-order yeast signaling networks for multicellular computation.TagsBiotechnologyCell signalingDrug developmentInventorsJames Ronald BrisboisJef BoekeMiguel JimenezManagerJoan MartinezDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2026-02-14
Cyclopropenimines for enhanced carbon capture and upcyclingCU22050Cyclopropenimines enable rapid, room-temperature CO2 capture and upcycling into organic products, usable in aqueous or organic systems.TagsCarbonCarbon capture and storageCarbon dioxideInventorsBenjamin WunschDaniel MalinowskiDino WuManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesTJ Watson Research CenterRelease Date2023-03-30
High-throughput metabolic profiling at single-cell resolutionCU19155High-throughput, single-cell metabolic profiling using multiplexed vibrational probes; rapid, scalable drug screening with low prep cost.TagsHigh-throughput screeningMetabolismMultiplexingInventorsWei MinZhilun ZhaoManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2021-03-16CollectionsPlatform/Research ToolDigital Health (Software, AI, bioinformatics, etc)
Non-viral gene delivery agentsCU16329Non-viral, cyclopropenium-based polymer transfection agents enable stable, low-toxicity DNA delivery across cell membranes.TagsCarbonDrug deliveryGene expressionInventorsJessica L. FreyerLuis CamposSpencer Daniel BrucksManagerCynthia LangDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2018-02-23
Cancer treatment for Tumor Cells Using RSL3M10-018RAS-selective-lethal compound RSL3 induces rapid, nonapoptotic death in HRAS-mutant tumor cells; promising targeted cancer therapy.TagsCarcinogenesisDrug discoveryMutationInventorsBrent StockwellRohitha SriRamaratnamManagerJoan MartinezDepartmentsChemistryBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2009-12-22
Near IR light photocatalyst for spatiotemporally controlled polymerizationCU21095Near-infrared light-driven ROMP catalyst enables precise, spillover-free, spatiotemporal polymerization with barrier penetration.TagsAgrochemicalBiopharmaceuticalCatalysisInventorsDavid CabaneroTomislav RovisManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2020-10-11
Easy-to-integrate thin-films with tunable optical, electrical, and thermal propertiesCU19396Solution-processable, atomically precise superatomic thin-films enabling high conductivity, ultra-low thermal losses, and device integration.TagsElectrical resistivity and conductivityNanoscopic scaleThermal conductivityInventorsAlexander D. ChristodoulidesAmirali Zangiabadi Ph.D.Boyuan ZhangManagerGreg MaskelDepartmentsChemistryCenter for Integrated Science & Engineering (CISE)Electrical EngineeringDivisionsFaculty of the Arts & SciencesFAS & SEASFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-07-21
Quantum dot surface treatments for enhancing photoluminescent quantum yieldCU22169Non-toxic organofluorine surface treatment boosts photoluminescent quantum yield of III-V quantum dots, enabling safer, scalable passivation.TagsOptoelectronicsOrganofluorine chemistryPassivation (chemistry)InventorsAbraham J. JordanJonathan S. OwenManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2023-01-31
Near infrared light-controlled olefin metathesis for polymer patterning and 3D printingCU22045Near-infrared, low-energy olefin metathesis enables deep, high-resolution 3D polymer printing with latent catalysts.Tags3D printingEnergyGelInventorsDavid CabaneroTomislav RovisManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2022-10-14
Strategy to attack SARS-CoV-2 and other coronavirusesCU20241Nucleotide-analogue viral inhibitors target coronavirus polymerases, offering selective, mutation-resistant, broad-spectrum COVID-19 therapies.TagsCoronavirusDNA sequencingNucleotideInventorsJames J. RussoJingyue JuShiv KumarManagerCynthia LangDepartmentsChemistryChemical Engineering/Applied ChemistryGenome CenterDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering andFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-01-31CollectionsSmall Molecule
Whole methylome sequencing at the single molecule levelCU16353Single-molecule, targeted methylome sequencing detects methylation types with high sensitivity, enabling precise epigenetic profiling and diagnostics.TagsChemistryDNA methylationEpigeneticsInventorsJames J. RussoJingyue JuSteffen JockuschManagerCynthia LangDepartmentsChemistryChemical Engineering/Applied ChemistryGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesFu Foundation School of Engineering andRelease Date2020-12-24
Organic materials for enhanced intramolecular singlet fissionCU15145Organic molecules enabling intramolecular singlet fission for high-yield, solution-processable solar energy conversion and devices.TagsEnergy conversion efficiencyInorganic compoundIntramolecular reactionInventorsLuis CamposMatthew Y. SfeirMichael SteigerwaldManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2018-04-02
Mitragynine analogs for pain and psychiatric disordersCU18415Synthetically tuned mitragynine analogs target opioid receptors for pain, depression, anxiety, and substance-use disorders with varied efficacy.TagsActive metaboliteAgonistAnalgesicInventorsAndrew KruegelDalibor SamesJonathan JavitchManagerJerry KokoshkaDepartmentsChemistryPsychiatryDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2018-06-19
Controllable protocol for ring-opening metathesis polymerization using visible lightCU18314A light-activated, visible-light photocatalyst enables on-demand initiation and termination of ROMP, enabling precise polymer control.TagsBiological specificityCatalysisChemical speciesInventorsCedric TheunissenTomislav RovisManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2023-08-07
Vibrational probes for metabolic imaging in live cells and organismsCU19023Vibrational IR probes enable non-destructive, real-time metabolic imaging in live cells and whole organisms at subcellular resolution.TagsAmino acidBrainCarbohydrate metabolismInventorsLingyan ShiWei MinManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2019-11-15CollectionsOncologyPlatform/Research ToolCardiovascular
Cyclopropenium polymer particles for improved gene deliveryCU15012Cyclopropenium polymer particles enable non-viral, pH-stable, modular, low-toxicity gene/drug delivery with targeted loading.TagsAntimicrobialBiomoleculeCytotoxicityInventorsJessica L. FreyerKathryn Louise KillopsLuis CamposManagerCynthia LangDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2018-04-02
Raman super-multiplexed cell and tissue imaging with tunable carbon atom wiresCU13332Ultra-bright Raman polyyne probes enable 20+ color, time-resolved, non-toxic multiplexed imaging of cells/tissues at organelle and molecular levels.TagsAlkyneAntigenAssayInventorsLu WeiWei MinManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2014-07-09
Inhibiting Insulin-Like Growth Decreases Cancer Cell Growth, Improves Chemotherapy Results2319IGF1R inhibitors like picropodophyllin slow cancer growth and boost chemotherapy efficacy; offers oral, cost-effective, targeted therapy.TagsAnimal testingBiological half-lifeBreast cancerInventorsApostolos KlinakisArgiris Efstratiadis M.D.David BerkowitzManagerJerry KokoshkaDepartmentsChemistryGenetics & DevelopmentPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2010-09-07
Single nucleotide polymorphism and short tandem repeat detection using carbon nanotubesM08-098Carbon nanotube–based DNA conductivity detects SNPs and STRs, enabling rapid, affordable genotyping for personalized medicine.TagsAdverse drug reactionCarbon nanotubeGene expressionInventorsAlon A. GorodetskyColin NuckollsJacqueline K. BartonManagerGreg MaskelDepartmentsChemistryMechanical EngineeringDivisionsBeckman Institute (139-74)Faculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2015-02-28
Conversion of carbon dioxide to formaldehyde via a bis(silyl)acetalCU19282CO2 to formaldehyde at room temperature via bis(silyl)acetal catalyst, enabling formaldehyde surrogates and isotopic labeling.TagsAcetalCarbon capture and storageCarbon dioxideInventorsGerard ParkinMichael RauchZack StraterManagerBeth KaudererDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2020-09-01
DNA sequencing by synthesis with nucleotide analogues and Raman detectionCU16261Fluorophore-free DNA sequencing by synthesis using nucleotide analogues and Raman detection for cost-effective, high-throughput reads.TagsBiologyDNA sequencingFluorophoreInventorsIrina MorozovaJames J. RussoJingyue JuManagerCynthia LangDepartmentsChemistryBiomedical InformaticsChemical Engineering/Applied ChemistryDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering andFu Foundation School of Engineering and Applied Science (SEAS)Release Date2016-03-28
Sulfur precursors for nanostructured materialsCU13315Low-cost, air-stable sulfur thiourea precursors enable tunable, uniform cadmium/lead sulfide nanocrystals for LEDs, bioimaging, and solar cells.TagsCadmiumCadmium sulfideChalcogenideInventorsJonathan OwenMark HendricksMichael P. CamposManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2014-08-25
Modular yeast biosensor for rapid pathogen detectionCU15035Modular yeast biosensor detects pathogens with visible red readout, enabling rapid, low-tech diagnostics in resource-poor settings.TagsBacteriaBiological warfareBiomarkerInventorsMiguel JimenezNili Ostrov Ph.D.Sonja BillerbeckManagerJoan MartinezDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2017-12-28
Highly tunable hybrid organic-inorganic materials for electronic devicesCU12234Hybrid organic-inorganic, solution-processed materials enable low-cost, highly tunable semiconductors for flexible electronics and displays.TagsInorganic compoundPhotovoltaicsSemiconductorInventorsChulho LeeColin NuckollsMichael SteigerwaldManagerGreg MaskelDepartmentsChemistryPhysicsDivisionsFaculty of the Arts & SciencesRelease Date2016-07-21
Ionic cyclopropenium cation-based materials with tunable propertiesCU12180Chiral, tunable CPC-based polymers enable versatile, ambient-synthesis ionic materials for coatings, membranes, drug delivery, and biotech substrates.TagsAntimicrobialBiofoulingCross-linkInventorsEmma Jane DellJeffrey BandarLuis CamposManagerCynthia LangDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2015-03-10
Specialty polymers for solar energyCU14235Polymer-based singlet fission boosts solar efficiency beyond 33% to potentially 44%, enabling low-cost, scalable photovoltaics.TagsCharge-transfer complexEnergyEnergy conversion efficiencyInventorsErik Michael Allan BusbyJianlong XiaLuis CamposManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2015-03-23
Small-molecule drugs for targeted cancer therapyM10-018-aSmall-molecule, RAS-selective cancer therapeutics inducing nonapoptotic death in RAS-driven tumors; improves precision, reduces toxicity.TagsApoptosisCarcinogenesisDrug discoveryInventorsBrent StockwellRohitha SriRamaratnamWan Seok YangManagerJoan MartinezDepartmentsChemistryBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2018-08-30
Fluorescent False Neurotransmitters capable of measuring pH of secretory vesicles for neuroscience researchM10-047pH-responsive fluorescent false neurotransmitters enable non-toxic, photostable, transfection-free vesicle pH imaging for neuroscience.TagsDopamineFluorescence microscopeHigh-throughput screeningInventorsDalibor SamesDavid Sulzer Ph.D.Minhee LeeManagerJerry KokoshkaDepartmentsChemistryPsychiatryDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2014-08-25
