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Chemistry
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Safer ibogaine analogs for the treatment of substance use disorders
CU24362
Safer oxa-ibogaine analogs reduce cardiac risk while retaining ibogaine’s anti-addiction effects and therapeutic potential.
Tags
Alkaloid
Analgesic
Arrhythmia
Inventors
Dalibor Sames
David Lankri
Vaclav Havel
Manager
Jerry Kokoshka
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2025-03-12
Collections
CNS/Neurology
Small molecule activators for preventing vision loss in Best vitelliform macular dystrophy
CU25176
Small molecule activators restore Best1 function to slow BVMD vision loss; targeted, potentially non-invasive retinal therapy.
Tags
4-Aminobenzoic acid
Drug development
Gene therapy
Inventors
Bingchen Yu
Tingting Yang
Yu Zhang
Manager
Joan Martinez
Departments
Chemistry
Ophthalmology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-05-01
Collections
Ophthalmology
Live yeast biosensors for pathogen detection
CU21127
Engineered live yeast biosensors emit color/fluorescent signals for rapid, sensitive pathogen detection, including fungi, viruses, and variants.
Tags
Antifungal
Antiviral drug
Assay
Inventors
Virginia W. Cornish
Manager
Joan Martinez
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2025-03-07
Synthesis of nitrogen isotopologues for pharmaceutical research
CU23020
One-pot, cost-effective synthesis to replace nitrogen with heavy 15N isotopologue for tracking in pharma, agriculture, and environments.
Tags
Bioavailability
Drug development
Environmental monitoring
Inventors
Julia Dorsheimer
Tomislav Rovis
Manager
Greg Maskel
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2023-08-04
Rapid, highly sensitive multiplexed viral detection with nanopores
CU21160
Ultrafast, amplification-free nanopore-based single-molecule assay for multiplexed viral detection (SARS-CoV-2) and antibodies.
Tags
Antibody
Antigen
Assay
Inventors
Chuanjuan Tao
James J. Russo
Jingyue Ju
Manager
Cynthia Lang
Departments
Chemistry
Chemical Engineering/Applied Chemistry
Genome Center
Divisions
Faculty of the Arts & Sciences
Fu Foundation School of Engineering and
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-07-20
Fluorescent substrates for imaging neurotransmission
M06-109-a
Fluorescent false neurotransmitters visualize dopamine vesicle content and release at single-synapse resolution for imaging and drug discovery.
Tags
Assay
Attention deficit hyperactivity disorder
Bipolar disorder
Inventors
Dalibor Sames
David Sulzer Ph.D.
Niko Gubernator
Manager
Jerry Kokoshka
Departments
Chemistry
Psychiatry
Divisions
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2018-11-13
Evolved CRISPR-associated transposase systems for genome engineering
CU19096
RNA-guided CRISPR-transposase enables kilobase-scale, precise DNA insertions in human cells without double-strand breaks or homologous repair.
Tags
CRISPR
Fibroblast
Genetically modified animal
Inventors
Samuel H. Sternberg
Sanne Klompe
Manager
Cynthia Lang
Departments
Chemistry
Biochemistry & Molecular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2025-12-18
Collections
Genomics & Multi-Omics
Solar-powered mechanical motion of crystals
CU22086
Solar-energy–driven crystals autonomously roll under visible light; fatigue-free, customizable, scalable for microdevices and soft robots.
Tags
Energy harvesting
Fatigue (material)
Laser cutting
Inventors
Amymarie K. Bartholomew
Ilana B. Stone
Michael Steigerwald
Manager
Greg Maskel
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2022-10-14
High-yield production of macroscopic 2D materials
CU20156
Ultra-flat gold tape enables scalable, high-yield production of macroscopic 2D materials for electronics and quantum tech.
Tags
Graphene
Metal
Monolayer
Inventors
Fang Liu
James Hone
Jue Wang
Manager
Dovina Qu
Departments
Chemistry
Mechanical Engineering
Divisions
Faculty of the Arts & Sciences
Fu Foundation School of Engineering and
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2020-05-13
Psychedelic based treatment for Parkinson’s disease and other psychiatric disorders
CU23079
Non-hallucinogenic 5-HT2A agonist Ariadne targets Parkinson’s and psychiatric disorders, offering safer, broader therapeutic potential.
Tags
5-HT2A receptor
Agonist
Bipolar disorder
Inventors
Dalibor Sames
Michael J. Cunningham
Manager
Jerry Kokoshka
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2023-11-03
Collections
Small Molecule
CNS/Neurology
Chemical painting for high-throughput single-cell drug response analysis
CU23332
Multiplexed infrared imaging enables high-throughput, single-cell drug profiling with ML-enabled mechanism-of-action predictions.
Tags
Combination therapy
DNA sequencing
Drug discovery
Inventors
Wei Min
Xinwen Liu
Manager
Dovina Qu
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2025-10-16
GPX4 inhibitors for cancer therapy
CU20261
Potent, selective GPX4 inhibitors induce ferroptosis to target EMT-driven, drug-resistant cancers and enable GPX4 research.
Tags
Active site
Allosteric regulation
Apoptosis
Inventors
Brent Stockwell
Hengrui Liu
Manager
Joan Martinez
Departments
Chemistry
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2025-05-01
Photocatalysis method with low-energy light
CU18169
Photon upconversion enables infrared-driven, safer photocatalysis with deeper penetration for pharma, biomedicine, and materials.
Tags
Antimicrobial
Biomedicine
Catalysis
Inventors
Andrew B. Pun
Benjamin Ravetz
Daniel N. Congreve
Manager
Greg Maskel
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Massachusetts Eye and Ear Infirmary
Release Date
2024-12-06
First-in-class organic materials for efficient multiple exciton generation
CU17103
First-in-class organic polymers enable intramolecular singlet fission with 170–200% triplet yield, boosting solar efficiency and tunability.
Tags
Aromaticity
Carrier generation and recombination
Charge-transfer complex
Inventors
Andrew B. Pun
Elango Kumarasamy
Luis Campos
Manager
Greg Maskel
Departments
Chemistry
Divisions
Center for Functional Nanomaterials
Faculty of the Arts & Sciences
Release Date
2019-03-18
Genome-wide qPCR with increased primer multiplexity for diagnostics and drug screening
CU23284
A qPCR platform using optically barcoded beads enables genome-wide multiplex expression analysis (100–10,000 targets) faster and cheaper.
Tags
Acid
Chain reaction
High-throughput screening
Inventors
Naixin Qian
Wei Min
Zhilun Zhao
Manager
Dovina Qu
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2025-10-16
Optical super-multiplexing for molecule detection and live-cell imaging
CU17371
Optical materials enable super-multiplexed imaging and Raman-based barcoding for high-throughput, live-cell molecular detection.
Tags
Chemical library
Dye
Fluorescence
Inventors
Fanghao Hu
Wei Min
Manager
Dovina Qu
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2023-10-20
Collections
Medical Device
Organic material for high-performance and rapidly-charging pseudocapacitors
CU20174
Organic dye-based pseudocapacitor combines PDI and HATN for high-capacitance, fast-charging energy storage with low cost.
Tags
Capacitor
Composite material
Dye
Inventors
Colin Nuckolls
Jake Carter Russell
Samuel Robert Peurifoy
Manager
Greg Maskel
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2021-01-15
Stimulated Raman fluorescence for enhanced biological imaging
CU19260
Stimulated Raman coupled fluorescence enables all-field, single-molecule imaging with high chemical specificity and sensitivity.
Tags
Biophysics
Confocal microscopy
Fluorescence spectroscopy
Inventors
Hanqing Xiong
Lixue Shi
Lu Wei
Manager
Dovina Qu
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2020-10-29
Organic semiconductor materials for improving solar cell performance
CU14323
Perylene diimide nanoribbons boost organic solar cell efficiency by precise fusion, enabling cheaper, flexible, scalable photovoltaic devices.
Tags
Electroluminescence
Energy
OLED
Inventors
Bharat Kumar
Chang-Yong Nam
Colin Nuckolls
Manager
Greg Maskel
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2016-08-26
Fluorescent substrates for imaging neurotransmission
M06-109
Fluorescent false neurotransmitters enable high-resolution, single-synapse imaging of monoamine release and VMAT2 activity.
Tags
Assay
Attention deficit hyperactivity disorder
Bipolar disorder
Inventors
Dalibor Sames
David Sulzer Ph.D.
Niko Gubernator
Manager
Jerry Kokoshka
Departments
Chemistry
Psychiatry
Divisions
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2006-06-15
Scalable intercellular signaling language for yeast
CU18278
A scalable GPCR/peptide intercellular language enabling long-range, switchable, high-order yeast signaling networks for multicellular computation.
Tags
Biotechnology
Cell signaling
Drug development
Inventors
James Ronald Brisbois
Jef Boeke
Miguel Jimenez
Manager
Joan Martinez
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2026-02-14
Cyclopropenimines for enhanced carbon capture and upcycling
CU22050
Cyclopropenimines enable rapid, room-temperature CO2 capture and upcycling into organic products, usable in aqueous or organic systems.
Tags
Carbon
Carbon capture and storage
Carbon dioxide
Inventors
Benjamin Wunsch
Daniel Malinowski
Dino Wu
Manager
Greg Maskel
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
TJ Watson Research Center
Release Date
2023-03-30
High-throughput metabolic profiling at single-cell resolution
CU19155
High-throughput, single-cell metabolic profiling using multiplexed vibrational probes; rapid, scalable drug screening with low prep cost.
Tags
High-throughput screening
Metabolism
Multiplexing
Inventors
Wei Min
Zhilun Zhao
Manager
Dovina Qu
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2021-03-16
Collections
Platform/Research Tool
Digital Health (Software, AI, bioinformatics, etc)
Non-viral gene delivery agents
CU16329
Non-viral, cyclopropenium-based polymer transfection agents enable stable, low-toxicity DNA delivery across cell membranes.
Tags
Carbon
Drug delivery
Gene expression
Inventors
Jessica L. Freyer
Luis Campos
Spencer Daniel Brucks
Manager
Cynthia Lang
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2018-02-23
Cancer treatment for Tumor Cells Using RSL3
M10-018
RAS-selective-lethal compound RSL3 induces rapid, nonapoptotic death in HRAS-mutant tumor cells; promising targeted cancer therapy.
Tags
Carcinogenesis
Drug discovery
Mutation
Inventors
Brent Stockwell
Rohitha SriRamaratnam
Manager
Joan Martinez
Departments
Chemistry
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2009-12-22
Near IR light photocatalyst for spatiotemporally controlled polymerization
CU21095
Near-infrared light-driven ROMP catalyst enables precise, spillover-free, spatiotemporal polymerization with barrier penetration.
Tags
Agrochemical
Biopharmaceutical
Catalysis
Inventors
David Cabanero
Tomislav Rovis
Manager
Greg Maskel
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2020-10-11
Easy-to-integrate thin-films with tunable optical, electrical, and thermal properties
CU19396
Solution-processable, atomically precise superatomic thin-films enabling high conductivity, ultra-low thermal losses, and device integration.
Tags
Electrical resistivity and conductivity
Nanoscopic scale
Thermal conductivity
Inventors
Alexander D. Christodoulides
Amirali Zangiabadi Ph.D.
Boyuan Zhang
Manager
Greg Maskel
Departments
Chemistry
Center for Integrated Science & Engineering (CISE)
Electrical Engineering
Divisions
Faculty of the Arts & Sciences
FAS & SEAS
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2020-07-21
Quantum dot surface treatments for enhancing photoluminescent quantum yield
CU22169
Non-toxic organofluorine surface treatment boosts photoluminescent quantum yield of III-V quantum dots, enabling safer, scalable passivation.
Tags
Optoelectronics
Organofluorine chemistry
Passivation (chemistry)
Inventors
Abraham J. Jordan
Jonathan S. Owen
Manager
Greg Maskel
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2023-01-31
Near infrared light-controlled olefin metathesis for polymer patterning and 3D printing
CU22045
Near-infrared, low-energy olefin metathesis enables deep, high-resolution 3D polymer printing with latent catalysts.
Tags
3D printing
Energy
Gel
Inventors
David Cabanero
Tomislav Rovis
Manager
Greg Maskel
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2022-10-14
Strategy to attack SARS-CoV-2 and other coronaviruses
CU20241
Nucleotide-analogue viral inhibitors target coronavirus polymerases, offering selective, mutation-resistant, broad-spectrum COVID-19 therapies.
Tags
Coronavirus
DNA sequencing
Nucleotide
Inventors
James J. Russo
Jingyue Ju
Shiv Kumar
Manager
Cynthia Lang
Departments
Chemistry
Chemical Engineering/Applied Chemistry
Genome Center
Divisions
Faculty of the Arts & Sciences
Fu Foundation School of Engineering and
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2020-01-31
Collections
Small Molecule
Whole methylome sequencing at the single molecule level
CU16353
Single-molecule, targeted methylome sequencing detects methylation types with high sensitivity, enabling precise epigenetic profiling and diagnostics.
Tags
Chemistry
DNA methylation
Epigenetics
Inventors
James J. Russo
Jingyue Ju
Steffen Jockusch
Manager
Cynthia Lang
Departments
Chemistry
Chemical Engineering/Applied Chemistry
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Fu Foundation School of Engineering and
Release Date
2020-12-24
Organic materials for enhanced intramolecular singlet fission
CU15145
Organic molecules enabling intramolecular singlet fission for high-yield, solution-processable solar energy conversion and devices.
Tags
Energy conversion efficiency
Inorganic compound
Intramolecular reaction
Inventors
Luis Campos
Matthew Y. Sfeir
Michael Steigerwald
Manager
Greg Maskel
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2018-04-02
Mitragynine analogs for pain and psychiatric disorders
CU18415
Synthetically tuned mitragynine analogs target opioid receptors for pain, depression, anxiety, and substance-use disorders with varied efficacy.
Tags
Active metabolite
Agonist
Analgesic
Inventors
Andrew Kruegel
Dalibor Sames
Jonathan Javitch
Manager
Jerry Kokoshka
Departments
Chemistry
Psychiatry
Divisions
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2018-06-19
Controllable protocol for ring-opening metathesis polymerization using visible light
CU18314
A light-activated, visible-light photocatalyst enables on-demand initiation and termination of ROMP, enabling precise polymer control.
Tags
Biological specificity
Catalysis
Chemical species
Inventors
Cedric Theunissen
Tomislav Rovis
Manager
Greg Maskel
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2023-08-07
Vibrational probes for metabolic imaging in live cells and organisms
CU19023
Vibrational IR probes enable non-destructive, real-time metabolic imaging in live cells and whole organisms at subcellular resolution.
Tags
Amino acid
Brain
Carbohydrate metabolism
Inventors
Lingyan Shi
Wei Min
Manager
Dovina Qu
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2019-11-15
Collections
Oncology
Platform/Research Tool
Cardiovascular
Cyclopropenium polymer particles for improved gene delivery
CU15012
Cyclopropenium polymer particles enable non-viral, pH-stable, modular, low-toxicity gene/drug delivery with targeted loading.
Tags
Antimicrobial
Biomolecule
Cytotoxicity
Inventors
Jessica L. Freyer
Kathryn Louise Killops
Luis Campos
Manager
Cynthia Lang
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2018-04-02
Raman super-multiplexed cell and tissue imaging with tunable carbon atom wires
CU13332
Ultra-bright Raman polyyne probes enable 20+ color, time-resolved, non-toxic multiplexed imaging of cells/tissues at organelle and molecular levels.
Tags
Alkyne
Antigen
Assay
Inventors
Lu Wei
Wei Min
Manager
Dovina Qu
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2014-07-09
Inhibiting Insulin-Like Growth Decreases Cancer Cell Growth, Improves Chemotherapy Results
2319
IGF1R inhibitors like picropodophyllin slow cancer growth and boost chemotherapy efficacy; offers oral, cost-effective, targeted therapy.
Tags
Animal testing
Biological half-life
Breast cancer
Inventors
Apostolos Klinakis
Argiris Efstratiadis M.D.
David Berkowitz
Manager
Jerry Kokoshka
Departments
Chemistry
Genetics & Development
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2010-09-07
Single nucleotide polymorphism and short tandem repeat detection using carbon nanotubes
M08-098
Carbon nanotube–based DNA conductivity detects SNPs and STRs, enabling rapid, affordable genotyping for personalized medicine.
Tags
Adverse drug reaction
Carbon nanotube
Gene expression
Inventors
Alon A. Gorodetsky
Colin Nuckolls
Jacqueline K. Barton
Manager
Greg Maskel
Departments
Chemistry
Mechanical Engineering
Divisions
Beckman Institute (139-74)
Faculty of the Arts & Sciences
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2015-02-28
Conversion of carbon dioxide to formaldehyde via a bis(silyl)acetal
CU19282
CO2 to formaldehyde at room temperature via bis(silyl)acetal catalyst, enabling formaldehyde surrogates and isotopic labeling.
Tags
Acetal
Carbon capture and storage
Carbon dioxide
Inventors
Gerard Parkin
Michael Rauch
Zack Strater
Manager
Beth Kauderer
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2020-09-01
DNA sequencing by synthesis with nucleotide analogues and Raman detection
CU16261
Fluorophore-free DNA sequencing by synthesis using nucleotide analogues and Raman detection for cost-effective, high-throughput reads.
Tags
Biology
DNA sequencing
Fluorophore
Inventors
Irina Morozova
James J. Russo
Jingyue Ju
Manager
Cynthia Lang
Departments
Chemistry
Biomedical Informatics
Chemical Engineering/Applied Chemistry
Divisions
Faculty of the Arts & Sciences
Fu Foundation School of Engineering and
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2016-03-28
Sulfur precursors for nanostructured materials
CU13315
Low-cost, air-stable sulfur thiourea precursors enable tunable, uniform cadmium/lead sulfide nanocrystals for LEDs, bioimaging, and solar cells.
Tags
Cadmium
Cadmium sulfide
Chalcogenide
Inventors
Jonathan Owen
Mark Hendricks
Michael P. Campos
Manager
Greg Maskel
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2014-08-25
Modular yeast biosensor for rapid pathogen detection
CU15035
Modular yeast biosensor detects pathogens with visible red readout, enabling rapid, low-tech diagnostics in resource-poor settings.
Tags
Bacteria
Biological warfare
Biomarker
Inventors
Miguel Jimenez
Nili Ostrov Ph.D.
Sonja Billerbeck
Manager
Joan Martinez
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2017-12-28
Highly tunable hybrid organic-inorganic materials for electronic devices
CU12234
Hybrid organic-inorganic, solution-processed materials enable low-cost, highly tunable semiconductors for flexible electronics and displays.
Tags
Inorganic compound
Photovoltaics
Semiconductor
Inventors
Chulho Lee
Colin Nuckolls
Michael Steigerwald
Manager
Greg Maskel
Departments
Chemistry
Physics
Divisions
Faculty of the Arts & Sciences
Release Date
2016-07-21
Ionic cyclopropenium cation-based materials with tunable properties
CU12180
Chiral, tunable CPC-based polymers enable versatile, ambient-synthesis ionic materials for coatings, membranes, drug delivery, and biotech substrates.
Tags
Antimicrobial
Biofouling
Cross-link
Inventors
Emma Jane Dell
Jeffrey Bandar
Luis Campos
Manager
Cynthia Lang
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2015-03-10
Specialty polymers for solar energy
CU14235
Polymer-based singlet fission boosts solar efficiency beyond 33% to potentially 44%, enabling low-cost, scalable photovoltaics.
Tags
Charge-transfer complex
Energy
Energy conversion efficiency
Inventors
Erik Michael Allan Busby
Jianlong Xia
Luis Campos
Manager
Greg Maskel
Departments
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2015-03-23
Small-molecule drugs for targeted cancer therapy
M10-018-a
Small-molecule, RAS-selective cancer therapeutics inducing nonapoptotic death in RAS-driven tumors; improves precision, reduces toxicity.
Tags
Apoptosis
Carcinogenesis
Drug discovery
Inventors
Brent Stockwell
Rohitha SriRamaratnam
Wan Seok Yang
Manager
Joan Martinez
Departments
Chemistry
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2018-08-30
Fluorescent False Neurotransmitters capable of measuring pH of secretory vesicles for neuroscience research
M10-047
pH-responsive fluorescent false neurotransmitters enable non-toxic, photostable, transfection-free vesicle pH imaging for neuroscience.
Tags
Dopamine
Fluorescence microscope
High-throughput screening
Inventors
Dalibor Sames
David Sulzer Ph.D.
Minhee Lee
Manager
Jerry Kokoshka
Departments
Chemistry
Psychiatry
Divisions
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2014-08-25
