NAPA-ID: a proximity-based system to decode protein-protein interactionsCU26166NAPA-ID enables antibody-guided, proximity labeling of protein interactions without genetic editing, compatible with standard proteomics workflows.TagsProteinAntibodyBiological engineeringInventorsJeremy CartalasSara ZaccaraManagerJerry KokoshkaDepartmentsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-17
Protein fragment to promote neurogenesisCU13345Dominant-negative ATF5 fragment drives differentiation of neuroprogenitors into mature neurons and glial cells, enabling brain regeneration research.TagsProteinAstrocyteCellular differentiationInventorsJames M. AngelastroLloyd Greene PhDManagerJerry KokoshkaDepartmentsMolecular BiosciencesPathologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-13
Inhibitory peptides targeting SARS-CoV-2 envelope proteinCU21015Inhibitory peptides block SARS-CoV-2 envelope protein, aiming for broad coronavirus protection by disrupting viral assembly and replication.TagsProteinCombination therapyGene therapyInventorsKazushige YoshidaMasayuki Yazawa Ph.D.Ramsey BekdashManagerKristin NeumanDepartmentsRehabilitation & Regenerative MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-10-03
Chimeric protein for directly modulating calcium ion channel activityCU23388Genetically encoded enhancer boosts L-type Ca2+ currents with tissue targeting, rescuing dysfunctional calcium channels.TagsProteinActuatorAntiarrhythmic agentInventorsManu Ben-JohnyPedro Javier del Rivero MorfinManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05CollectionsCardiovascular
High-throughput single-cell multi-omics platform for integrated RNA, DNA, and protein analysisCU21072Integrated single-cell platform enabling high-throughput RNA, DNA, and protein profiling for holistic cellular insights and scalable studies.TagsProteinBiomarkerCell nucleusInventorsPeter A. SimsTimothy R. OlsenManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-02CollectionsGenomics & Multi-Omics
Engineered cell line for inducible protein expression for single-molecule imagingCU24352Inducible CHO cell line enables single-molecule GPCR interaction tracking in live cells with high-resolution smFRET.TagsProteinCell membraneCell signalingInventorsJonathan JavitchWesley AsherManagerJerry KokoshkaDepartmentsPsychiatryDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05
Bacterial strain for improved protein productionCU15280Engineered BL21(DE3) E. coli strain boosts protein yield, enabling reliable production of unstable proteins for faster biotech development.TagsProteinCell cultureEscherichia coliInventorsMaxwell E. GottesmanManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-17
Recombinant protein to treat inflammationCU23248Recombinant FSTL-1 protein targets and reduces cardiac inflammation, aiding Kawasaki disease research and myocarditis treatment.TagsProteinAnti-inflammatoryAtherosclerosisInventorsMark GorelikManagerSara GusikDepartmentsPediatrics/RheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-10CollectionsCardiovascular
Human ALFY knock-in mice for studying neurodegenerative diseaseCU26143Human ALFY knock-in mice enable tissue-specific, controllable hALFY expression to study neurodegenerative protein aggregation.TagsProteinAutophagyCopy number variationInventorsAi YamamotoManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08CollectionsCNS/Neurology
Therapeutic antibodies against amyloid aggregatesCU23354Antibody platform targets TMEM106B amyloid aggregates for diagnosis, therapeutics, and research across neurodegenerative diseases.TagsProteinAmyloid betaAntibodyInventorsAnthony William Paul FitzpatrickCarolyn LeeJunqiang Ye Ph.D.ManagerKristin NeumanDepartmentsBiochemistryBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-26
Platform to identify causal proteins in Alzheimer's for drug discoveryCU25371Integrated Mendelian-randomization and AlphaFold3 pipeline identifies causal Alzheimer's proteins to guide drug targets and diagnostics.TagsProteinAssayCausalityInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-07-31
Method for generating biodegradable textiles with vivid color and enhanced performanceCU20256Biodegradable, dye-free protein fibers with inherent color and UV properties; sustainable, low-water/energy use, compostable textiles.TagsProteinBiodegradationBiomaterialInventorsAllie ObermeyerChui Lian LeeHelen LuManagerDovina QuDepartmentsBiomedical EngineeringCenter for Integrated Science & Engineering (CISE)Chemical Engineering/Applied ChemistryDivisionsFAS & SEASFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-07-28
Conditional depletion of WDFY3 in murine models of diseaseCU26144Engineered mouse with conditional WDFY3 knockout to study autophagy, mitophagy, efferocytosis, and neurodegenerative disease mechanisms.TagsProteinAmino acidAutism spectrumInventorsAi YamamotoManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08CollectionsCNS/Neurology
Chimeric CRISPR-associated transposon system for RNA-mediated DNA integrationCU24119Chimeric CAST enables efficient, RNA-guided DNA insertion without breaks, combining components for larger cargo in cells.TagsProteinCoevolutionDNA repairInventorsGeorge Davis LampeSamuel H. SternbergManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-09CollectionsGenomics & Multi-Omics
Improved specificity of CRISPR-associated transposon (CAST) systemsCU24013Engineered CAST systems boost on-target DNA insertion accuracy, reducing off-target events for RNA-guided, large‑payload genome integration.TagsProteinBiopharmaceuticalCRISPRInventorsJerrin Thomas GeorgeSamuel H. SternbergManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-09CollectionsGenomics & Multi-Omics
Compact RNA-guided DNA targeting, cleavage, and transcriptional activationCU23100Compact RNA-guided DNA targeting with Cas12/TnpB family enables programmable, compact gene regulation via binding, cleavage, or transcription activation.TagsProteinArtificial intelligenceEscherichia coliInventorsChance MeersSamuel H. SternbergManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-17
Biofluid preparation method for chemical analysisCU26156Three-component chromatography column enables rapid, affordable biofluid cleanup for mass spectrometry, boosting throughput and automation.TagsProteinBody fluidChromatographyInventorsMazdak M. BradberryManagerJerry KokoshkaDepartmentsPsychiatryDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-17
Selective COX-2 radioligands for PET imaging of neuroinflammationCU19254Fluorine-18 COX-2 PET radioligands enable noninvasive imaging of neuroinflammation with higher affinity and broad clinical reach.TagsProteinAgonistCOX-2 inhibitorInventorsAkiva MintzJ. John MannJ.S. Dileep KumarManagerJerry KokoshkaDepartmentsPsychiatryRadiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-12-17
Enhanced hematopoietic stem cell regenerationCU25234Partial inhibition of fatty acid metabolism boosts hematopoietic stem cell self-renewal, enhancing bone marrow transplants and regeneration.TagsProteinBone marrowFatty acidInventorsLei DingYue ZhangManagerKristin NeumanDepartmentsMicrobiologyRehabilitation & Regenerative MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-26
Targeting big potassium (BK+) channels for therapeutic treatmentCU25219A metabolically stable BK+ agonist selectively activates lysosomal channels to degrade deposits, restoring autophagy for AMD and related diseases.TagsProteinAgonistAutophagyInventorsChristopher L. CioffiKonstantin PetrukhinManagerKristin NeumanDepartmentsChemistry and Chemical BiologyOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-14
Conditional knockout mouse model for studying autosomal-dominant optic atrophyCU26140A mammalian, cell-type–specific conditional Ssbp1 R107Q mouse model to dissect autosomal-dominant optic atrophy mechanisms.TagsProteinAlleleArginineInventorsChyuan-Sheng (Victor) LinNan-Kai WangYunju TsengManagerKristin NeumanDepartmentsOphthalmologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
PDE5 inhibitor for Alzheimer's treatment2439A brain-penetrant PDE5 inhibitor enhances cGMP signaling, reduces amyloid, and supports synaptic plasticity in Alzheimer’s models.TagsProteinAmyloid betaAmyloid plaquesInventorsDonald William Landry MD, Ph.D.Ottavio Arancio MD, PhDShi-xian DengManagerJerry KokoshkaDepartmentsMedicinePathologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-18
Programmed bacteria for intracellular delivery of viral RNACU23238Engineered Salmonella delivers viral RNA inside tumor cells to initialize oncolytic virus therapy and enhanced cancer targeting.TagsProteinBacteriaCytoplasmInventorsCharles M. Rice Ph.D.Jonathan PabonTal DaninoManagerCynthia LangDepartmentsBiomedical EngineeringLaboratory of Virology and Infectious DiseaseProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-12-17
Mouse model with impaired bipolar cell function for congenital stationary night blindnessCU26066A Grm6-missense mouse model mimics human CSNB, enabling targeted gene editing studies and biomarker discovery for therapy.TagsProteinGenetic disorderGenome editingInventorsNan-Kai WangYunju TsengManagerKristin NeumanDepartmentsOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-11-07
Calibration-free affinity biosensors for rapid, accurate biomarker detectionCU22223Calibration-free graphene FET biosensor uses aptamer kinetics for rapid, device-wide reproducible biomarker detection without per-sensor calibration.TagsProteinAptamerBiomarkerInventorsMilan N. Stojanovic M.D.Qiao LinWenting DaiManagerDovina QuDepartmentsMechanical EngineeringMedicineDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-08-21
IL-6 Inhibitor for acute inflammatory disordersCU24063Synthetic peptide suppressing IL-6 production to treat acute inflammatory conditions like sepsis, endotoxin shock, and cytokine storms.TagsProteinAntibioticBiopharmaceuticalInventorsKazuya MasudaMoriya TsujiZizhang ShengManagerKristin NeumanDepartmentsAaron Diamond AIDS Research Center (ADARC)MedicineNeuroscienceDivisionsColumbia University Medical Center (CUMC)Zuckerman Mind Brain Behavior InstRelease Date2025-08-21
Adeno-associated virus Glut1 gene therapy for rescuing glucose transport in Glut1 deficiency syndromeCU15054AAV-based Glut1 gene therapy restores brain glucose transport in Glut1 deficiency, offering a one-time, long-term treatment.TagsProteinAdeno-associated virusBlood–brain barrierInventorsDarryl C. De VivoGuangping GaoKristin EngelstadManagerKristin NeumanDepartmentsNeurologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Office of Technology ManagementRelease Date2025-08-19
Serochip for the diagnosis of tick-borne diseasesCU19325A programmable peptide microarray enables rapid, high-throughput, single-step serologic diagnosis of multiple tick-borne diseases.TagsProteinAntibodyAssayInventorsAdrian CaciulaNischay MishraRafal TokarzManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2025-09-04
Targeting the RhoA signaling pathway for the treatment of Alzheimer's diseaseCU25028Targeting RhoA signaling to restore retromer-dependent endosomal trafficking, using ARHGEF12/ROCK2 inhibitors and shRNA for Alzheimer’s therapy.TagsProteinCell surface receptorCentral nervous systemInventorsGregory A. PetskoScott A. Small M.D.Yasir H. QureshiManagerJerry KokoshkaDepartmentsAnn Romney Center for Neurologic DiseasesNeurologyTaub InstituteDivisionsColumbia University Medical Center (CUMC)Harvard Medical School and Brigham & Women’s HospitalRelease Date2025-07-31
Gene therapy for metabolic dysfunction-associated steatohepatitis (MASH)CU25230Gene therapy restoring retromer activity to treat MASH by normalizing lipid metabolism and reducing fibrosis risk.TagsProteinCirrhosisDrug discoveryInventorsGregory A. PetskoScott A. Small M.D.ManagerJerry KokoshkaDepartmentsAnn Romney Center for Neurologic DiseasesNeurologyDivisionsColumbia University Medical Center (CUMC)Harvard Medical School and Brigham & Women’s HospitalRelease Date2025-07-31
Neuroproteasome-inhibiting bioconjugate for prevention of tau aggregation in Alzheimer's diseaseCU23159A neuronal proteasome-targeting bioconjugate inhibits early Tau aggregation, offering ApoE-selective, precise tauopathy intervention.TagsProteinApolipoprotein EBioconjugationInventorsKapil RamachandranManagerJerry KokoshkaDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-01
Vps26a heterozygous mice for studying the retromer core in Alzheimer's diseaseCU25396Transgenic Vps26a+/− mice model retromer function in Alzheimer’s, enabling hippocampal research and targeted therapeutic testing.TagsProteinEndosomeHippocampusInventorsScott A. Small M.D.ManagerJerry KokoshkaDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-31
Fluorescent labeling of cell surface proteins in vivo with spatiotemporal controlCU25172Fluorescently label cell-surface proteins in vivo using DogTag-DogCatcher for spatiotemporal, loop-targeted GFP tagging.TagsProteinBiopsyCell membraneInventorsKevin RostamRichard S. MannManagerJerry KokoshkaDepartmentsBiochemistry & Molecular BiophysicsBiological SciencesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2025-03-21
SUMO2 conjugation therapy for restoring cognitive function in Alzheimer's diseaseCU23265SUMO2-based biologic restores synaptic function and memory in Alzheimer's without reducing amyloid, enabling late-stage cognitive recovery.TagsProteinAdjuvant therapyAmyloid betaInventorsLuana Fioriti Ph.D.Ottavio ArancioPaul Edward FraserManagerJerry KokoshkaDepartmentsMortimer B. Zuckerman Mind Brain Behavior InstitutePathologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-06-26
Rapid, point-of-care assessment of radiation exposure in human bloodCU24211ELISA-based biodosimeter profiles blood biomarkers and uses ML to triage ionizing-radiation exposure-assessment at point-of-care.TagsProteinAssayBioassayInventorsHelen TurnerIgor ShuryakKarthik KanagarajManagerJoan MartinezDepartmentsCenter for Radiological ResearchRadiation OncologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-05-05
Monoclonal antibody for isolation of LRP1 for treatment of neurodegenerative diseasesCU25221Monoclonal antibody enables native LRP1 purification across species, boosting neurodegenerative therapy research and production.TagsProteinAffinity chromatographyChromatographyInventorsGabriele CeruttiLawrence S. Shapiro Ph.D.Susan Brenner-MortonManagerKristin NeumanDepartmentsBiochemistryBiochemistry and Molecular Biophysics / OphthalmologyMortimer B. Zuckerman Mind Brain Behavior InstituteRelease Date2025-04-24
Erastin analogs for genotype-selective ferroptosis inductionCU14068ERS: Genotype-selective ferroptosis induction using enhanced erastin analogs targeting RAS V12+ tumors for potent, soluble, stable anticancer activity.TagsProteinApoptosisFunctional groupInventorsBrent StockwellMarie-Helene LarraufieWan Seok YangManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2025-05-22
Therapeutic method to overcome basal cell carcinoma resistanceCU17185BRD7/BRD9 inhibitors restore SMO inhibitor sensitivity in drug-resistant basal cell carcinomas, enabling combo therapies.TagsProteinBasal-cell carcinomaCancerInventorsArianna Kim Ph.D.David Bickers M.D.ManagerSara GusikDepartmentsDermatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-05-08
Targeting PAG for cancer immunotherapyCU23123PAG-targeting antibodies boost T cell activation, inhibit PD-1 signaling, and reduce tumor growth, enabling monotherapy or combo immunotherapy.TagsProteinAnimal disease modelCancer immunotherapyInventorsAdam MorManagerCynthia LangDepartmentsRheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-07
Insulin mimetics for insulin resistance disordersCU22400Insulin-mimetic peptides activate mutant insulin receptors, restoring signaling and lowering glucose in resistant cases unresponsive to insulin.TagsProteinBlood sugar levelDiabetes medicationInventorsEunhee ChoiMichael StowellXiaochen BaiManagerCynthia LangDepartmentsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-24
Method for studying in-cell single-molecule FRET data collected from proteins diffusing at membrane surfaces using wide-field imagingCU15268In-cell smFRET tracking links membrane diffusion states with real-time structural dynamics using wide-field imaging and integrated analysis.TagsProteinBiophysicsCell membraneInventorsJonathan JavitchKhuloud JaqamanPeter GeggierManagerJerry KokoshkaDepartmentsBiophysicsPsychiatryDivisionsColumbia University Medical Center (CUMC)Release Date2025-03-05CollectionsPlatform/Research Tool
Live yeast biosensors for pathogen detectionCU21127Engineered live yeast biosensors emit color/fluorescent signals for rapid, sensitive pathogen detection, including fungi, viruses, and variants.TagsProteinAntifungalAntiviral drugInventorsVirginia W. CornishManagerJoan MartinezDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-03-07
Autophagy activating nucleotide sequence for neurodegenerative disease treatmentCU23286Nucleotide sequence boosts ALFY (WDFY3) to enhance autophagic clearance of neurodegenerative protein aggregates.TagsProteinAutophagyDrug discoveryInventorsAi YamamotoKatherine R. CroceManagerKristin NeumanDepartmentsPathology & Cell BiologyPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2024-12-20CollectionsCNS/Neurology
Palmitoylation modulators for targeted therapeuticsCU24204Engineered depalmitoylases selectively disrupt NRas signaling, enabling inducible, targeted palmitoylation control for cancer and neuro diseases.TagsProteinCancerCell membraneInventorsManu Ben-JohnySrinidhi JayaramanManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2025-02-20CollectionsOncology
Conditional 5-HT1A receptor knockout mouse model for studying antidepressant responseCU25138Inducible, cell-type specific 5HT1AR knockout mouse model reveals dentate gyrus roles in antidepressant response and mood regulation.TagsProtein5-HT receptor5-HT1A receptorInventorsRene HenManagerKristin NeumanDepartmentsPharmacologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-02-28
High throughput, automated method for chromatin profiling using low-cell input samplesCU23333Automated, high-throughput ChIP-seq profiling from low-cell inputs enables scalable chromatin mapping and clinical diagnostics.TagsProteinAutomationChIP sequencingInventorsAaron VinyManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-03-13
Targeted Cdkn2a suppression to prevent muscle degeneration in spinal muscular atrophyCU23330Targeted Cdkn2a suppression preserves muscle stem cell function to counteract SMA-related degeneration and enhance therapy.TagsProteinAtrophyCombination therapyInventorsNarendra JhaUmrao R. Monani Ph.D.ManagerKristin NeumanDepartmentsNeurologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-30CollectionsGene Therapy
Gene silencing for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)CU23021Silencing CASP8-METRN halts progression from steatosis to MASH, offering non-invasive therapy and diagnostic biomarkers.TagsProteinBiomarkerBlood plasmaInventorsDanish SaleheenIra Tabas MD, PhDShareef KhalidManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08
Therapeutic target for reversing PARP inhibitor resistance in breast cancerCU24001Target FLT1/VEGFR1 signaling to re-sensitize PARP inhibitor–resistant BRCA-mutant breast cancers, boosting PARPi efficacy.TagsProteinBreast cancerCancerInventorsAngela ChowAnup BiswasCourtney CokerManagerKristin NeumanDepartmentsInstitute for Cancer GeneticsOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-09-26CollectionsOncology
Bacterial genetic engineering system to treat infectionsCU24061Efficient CAST-based bacterial genome editing enables targeted cargo insertion to treat infections and reprogram microbiomes.TagsProteinAntibioticBacteriaInventorsCarlotta RondaDiego GelsingerHarris WangManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsBiological SciencesPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2024-08-29
