Clinical application of Electromechanical Wave Imaging (EWI) to localize arrhythmiasCU25148Non-invasive arrhythmia source localization using EWI on standard ultrasound scanners, enabling clinical mapping without high-framerate data.TagsArrhythmiaCardiac muscleEchocardiographyInventorsElisa KonofagouMelina TourniManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-01-16
Focused ultrasound nanoparticles for targeted imaging and neuroregenerationCU21224Ultrasound-activated nanocup theranostics cross BBB for targeted Alzheimer’s imaging and neuroregenerative therapy.TagsAmyloid betaAntibodyBlood–brain barrierInventorsElisa KonofagouAntonios PoulipoulosManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-07-29
Blood-brain barrier opening and cavitation imaging using a single diagnostic imaging arrayCU21007Single diagnostic ultrasound array opens the blood-brain barrier and images cavitation simultaneously for cost-effective, targeted brain therapy.TagsBeamformingBlood–brain barrierCavitationInventorsElisa KonofagouMark T. BurgessRobin JiManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-07-29
Focused ultrasound system for localized drug delivery across the blood brain barrier2039Focused ultrasound with microbubbles locally and reversibly opens the BBB, enabling targeted brain drug delivery and CNS research.TagsApertureBlood–brain barrierBrainInventorsElisa KonofagouJames Junesik J. ChoiMathieu PernotManagerDovina QuDepartmentsBiomedical EngineeringNeurologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-09-15
Focused ultrasound planning system enables blood-brain barrier opening with a single element transducer2687A low-cost, MR-guidance-free focused ultrasound method opens the blood-brain barrier with a single transducer.TagsAntibodyBacteriaBlood–brain barrierInventorsElisa KonofagouThomas DeffieuxManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-07-09
Cardiac ablation monitoring with intracardiac echocardiography (ICE)CU19295Intracardiac echocardiography enables real-time visualization and classification of ablation lesions, reducing repeat procedures.TagsCardiac muscleCatheterEchocardiographyInventorsElisa KonofagouVincent SaysengManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2022-10-09CollectionsCardiovascular
Diagnostic mechanical mapping of cardiac rhythm using ultrasoundCU13088Ultrasound-based, noninvasive electromechanical mapping reveals cardiac arrhythmia origins at high frame rates for targeted treatment.TagsAtrial fibrillationBiomechanicsCardiologyInventorsElisa KonofagouJean ProvostManagerDovina QuDepartmentsBiomedical EngineeringBiomedical InformaticsDivisionsColumbia University Medical Center ( CUMFu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-09-16
Ultrasound technique for opening the blood-brain barrier to treat neurological disorders2965Real-time, noninvasive ultrasound monitoring of safe blood-brain barrier opening via cavitation spectra, enabling adaptive, MRI-free drug delivery.TagsAcousticsBlood–brain barrierCavitationInventorsElisa KonofagouFabrice MarquetYao-Sheng TungManagerDovina QuDepartmentsBiomedical EngineeringBiomedical InformaticsDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-09-15
Electromechanical wave imaging with automated activation mappingCU21074Non-invasive electromechanical wave imaging with ML-driven automated activation mapping for real-time, unbiased cardiac conduction diagnosis.TagsAtrial fibrillationElectromechanicsHeart arrhythmiaInventorsElisa KonofagouLea MelkiManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-09-14CollectionsMedical DeviceCardiovascular
Focused ultrasound for measuring elastic properties of biological tissues2887Focused ultrasound non-invasively maps tissue elasticity in vivo, enabling real-time tumor, fibrosis, and treatment monitoring.TagsAblationAmplitude modulationBrachytherapyInventorsElisa KonofagouJonathan VappouManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-09-15
Low-tech, minimally invasive localized brain drug delivery systemCU14052Portable, MRI-free, single-transducer brain BBB opening using intermediate-frequency ultrasound for targeted, low-tech drug delivery.TagsBlood–brain barrierCavitationDrug deliveryInventorsElisa KonofagouFabrice MarquetTobias TeichertManagerDovina QuDepartmentsBiomedical EngineeringBiomedical InformaticsNeuroscienceDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-08-25
Targeted drug delivery using focused ultrasound-induced blood-brain barrier openingCU14367Focused ultrasound opens the blood-brain barrier to enable targeted intranasal drug delivery for neurological disorders.TagsBlood vesselBlood–brain barrierDrug deliveryInventorsElisa KonofagouChen ChenManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-08-25
Wearable ultrasound device for targeted mapping and modulation of brain tissueCU15312Wearable focused ultrasound maps and modulates brain tissue, temporarily opening the BBB for noninvasive, localized neuromodulation and drug delivery.TagsBlood–brain barrierBrainBrain mappingInventorsElisa KonofagouGesthimani SamiotakiManagerDovina QuDepartmentsBiomedical EngineeringRadiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-04-13
Periodic motion algorithm for ultrasound imaging of the heartbeat2442Non-invasive ultrasound-based heart imaging detects arrhythmias by comparing cycle-to-cycle structural changes, enabling automated electrical mapping.TagsBird anatomyCT scanCatheterInventorsElisa KonofagouJean ProvostManagerDovina QuDepartmentsBiomedical EngineeringBiomedical InformaticsDivisionsColumbia University Medical Center ( CUMFu Foundation School of Engineering and Applied Science (SEAS)Release Date2009-04-10
High-resolution ultrasound imaging of cardiac arrhythmiasCU17221Non-invasive 3D ultrasound maps electromechanical activation in a beating heart to diagnose, monitor, and guide arrhythmia treatment.Tags3D reconstructionCardiac muscleCatheterInventorsElisa KonofagouElaine Y. WanLea MelkiManagerDovina QuDepartmentsBiomedical EngineeringMedicineDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2019-10-22CollectionsMedical DeviceCardiovascular
Coherent factor-based passive cavitation mapping for monitoring of focused ultrasound treatmentCU22079Coherent factor-based passive acoustic mapping enables real-time, high-resolution, low-cost monitoring of transcranial focused ultrasound treatment.TagsAblationAcousticsAttenuationInventorsElisa KonofagouSua BaeManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-11-07
Focused ultrasound-induced blood-brain barrier opening for noninvasive extracellular vesicle releaseCU23167Focused ultrasound opens the blood-brain barrier to boost peripheral extracellular vesicle release, enabling sensitive neurological biomarkers.TagsBiomarkerBlood–brain barrierCavitationInventorsElisa KonofagouAlec J. BattsAlina R. Kline-SchoderManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-01-18CollectionsCNS/NeurologyPlatform/Research ToolMedical Device
Single transducer harmonic motion imaging for disease detection and monitoringCU20327Single-transducer harmonic motion imaging enables robust, high-resolution tissue stiffness maps for cancer detection and treatment monitoring.TagsAnisotropyBreast cancerChemotherapyInventorsElisa KonofagouMurad HossainManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-04-21CollectionsOncologyMedical DeviceWomen's Health
Harmonic motion imaging in non-invasive tissue characterizationCU13179Noninvasive ultrasound method using two transducers to map tissue stiffness via harmonic-motion displacement.TagsAcousticsDiffractionLesionInventorsElisa KonofagouJiangang ChenYi (Gary) HouManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-09-16
Focused ultrasound protocol for drug delivery2781Focused ultrasound with optimized short pulse sequences opens the blood-brain barrier for targeted, non-invasive brain drug delivery.TagsBlood–brain barrierBrainBrain-derived neurotrophic factorInventorsElisa KonofagouJames Junesik J. ChoiManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-09-15
Harmonic motion elastography for noninvasive tumor imaging in vivoCU19055Noninvasive harmonic motion elastography images tumor stiffness in real time, improving margins, monitoring therapy, and guiding surgery.TagsBreastBreast cancerChemotherapyInventorsElisa KonofagouAlireza NabavizadehrafsanjaniManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2019-12-16CollectionsOncologyWomen's Health
Neurotherapeutic Drug Delivery via Focused UltrasoundM09-025Focused ultrasound transiently opens the blood-brain barrier for targeted, noninvasive brain drug delivery and screening.TagsBiomimeticsBlood–brain barrierBrainInventorsElisa KonofagouJames Junesik J. ChoiMark Andrew BordenManagerDovina QuDepartmentsBiomedical EngineeringChemical Engineering/Applied ChemistryDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2009-10-05
Elasticity mapping technique for real-time treatment monitoringCU14378High-frame-rate elasticity imaging for real-time HIFU treatment monitoring, mapping lesions to prevent overtreatment and guide therapy.TagsAblationBeamformingFrame rateInventorsElisa KonofagouJean ProvostYi (Gary) HouManagerDovina QuDepartmentsBiomedical EngineeringBiomedical InformaticsDivisionsColumbia University Medical Center ( CUMFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-04-20
Ultrasound-based imaging method for real-time detection of single-heartbeats2945Single-heartbeat ultrasound imaging with temporally-unequispaced acquisition enhances real-time, noninvasive detection of non-periodic cardiac events.TagsCardiac muscleCommon carotid arteryData acquisitionInventorsElisa KonofagouJean ProvostJianwen LuoManagerDovina QuDepartmentsBiomedical EngineeringBiomedical InformaticsDivisionsColumbia University Medical Center ( CUMFu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-09-15
Targeted drug delivery with focused ultrasound induced blood-brain barrier openingCU14035Acoustically activated nanodroplets enable focused ultrasound–mediated blood-brain barrier opening for targeted brain drug delivery.TagsAcousticsBlood vesselBlood–brain barrierInventorsElisa KonofagouChen ChenManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-09-16
Real-time Electromechanical Wave ImagingCU13163Electromechanical Wave Imaging integrates ultrasound data to map unified heart electromechanical function for rapid, noninvasive cardiac assessment.TagsCT scanCardiac outputCardiologyInventorsElisa KonofagouJean ProvostManagerDovina QuDepartmentsBiomedical EngineeringBiomedical InformaticsDivisionsColumbia University Medical Center ( CUMFu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-09-16
Electromechanical Wave Imaging of the Cardiovascular System1781Electromechanical wave imaging noninvasively maps heart electrical activation with high-speed ultrasound, detecting ischemia and tissue viability.TagsAbdominal aortic aneurysmAortaArtificial cardiac pacemakerInventorsElisa KonofagouMathieu PernotManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2009-04-10
ECG coupled ultrasound cardiac imaging for the early detection of cardiovascular disease1963ECG-gated ultrasound images millisecond tissue motion to assess cardiac stiffness, enabling earlier, more sensitive cardiovascular disease detection.TagsAortic aneurysmCardiac cycleCardiovascular diseaseInventorsElisa KonofagouSimon Fung-Kee-FungManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2009-04-10
