Automated MRI-based breast cancer segmentationCU26095AI-driven, scalable MRI segmentation for breast cancer (DCIS); automates lesion delineation, boosting speed, consistency, and research utility.TagsBiomarkerBreast cancerBreast cancer screeningInventorsDespina KontosKalina SlavkovaManagerJoan MartinezDepartmentsRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-20
Dephasing optimization through coherence order pathway selection (DOTCOPS) for improved crusher and phase cycling schemes in MR spectroscopyCU18146DOTCOPS automates optimal crusher and phase-cycle schemes in MR spectroscopy, suppressing unwanted coherence pathways across sequences.TagsAlgorithmMagnetic fieldMagnetic resonance imagingInventorsChristoph JuchemKarl LandheerManagerJoan MartinezDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-09-18CollectionsMedical DeviceDigital Health (Software, AI, bioinformatics, etc)
Machine learning pipeline for neoantigen prioritization in personalized immunotherapiesCU25375ImmuneMirror: integrative ML pipeline predicting immunogenic neoantigens by combining processing, transport, binding, and recognition factors.TagsAntigenBiomarkerCancer immunotherapyInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Small molecule activators for preventing vision loss in Best vitelliform macular dystrophyCU25176Small molecule activators restore Best1 function to slow BVMD vision loss; targeted, potentially non-invasive retinal therapy.Tags4-Aminobenzoic acidDrug developmentGene therapyInventorsBingchen YuTingting YangYu ZhangManagerJoan MartinezDepartmentsChemistryOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-05-01CollectionsOphthalmology
Integrated AI platform for causal discovery and drug validationCU25378Cloud-based AI suite enabling causal discovery, multimodal data integration, and translational drug validation for personalized medicine.TagsAntigenArtificial intelligenceBias (statistics)InventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
tomoLIBRA: Deep learning software for automated volumetric breast density estimationCU26015AI-based tomoLIBRA estimates volumetric breast density from standard 3D DBT images, enabling scalable, retrospective risk assessment without raw data.TagsBreast cancerBreast cancer screeningCase–control studyInventorsAimilia GastouniotiAri BrooksCeline VachonManagerJoan MartinezDepartmentsBiomedical EngineeringRadiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)School of MedicineRelease Date2026-02-20
Encryption method for secure storage and analysis of patient data on the cloudCU24094A cloud-friendly, privacy-preserving genomic analysis method using homomorphic encryption to enable multi-user queries on encrypted patient data.TagsCiphertextCloud computingData managementInventorsGamze GursoyJacob BlindenbachJiayi KangManagerJoan MartinezDepartmentsBiomedical InformaticsComputer ScienceDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-02-03
Optical in situ nucleotide sequence detection using combinatorial hybridizationCU24118High-throughput optical CRISPR screening with combinatorial hybridization enables scalable, cost-efficient, multi-omic readouts in situ.TagsBreast cancerCRISPRCohort studyInventorsJellert GaublommeManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2026-01-29CollectionsGenomics & Multi-Omics
Live yeast biosensors for pathogen detectionCU21127Engineered live yeast biosensors emit color/fluorescent signals for rapid, sensitive pathogen detection, including fungi, viruses, and variants.TagsAntifungalAntiviral drugAssayInventorsVirginia W. CornishManagerJoan MartinezDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-03-07
MicronuclAI: pipeline for automated and reliable micronuclei quantification to assess chromosomal instabilityCU24358MicronuclAI automates and standardizes micronuclei quantification across cell lines, boosting speed, accuracy, and chromosomal instability assessment.TagsCancerCell nucleusCytogeneticsInventorsAroj HadaBenjamin Izar MD, PhDDenis SchapiroManagerJoan MartinezDepartmentsInstitute for Computational BiomedicineMedicineProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2024-07-05
Hybrid multi-coil technique for improving magnetic resonance imaging (MRI)CU23207Hybrid, compact multi-coil and RF magnet system enhances MRI field homogeneity, boosting clinical brain imaging on standard machines.TagsHuman brainMagnetic fieldMagnetic resonance imagingInventorsCarlotta IannielloChristoph JuchemSebastian TheilenbergManagerJoan MartinezDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-03-26CollectionsCNS/NeurologyMedical Device
3D organoids for modeling squamous epithelial pathology and personalized medicineCU223013D squamous epithelial organoids enable patient-specific disease modeling and rapid, predictive drug testing for ESCC/EAC.TagsAdenocarcinomaCarcinomaEpitheliumInventorsAnil K. Rustgi M.D.Hiroshi NakagawaManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-01-04CollectionsOncology
Clinical decision tool for HIV testing in dental settingsCU24031Integrated dental EHR prompts HIV screening, streamlining point-of-care testing to broaden access and awareness.TagsAIDSElectronic health recordHIVInventorsSharon PerelmanTunaidi AnsariManagerJoan MartinezDepartmentsCollege of Dental MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-30CollectionsMedical DeviceDigital Health (Software, AI, bioinformatics, etc)
Transgenic zebrafish lines for Alzheimer’s disease modelsCU23304Transgenic zebrafish expressing amyloid beta and Tau model Alzheimer's pathology for in vivo drug screening and biomarker research.TagsAmyloid betaBiomarkerDrug developmentInventorsCaghan KizilManagerJoan MartinezDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-09-25CollectionsCNS/Neurology
Conditional knockout mouse model for the Phf6 geneCU22370A tissue-specific Phf6 conditional knockout mouse model for studying Börjeson-Forssman-Lehmann syndrome and hematologic cancers.TagsAcute myeloid leukemiaGeneHigh-throughput screeningInventorsAdolfo A. Ferrando M.D., Ph.D.Teresa Palomero VasquezManagerJoan MartinezDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2022-08-20
COWS: Water suppression algorithm for magnetic resonance spectroscopyCU21111Flexible COWS water suppression for MRSI, customizable pulses/durations, shorter experiments, improved macromolecule visualization.TagsAlgorithmMacromoleculeNuclear magnetic resonance spectroscopyInventorsChristoph JuchemKarl LandheerMartin GajdosikManagerJoan MartinezDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-11-13CollectionsDigital Health (Software, AI, bioinformatics, etc)
Disease-in-a-dish model of neuropsychiatric diseases for high-throughput therapeutic screeningCU20125In vitro hiPSC SETD1A-mutant platform enables high-throughput neuropsychiatric drug screening and pathway discovery.TagsAmyotrophic lateral sclerosisAutismEnzymeInventorsBin XuJoseph A. GogosManagerJoan MartinezDepartmentsPhysiology and Cellular BiophysicsPsychiatryDivisionsColumbia University Medical Center (CUMC)Release Date2020-10-02CollectionsCNS/NeurologyPlatform/Research Tool
Radiomic harmonization tool for multicenter disease studiesProxy118Advanced radiomic harmonization: data-driven, multi-source correction across scanners to boost cross-site biomarker reliability.TagsAlgorithmBiomarkerCT scanInventorsDespina KontosHannah HorngRussell ShinoharaManagerJoan MartinezDepartmentsBioengineeringBiostatistics, Epidemiology and InformaticsRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-04
AI-powered breast density assessment for improved cancer risk predictionProxy117AI-driven Deep-LIBRA quantifies breast density with spatial maps, improving risk prediction and enabling open, validated research tools.TagsArtificial intelligenceBreastBreast cancerInventorsDespina KontosOmid Haji MaghsoudiaManagerJoan MartinezDepartmentsRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-04
Attention-based framework for cell-cell communication analysisCU26099Dynamic, attention-based AMICI framework reveals time-varying cell-cell interactions and signaling nodes in tissue contexts.TagsAttention (machine learning)Cell signalingDevelopmental biologyInventorsElham AziziJustin HongKhushi DesaiManagerJoan MartinezDepartmentsBiomedical EngineeringComputer ScienceDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-12-04
Deep learning framework for generating nonfat-suppressed MR images from fat-suppressed scansCU26094Sat2Nu: a U-Net framework converts fat-suppressed breast MRIs into nonfat-suppressed images, boosting diagnostic workflow without extra scans.TagsAdipose tissueBreast cancerDeep learningInventorsDespina KontosKalina SlavkovaManagerJoan MartinezDepartmentsRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-01
Colorectal cancer organoid model for therapeutic testingCU26010Patient-derived 3D colorectal cancer organoids enable precise drug screening, personalized therapy, and biomarker discovery.TagsColorectal cancerExtracellular matrixHigh-throughput screeningInventorsCasidhe-Nicole BethancourtDavid CohenJoel T. Gabre MDManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedicineSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2025-10-09
Penalized inverse-variance weighted estimator for robust Mendelian randomizationCU25374Penalized IVW estimator improves Mendelian randomization robustness to weak instruments and pleiotropy, with fast, bias-reducing correction.TagsBiomarkerBiometricsCausal inferenceInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Erastin analogs for genotype-selective ferroptosis inductionCU14068ERS: Genotype-selective ferroptosis induction using enhanced erastin analogs targeting RAS V12+ tumors for potent, soluble, stable anticancer activity.TagsApoptosisFunctional groupGenotypeInventorsBrent StockwellMarie-Helene LarraufieWan Seok YangManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2025-05-22
Precision-engineered biomaterial scaffold for periodontal ligament regenerationCU25075A customizable templated scaffold guides periodontal ligament regeneration, closely mimicking native structure for full periodontium recovery.TagsBiomaterialCollagenDental implantInventorsHelen Lu Ph.D.Philip Andrew Patrick BrudnickiThomas BinaManagerJoan MartinezDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-05-08
Lymphocyte therapeutic method for hematological conditionsCU24081Enriched CD8+ T cell isolation enables targeted leukemia therapy; biomarkers predict potency and may boost DLI efficacy.TagsAcute myeloid leukemiaCD3 (immunology)Cell therapyInventorsCameron Young ParkElham AziziManagerJoan MartinezDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-05-08
Quantitative measurement of eye and head movements for the diagnosis of traumatic brain injury and neurodegenerationCU21135Quantitative eye-head movement tracking diagnoses concussion and neurodegeneration, enabling rapid, objective tremor-based brain injury assessment.TagsBiomarkerCase–control studyCognitive deficitInventorsChristopher DriscollLinus SunThomas BottiglieriManagerJoan MartinezDepartmentsInstitute of Human NutritionOphthalmologyOrthopedic SurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-21CollectionsCNS/Neurology
Combination therapies for Diffuse Midline Glioma (DMG) treatmentCU24228Targeted, MR-driven DMG combination therapy to overcome tumor heterogeneity; predicts and inverts master regulator activity for improved efficacy.TagsCentral nervous systemDrug developmentGliomaInventorsAndrea CalifanoEster Calvo FernandezJovana PavisicManagerJoan MartinezDepartmentsBiomedical InformaticsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-02
Targeting a neural fat-sensing pathway for the treatment of obesityCU22137Target fat-sensing gut-brain pathway to curb high-fat eating; potential obesity, diabetes, and heart-disease therapeutics.TagsCardiovascular diseaseChronic kidney diseaseDrug developmentInventorsCharles S. ZukerMengtong LiZhengyuan LuManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsBiological SciencesMortimer B. Zuckerman Mind Brain Behavior InstituteDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2024-08-01
Combination therapy to increase the efficacy of antibody-drug conjugates in bladder cancerCU24095Small molecule reprograms bladder cancer cells to upregulate antigens, boosting antibody-drug conjugate efficacy. 14 words.TagsAntibody-drug conjugateAntigenBiopharmaceuticalInventorsJohn Robert ChristinMichael Shen Ph.D.ManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-09
Multi-target directed ligand drug development pipeline for Alzheimer's DiseaseCU23303A high-throughput, cost-efficient preclinical pipeline synthesizes and tests multi-target ligands for Alzheimer's, using zebrafish models.TagsBiomarkerCholinesteraseDrug developmentInventorsCaghan KizilManagerJoan MartinezDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-06-21
ARP-154 (HeLa T4+) human cancer cell line generated by gene transfer for AIDS researchCU24290CD4-expressing HeLa-derived cell line enables AIDS research; facilitates HIV binding studies, drug screening, and therapeutic development.TagsAIDSAntigenAutoimmune diseaseInventorsPaul J. MaddonRichard Axel M.D.ManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2024-05-29
Efficient drug discovery pipeline and lead compounds for Alzheimer's diseaseCU23156Multi-target Alzheimer’s drug discovery platform accelerates preclinical lead compounds with in vitro/in vivo efficacy and safety.TagsAgonistAmyloid betaAnimal testingInventorsCaghan KizilManagerJoan MartinezDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-10CollectionsSmall MoleculeCNS/NeurologyPlatform/Research Tool
Inducible genetic knockdown library for Saccharomyces cerevisiaeCU21052Inducible CRISPRi library for yeast enables tetracycline-controlled, genome-wide gene knockdown with high coverage and precision.TagsCRISPREpistasisEukaryoteInventorsAmir Momen-RoknabadiPanagiotis OikonomouSaeed TavazoieManagerJoan MartinezDepartmentsBiochemistryBiological SciencesSystems BiologyDivisionsColumbia University Medical CenterColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2020-10-23
Environmentally-friendly electrospinning methodCU19028Green electrospinning uses safer Class 3 solvents (acetic acid) with PLGA/PCL blends for versatile, low-toxicity biofibers.TagsApatiteBoneCalciumInventorsChristopher Zachary MosherHelen LuZhengxiang GongManagerJoan MartinezDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-01-27
MRI-based radiomic analysis for DCIS risk stratification and treatment planningCU26092MRI radiomics from standard breast MRI predicts DCIS upstaging to guide active surveillance and personalized treatment.TagsBreast cancerCancerCarcinomaInventorsDespina KontosHabib RabharManagerJoan MartinezDepartmentsRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-01
Novel algorithms for population structure inferenceCU25377ERStruct: fast, AI-augmented population structure inference from whole-genome data; scalable, MATLAB/Python package for precise PCA components.TagsAlgorithmAllele frequencyArtificial intelligenceInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
A self-reportable scale for measuring perceived cognitive changeCU25123A self-report scale (Cognitive Change Scale) tracks subtle, year-over-year cognitive changes in neurologic patients, especially MS.TagsCognitionMild cognitive impairmentMultiple sclerosisInventorsVictoria LeavittManagerJoan MartinezDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-10
Highly efficient T cell base editing for enhanced immunotherapiesCU24092Ultra-efficient base editing in human T cells using adenine/cytosine editors; enhances CAR-T, autoimmune therapies with lower toxicity.TagsAdenineCancerChimeric antigen receptor T cellInventorsBenjamin Izar MD, PhDZachary WalshManagerJoan MartinezDepartmentsMedicineMedicine - Hematology/OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08
Lung organoid cells for therapeutic interventionCU23361Therapeutic lung regeneration via patient-specific stem cell–derived distal lung organoids with graftable basal and secretory cells.TagsCell therapyChronic obstructive pulmonary diseaseCoatingInventorsHans-Willem SnoeckManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-09-08
Tumor irradiation role in adenosine signalingCU22323Examines how tumor irradiation modulates adenosine signaling to enhance immunotherapy and tumor microenvironment targeting.TagsAdenosineCancer immunotherapyCancer vaccineInventorsCatherine Spina MD, PhDShruti BansalManagerJoan MartinezDepartmentsRadiation OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-06-02CollectionsOncology
Blockchain platform for the storage of clinical and genetic dataCU23145A secure, scalable blockchain system harmonizes clinical and genetic data for precision medicine, enabling privacy-respecting sharing and queries.TagsAmyotrophic lateral sclerosisBlockchainClinical trialInventorsAhmed ElhusseinGamze GursoyManagerJoan MartinezDepartmentsBiomedical InformaticsDivisionsColumbia University Medical Center (CUMC)Release Date2023-02-28CollectionsPlatform/Research ToolDigital Health (Software, AI, bioinformatics, etc)
Inducible mouse line for cardiac NOX2 inhibitionCU22219Inducible cardiac NRROS-based NOX2 inhibition in mice; tissue-specific ROS control to protect against diet-induced arrhythmias.TagsAntioxidantAtherosclerosisCardiac muscleInventorsJohn MorrowManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2022-02-16CollectionsCardiovascular
Magnetic Resonance Spectrum Simulator - MARSSCU19215A fast MATLAB-based tool to simulate and optimize MRS/NMR spectra, enabling 10–100x speedups and accurate quantification.TagsMATLABNuclear magnetic resonanceNuclear magnetic resonance spectroscopyInventorsChristoph JuchemKarl LandheerManagerJoan MartinezDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2019-03-22CollectionsDigital Health (Software, AI, bioinformatics, etc)
FIN56, a well-characterized small molecule for modeling ferroptosis-mediated cell deathCU17131FIN56 triggers ferroptosis by GPX4 suppression and lipid oxidation, enabling research tools and drug discovery for neurodegenerative and cancer therapies.TagsBiosynthesisCancerCancer cellInventorsBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2018-05-25CollectionsSmall MoleculeOncologyCNS/Neurology
Platform to produce zero-calorie sweet proteins as a sugar alternativeCU25177Yeast-produced, zero-calorie sweet proteins offer natural, sweeter-than-artificial sugar substitutes for foods, beverages, and processing.TagsBakingDietary supplementMedicationInventorsAnum GlasgowDaniel SultanovKyle Clark WeberManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-15
Computer algorithm for volumetric breast density estimationCU26093Fully automated algorithm quantifies volumetric breast density from 3D tomosynthesis images, improving objectivity and risk assessment.Tags3D modelingAlgorithmBreast cancerInventorsDespina KontosSaid PertuzManagerJoan MartinezDepartmentsRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-01
Gut endocrine Rbp2 knockout mouse model for metabolic hormone studiesCU25453Gut-endocrine cell-specific Rbp2 knockout mouse enables retinoid-driven regulation study of gut hormones and metabolic outcomes.TagsAlleleCausal inferenceCre recombinaseInventorsRossana M. CalderonManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-10-16
Multi-knockoff filter for high-dimensional survival -omics with controlled false discovery rateCU25376CoxMKF: a multi-knockoff survival mediation method that guarantees finite-sample FDR control with stable, data-driven thresholds.TagsAssayBioinformaticsBiomarkerInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Deep learning framework for semiparametric causal mediation analysisCU25372DeepMed enables bias-reduced causal mediation with non-sparse deep nets, offering semiparametric guarantees and an open-source R package.TagsArtificial neural networkB testingBig dataInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
