Inventors
Elisa Konofagou
View all technologies
Clinical application of Electromechanical Wave Imaging (EWI) to localize arrhythmias
CU25148
Non-invasive arrhythmia source localization using EWI on standard ultrasound scanners, enabling clinical mapping without high-framerate data.
Tags
Arrhythmia
Cardiac muscle
Echocardiography
Inventors
Elisa Konofagou
Melina Tourni
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2026-01-16
Focused ultrasound nanoparticles for targeted imaging and neuroregeneration
CU21224
Ultrasound-activated nanocup theranostics cross BBB for targeted Alzheimer’s imaging and neuroregenerative therapy.
Tags
Amyloid beta
Antibody
Blood–brain barrier
Inventors
Elisa Konofagou
Antonios Poulipoulos
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2025-07-29
Blood-brain barrier opening and cavitation imaging using a single diagnostic imaging array
CU21007
Single diagnostic ultrasound array opens the blood-brain barrier and images cavitation simultaneously for cost-effective, targeted brain therapy.
Tags
Beamforming
Blood–brain barrier
Cavitation
Inventors
Elisa Konofagou
Mark T. Burgess
Robin Ji
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2025-07-29
Focused ultrasound system for localized drug delivery across the blood brain barrier
2039
Focused ultrasound with microbubbles locally and reversibly opens the BBB, enabling targeted brain drug delivery and CNS research.
Tags
Aperture
Blood–brain barrier
Brain
Inventors
Elisa Konofagou
James Junesik J. Choi
Mathieu Pernot
Manager
Dovina Qu
Departments
Biomedical Engineering
Neurology
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2014-09-15
Focused ultrasound planning system enables blood-brain barrier opening with a single element transducer
2687
A low-cost, MR-guidance-free focused ultrasound method opens the blood-brain barrier with a single transducer.
Tags
Antibody
Bacteria
Blood–brain barrier
Inventors
Elisa Konofagou
Thomas Deffieux
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2014-07-09
Cardiac ablation monitoring with intracardiac echocardiography (ICE)
CU19295
Intracardiac echocardiography enables real-time visualization and classification of ablation lesions, reducing repeat procedures.
Tags
Cardiac muscle
Catheter
Echocardiography
Inventors
Elisa Konofagou
Vincent Sayseng
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2022-10-09
Collections
Cardiovascular
Diagnostic mechanical mapping of cardiac rhythm using ultrasound
CU13088
Ultrasound-based, noninvasive electromechanical mapping reveals cardiac arrhythmia origins at high frame rates for targeted treatment.
Tags
Atrial fibrillation
Biomechanics
Cardiology
Inventors
Elisa Konofagou
Jean Provost
Manager
Dovina Qu
Departments
Biomedical Engineering
Biomedical Informatics
Divisions
Columbia University Medical Center ( CUM
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2014-09-16
Ultrasound technique for opening the blood-brain barrier to treat neurological disorders
2965
Real-time, noninvasive ultrasound monitoring of safe blood-brain barrier opening via cavitation spectra, enabling adaptive, MRI-free drug delivery.
Tags
Acoustics
Blood–brain barrier
Cavitation
Inventors
Elisa Konofagou
Fabrice Marquet
Yao-Sheng Tung
Manager
Dovina Qu
Departments
Biomedical Engineering
Biomedical Informatics
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2014-09-15
Electromechanical wave imaging with automated activation mapping
CU21074
Non-invasive electromechanical wave imaging with ML-driven automated activation mapping for real-time, unbiased cardiac conduction diagnosis.
Tags
Atrial fibrillation
Electromechanics
Heart arrhythmia
Inventors
Elisa Konofagou
Lea Melki
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2020-09-14
Collections
Medical Device
Cardiovascular
Focused ultrasound for measuring elastic properties of biological tissues
2887
Focused ultrasound non-invasively maps tissue elasticity in vivo, enabling real-time tumor, fibrosis, and treatment monitoring.
Tags
Ablation
Amplitude modulation
Brachytherapy
Inventors
Elisa Konofagou
Jonathan Vappou
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2014-09-15
Low-tech, minimally invasive localized brain drug delivery system
CU14052
Portable, MRI-free, single-transducer brain BBB opening using intermediate-frequency ultrasound for targeted, low-tech drug delivery.
Tags
Blood–brain barrier
Cavitation
Drug delivery
Inventors
Elisa Konofagou
Fabrice Marquet
Tobias Teichert
Manager
Dovina Qu
Departments
Biomedical Engineering
Biomedical Informatics
Neuroscience
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2014-08-25
Targeted drug delivery using focused ultrasound-induced blood-brain barrier opening
CU14367
Focused ultrasound opens the blood-brain barrier to enable targeted intranasal drug delivery for neurological disorders.
Tags
Blood vessel
Blood–brain barrier
Drug delivery
Inventors
Elisa Konofagou
Chen Chen
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2014-08-25
Wearable ultrasound device for targeted mapping and modulation of brain tissue
CU15312
Wearable focused ultrasound maps and modulates brain tissue, temporarily opening the BBB for noninvasive, localized neuromodulation and drug delivery.
Tags
Blood–brain barrier
Brain
Brain mapping
Inventors
Elisa Konofagou
Gesthimani Samiotaki
Manager
Dovina Qu
Departments
Biomedical Engineering
Radiology
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2018-04-13
Periodic motion algorithm for ultrasound imaging of the heartbeat
2442
Non-invasive ultrasound-based heart imaging detects arrhythmias by comparing cycle-to-cycle structural changes, enabling automated electrical mapping.
Tags
Bird anatomy
CT scan
Catheter
Inventors
Elisa Konofagou
Jean Provost
Manager
Dovina Qu
Departments
Biomedical Engineering
Biomedical Informatics
Divisions
Columbia University Medical Center ( CUM
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2009-04-10
High-resolution ultrasound imaging of cardiac arrhythmias
CU17221
Non-invasive 3D ultrasound maps electromechanical activation in a beating heart to diagnose, monitor, and guide arrhythmia treatment.
Tags
3D reconstruction
Cardiac muscle
Catheter
Inventors
Elisa Konofagou
Elaine Y. Wan
Lea Melki
Manager
Dovina Qu
Departments
Biomedical Engineering
Medicine
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2019-10-22
Collections
Medical Device
Cardiovascular
Coherent factor-based passive cavitation mapping for monitoring of focused ultrasound treatment
CU22079
Coherent factor-based passive acoustic mapping enables real-time, high-resolution, low-cost monitoring of transcranial focused ultrasound treatment.
Tags
Ablation
Acoustics
Attenuation
Inventors
Elisa Konofagou
Sua Bae
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2025-11-07
Focused ultrasound-induced blood-brain barrier opening for noninvasive extracellular vesicle release
CU23167
Focused ultrasound opens the blood-brain barrier to boost peripheral extracellular vesicle release, enabling sensitive neurological biomarkers.
Tags
Biomarker
Blood–brain barrier
Cavitation
Inventors
Elisa Konofagou
Alec J. Batts
Alina R. Kline-Schoder
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-01-18
Collections
CNS/Neurology
Platform/Research Tool
Medical Device
Single transducer harmonic motion imaging for disease detection and monitoring
CU20327
Single-transducer harmonic motion imaging enables robust, high-resolution tissue stiffness maps for cancer detection and treatment monitoring.
Tags
Anisotropy
Breast cancer
Chemotherapy
Inventors
Elisa Konofagou
Murad Hossain
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2020-04-21
Collections
Oncology
Medical Device
Women's Health
Harmonic motion imaging in non-invasive tissue characterization
CU13179
Noninvasive ultrasound method using two transducers to map tissue stiffness via harmonic-motion displacement.
Tags
Acoustics
Diffraction
Lesion
Inventors
Elisa Konofagou
Jiangang Chen
Yi (Gary) Hou
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2014-09-16
Focused ultrasound protocol for drug delivery
2781
Focused ultrasound with optimized short pulse sequences opens the blood-brain barrier for targeted, non-invasive brain drug delivery.
Tags
Blood–brain barrier
Brain
Brain-derived neurotrophic factor
Inventors
Elisa Konofagou
James Junesik J. Choi
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2014-09-15
Harmonic motion elastography for noninvasive tumor imaging in vivo
CU19055
Noninvasive harmonic motion elastography images tumor stiffness in real time, improving margins, monitoring therapy, and guiding surgery.
Tags
Breast
Breast cancer
Chemotherapy
Inventors
Elisa Konofagou
Alireza Nabavizadehrafsanjani
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2019-12-16
Collections
Oncology
Women's Health
Neurotherapeutic Drug Delivery via Focused Ultrasound
M09-025
Focused ultrasound transiently opens the blood-brain barrier for targeted, noninvasive brain drug delivery and screening.
Tags
Biomimetics
Blood–brain barrier
Brain
Inventors
Elisa Konofagou
James Junesik J. Choi
Mark Andrew Borden
Manager
Dovina Qu
Departments
Biomedical Engineering
Chemical Engineering/Applied Chemistry
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2009-10-05
Elasticity mapping technique for real-time treatment monitoring
CU14378
High-frame-rate elasticity imaging for real-time HIFU treatment monitoring, mapping lesions to prevent overtreatment and guide therapy.
Tags
Ablation
Beamforming
Frame rate
Inventors
Elisa Konofagou
Jean Provost
Yi (Gary) Hou
Manager
Dovina Qu
Departments
Biomedical Engineering
Biomedical Informatics
Divisions
Columbia University Medical Center ( CUM
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2018-04-20
Ultrasound-based imaging method for real-time detection of single-heartbeats
2945
Single-heartbeat ultrasound imaging with temporally-unequispaced acquisition enhances real-time, noninvasive detection of non-periodic cardiac events.
Tags
Cardiac muscle
Common carotid artery
Data acquisition
Inventors
Elisa Konofagou
Jean Provost
Jianwen Luo
Manager
Dovina Qu
Departments
Biomedical Engineering
Biomedical Informatics
Divisions
Columbia University Medical Center ( CUM
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2014-09-15
Targeted drug delivery with focused ultrasound induced blood-brain barrier opening
CU14035
Acoustically activated nanodroplets enable focused ultrasound–mediated blood-brain barrier opening for targeted brain drug delivery.
Tags
Acoustics
Blood vessel
Blood–brain barrier
Inventors
Elisa Konofagou
Chen Chen
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2014-09-16
Real-time Electromechanical Wave Imaging
CU13163
Electromechanical Wave Imaging integrates ultrasound data to map unified heart electromechanical function for rapid, noninvasive cardiac assessment.
Tags
CT scan
Cardiac output
Cardiology
Inventors
Elisa Konofagou
Jean Provost
Manager
Dovina Qu
Departments
Biomedical Engineering
Biomedical Informatics
Divisions
Columbia University Medical Center ( CUM
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2014-09-16
Electromechanical Wave Imaging of the Cardiovascular System
1781
Electromechanical wave imaging noninvasively maps heart electrical activation with high-speed ultrasound, detecting ischemia and tissue viability.
Tags
Abdominal aortic aneurysm
Aorta
Artificial cardiac pacemaker
Inventors
Elisa Konofagou
Mathieu Pernot
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2009-04-10
ECG coupled ultrasound cardiac imaging for the early detection of cardiovascular disease
1963
ECG-gated ultrasound images millisecond tissue motion to assess cardiac stiffness, enabling earlier, more sensitive cardiovascular disease detection.
Tags
Aortic aneurysm
Cardiac cycle
Cardiovascular disease
Inventors
Elisa Konofagou
Simon Fung-Kee-Fung
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2009-04-10
