Safer ibogaine analogs for the treatment of substance use disordersCU24362Safer oxa-ibogaine analogs reduce cardiac risk while retaining ibogaine’s anti-addiction effects and therapeutic potential.TagsAlkaloidAnalgesicArrhythmiaInventorsDalibor SamesDavid LankriVaclav HavelManagerJerry KokoshkaDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-03-12CollectionsCNS/Neurology
Two-photon holographic microscope system for 3D neuronal circuit imaging and stimulationCU23132A holographic two-photon microscope enables simultaneous, high-resolution 3D neuronal imaging and optogenetic stimulation in vivo.TagsAdaptive opticsHolographyMicroscopyInventorsRafael YusteYuriy ShymkivManagerKristin NeumanDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2023-12-04CollectionsCNS/NeurologyPlatform/Research Tool
Optical in situ nucleotide sequence detection using combinatorial hybridizationCU24118High-throughput optical CRISPR screening with combinatorial hybridization enables scalable, cost-efficient, multi-omic readouts in situ.TagsBreast cancerCRISPRCohort studyInventorsJellert GaublommeManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2026-01-29CollectionsGenomics & Multi-Omics
Live yeast biosensors for pathogen detectionCU21127Engineered live yeast biosensors emit color/fluorescent signals for rapid, sensitive pathogen detection, including fungi, viruses, and variants.TagsAntifungalAntiviral drugAssayInventorsVirginia W. CornishManagerJoan MartinezDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-03-07
MicronuclAI: pipeline for automated and reliable micronuclei quantification to assess chromosomal instabilityCU24358MicronuclAI automates and standardizes micronuclei quantification across cell lines, boosting speed, accuracy, and chromosomal instability assessment.TagsCancerCell nucleusCytogeneticsInventorsAroj HadaBenjamin Izar MD, PhDDenis SchapiroManagerJoan MartinezDepartmentsInstitute for Computational BiomedicineMedicineProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsFaculty of the Arts & SciencesColumbia University Medical Center (CUMC)Release Date2024-07-05
Easily searchable database of state diplomacy documents for researchersCU24252Machine-learning powered database of US diplomatic documents (1973–present) with automated tagging for rapid search, analysis, and forecasting.TagsAmortized analysisCommunicationDatabaseInventorsMatthew J. ConnellyManagerDovina QuDepartmentsHistoryDivisionsFaculty of the Arts & SciencesRelease Date2024-05-27
Metasurface Holographic Optical Traps for Ultracold AtomsCU24064Metasurface holographic traps enable compact, scalable, high-precision ultracold-atom control for quantum computing and simulation.TagsAcousticsAmplitudeDielectricInventorsNanfang YuSebastian Will Ph.D.ManagerGreg MaskelDepartmentsApplied Physics & Applied MathPhysicsDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-05-27
Humidity-responsive textiles for adaptive moisture managementCU22375Humidity-responsive textiles dynamically adjust breathability via reversible hygromorphing, passively regulating moisture and comfort without power.TagsElastic modulusHumidityLipid bilayerInventorsOzgur SahinYocheved UngarManagerDovina QuDepartmentsApplied Physics & Applied Math (APAM)Biological SciencesDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-02-14
Erastin analogs for genotype-selective ferroptosis inductionCU14068ERS: Genotype-selective ferroptosis induction using enhanced erastin analogs targeting RAS V12+ tumors for potent, soluble, stable anticancer activity.TagsApoptosisFunctional groupGenotypeInventorsBrent StockwellMarie-Helene LarraufieWan Seok YangManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2025-05-22
Targeting a neural fat-sensing pathway for the treatment of obesityCU22137Target fat-sensing gut-brain pathway to curb high-fat eating; potential obesity, diabetes, and heart-disease therapeutics.TagsCardiovascular diseaseChronic kidney diseaseDrug developmentInventorsCharles S. ZukerMengtong LiZhengyuan LuManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsBiological SciencesMortimer B. Zuckerman Mind Brain Behavior InstituteDivisionsFaculty of the Arts & SciencesColumbia University Medical Center (CUMC)Release Date2024-08-01
Gene editing system for the treatment of autosomal dominant disease-related genesCU18283Mutation-independent CRISPR pair replaces dominant alleles with a functional gene to treat autosomal dominant diseases.TagsCRISPRGene therapyGenetic disorderInventorsStephen H. Tsang M.D., Ph.D.Wen-Hsuan WuYi-Ting TsaiManagerKristin NeumanDepartmentsNutritional and Metabolic BiologyOphthalmologyDivisionsFaculty of the Arts & SciencesCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Release Date2023-12-28CollectionsOphthalmologyGene Therapy
Synthesis of nitrogen isotopologues for pharmaceutical researchCU23020One-pot, cost-effective synthesis to replace nitrogen with heavy 15N isotopologue for tracking in pharma, agriculture, and environments.TagsBioavailabilityDrug developmentEnvironmental monitoringInventorsJulia DorsheimerTomislav RovisManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2023-08-04
Rapid, highly sensitive multiplexed viral detection with nanoporesCU21160Ultrafast, amplification-free nanopore-based single-molecule assay for multiplexed viral detection (SARS-CoV-2) and antibodies.TagsAntibodyAntigenAssayInventorsChuanjuan TaoJames J. RussoJingyue JuManagerCynthia LangDepartmentsChemical Engineering/Applied ChemistryChemistryGenome CenterDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering andFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-07-20
Identifying ransomware actors in the bitcoin networkCU22320Algorithm row: uses clustering and supervised ML on blockchain data to pinpoint ransomware actors with 85% accuracy.TagsAlgorithmBitcoinData setInventorsSiddhanth SabharwalSiddhartha DalalZihe WangManagerGreg MaskelDepartmentsStatisticsDivisionsFaculty of the Arts & SciencesSchool of Professional Studies (fka School of Continuing Education)Release Date2023-06-27
Light Guided Patterning of Stimuli-Responsive ActuatorsCU17117Photolithography-patterned water-responsive bacterial spores power humidity-driven actuators in polymer sheets, enabling energy-free adaptive architecture.TagsBacillusEndosporeHumidityInventorsOnur CakmakOzgur SahinXi ChenManagerDovina QuDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2023-03-08
Inducible genetic knockdown library for Saccharomyces cerevisiaeCU21052Inducible CRISPRi library for yeast enables tetracycline-controlled, genome-wide gene knockdown with high coverage and precision.TagsCRISPREpistasisEukaryoteInventorsAmir Momen-RoknabadiPanagiotis OikonomouSaeed TavazoieManagerJoan MartinezDepartmentsBiochemistryBiological SciencesSystems BiologyDivisionsFaculty of the Arts & SciencesColumbia University Medical CenterColumbia University Medical Center (CUMC)Release Date2020-10-23
DSSR: an integrated software tool for dissecting the spatial structure of RNACU20391Integrated DSSR software automates RNA/DNA 3D structure analysis, annotation, and in silico mutations, streamlining bioinformatics workflows.TagsAcidBioinformaticsIn silicoInventorsHarmen J. BussemakerXiang-Jun LuManagerDovina QuDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2020-06-15CollectionsPlatform/Research ToolDigital Health (Software, AI, bioinformatics, etc)
Fluorescent substrates for imaging neurotransmissionM06-109-aFluorescent false neurotransmitters visualize dopamine vesicle content and release at single-synapse resolution for imaging and drug discovery.TagsAssayAttention deficit hyperactivity disorderBipolar disorderInventorsDalibor SamesDavid Sulzer Ph.D.Niko GubernatorManagerJerry KokoshkaDepartmentsChemistryPsychiatryDivisionsFaculty of the Arts & SciencesColumbia University Medical Center (CUMC)Release Date2018-11-13
Evolved CRISPR-associated transposase systems for genome engineeringCU19096RNA-guided CRISPR-transposase enables kilobase-scale, precise DNA insertions in human cells without double-strand breaks or homologous repair.TagsCRISPRFibroblastGenetically modified animalInventorsSamuel H. SternbergSanne KlompeManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsChemistryDivisionsFaculty of the Arts & SciencesColumbia University Medical Center (CUMC)Release Date2025-12-18CollectionsGenomics & Multi-Omics
Circularly polarized microwave fields for quantum state controlCU23364Planar cloverleaf antennas enable precise, tunable circularly polarized microwave fields for quantum state control and simulations.TagsAmplitudeCircular polarizationDipoleInventorsIan StevensonNiccolo BigagliSebastian Will Ph.D.ManagerGreg MaskelDepartmentsPhysicsDivisionsFaculty of the Arts & SciencesRelease Date2024-04-08
Improved atomic loading for quantum computingCU23164Two-stage cooling loads strontium atoms into optical tweezer arrays, boosting quantum computer stability, efficiency, and scalability.TagsDrug discoveryFluxIsotopeInventorsSebastian Will Ph.D.ManagerGreg MaskelDepartmentsPhysicsDivisionsFaculty of the Arts & SciencesRelease Date2023-11-17
Ultra-compact and efficient semiconductors for nonlinear opticsCU23019Ultra-compact, efficient noncentrosymmetric MoS2 multilayers enable high nonlinear optical conversion for on-chip quantum photonics.TagsAnisotropyBirefringenceChalcogenideInventorsChiara TrovatelloDmitri N. BasovFabian MooshammerManagerGreg MaskelDepartmentsMechanical EngineeringPhysicsDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-05-02
Method to Enhance Optical Coherence Tomography (OCT) for Eye Disease DetectionCU22266AI-enhanced portable OCT improves image quality and automatically detects AMD, enabling low-cost, accessible eye disease screening.TagsInternal medicineMacular degenerationNatural disasterInventorsChristine P. HendonDesmond YaoDonald Charles HoodManagerDovina QuDepartmentsBiomedical EngineeringElectrical EngineeringOphthalmologyDivisionsFaculty of the Arts & SciencesColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-02-20CollectionsOphthalmologyMedical DeviceDigital Health (Software, AI, bioinformatics, etc)
Solar-powered mechanical motion of crystalsCU22086Solar-energy–driven crystals autonomously roll under visible light; fatigue-free, customizable, scalable for microdevices and soft robots.TagsEnergy harvestingFatigue (material)Laser cuttingInventorsAmymarie K. BartholomewIlana B. StoneMichael SteigerwaldManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2022-10-14
High-yield production of macroscopic 2D materialsCU20156Ultra-flat gold tape enables scalable, high-yield production of macroscopic 2D materials for electronics and quantum tech.TagsGrapheneMetalMonolayerInventorsFang LiuJames HoneJue WangManagerDovina QuDepartmentsChemistryMechanical EngineeringDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering andFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-05-13
High-pressure injector device for comfortable and rapid drug deliveryCU18187High-pressure, spring-free injector enables rapid, quiet delivery of viscous drugs for self-administration and higher concentration dosing.TagsAdrenalineBiopharmaceuticalDrug deliveryInventorsOzgur SahinManagerDovina QuDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2019-12-03
FIN56, a well-characterized small molecule for modeling ferroptosis-mediated cell deathCU17131FIN56 triggers ferroptosis by GPX4 suppression and lipid oxidation, enabling research tools and drug discovery for neurodegenerative and cancer therapies.TagsBiosynthesisCancerCancer cellInventorsBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2018-05-25CollectionsSmall MoleculeOncologyCNS/Neurology
Production method of the essential metabolic enzyme Propionyl-CoA carboxylase (PCC)CU16014Method to produce and purify human/bacterial Propionyl-CoA carboxylase in E. coli for PA therapeutics and research.TagsAcidosisAmino acidCarboxylationInventorsLiang TongManagerBeth KaudererDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2015-09-23
Trainable template search algorithm for efficient signal processingCU24045Trainable, low-dimensional template optimization rapidly detects signals in noisy, high-dimensional data with scalable, unrolled optimization.TagsAlgorithmComputer visionGradient descentInventorsJingkai YanJohn N. WrightShiyu WangManagerGreg MaskelDepartmentsComputer ScienceElectrical EngineeringPhysicsDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-08-23
Psychedelic based treatment for Parkinson’s disease and other psychiatric disordersCU23079Non-hallucinogenic 5-HT2A agonist Ariadne targets Parkinson’s and psychiatric disorders, offering safer, broader therapeutic potential.Tags5-HT2A receptorAgonistBipolar disorderInventorsDalibor SamesMichael J. CunninghamManagerJerry KokoshkaDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2023-11-03CollectionsSmall MoleculeCNS/Neurology
Chemical-free, scalable, optical insect repellantCU16085NIR light creates scalable, chemical-free insect barriers, repelling pests without toxins for homes, crops, and public spaces.TagsAnophelesInfraredInsectInventorsImre BartosSzabolcs MarkaZsuzsanna MarkaManagerGreg MaskelDepartmentsPhysicsDivisionsFaculty of the Arts & SciencesRelease Date2020-07-21
Chemical painting for high-throughput single-cell drug response analysisCU23332Multiplexed infrared imaging enables high-throughput, single-cell drug profiling with ML-enabled mechanism-of-action predictions.TagsCombination therapyDNA sequencingDrug discoveryInventorsWei MinXinwen LiuManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-10-16
Dynamic, tailorable conjoint experimental modelCU25452Dynamic, bias-reducing conjoint design via a tailorable language-model survey that free-forms attributes per participant.TagsDesign of experimentsLanguage modelInventorsYamil R. VelezManagerDovina QuDepartmentsPolitical ScienceDivisionsFaculty of the Arts & SciencesRelease Date2025-08-21
Engineered CAST systems for RNA-guided DNA integrationCU24123Programmable, break-free RNA-guided DNA integration in mammalian cells using engineered CAST with Cas8 mutations for broader genomic targeting.TagsCell therapyGenetic engineeringGenome editingInventorsAshley LiangGeorge Davis LampeSamuel H. SternbergManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsBiological SciencesDivisionsFaculty of the Arts & SciencesColumbia University Medical Center (CUMC)Release Date2026-02-17
Fluorescent labeling of cell surface proteins in vivo with spatiotemporal controlCU25172Fluorescently label cell-surface proteins in vivo using DogTag-DogCatcher for spatiotemporal, loop-targeted GFP tagging.TagsBiopsyCell membraneCovalent bondInventorsKevin RostamRichard S. MannManagerJerry KokoshkaDepartmentsBiochemistry & Molecular BiophysicsBiological SciencesDivisionsFaculty of the Arts & SciencesColumbia University Medical Center (CUMC)Release Date2025-03-21
Cell-based model for early-onset restrictive cardiomyopathy (RCM)CU22246Patient-derived iPSC heart tissue model reproduces FLNC-linked RCM for drug screening and therapy discovery.TagsCardiac muscle cellCardiomyopathyDrug discoveryInventorsBarry FineBryan WangGordana Vunjak-NovakovicManagerKristin NeumanDepartmentsBiomedical EngineeringMedicineProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsFaculty of the Arts & SciencesColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-11-10CollectionsCardiovascular
Computational Method to Identify Bacterial Genes and Strains for Enhanced GI Tract ColonizationCU24221Computationally identifies bacterial genes driving GI tract colonization to guide engineered strains and therapeutic microbiome tools.TagsBacteriaEscherichia coliGastrointestinal tractInventorsMenghan LiuSaeed TavazoieManagerJoan MartinezDepartmentsBiochemistryBiological SciencesDivisionsFaculty of the Arts & SciencesColumbia University Medical Center (CUMC)Release Date2025-09-18
GPX4 inhibitors for cancer therapyCU20261Potent, selective GPX4 inhibitors induce ferroptosis to target EMT-driven, drug-resistant cancers and enable GPX4 research.TagsActive siteAllosteric regulationApoptosisInventorsBrent StockwellHengrui LiuManagerJoan MartinezDepartmentsBiological SciencesChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-05-01
Photocatalysis method with low-energy lightCU18169Photon upconversion enables infrared-driven, safer photocatalysis with deeper penetration for pharma, biomedicine, and materials.TagsAntimicrobialBiomedicineCatalysisInventorsAndrew B. PunBenjamin RavetzDaniel N. CongreveManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesMassachusetts Eye and Ear InfirmaryRelease Date2024-12-06
Dietary factors for the treatment of lymphomaCU24111Dietary iron and PUFA phospholipids induce ferroptosis to suppress DLBCL tumors, offering non-invasive, low-cost lymphoma therapy options.TagsAcyl groupChemotherapyDietary supplementInventorsBrent StockwellEman Riaz AhmedManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2024-11-08
cGAS inhibitor for robust anti-tumor immunity activationCU23316Bioavailable, chemically modified cGAS inhibitors enhance oral bioavailability to boost anti-tumor immunity via the cGAS–STING pathway.TagsAminopeptidaseAutoimmune diseaseBioavailabilityInventorsBenjamin Izar MD, PhDDonald William Landry MD, Ph.D.Lindsay CaprioManagerJoan MartinezDepartmentsMedicineProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsFaculty of the Arts & SciencesColumbia University Medical Center (CUMC)Release Date2024-09-26
First-in-class organic materials for efficient multiple exciton generationCU17103First-in-class organic polymers enable intramolecular singlet fission with 170–200% triplet yield, boosting solar efficiency and tunability.TagsAromaticityCarrier generation and recombinationCharge-transfer complexInventorsAndrew B. PunElango KumarasamyLuis CamposManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesCenter for Functional NanomaterialsRelease Date2019-03-18
High-resolution method for determining the molecular structure of biomoleculesCU13086AFM-based molecular sequencing maps biomolecules at Ångstrom resolution using DNA-labeled probes and cantilever twist.TagsAmino acidAtomic force microscopyBiomoleculeInventorsOzgur SahinManagerDovina QuDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2019-01-19
Evaporation-driven engines for renewable energy generationCU14162Evaporation-powered bio-hybrid actuators harvest humidity differences to generate robust, high-density mechanical energy for renewables.TagsBacillusElectricityEndosporeInventorsOzgur SahinXi ChenManagerDovina QuDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2015-06-12
Genome-wide qPCR with increased primer multiplexity for diagnostics and drug screeningCU23284A qPCR platform using optically barcoded beads enables genome-wide multiplex expression analysis (100–10,000 targets) faster and cheaper.TagsAcidChain reactionHigh-throughput screeningInventorsNaixin QianWei MinZhilun ZhaoManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-10-16
Lipid targets and biomarkers for ferroptosisCU24174Lipid biomarkers (PC-PUFA2s) drive ferroptosis; enables diagnostics and targeted therapies by regulating iron-dependent cell death.TagsAcyl groupApoptosisBiomarkerInventorsBaiyu QiuBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2024-12-20
Optical super-multiplexing for molecule detection and live-cell imagingCU17371Optical materials enable super-multiplexed imaging and Raman-based barcoding for high-throughput, live-cell molecular detection.TagsChemical libraryDyeFluorescenceInventorsFanghao HuWei MinManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2023-10-20CollectionsMedical Device
Organic material for high-performance and rapidly-charging pseudocapacitorsCU20174Organic dye-based pseudocapacitor combines PDI and HATN for high-capacitance, fast-charging energy storage with low cost.TagsCapacitorComposite materialDyeInventorsColin NuckollsJake Carter RussellSamuel Robert PeurifoyManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2021-01-15
Stimulated Raman fluorescence for enhanced biological imagingCU19260Stimulated Raman coupled fluorescence enables all-field, single-molecule imaging with high chemical specificity and sensitivity.TagsBiophysicsConfocal microscopyFluorescence spectroscopyInventorsHanqing XiongLixue ShiLu WeiManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2020-10-29
Organic semiconductor materials for improving solar cell performanceCU14323Perylene diimide nanoribbons boost organic solar cell efficiency by precise fusion, enabling cheaper, flexible, scalable photovoltaic devices.TagsElectroluminescenceEnergyOLEDInventorsBharat KumarChang-Yong NamColin NuckollsManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2016-08-26
