High-throughput method for gene insertionCU19411A high-throughput, vector-based CRISPR system enabling parallel, precise DNA insertions in human cells for scalable genome editing.TagsHigh-throughput screeningBacteriaCas9InventorsAlejandro ChavezBrijesh Kumar SinghManagerCynthia LangDepartmentsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-17
Chemical painting for high-throughput single-cell drug response analysisCU23332Multiplexed infrared imaging enables high-throughput, single-cell drug profiling with ML-enabled mechanism-of-action predictions.TagsHigh-throughput screeningCombination therapyDNA sequencingInventorsWei MinXinwen LiuManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-10-16
Mechanobiological assay for glaucoma drug screeningCU23377In vitro mechanobiological assay using patient Schlemm’s canal cells; high-throughput pore formation tests to screen glaucoma drugs.TagsHigh-throughput screeningAqueous humourAssayInventorsDarryl OverbyJoseph van Batenburg-SherwoodKrishnakumar KizhatilManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of EngineeringColumbia University Medical Center (CUMC)Release Date2025-01-13
High-throughput approach for base editing the kinomeCU24051High-throughput base editing to selectively inhibit kinases endogenously, enabling scalable kinase function studies and drug target discovery.TagsHigh-throughput screeningChemical libraryEndogenous retrovirusInventorsNeil Vasan MD, PhDManagerJerry KokoshkaDepartmentsOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-12
High throughput, automated method for chromatin profiling using low-cell input samplesCU23333Automated, high-throughput ChIP-seq profiling from low-cell inputs enables scalable chromatin mapping and clinical diagnostics.TagsHigh-throughput screeningAutomationChIP sequencingInventorsAaron VinyManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-03-13
Genome-wide qPCR with increased primer multiplexity for diagnostics and drug screeningCU23284A qPCR platform using optically barcoded beads enables genome-wide multiplex expression analysis (100–10,000 targets) faster and cheaper.TagsHigh-throughput screeningAcidChain reactionInventorsNaixin QianWei MinZhilun ZhaoManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-10-16
Small scale screening bioreactor with airway tissues and mucosa for the progression and treatment of lung diseaseCU23307Bioreactor recreating mucus-lined airways ex vivo for real-time, high-throughput modeling and therapeutic screening.TagsHigh-throughput screeningBiomimeticsBioreactorInventorsGordana Vunjak-NovakovicJinho KimKeith YeagerManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-04-08
Patient-specific organoid system for pancreatic ductal adenocarcinoma (PDAC) drug screeningCU24025Patient-specific pancreatic cancer organoids with patient immune cells enable high-throughput drug screening and personalized therapy insights.TagsHigh-throughput screeningCell therapyImmune systemInventorsGulam ManjiIlenia PellicciottaManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-30CollectionsOncology
Predicting breast cancer treatment response through PIK3R1 mutation profilingCU26021Predicts breast cancer drug response via endogenous kinase inhibition models using PIK3R1 mutations; rapid, high-throughput screening.TagsHigh-throughput screeningAKT1AdenineInventorsNeil Vasan MD, PhDManagerJerry KokoshkaRelease Date2025-10-09
CMOS imaging arrays for high-speed fluorescence lifetime imagingCU12003CMOS-SPAD FLIM array enables 200 fps wide-field imaging with on-chip timing, compact, cost-effective for live-cell and high-throughput assays.TagsHigh-throughput screeningCMOSDNA sequencingInventorsKenneth ShepardRyan M. FieldManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-10-09
Optimizing multiplex decisions using machine learning for cancer screeningCU23231Bayesian optimization reduces calculations for multiplex cancer screening without assumptions, updating predictions with real-world data.TagsHigh-throughput screeningAlgorithmBayesian inferenceInventorsYing Kuen (Ken) CheungManagerSara GusikDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2023-07-14CollectionsOncologyMedical DeviceDigital Health (Software, AI, bioinformatics, etc)
Selective peptide inhibitor of late sodium current for precision arrhythmia treatmentCU24196A computationally designed peptide ELIXIR selectively inhibits pathogenic cardiac late sodium current, preserving normal flow and reducing arrhythmia risk.TagsHigh-throughput screeningArrhythmiaC-terminusInventorsBence HegyiDonald M. BersManu Ben-JohnyManagerKristin NeumanDepartmentsMedicinePharmacologyPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-26
High-efficiency CRISPR-Cas nucleaseCU25094Compact, high-efficiency CRISPR-Cas12j nuclease delivers AAV-packagable, 2x faster gene editing with high fidelity for therapeutics.TagsHigh-throughput screeningCRISPRDrug discoveryInventorsAnders Steen KnudsenStephen H. Tsang M.D., Ph.D.ManagerKristin NeumanDepartmentsBiomedical EngineeringOphthalmologyDivisionsCollege of Physicians and Surgeons (CUMCFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-12-18CollectionsOphthalmology
Calibration-free affinity biosensors for rapid, accurate biomarker detectionCU22223Calibration-free graphene FET biosensor uses aptamer kinetics for rapid, device-wide reproducible biomarker detection without per-sensor calibration.TagsHigh-throughput screeningAptamerBiomarkerInventorsMilan N. Stojanovic M.D.Qiao LinWenting DaiManagerDovina QuDepartmentsMechanical EngineeringMedicineDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-08-21
Optical in situ nucleotide sequence detection using combinatorial hybridizationCU24118High-throughput optical CRISPR screening with combinatorial hybridization enables scalable, cost-efficient, multi-omic readouts in situ.TagsHigh-throughput screeningBreast cancerCRISPRInventorsJellert GaublommeManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2026-01-29CollectionsGenomics & Multi-Omics
GPX4 inhibitors for cancer therapyCU20261Potent, selective GPX4 inhibitors induce ferroptosis to target EMT-driven, drug-resistant cancers and enable GPX4 research.TagsHigh-throughput screeningActive siteAllosteric regulationInventorsBrent StockwellHengrui LiuManagerJoan MartinezDepartmentsBiological SciencesChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-05-01
Highly efficient T cell base editing for enhanced immunotherapiesCU24092Ultra-efficient base editing in human T cells using adenine/cytosine editors; enhances CAR-T, autoimmune therapies with lower toxicity.TagsHigh-throughput screeningAdenineCancerInventorsBenjamin Izar MD, PhDZachary WalshManagerJoan MartinezDepartmentsMedicineMedicine - Hematology/OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-11-08
Integrated AI platform for causal discovery and drug validationCU25378Cloud-based AI suite enabling causal discovery, multimodal data integration, and translational drug validation for personalized medicine.TagsHigh-throughput screeningAntigenArtificial intelligenceInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Scalable, reproducible, immune-intact tumor organoid co-culture platformCU24328Patient-derived immune-intact tumor organoids enable scalable, reproducible co-culture for personalized immunotherapy and drug screening.TagsHigh-throughput screeningBiomarkerBiotechnologyInventorsDavid CohenJoel T. Gabre MDManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Colorectal cancer organoid model for therapeutic testingCU26010Patient-derived 3D colorectal cancer organoids enable precise drug screening, personalized therapy, and biomarker discovery.TagsHigh-throughput screeningColorectal cancerExtracellular matrixInventorsCasidhe-Nicole BethancourtDavid CohenJoel T. Gabre MDManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedicineSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2025-10-09
Universal gene editing strategy for cardiac arrhythmiaCU24243Universal gene-editing of Rad phosphorylation sites to curb adrenergic CaV1.2 signaling, offering targeted, long-term arrhythmia therapy.TagsHigh-throughput screeningArrhythmiaBeta blockerInventorsGregory NewbyGuoxia LiuSteven MarxManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-14
Immature myeloid cell activation pathway in inflammation-linked cancerCU26121IL-8–driven immature myeloid cell mobilization fuels inflammation-linked GI cancer; targets IMCs for therapy and biomarkers.TagsHigh-throughput screeningAngiogenesisBiomarkerInventorsTimothy Wang M.D.ManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Conditional knockout mouse model for studying autosomal-dominant optic atrophyCU26140A mammalian, cell-type–specific conditional Ssbp1 R107Q mouse model to dissect autosomal-dominant optic atrophy mechanisms.TagsHigh-throughput screeningAlleleArginineInventorsChyuan-Sheng (Victor) LinNan-Kai WangYunju TsengManagerKristin NeumanDepartmentsOphthalmologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
PDE5 inhibitor for Alzheimer's treatment2439A brain-penetrant PDE5 inhibitor enhances cGMP signaling, reduces amyloid, and supports synaptic plasticity in Alzheimer’s models.TagsHigh-throughput screeningAmyloid betaAmyloid plaquesInventorsDonald William Landry MD, Ph.D.Ottavio Arancio MD, PhDShi-xian DengManagerJerry KokoshkaDepartmentsMedicinePathologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-18
VRK2 kinase inhibitors for enhanced cancer immunotherapyCU21245VRK2 inhibitors boost PD-1 therapy by targeting downstream signaling, enhancing T cell activation and tumor clearance.TagsHigh-throughput screeningAdenocarcinomaBladder cancerInventorsAdam MorManagerCynthia LangDepartmentsRheumatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-17
Conformational DNA aptamers enabling small-molecule lateral flow assaysCU26117Conformational DNA aptamers enable rapid, cost-effective small-molecule detection in lateral flow assays via structure-switching binding.TagsHigh-throughput screeningAnalyteAntibodyInventorsKyungae YangManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-01
Foxo1 inhibition for disease treatmentCU24187Foxo1 inhibitors spark enteroendocrine-to-beta cell conversion, boosting natural insulin production for diabetes treatment.TagsHigh-throughput screeningBeta cellDrug developmentInventorsDomenico Accili M.D.Sandro BelvedereManagerCynthia LangDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-11-13
Targeted knock-in mouse line for studying neuropsychiatric diseaseCU26034A knock-in mouse line enabling precise A2a-expressing neuron targeting in basal ganglia for neuropsychiatric research and drug validation.TagsHigh-throughput screeningAdenosine A2A receptorBasal gangliaInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-13
A2a-FlpO mouse model for neuroscience studiesCU26036Precise, cell-type specific A2a-FlpO knock-in mice enable orthogonal D1/D2 dopaminergic studies in basal ganglia circuits.TagsHigh-throughput screeningBasal gangliaBehavioral neuroscienceInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-13
Anxa1-Cre mouse for selective modeling of dopaminergic neurons in Parkinson's diseaseCU26032Anxa1-Cre mouse enables precise manipulation of a vulnerable dopaminergic neuron subtype to study early Parkinson’s motor deficits.TagsHigh-throughput screeningBiomarkerCausalityInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-07
Microfluidic platform for large-scale single-cell sequencing and imagingCU16248Scalable, low-cost microfluidic platform linking live-cell imaging with single-cell RNA sequencing via optical barcodes.TagsHigh-throughput screeningBrain mappingCell cultureInventorsJinzhou YuanPeter A. SimsSayantan BoseManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-02CollectionsGenomics & Multi-Omics
Gut endocrine Rbp2 knockout mouse model for metabolic hormone studiesCU25453Gut-endocrine cell-specific Rbp2 knockout mouse enables retinoid-driven regulation study of gut hormones and metabolic outcomes.TagsHigh-throughput screeningAlleleCausal inferenceInventorsRossana M. CalderonManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-10-16
Riboswitch sensors to detect clinical biomarkersCU25097Real-time riboswitch–aptamer biosensors monitor creatine, urea, electrolytes for dynamic antibiotic dosing during kidney injury treatment.TagsHigh-throughput screeningAcute kidney injuryAntibioticInventorsMilan N. Stojanovic M.D.Nenad MilosavicSteven M.F. Kennedy TaylorManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchMedicineNephrologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-21
Machine learning pipeline for neoantigen prioritization in personalized immunotherapiesCU25375ImmuneMirror: integrative ML pipeline predicting immunogenic neoantigens by combining processing, transport, binding, and recognition factors.TagsHigh-throughput screeningAntigenBiomarkerInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Gene therapy for metabolic dysfunction-associated steatohepatitis (MASH)CU25230Gene therapy restoring retromer activity to treat MASH by normalizing lipid metabolism and reducing fibrosis risk.TagsHigh-throughput screeningCirrhosisDrug discoveryInventorsGregory A. PetskoScott A. Small M.D.ManagerJerry KokoshkaDepartmentsAnn Romney Center for Neurologic DiseasesNeurologyDivisionsColumbia University Medical Center (CUMC)Harvard Medical School and Brigham & Women’s HospitalRelease Date2025-07-31
Natural language processing tool for cognitive scoring in Alzheimer's Disease patientsCU25391NLP platform predicts MMSE scores from unstructured clinical notes, enabling retrospective cognitive assessment in Alzheimer’s patients.TagsHigh-throughput screeningEHealthElectronic health recordInventorsBetina Ross S IdnayChunhua WengFangyi ChenManagerJoan MartinezDepartmentsBiomedical InformaticsDivisionsColumbia University Medical Center ( CUMColumbia University Medical Center (CUMC)Release Date2025-07-31
Focused ultrasound nanoparticles for targeted imaging and neuroregenerationCU21224Ultrasound-activated nanocup theranostics cross BBB for targeted Alzheimer’s imaging and neuroregenerative therapy.TagsHigh-throughput screeningAmyloid betaAntibodyInventorsAntonios PoulipoulosElisa KonofagouManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-07-29
Combinatorial treatment for amyotrophic lateral sclerosis (ALS)CU25447Combinatorial ASO therapy targets 15 dysregulated genes in SOD1-ALS, mitigating neuron death and boosting motor function.TagsHigh-throughput screeningAmyotrophic lateral sclerosisBiomarkerInventorsGeorge Z. Mentis Ph.D.JoonHyung ParkManagerJerry KokoshkaDepartmentsPathology & Cell BiologyPathology and Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-29
Chaperone-enhanced platform for rescuing protein misfolding in neurodegenerative diseasesCU22082Chaperone-based gene therapy stabilizes RNA-binding proteins, reducing misfolding and aggregation in ALS/FTD. 120-150 chars.TagsHigh-throughput screeningAmyotrophic lateral sclerosisBiomarkerInventorsAlejandro ChavezSamuel J. ResnickManagerCynthia LangDepartmentsPathology & Cell BiologyProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2025-07-17
SUMO2 conjugation therapy for restoring cognitive function in Alzheimer's diseaseCU23265SUMO2-based biologic restores synaptic function and memory in Alzheimer's without reducing amyloid, enabling late-stage cognitive recovery.TagsHigh-throughput screeningAdjuvant therapyAmyloid betaInventorsLuana Fioriti Ph.D.Ottavio ArancioPaul Edward FraserManagerJerry KokoshkaDepartmentsMortimer B. Zuckerman Mind Brain Behavior InstitutePathologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-06-26
Photocatalysis method with low-energy lightCU18169Photon upconversion enables infrared-driven, safer photocatalysis with deeper penetration for pharma, biomedicine, and materials.TagsHigh-throughput screeningAntimicrobialBiomedicineInventorsAndrew B. PunBenjamin RavetzDaniel N. CongreveManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesMassachusetts Eye and Ear InfirmaryRelease Date2024-12-06
Lymphocyte therapeutic method for hematological conditionsCU24081Enriched CD8+ T cell isolation enables targeted leukemia therapy; biomarkers predict potency and may boost DLI efficacy.TagsHigh-throughput screeningAcute myeloid leukemiaCD3 (immunology)InventorsCameron Young ParkElham AziziManagerJoan MartinezDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-05-08
Rapid DNA extraction and direct-barcoding for efficient nanopore-based DNA sequencingCU19244Rapid nanopore DNA sequencing with 15-minute extraction, direct barcoding, and low-cost, high-throughput genetic analysis.TagsHigh-throughput screeningAmniotic fluidAneuploidyInventorsSamuel Z. "Zev" WilliamsShan WeiManagerCynthia LangDepartmentsObstetrics & GynecologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05
Fluorescent labeling of cell surface proteins in vivo with spatiotemporal controlCU25172Fluorescently label cell-surface proteins in vivo using DogTag-DogCatcher for spatiotemporal, loop-targeted GFP tagging.TagsHigh-throughput screeningBiopsyCell membraneInventorsKevin RostamRichard S. MannManagerJerry KokoshkaDepartmentsBiochemistry & Molecular BiophysicsBiological SciencesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2025-03-21
A user-friendly, microwell-based multi-tissue culture platformCU22271A microwell multi-tissue culture platform enabling automated, standardized, high-throughput modeling of native tissue environments.TagsHigh-throughput screeningBiologyCell cultureInventorsKeith YeagerManagerSara GusikDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-07-09
iPSC-derived organoids for treating ischemia and other vascular diseasesCU24026Patient-specific, high-throughput iPSC-derived prevascularized organoids injected into ischemic tissue to rapidly promote angiogenesis.TagsHigh-throughput screeningAngiogenesisBlood vesselInventorsDarragh KennedyMary Katharyn FatehiSamuel Sia Ph.D.ManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-07-05
CRISPR deletion of endogenous T cell receptor chains for optimized immunotherapiesCU20245CRISPR deletes endogenous TCR chains while preserving transgenic TCRs, enabling safer, off-the-shelf CAR-T/TCR therapies.TagsHigh-throughput screeningCancerChimeric antigen receptor T cellInventorsMegan Sykes M.D.Mohsen Khosravi MaharlooeiRemi CreusotManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-30
Targeted Cdkn2a suppression to prevent muscle degeneration in spinal muscular atrophyCU23330Targeted Cdkn2a suppression preserves muscle stem cell function to counteract SMA-related degeneration and enhance therapy.TagsHigh-throughput screeningAtrophyCombination therapyInventorsNarendra JhaUmrao R. Monani Ph.D.ManagerKristin NeumanDepartmentsNeurologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-30CollectionsGene Therapy
Generation of mature neurons differentiated from differentiated stem cells by manipulating RNA splicingCU24262Accelerates maturation of iPSC-derived neurons by boosting Mbnl2 splicing, enabling adult-like models for neurodegenerative diseases.TagsHigh-throughput screeningAlternative splicingBrainInventorsBrian Jude JosephChaolin Zhang PhDHynek WichterleManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-16
Combination therapies for Diffuse Midline Glioma (DMG) treatmentCU24228Targeted, MR-driven DMG combination therapy to overcome tumor heterogeneity; predicts and inverts master regulator activity for improved efficacy.TagsHigh-throughput screeningCentral nervous systemDrug developmentInventorsAndrea CalifanoEster Calvo FernandezJovana PavisicManagerJoan MartinezDepartmentsBiomedical InformaticsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-02
