Calibration-free affinity biosensors for rapid, accurate biomarker detectionCU22223Calibration-free graphene FET biosensor uses aptamer kinetics for rapid, device-wide reproducible biomarker detection without per-sensor calibration.TagsBiomarkerAptamerBiosensorInventorsMilan N. Stojanovic M.D.Qiao LinWenting DaiManagerDovina QuDepartmentsMechanical EngineeringMedicineDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-08-21
Biomarker and treatment for autoimmune hemolytic anemia (AIHA)CU24097Biomarker predicts AIHA onset; apyrase therapy prevents/mitigates AIHA in preclinical models by modulating purinergic signaling.TagsBiomarkerAnemiaAutoantibodyInventorsFlavia Dei ZottiKrystalyn HudsonManagerJerry KokoshkaDepartmentsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-12-18CollectionsRare Disease
Immature myeloid cell activation pathway in inflammation-linked cancerCU26121IL-8–driven immature myeloid cell mobilization fuels inflammation-linked GI cancer; targets IMCs for therapy and biomarkers.TagsBiomarkerAngiogenesisBone marrowInventorsTimothy Wang M.D.ManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Radiomic harmonization tool for multicenter disease studiesProxy118Advanced radiomic harmonization: data-driven, multi-source correction across scanners to boost cross-site biomarker reliability.TagsBiomarkerAlgorithmCT scanInventorsDespina KontosHannah HorngRussell ShinoharaManagerJoan MartinezDepartmentsBioengineeringBiostatistics, Epidemiology and InformaticsRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-04
Restoring cerebellar circuit function to treat ataxiaCU26133Restores CF-PC synapse function to normalize cerebellar rhythm, alleviating ataxia by repairing circuit defects.TagsBiomarkerAlpha waveAtaxiaInventorsSheng-Han KuoManagerJerry KokoshkaDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Acoustically enhanced biomolecular sensing for rapid diagnosticsCU24184Acoustic-driven nanoparticle clustering boosts biosensor speed and sensitivity, enabling rapid, cross-target biomarker diagnostics.TagsBiomarkerBiosensorDiffusionInventorsFeiyue TengOleg GangZohar Albert ArnonManagerGreg MaskelDepartmentsChemical Engineering/Applied ChemistryMaterials ScienceDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-10-03
Anxa1-Cre mouse for selective modeling of dopaminergic neurons in Parkinson's diseaseCU26032Anxa1-Cre mouse enables precise manipulation of a vulnerable dopaminergic neuron subtype to study early Parkinson’s motor deficits.TagsBiomarkerCausalityCre recombinaseInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-07
Therapeutic antibodies against amyloid aggregatesCU23354Antibody platform targets TMEM106B amyloid aggregates for diagnosis, therapeutics, and research across neurodegenerative diseases.TagsBiomarkerAmyloid betaAntibodyInventorsAnthony William Paul FitzpatrickCarolyn LeeJunqiang Ye Ph.D.ManagerKristin NeumanDepartmentsBiochemistryBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-26
Heterochiral translators for nuclease-resistant DNA computingCU19156Heterochiral DNA logic circuits convert D-DNA/RNA inputs to nuclease-resistant L-DNA outputs, enabling biorthogonal, intracellular sensing.TagsBiomarkerChiralityDNA nanotechnologyInventorsDarko StefanovicMatthew R. LakinMilan N. Stojanovic M.D.ManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)STC.UNMRelease Date2026-02-20
Automated MRI-based breast cancer segmentationCU26095AI-driven, scalable MRI segmentation for breast cancer (DCIS); automates lesion delineation, boosting speed, consistency, and research utility.TagsBiomarkerBreast cancerBreast cancer screeningInventorsDespina KontosKalina SlavkovaManagerJoan MartinezDepartmentsRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-20
NAPA-ID: a proximity-based system to decode protein-protein interactionsCU26166NAPA-ID enables antibody-guided, proximity labeling of protein interactions without genetic editing, compatible with standard proteomics workflows.TagsBiomarkerAntibodyBiological engineeringInventorsJeremy CartalasSara ZaccaraManagerJerry KokoshkaDepartmentsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-17
Scalable, reproducible, immune-intact tumor organoid co-culture platformCU24328Patient-derived immune-intact tumor organoids enable scalable, reproducible co-culture for personalized immunotherapy and drug screening.TagsBiomarkerBiotechnologyCancer immunotherapyInventorsDavid CohenJoel T. Gabre MDManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Enzyme target for fat regulation to treat obesity, diabetes, and cachexiaCU25092Methionine sulfoxide reductase–iron interaction triggers adipose browning, boosting energy use to combat obesity, diabetes, and cachexia.TagsBiomarkerAdipose tissueCachexiaInventorsChristine Iok In Chio PhDManagerJoan MartinezDepartmentsInstitute for Cancer GeneticsDivisionsColumbia University Medical Center (CUMC)Release Date2025-10-13
Multi-knockoff filter for high-dimensional survival -omics with controlled false discovery rateCU25376CoxMKF: a multi-knockoff survival mediation method that guarantees finite-sample FDR control with stable, data-driven thresholds.TagsBiomarkerAssayBioinformaticsInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Novel algorithms for population structure inferenceCU25377ERStruct: fast, AI-augmented population structure inference from whole-genome data; scalable, MATLAB/Python package for precise PCA components.TagsBiomarkerAlgorithmAllele frequencyInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Integrated AI platform for causal discovery and drug validationCU25378Cloud-based AI suite enabling causal discovery, multimodal data integration, and translational drug validation for personalized medicine.TagsBiomarkerAntigenArtificial intelligenceInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Penalized inverse-variance weighted estimator for robust Mendelian randomizationCU25374Penalized IVW estimator improves Mendelian randomization robustness to weak instruments and pleiotropy, with fast, bias-reducing correction.TagsBiomarkerBiometricsCausal inferenceInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Machine learning pipeline for neoantigen prioritization in personalized immunotherapiesCU25375ImmuneMirror: integrative ML pipeline predicting immunogenic neoantigens by combining processing, transport, binding, and recognition factors.TagsBiomarkerAntigenCancer immunotherapyInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
VPS35 floxed mouse model for Alzheimer's drug discoveryCU25395Inducible, tissue-specific VPS35 knockout mouse enabling controlled adult-onset retromer disruption for Alzheimer’s research.TagsBiomarkerCerebrospinal fluidDrug discoveryInventorsScott A. Small M.D.ManagerJerry KokoshkaDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-31
Combinatorial treatment for amyotrophic lateral sclerosis (ALS)CU25447Combinatorial ASO therapy targets 15 dysregulated genes in SOD1-ALS, mitigating neuron death and boosting motor function.TagsBiomarkerAmyotrophic lateral sclerosisCombinatoricsInventorsGeorge Z. Mentis Ph.D.JoonHyung ParkManagerJerry KokoshkaDepartmentsPathology & Cell BiologyPathology and Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-29
Chaperone-enhanced platform for rescuing protein misfolding in neurodegenerative diseasesCU22082Chaperone-based gene therapy stabilizes RNA-binding proteins, reducing misfolding and aggregation in ALS/FTD. 120-150 chars.TagsBiomarkerAmyotrophic lateral sclerosisChaperone (protein)InventorsAlejandro ChavezSamuel J. ResnickManagerCynthia LangDepartmentsPathology & Cell BiologyProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2025-07-17
Neuroproteasome-inhibiting bioconjugate for prevention of tau aggregation in Alzheimer's diseaseCU23159A neuronal proteasome-targeting bioconjugate inhibits early Tau aggregation, offering ApoE-selective, precise tauopathy intervention.TagsBiomarkerApolipoprotein EBioconjugationInventorsKapil RamachandranManagerJerry KokoshkaDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-01
Rapid, point-of-care assessment of radiation exposure in human bloodCU24211ELISA-based biodosimeter profiles blood biomarkers and uses ML to triage ionizing-radiation exposure-assessment at point-of-care.TagsBiomarkerAssayBioassayInventorsHelen TurnerIgor ShuryakKarthik KanagarajManagerJoan MartinezDepartmentsCenter for Radiological ResearchRadiation OncologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-05-05
Quantitative measurement of eye and head movements for the diagnosis of traumatic brain injury and neurodegenerationCU21135Quantitative eye-head movement tracking diagnoses concussion and neurodegeneration, enabling rapid, objective tremor-based brain injury assessment.TagsBiomarkerCase–control studyCognitive deficitInventorsChristopher DriscollLinus SunThomas BottiglieriManagerJoan MartinezDepartmentsInstitute of Human NutritionOphthalmologyOrthopedic SurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-21CollectionsCNS/Neurology
Targeting EGFR and IL-6 for the treatment of liver fibrosis and insulin resistanceCU23130Targeting Treg-derived amphiregulin–EGFR axis and IL-6 to treat liver fibrosis and insulin resistance in MASH.TagsBiomarkerCrosstalkCytokineInventorsNicholas ArpaiaThomas SavageManagerCynthia LangDepartmentsMicrobiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-24
Lipid targets and biomarkers for ferroptosisCU24174Lipid biomarkers (PC-PUFA2s) drive ferroptosis; enables diagnostics and targeted therapies by regulating iron-dependent cell death.TagsBiomarkerAcyl groupApoptosisInventorsBaiyu QiuBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2024-12-20
Clinical management of Interstitial Lung Disease using a multiplex real-time PCR assay to quantify leukocyte telomere lengthCU24245Multiplex real-time PCR quantifies average leukocyte telomere length to guide ILD treatment decisions and outcomes.TagsBiomarkerAssayImmunosuppressionInventorsChad NewtonChristine K. GarciaDavid ZhangManagerKristin NeumanDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-13
Metabolic biomarkers for targeted treatment of schizophrenia and related disordersCU25032Metabolic biomarkers identify GLS1-driven glutamate elevation in early schizophrenia via 3T 1H-MRS, enabling targeted therapies and trials.TagsBiomarkerAtrophyAttention deficit hyperactivity disorderInventorsDouglas RothmanJia GuoScott A. Small M.D.ManagerJerry KokoshkaDepartmentsNeurologyPsychiatryDivisionsColumbia University Medical Center (CUMC)Release Date2024-12-06
High-throughput single-cell multi-omics platform for integrated RNA, DNA, and protein analysisCU21072Integrated single-cell platform enabling high-throughput RNA, DNA, and protein profiling for holistic cellular insights and scalable studies.TagsBiomarkerCell nucleusDrug discoveryInventorsPeter A. SimsTimothy R. OlsenManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-02CollectionsGenomics & Multi-Omics
Gene silencing for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)CU23021Silencing CASP8-METRN halts progression from steatosis to MASH, offering non-invasive therapy and diagnostic biomarkers.TagsBiomarkerBlood plasmaCaspase 8InventorsDanish SaleheenIra Tabas MD, PhDShareef KhalidManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08
Targeting glial cells for treating myelofibrosisCU23243Targeting Sox10+ and ErbB3+ glial cells in bone marrow to slow or halt myelofibrosis progression.TagsBiomarkerAortic dissectionCell therapyInventorsJunsong ZhouLei DingShawn SarkariaManagerKristin NeumanDepartmentsMicrobiologyOncologyRehabilitation & Regenerative MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-21CollectionsOncology
CD58 modulation for improved cancer immunotherapy outcomesCU21046CD58 modulation enhances antitumor immunity, overcoming resistance and informing biomarkers for optimized, combinational cancer immunotherapy.TagsBiomarkerAntigen presentationCancer cellInventorsBenjamin Izar MD, PhDJohannes MelmsManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-10-17
Pharmacological inhibitors and mouse models of mitochondrial DNA depletion-deletion syndromes (MDDS)CU23197Therapeutic mouse models and deoxynucleoside-based treatment restore mtDNA balance in GUK1-related MDDS, enabling mtDNA repair.TagsBiomarkerAcute respiratory distress syndromeBiopharmaceuticalInventorsAgustin Hidalgo GutierrezJonathan ShintakuMichio Hirano M.D.ManagerKristin NeumanDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08CollectionsRare Disease
Modulation of mitochondrial transport for neuropathy treatmentCU24079Modulates MFN2-driven ATAT1 recruitment to restore tubulin acetylation and mitochondrial transport to treat CMT2A neuropathy.TagsBiomarkerAcetylationCharcot–Marie–Tooth diseaseInventorsAtul KumarFrancesca Bartolini Ph.D.ManagerKristin NeumanDepartmentsPathology & Cell BiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2024-08-29CollectionsCNS/Neurology
Multi-target directed ligand drug development pipeline for Alzheimer's DiseaseCU23303A high-throughput, cost-efficient preclinical pipeline synthesizes and tests multi-target ligands for Alzheimer's, using zebrafish models.TagsBiomarkerCholinesteraseDrug developmentInventorsCaghan KizilManagerJoan MartinezDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-06-21
Potential therapeutic target or biomarker of myalgic encephalomyelitis/chronic fatigue syndromeCU22395Proposes immune dysfunction biomarkers and targets in ME/CFS linked to gut barrier failure, enabling diagnostics and therapy.TagsBiomarkerC-reactive proteinChronic fatigue syndromeInventorsArmin AlaediniSuzanne D. VernonManagerJerry KokoshkaDepartmentsMedicineResearchDivisionsColumbia University Medical Center (CUMC)Release Date2022-08-19
Real-time in situ measurement of electrical impedance of lung tissueCU22293Real-time in situ airway impedance device assesses epithelial health, enabling rapid COPD, asthma, and lung disease monitoring.TagsBiomarkerAsthmaCystic fibrosisInventorsGordana Vunjak-NovakovicJiawen ChenJinho KimManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-05-29
ARP-154 (HeLa T4+) human cancer cell line generated by gene transfer for AIDS researchCU24290CD4-expressing HeLa-derived cell line enables AIDS research; facilitates HIV binding studies, drug screening, and therapeutic development.TagsBiomarkerAIDSAntigenInventorsPaul J. MaddonRichard Axel M.D.ManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2024-05-29
Alzheimer's disease detection and treatment based on ceramide and sphingolipid levelsCU15147Gene-targeted reduction of ER-MAM APP-C99 via ceramide/sphingolipid biomarkers enables early Alzheimer’s detection and therapeutic modulation.TagsBiomarkerAmyloid betaCell membraneInventorsEric A. Schon Ph.D.Estela Area-GomezManagerKristin NeumanDepartmentsNeurologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Release Date2024-04-25CollectionsCNS/Neurology
Targeting IL-17A for treating neuroinflammation from Group A Streptococcus infectionsCU19125IL-17A neutralization targets GAS-induced neuroinflammation, offering PANDAS/Sydenhams treatment potential and Th17 pathway insights.TagsBiomarkerAntibioticAntibodyInventorsAndrew Sproul Ph.D.Dritan AgalliuIlir AgalliuManagerSara GusikDepartmentsEpidemiology & Population Health, UrologyNeurologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Yeshiva UniversityRelease Date2024-04-12CollectionsCNS/Neurology
Focused ultrasound-induced blood-brain barrier opening for noninvasive extracellular vesicle releaseCU23167Focused ultrasound opens the blood-brain barrier to boost peripheral extracellular vesicle release, enabling sensitive neurological biomarkers.TagsBiomarkerBlood–brain barrierCavitationInventorsAlec J. BattsAlina R. Kline-SchoderElisa KonofagouManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-01-18CollectionsCNS/NeurologyPlatform/Research ToolMedical Device
Transgenic zebrafish lines for Alzheimer’s disease modelsCU23304Transgenic zebrafish expressing amyloid beta and Tau model Alzheimer's pathology for in vivo drug screening and biomarker research.TagsBiomarkerAmyloid betaDrug developmentInventorsCaghan KizilManagerJoan MartinezDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-09-25CollectionsCNS/Neurology
ssg-MeDIP-Seq and sscf-MeDIP-Seq for DNA methylation detectionCU24002Integrated ssg- and sscf-MeDIP-Seq detect methylation and hemi-methylation for higher-precision tumor diagnosis via cfDNA.TagsBiomarkerArtificial intelligenceBlood plasmaInventorsHui ZhouXu HuaZhiguo Zhang Ph.D.ManagerJoan MartinezDepartmentsGenetics & DevelopmentInstitute for Cancer GeneticsDivisionsColumbia University Medical Center (CUMC)Release Date2023-09-25CollectionsOncologyMedical Device
Non-invasive method for detection of cancer methylomesCU21185Non-invasive methylation profiling of tumor cfDNA enables early cancer detection, tumor origin, and targeted treatment insights.TagsBiomarker5-MethylcytosineAntibodyInventorsHui ZhouRegina Santella Ph.D.Zhiguo ZhangManagerJoan MartinezDepartmentsEnvironmental Health ScienceGenetics & DevelopmentInstitute for Cancer GeneticsDivisionsColumbia University Medical Center (CUMC)Mailman School Of Public Health (MSPH)Release Date2023-08-04CollectionsOncology
Rapid, highly sensitive multiplexed viral detection with nanoporesCU21160Ultrafast, amplification-free nanopore-based single-molecule assay for multiplexed viral detection (SARS-CoV-2) and antibodies.TagsBiomarkerAntibodyAntigenInventorsChuanjuan TaoJames J. RussoJingyue JuManagerCynthia LangDepartmentsChemical Engineering/Applied ChemistryChemistryGenome CenterDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering andFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-07-20
Optimizing multiplex decisions using machine learning for cancer screeningCU23231Bayesian optimization reduces calculations for multiplex cancer screening without assumptions, updating predictions with real-world data.TagsBiomarkerAlgorithmBayesian inferenceInventorsYing Kuen (Ken) CheungManagerSara GusikDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2023-07-14CollectionsOncologyMedical DeviceDigital Health (Software, AI, bioinformatics, etc)
Recombinant protein to treat inflammationCU23248Recombinant FSTL-1 protein targets and reduces cardiac inflammation, aiding Kawasaki disease research and myocarditis treatment.TagsBiomarkerAnti-inflammatoryAtherosclerosisInventorsMark GorelikManagerSara GusikDepartmentsPediatrics/RheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-10CollectionsCardiovascular
A preclinical Gba p.E326K mouse model for precision-medicine researchCU23198CRISPR-generated Gba p.E326K mouse model for Gaucher, PD, and DLB research; enables biomarker discovery and preclinical drug testing.TagsBiomarkerCognitive deficitDementiaInventorsLorraine ClarkManagerKristin NeumanDepartmentsPathologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-03-17CollectionsCNS/NeurologyPlatform/Research Tool
Inhibition of osteoblast activity to treat acute myeloid leukemia (AML) and myelodysplasia (MD)CU21283Inhibits osteoblast–AML crosstalk via kynurenine/SAA axis, reducing leukemia progression; therapeutic and biomarker potential.TagsBiomarker5-HT receptorAcute myeloid leukemiaInventorsMarta Galan-DiezStavroula KousteniManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2023-01-24CollectionsOncology
Selective T cell repopulation for enhanced immunotherapyCU20336Selective T cell repopulation boosts immunotherapy by expanding progenitor T cells in blood/tumor to predict and enhance response.TagsBiomarkerAssayAutoimmune diseaseInventorsBrian HenickSteven ReinerManagerKristin NeumanDepartmentsMedicineMicrobiologyDivisionsColumbia University Medical Center (CUMC)Release Date2021-01-29CollectionsOncology
