High-throughput method for gene insertionCU19411A high-throughput, vector-based CRISPR system enabling parallel, precise DNA insertions in human cells for scalable genome editing.TagsHigh-throughput screeningBacteriaCas9InventorsAlejandro ChavezBrijesh Kumar SinghManagerCynthia LangDepartmentsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-17
Chemical painting for high-throughput single-cell drug response analysisCU23332Multiplexed infrared imaging enables high-throughput, single-cell drug profiling with ML-enabled mechanism-of-action predictions.TagsHigh-throughput screeningCombination therapyDNA sequencingInventorsWei MinXinwen LiuManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-10-16
Mechanobiological assay for glaucoma drug screeningCU23377In vitro mechanobiological assay using patient Schlemm’s canal cells; high-throughput pore formation tests to screen glaucoma drugs.TagsHigh-throughput screeningAqueous humourAssayInventorsDarryl OverbyJoseph van Batenburg-SherwoodKrishnakumar KizhatilManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of EngineeringColumbia University Medical Center (CUMC)Release Date2025-01-13
High-throughput approach for base editing the kinomeCU24051High-throughput base editing to selectively inhibit kinases endogenously, enabling scalable kinase function studies and drug target discovery.TagsHigh-throughput screeningChemical libraryEndogenous retrovirusInventorsNeil Vasan MD, PhDManagerJerry KokoshkaDepartmentsOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-12
High throughput, automated method for chromatin profiling using low-cell input samplesCU23333Automated, high-throughput ChIP-seq profiling from low-cell inputs enables scalable chromatin mapping and clinical diagnostics.TagsHigh-throughput screeningAutomationChIP sequencingInventorsAaron VinyManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-03-13
Genome-wide qPCR with increased primer multiplexity for diagnostics and drug screeningCU23284A qPCR platform using optically barcoded beads enables genome-wide multiplex expression analysis (100–10,000 targets) faster and cheaper.TagsHigh-throughput screeningAcidChain reactionInventorsNaixin QianWei MinZhilun ZhaoManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-10-16
Small scale screening bioreactor with airway tissues and mucosa for the progression and treatment of lung diseaseCU23307Bioreactor recreating mucus-lined airways ex vivo for real-time, high-throughput modeling and therapeutic screening.TagsHigh-throughput screeningBiomimeticsBioreactorInventorsGordana Vunjak-NovakovicJinho KimKeith YeagerManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-04-08
Patient-specific organoid system for pancreatic ductal adenocarcinoma (PDAC) drug screeningCU24025Patient-specific pancreatic cancer organoids with patient immune cells enable high-throughput drug screening and personalized therapy insights.TagsHigh-throughput screeningCell therapyImmune systemInventorsGulam ManjiIlenia PellicciottaManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-30CollectionsOncology
Predicting breast cancer treatment response through PIK3R1 mutation profilingCU26021Predicts breast cancer drug response via endogenous kinase inhibition models using PIK3R1 mutations; rapid, high-throughput screening.TagsHigh-throughput screeningAKT1AdenineInventorsNeil Vasan MD, PhDManagerJerry KokoshkaRelease Date2025-10-09
Optimizing multiplex decisions using machine learning for cancer screeningCU23231Bayesian optimization reduces calculations for multiplex cancer screening without assumptions, updating predictions with real-world data.TagsHigh-throughput screeningAlgorithmBayesian inferenceInventorsYing Kuen (Ken) CheungManagerSara GusikDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2023-07-14CollectionsOncologyMedical DeviceDigital Health (Software, AI, bioinformatics, etc)
CMOS imaging arrays for high-speed fluorescence lifetime imagingCU12003CMOS-SPAD FLIM array enables 200 fps wide-field imaging with on-chip timing, compact, cost-effective for live-cell and high-throughput assays.TagsHigh-throughput screeningCMOSDNA sequencingInventorsKenneth ShepardRyan M. FieldManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-10-09
Selective peptide inhibitor of late sodium current for precision arrhythmia treatmentCU24196A computationally designed peptide ELIXIR selectively inhibits pathogenic cardiac late sodium current, preserving normal flow and reducing arrhythmia risk.TagsHigh-throughput screeningArrhythmiaC-terminusInventorsBence HegyiDonald M. BersManu Ben-JohnyManagerKristin NeumanDepartmentsMedicinePharmacologyPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-26
High-efficiency CRISPR-Cas nucleaseCU25094Compact, high-efficiency CRISPR-Cas12j nuclease delivers AAV-packagable, 2x faster gene editing with high fidelity for therapeutics.TagsHigh-throughput screeningCRISPRDrug discoveryInventorsAnders Steen KnudsenStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-12-18CollectionsOphthalmology
Calibration-free affinity biosensors for rapid, accurate biomarker detectionCU22223Calibration-free graphene FET biosensor uses aptamer kinetics for rapid, device-wide reproducible biomarker detection without per-sensor calibration.TagsHigh-throughput screeningAptamerBiomarkerInventorsMilan N. Stojanovic M.D.Qiao LinWenting DaiManagerDovina QuDepartmentsMechanical EngineeringMedicineDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-08-21
Optical in situ nucleotide sequence detection using combinatorial hybridizationCU24118High-throughput optical CRISPR screening with combinatorial hybridization enables scalable, cost-efficient, multi-omic readouts in situ.TagsHigh-throughput screeningBreast cancerCRISPRInventorsJellert GaublommeManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2026-01-29CollectionsGenomics & Multi-Omics
GPX4 inhibitors for cancer therapyCU20261Potent, selective GPX4 inhibitors induce ferroptosis to target EMT-driven, drug-resistant cancers and enable GPX4 research.TagsHigh-throughput screeningActive siteAllosteric regulationInventorsBrent StockwellHengrui LiuManagerJoan MartinezDepartmentsBiological SciencesChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-05-01
Highly efficient T cell base editing for enhanced immunotherapiesCU24092Ultra-efficient base editing in human T cells using adenine/cytosine editors; enhances CAR-T, autoimmune therapies with lower toxicity.TagsHigh-throughput screeningAdenineCancerInventorsBenjamin Izar MD, PhDZachary WalshManagerJoan MartinezDepartmentsMedicineMedicine - Hematology/OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08
Integrated AI platform for causal discovery and drug validationCU25378Cloud-based AI suite enabling causal discovery, multimodal data integration, and translational drug validation for personalized medicine.TagsHigh-throughput screeningAntigenArtificial intelligenceInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Scalable, reproducible, immune-intact tumor organoid co-culture platformCU24328Patient-derived immune-intact tumor organoids enable scalable, reproducible co-culture for personalized immunotherapy and drug screening.TagsHigh-throughput screeningBiomarkerBiotechnologyInventorsDavid CohenJoel T. Gabre MDManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Colorectal cancer organoid model for therapeutic testingCU26010Patient-derived 3D colorectal cancer organoids enable precise drug screening, personalized therapy, and biomarker discovery.TagsHigh-throughput screeningColorectal cancerExtracellular matrixInventorsCasidhe-Nicole BethancourtDavid CohenJoel T. Gabre MDManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedicineSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2025-10-09
Universal gene editing strategy for cardiac arrhythmiaCU24243Universal gene-editing of Rad phosphorylation sites to curb adrenergic CaV1.2 signaling, offering targeted, long-term arrhythmia therapy.TagsHigh-throughput screeningArrhythmiaBeta blockerInventorsGregory NewbyGuoxia LiuSteven MarxManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-14
Immature myeloid cell activation pathway in inflammation-linked cancerCU26121IL-8–driven immature myeloid cell mobilization fuels inflammation-linked GI cancer; targets IMCs for therapy and biomarkers.TagsHigh-throughput screeningAngiogenesisBiomarkerInventorsTimothy Wang M.D.ManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Conditional knockout mouse model for studying autosomal-dominant optic atrophyCU26140A mammalian, cell-type–specific conditional Ssbp1 R107Q mouse model to dissect autosomal-dominant optic atrophy mechanisms.TagsHigh-throughput screeningAlleleArginineInventorsChyuan-Sheng (Victor) LinNan-Kai WangYunju TsengManagerKristin NeumanDepartmentsOphthalmologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
PDE5 inhibitor for Alzheimer's treatment2439A brain-penetrant PDE5 inhibitor enhances cGMP signaling, reduces amyloid, and supports synaptic plasticity in Alzheimer’s models.TagsHigh-throughput screeningAmyloid betaAmyloid plaquesInventorsDonald William Landry MD, Ph.D.Ottavio Arancio MD, PhDShi-xian DengManagerJerry KokoshkaDepartmentsMedicinePathologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-18
VRK2 kinase inhibitors for enhanced cancer immunotherapyCU21245VRK2 inhibitors boost PD-1 therapy by targeting downstream signaling, enhancing T cell activation and tumor clearance.TagsHigh-throughput screeningAdenocarcinomaBladder cancerInventorsAdam MorManagerCynthia LangDepartmentsRheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-17
Conformational DNA aptamers enabling small-molecule lateral flow assaysCU26117Conformational DNA aptamers enable rapid, cost-effective small-molecule detection in lateral flow assays via structure-switching binding.TagsHigh-throughput screeningAnalyteAntibodyInventorsKyungae YangManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-01
Microfluidic platform for large-scale single-cell sequencing and imagingCU16248Scalable, low-cost microfluidic platform linking live-cell imaging with single-cell RNA sequencing via optical barcodes.TagsHigh-throughput screeningBrain mappingCell cultureInventorsJinzhou YuanPeter A. SimsSayantan BoseManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-02CollectionsGenomics & Multi-Omics
Foxo1 inhibition for disease treatmentCU24187Foxo1 inhibitors spark enteroendocrine-to-beta cell conversion, boosting natural insulin production for diabetes treatment.TagsHigh-throughput screeningBeta cellDrug developmentInventorsDomenico Accili M.D.Sandro BelvedereManagerCynthia LangDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-11-13
Targeted knock-in mouse line for studying neuropsychiatric diseaseCU26034A knock-in mouse line enabling precise A2a-expressing neuron targeting in basal ganglia for neuropsychiatric research and drug validation.TagsHigh-throughput screeningAdenosine A2A receptorBasal gangliaInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-13
A2a-FlpO mouse model for neuroscience studiesCU26036Precise, cell-type specific A2a-FlpO knock-in mice enable orthogonal D1/D2 dopaminergic studies in basal ganglia circuits.TagsHigh-throughput screeningBasal gangliaBehavioral neuroscienceInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-13
Anxa1-Cre mouse for selective modeling of dopaminergic neurons in Parkinson's diseaseCU26032Anxa1-Cre mouse enables precise manipulation of a vulnerable dopaminergic neuron subtype to study early Parkinson’s motor deficits.TagsHigh-throughput screeningBiomarkerCausalityInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-07
Gut endocrine Rbp2 knockout mouse model for metabolic hormone studiesCU25453Gut-endocrine cell-specific Rbp2 knockout mouse enables retinoid-driven regulation study of gut hormones and metabolic outcomes.TagsHigh-throughput screeningAlleleCausal inferenceInventorsRossana M. CalderonManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-10-16
Riboswitch sensors to detect clinical biomarkersCU25097Real-time riboswitch–aptamer biosensors monitor creatine, urea, electrolytes for dynamic antibiotic dosing during kidney injury treatment.TagsHigh-throughput screeningAcute kidney injuryAntibioticInventorsMilan N. Stojanovic M.D.Nenad MilosavicSteven M.F. Kennedy TaylorManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchMedicineNephrologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-21
Machine learning pipeline for neoantigen prioritization in personalized immunotherapiesCU25375ImmuneMirror: integrative ML pipeline predicting immunogenic neoantigens by combining processing, transport, binding, and recognition factors.TagsHigh-throughput screeningAntigenBiomarkerInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Gene therapy for metabolic dysfunction-associated steatohepatitis (MASH)CU25230Gene therapy restoring retromer activity to treat MASH by normalizing lipid metabolism and reducing fibrosis risk.TagsHigh-throughput screeningCirrhosisDrug discoveryInventorsGregory A. PetskoScott A. Small M.D.ManagerJerry KokoshkaDepartmentsAnn Romney Center for Neurologic DiseasesNeurologyDivisionsColumbia University Medical Center (CUMC)Harvard Medical School and Brigham & Women’s HospitalRelease Date2025-07-31
Natural language processing tool for cognitive scoring in Alzheimer's Disease patientsCU25391NLP platform predicts MMSE scores from unstructured clinical notes, enabling retrospective cognitive assessment in Alzheimer’s patients.TagsHigh-throughput screeningEHealthElectronic health recordInventorsBetina Ross S IdnayChunhua WengFangyi ChenManagerJoan MartinezDepartmentsBiomedical InformaticsDivisionsColumbia University Medical Center ( CUMColumbia University Medical Center (CUMC)Release Date2025-07-31
Focused ultrasound nanoparticles for targeted imaging and neuroregenerationCU21224Ultrasound-activated nanocup theranostics cross BBB for targeted Alzheimer’s imaging and neuroregenerative therapy.TagsHigh-throughput screeningAmyloid betaAntibodyInventorsAntonios PoulipoulosElisa KonofagouManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-07-29
Combinatorial treatment for amyotrophic lateral sclerosis (ALS)CU25447Combinatorial ASO therapy targets 15 dysregulated genes in SOD1-ALS, mitigating neuron death and boosting motor function.TagsHigh-throughput screeningAmyotrophic lateral sclerosisBiomarkerInventorsGeorge Z. Mentis Ph.D.JoonHyung ParkManagerJerry KokoshkaDepartmentsPathology & Cell BiologyPathology and Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-29
Chaperone-enhanced platform for rescuing protein misfolding in neurodegenerative diseasesCU22082Chaperone-based gene therapy stabilizes RNA-binding proteins, reducing misfolding and aggregation in ALS/FTD. 120-150 chars.TagsHigh-throughput screeningAmyotrophic lateral sclerosisBiomarkerInventorsAlejandro ChavezSamuel J. ResnickManagerCynthia LangDepartmentsPathology & Cell BiologyProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2025-07-17
Photocatalysis method with low-energy lightCU18169Photon upconversion enables infrared-driven, safer photocatalysis with deeper penetration for pharma, biomedicine, and materials.TagsHigh-throughput screeningAntimicrobialBiomedicineInventorsAndrew B. PunBenjamin RavetzDaniel N. CongreveManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesMassachusetts Eye and Ear InfirmaryRelease Date2024-12-06
SUMO2 conjugation therapy for restoring cognitive function in Alzheimer's diseaseCU23265SUMO2-based biologic restores synaptic function and memory in Alzheimer's without reducing amyloid, enabling late-stage cognitive recovery.TagsHigh-throughput screeningAdjuvant therapyAmyloid betaInventorsLuana Fioriti Ph.D.Ottavio ArancioPaul Edward FraserManagerJerry KokoshkaDepartmentsMortimer B. Zuckerman Mind Brain Behavior InstitutePathologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-06-26
Lymphocyte therapeutic method for hematological conditionsCU24081Enriched CD8+ T cell isolation enables targeted leukemia therapy; biomarkers predict potency and may boost DLI efficacy.TagsHigh-throughput screeningAcute myeloid leukemiaCD3 (immunology)InventorsCameron Young ParkElham AziziManagerJoan MartinezDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-05-08
Rapid DNA extraction and direct-barcoding for efficient nanopore-based DNA sequencingCU19244Rapid nanopore DNA sequencing with 15-minute extraction, direct barcoding, and low-cost, high-throughput genetic analysis.TagsHigh-throughput screeningAmniotic fluidAneuploidyInventorsSamuel Z. "Zev" WilliamsShan WeiManagerCynthia LangDepartmentsObstetrics & GynecologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05
Fluorescent labeling of cell surface proteins in vivo with spatiotemporal controlCU25172Fluorescently label cell-surface proteins in vivo using DogTag-DogCatcher for spatiotemporal, loop-targeted GFP tagging.TagsHigh-throughput screeningBiopsyCell membraneInventorsKevin RostamRichard S. MannManagerJerry KokoshkaDepartmentsBiochemistry & Molecular BiophysicsBiological SciencesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2025-03-21
A user-friendly, microwell-based multi-tissue culture platformCU22271A microwell multi-tissue culture platform enabling automated, standardized, high-throughput modeling of native tissue environments.TagsHigh-throughput screeningBiologyCell cultureInventorsKeith YeagerManagerSara GusikDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-07-09
iPSC-derived organoids for treating ischemia and other vascular diseasesCU24026Patient-specific, high-throughput iPSC-derived prevascularized organoids injected into ischemic tissue to rapidly promote angiogenesis.TagsHigh-throughput screeningAngiogenesisBlood vesselInventorsDarragh KennedyMary Katharyn FatehiSamuel Sia Ph.D.ManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-07-05
CRISPR deletion of endogenous T cell receptor chains for optimized immunotherapiesCU20245CRISPR deletes endogenous TCR chains while preserving transgenic TCRs, enabling safer, off-the-shelf CAR-T/TCR therapies.TagsHigh-throughput screeningCancerChimeric antigen receptor T cellInventorsMegan Sykes M.D.Mohsen Khosravi MaharlooeiRemi CreusotManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-30
Targeted Cdkn2a suppression to prevent muscle degeneration in spinal muscular atrophyCU23330Targeted Cdkn2a suppression preserves muscle stem cell function to counteract SMA-related degeneration and enhance therapy.TagsHigh-throughput screeningAtrophyCombination therapyInventorsNarendra JhaUmrao R. Monani Ph.D.ManagerKristin NeumanDepartmentsNeurologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-30CollectionsGene Therapy
Generation of mature neurons differentiated from differentiated stem cells by manipulating RNA splicingCU24262Accelerates maturation of iPSC-derived neurons by boosting Mbnl2 splicing, enabling adult-like models for neurodegenerative diseases.TagsHigh-throughput screeningAlternative splicingBrainInventorsBrian Jude JosephChaolin Zhang PhDHynek WichterleManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-16
Combination therapies for Diffuse Midline Glioma (DMG) treatmentCU24228Targeted, MR-driven DMG combination therapy to overcome tumor heterogeneity; predicts and inverts master regulator activity for improved efficacy.TagsHigh-throughput screeningCentral nervous systemDrug developmentInventorsAndrea CalifanoEster Calvo FernandezJovana PavisicManagerJoan MartinezDepartmentsBiomedical InformaticsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-02
