Parameters to maximize nebulized drug delivery to larynxCU24050Patient-specific CT-based nebulization parameters optimize aerosol size and velocity to maximize laryngeal drug deposition.TagsDrug deliveryAerosolHypersensitivityInventorsMichael Pitman MDManagerCynthia LangDepartmentsOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05
Multi-lumen microneedle for intracochlear drug delivery and samplingCU21117Ultra-sharp multi-lumen microneedles enable simultaneous intracochlear drug delivery and perilymph sampling with zero net volume change.TagsDrug deliveryCochleaDiffusionInventorsAnil LalwaniAykut AksitJeffrey W. KysarManagerDovina QuDepartmentsMechanical EngineeringOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-09-26
Ultrasound-responsive microcapsules for localized and on-demand drug deliveryCU22072Ultrasound-triggered, biphasic microcapsules enable on-demand, localized drug release with reduced systemic toxicity and long-term payload stability.TagsDrug deliveryChemotherapyDextranInventorsMargaret JakusRachel D. FieldSamuel Sia Ph.D.ManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-07-20
Microneedle array for cross-barrier drug delivery in the eye, ear and central nervous systemCU18171Biodegradable microneedle arrays enable precise, cross-barrier drug delivery to the eye, ear, and CNS with controlled release.TagsDrug delivery3D printingBiodegradationInventorsAnil LalwaniAykut AksitDaniel N. ArteagaManagerDovina QuDepartmentsMechanical EngineeringOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-01-24
Injectable hydrogels for therapeutic deliveryCU25086Injectable, biocompatible hydrogels crosslinked by extracellular vesicles for bioactive, scalable regenerative therapy delivery.TagsDrug deliveryBiocompatibilityBiomaterialInventorsArtemis MargaronisCaterina PiuntiCindy Huilin LuManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-07-15
Convection-enhanced delivery of topotecan and dexamethasone for malignant gliomasCU25031Implantable pump enables chronic, targeted brain delivery of topotecan plus dexamethasone via convection-enhanced delivery for glioma.TagsDrug deliveryAdjuvant therapyAnimal disease modelInventorsJeffrey BrucePeter CanollManagerJerry KokoshkaDepartmentsNeurological SurgeryPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-29
Inhalation device for targeted therapeutic delivery to the throatCU23297A portable, disposable inhaler delivering nebulized natural therapeutics to the larynx with precise 10–35 micron particles.TagsDrug deliveryDisposable productHoarse voiceInventorsMichael Pitman MDManagerCynthia LangDepartmentsOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-05
Collagen wrap for ligament repairCU25026Collagen wrap shields ACL wounds from negative synovial factors while enabling nutrient diffusion and targeted drug delivery for healing.TagsDrug deliveryAnterior cruciate ligamentCollagenInventorsAndy J. LeeClark HungGerard Agop AteshianManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-11-12
Modified exosomes for enhanced cargo deliveryCU21165ATP-loaded exosomes boost cellular uptake of cargo by delivering energy currencies (ATP/NADH) for enhanced therapeutic delivery.TagsDrug deliveryBiocompatibilityEndocytosisInventorsAkiva MintzFatemeh Momen-HeraviManagerJoan MartinezDepartmentsCollege of Dental MedicineRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-08-24
In vivo internalizing RGD peptide production for enhanced treatment of solid tumorsCU25033In vivo iRGD plasmid drives tumor penetration, reducing immunosuppression; co-administers with CAR-T/ therapies for enhanced efficacy.TagsDrug deliveryAngiogenesisCancer immunotherapyInventorsKazuki N. SugaharaNorio MiyamuraManagerJerry KokoshkaDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2025-11-20
Blood-brain barrier opening and cavitation imaging using a single diagnostic imaging arrayCU21007Single diagnostic ultrasound array opens the blood-brain barrier and images cavitation simultaneously for cost-effective, targeted brain therapy.TagsDrug deliveryBeamformingBlood–brain barrierInventorsElisa KonofagouMark T. BurgessRobin JiManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-07-29
Coherent factor-based passive cavitation mapping for monitoring of focused ultrasound treatmentCU22079Coherent factor-based passive acoustic mapping enables real-time, high-resolution, low-cost monitoring of transcranial focused ultrasound treatment.TagsDrug deliveryAblationAcousticsInventorsElisa KonofagouSua BaeManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-11-07
Focused ultrasound nanoparticles for targeted imaging and neuroregenerationCU21224Ultrasound-activated nanocup theranostics cross BBB for targeted Alzheimer’s imaging and neuroregenerative therapy.TagsDrug deliveryAmyloid betaAntibodyInventorsAntonios PoulipoulosElisa KonofagouManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-07-29
Nanoparticle-functionalized scaffolds for biomedical applicationsCU24234Electrospun, nanoparticle-functionalized scaffolds deliver immunomodulatory cues for enhanced wound healing and tissue regeneration.TagsDrug deliveryAgonistAntibodyInventorsJose McFaline-FigueroaSantiago CorreaTreena ArinzehManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-02-16
Microneedle for eye injection surgeryCU24034Minimally invasive ophthalmic microneedle enables precise subretinal/intravascular injections, improving retinal safety and targeting.TagsDrug deliveryArteryBirth defectInventorsAhmet HondurAnil LalwaniAykut AksitManagerDovina QuDepartmentsMechanical EngineeringOphthalmologyOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-12-12
Photocatalysis method with low-energy lightCU18169Photon upconversion enables infrared-driven, safer photocatalysis with deeper penetration for pharma, biomedicine, and materials.TagsDrug deliveryAntimicrobialBiomedicineInventorsAndrew B. PunBenjamin RavetzDaniel N. CongreveManagerGreg MaskelDepartmentsChemistryDivisionsFaculty of the Arts & SciencesMassachusetts Eye and Ear InfirmaryRelease Date2024-12-06
Self-assembling DNA polymer scaffolds with material templatesCU240733D DNA frameworks templated with metals/semiconductors enable advanced nanolithography and multifunctional nanoscale material integration.TagsDrug deliveryCrystal structureInorganic compoundInventorsOleg GangManagerGreg MaskelDepartmentsChemical Engineering/Applied ChemistryDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-12-06
Programmable nanoencapsulation for probiotic deliveryCU21284Programmable nanoencapsulated probiotics boost cancer therapy safety and efficacy by tunable, immune-evasive bacterial delivery.TagsDrug deliveryBacteriaBacterial capsuleInventorsJaeseung HahnKam LeongTal DaninoManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-01-30CollectionsOncology
Microneedle-endoscope for drugging and sampling of inner earCU21365A camera-guided microneedle endoscope perforates the round window to deliver drugs and sample inner ear fluids safely.TagsDrug delivery3D printingInventorsAnil LalwaniAykut AksitJeffrey W. KysarManagerDovina QuDepartmentsMechanical EngineeringOtolaryngologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-07-18
Endogenous pro-fertility capsidsCU23365Endogenous capsid-like delivery targets subfertility non-invasively, enabling hormone-independent pro-fertility treatment for both sexes.TagsDrug deliveryAssisted reproductive technologyCapsidInventorsHarrison CullenLuke E. Berchowitz PhDThomas WoodManagerJerry KokoshkaDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2024-07-09
Nanofibrous scaffold for controlled release of small molecule immunomodulatorsCU24040Nanofibrous scaffold locally releases ACHP to inhibit NF-kB, enabling targeted immunomodulation with reduced systemic effects.TagsDrug deliveryAutoimmune diseaseBiomaterialInventorsFereshteh ZandkarimiHannah ChildsHelen Lu Ph.D.ManagerJoan MartinezDepartmentsBiological SciencesBiomedical EngineeringDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-12-18CollectionsSmall Molecule
A deep learning substitute for Gadolinium contrast detects focused ultrasound-induced blood-brain barrier (BBB) openingCU23205AI predicts focused ultrasound BBB openings from low-dose GBCA MRI, reducing gadolinium exposure and scan time.TagsDrug deliveryBlood–brain barrierCentral nervous systemInventorsAndrew F. LaineCheng-Chia WuJia GuoManagerJerry KokoshkaDepartmentsBiomedical EngineeringPsychiatryRadiation OncologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-11-30CollectionsCNS/NeurologyPlatform/Research ToolMedical Device
Probiotic scaffolds for COPD prevention and treatmentCU23062Probiotic-infused electrospun scaffolds deliver targeted oral therapy to prevent COPD progression by combating respiratory pathogens.TagsDrug deliveryAdjuvantBronchodilatorInventorsAaron J. MomentHelen Lu Ph.D.Ming Chau ChanManagerJoan MartinezDepartmentsBiomedical EngineeringChemical Engineering/Applied ChemistryDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-05-02
γ-secretase complex inhibitor nanoparticles for NASHCU20227Liver-targeted γ-secretase inhibitor nanoparticles reverse NASH fibrosis, reducing Notch-associated toxicity and enabling liver-specific therapy.TagsDrug deliveryAtherosclerosisDyslipidemiaInventorsLi QiangUtpal PajvaniZhen GuManagerCynthia LangDepartmentsMedicinePathology and Cell BiologyDivisionsColumbia University Medical Center (CUMC)Naomi Berrie Diabetes CenterRelease Date2023-01-31
Conversion and condition-resistant regulatory T-cells for immunosuppressive therapy and tissue repairCU22040CRISPR-edited, CAR Tregs with enhanced stability resist conversion and antibody depletion, boosting immunosuppression and transplant tolerance.TagsDrug deliveryAutoimmune diseaseChimeric antigen receptor T cellInventorsMegan Sykes M.D.Mohsen Khosravi MaharlooeiRemi CreusotManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2023-01-30CollectionsOncology
Scalable, high-throughput drug delivery platform using cell-membrane coating technology for nanoparticlesCU20253Rapid, scalable membrane-coated nanoparticle production via flash nanocomplexation enables uniform biomimetic drug/gene delivery carriers.TagsDrug deliveryBiomaterialBiomimeticsInventorsHanze HuKam LeongManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-07-16CollectionsPlatform/Research Tool
Myopia treatment and prevention using S-methyl-L-Thiocitrulline and its derivativesCU20384Inhibits neuronal NO synthase with S-methyl-L-thiocitrulline derivatives to prevent and treat myopia, via oral/topical delivery.TagsDrug deliveryContact lensEnzyme inhibitorInventorsAndrei TkatchenkoTatiana V. TkatchenkoManagerKristin NeumanDepartmentsOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2022-10-08CollectionsOphthalmologySmall Molecule
Compounds for treating myopiaCU20379A library of eye-development–targeting compounds treats or prevents myopia via versatile administration with minimal side effects.TagsDrug deliveryAtropineCombination therapyInventorsAndrei TkatchenkoTatiana V. TkatchenkoManagerKristin NeumanDepartmentsOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2022-10-08CollectionsOphthalmologySmall Molecule
High-pressure injector device for comfortable and rapid drug deliveryCU18187High-pressure, spring-free injector enables rapid, quiet delivery of viscous drugs for self-administration and higher concentration dosing.TagsDrug deliveryAdrenalineBiopharmaceuticalInventorsOzgur SahinManagerDovina QuDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2019-12-03
Intra-arterial administration of peptide-drug conjugates for tumor-selective drug deliveryCU17144Intra-arterial, flow-arrest delivery preserves cationic peptide-drug charge, enhancing tumor and brain tumor targeting.TagsDrug deliveryApoptosisBlood–brain barrierInventorsShailendra JoshiManagerSara GusikDepartmentsAnesthesiologyRelease Date2019-08-21
Serotonin targeting in the gut to treat anxiety and depressionCU21281Gut-targeted serotonin modulation offers safer, pregnancy-safe mood disorder treatment with fewer systemic side effects.TagsDrug deliveryAttention deficit hyperactivity disorderBreastfeedingInventorsKam LeongKara MargolisMark AnsorgeManagerDovina QuDepartmentsBiomedical EngineeringPediatricsPsychiatryDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2021-04-16CollectionsCNS/NeurologyWomen's Health
Cell-penetrating TAT oligomers for drug deliveryCU17314Cell-penetrating TAT oligomers enable targeted drug delivery across membranes, including blood-brain barriers, for tumors and CNS.TagsDrug deliveryApoptosisBiopharmaceuticalInventorsShailendra JoshiManagerSara GusikDepartmentsAnesthesiologyRelease Date2018-07-16CollectionsOncology
Structure-stabilized DNA origami-based drug and gene deliveryCU20002Peptoid-coated DNA origami stabilizes nanocarriers for drug/gene delivery under physiological conditions, enabling targeted, protected therapeutics.TagsDrug deliveryBiomaterialBuffer solutionInventorsCarolyn BertozziOleg GangRonald ZuckermanManagerGreg MaskelDepartmentsChemical Engineering/Applied ChemistrySponsored Projects OfficeDivisionsFu Foundation School of Engineering and Applied Science (SEAS)LBNLRelease Date2019-07-01
Wearable engineered human skin that can be generated in curved, custom shapesCU20263Wearable, curved-skin grafts: custom-shaped, vascularized human skin for improved grafting, disease modeling, and drug screening.TagsDrug deliveryAutotransplantationBiophysical environmentInventorsHasan Erbil AbaciManagerDovina QuDepartmentsDermatologyDivisionsColumbia University Medical Center (CUMC)Release Date2020-02-18CollectionsPlatform/Research ToolMedical Device
Stem cell-based gene delivery for biological pacemakers1352Biological pacemaker using engineered human mesenchymal stem cells to autonomously regulate heart rhythm without batteries.TagsDrug deliveryArtificial cardiac pacemakerCardiac muscle cellInventorsIra S. CohenMichael Rosen M.D.Peter BrinkManagerJerry KokoshkaDepartmentsAnesthesiologyPharmacologyPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2018-11-30
Cyclopropenium polymer particles for improved gene deliveryCU15012Cyclopropenium polymer particles enable non-viral, pH-stable, modular, low-toxicity gene/drug delivery with targeted loading.TagsDrug deliveryAntimicrobialBiomoleculeInventorsJessica L. FreyerKathryn Louise KillopsLuis CamposManagerCynthia LangDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2018-04-02
Non-viral gene delivery agentsCU16329Non-viral, cyclopropenium-based polymer transfection agents enable stable, low-toxicity DNA delivery across cell membranes.TagsDrug deliveryCarbonGene expressionInventorsJessica L. FreyerLuis CamposSpencer Daniel BrucksManagerCynthia LangDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2018-02-23
Wearable ultrasound device for targeted mapping and modulation of brain tissueCU15312Wearable focused ultrasound maps and modulates brain tissue, temporarily opening the BBB for noninvasive, localized neuromodulation and drug delivery.TagsDrug deliveryBlood–brain barrierBrainInventorsElisa KonofagouGesthimani SamiotakiManagerDovina QuDepartmentsBiomedical EngineeringRadiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-04-13
Implantable ultrasound-powered microchipsCU15073Ultrasound-powered micron-scale IC chips wirelessly power and transmit real-time physiological data, enabling battery-free implants.TagsDrug deliveryElectric batteryElectrical energyInventorsChen ShiHongki KangJordan ThimotManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-04-07
Improved security architecture for cyber-physical systems using rebooting and diversificationCU16331YOLO CPS security: periodic micro-reboots with program diversification to curb attacks, using inertia to preserve operation.TagsDrug deliveryComputer securityIndustrial control systemInventorsJonathan WeiszLakshminarasimhan SethumadhavanMiguel A. ArroyoManagerGreg MaskelDepartmentsComputer ScienceDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-03-09
Remotely-activated implantable device for targeted drug deliveryCU12228Biocompatible hydrogel iMEMS delivers targeted, externally triggered doxorubicin release (HIFU preferred) with deep tissue access.TagsDrug delivery3D printingBiocompatibilityInventorsOlga OrdeigSamuel SiaManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2016-04-04
Microbubbles for blood oxygenation and drug delivery2420Microbubble-based oxygen delivery and targeted drug transport offer rapid, portable, customizable emergency and research applications.TagsDrug deliveryAcute respiratory distress syndromeAnticonvulsantInventorsFrancis X. McGowanJohn KheirMark Andrew BordenManagerDovina QuDepartmentsAnesthesiology, Perioperative and Pain MedicineChemical Engineering/Applied ChemistryDivisionsAnesthesiologyDivision of Critical Care MedicineDepartment of Anesthesiology,Perioperative aFu Foundation School of Engineering and Applied Science (SEAS)Release Date2016-03-02
Targeted, thermo-responsive drug delivery for treating cancerCU15296Thermo-responsive, biodegradable polymer-drug conjugate enables targeted, heat-triggered cancer delivery with low toxicity and tunable release.TagsDrug deliveryBiodegradationHyperthermiaInventorsChathuranga De SilvaJeffrey Thomas KobersteinSanjoy SamantaManagerDovina QuDepartmentsChemical Engineering/Applied ChemistryDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2015-10-30
Thermo-responsive, biodegradable polymers for targeted drug deliveryCU14314Thermo-responsive, biodegradable polymers enable targeted, pH-triggered drug delivery with tunable LCST and non-toxic degradation.TagsDrug deliveryBiodegradationChemical synthesisInventorsJeffrey Thomas KobersteinSanjoy SamantaManagerDovina QuDepartmentsChemical Engineering/Applied ChemistryDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2015-03-28
Core-centered, porous ceramic granules employ bio-agent delivery system for enhanced bone repair/regenerationCU13158Core-centered porous ceramic granules with micro-pores and drug-delivery microspheres enhance bone repair and infection prevention.TagsDrug deliveryAntibioticBiodegradationInventorsDaniel Sunho OhDepartmentsOrthopedic SurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2015-11-10
Focused ultrasound protocol for drug delivery2781Focused ultrasound with optimized short pulse sequences opens the blood-brain barrier for targeted, non-invasive brain drug delivery.TagsDrug deliveryBlood–brain barrierBrainInventorsElisa KonofagouJames Junesik J. ChoiManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-09-15
Specific inhibition of caspase-2 activation for the treatment of neurodegenerative diseasesCU12019Membrane-penetrable hexapeptide selectively blocks caspase-2-RAIDD, halting neuron death for neurodegenerative therapies.TagsDrug deliveryAmyotrophic lateral sclerosisCaspaseInventorsCarol M. Troy MD, PhDManagerJerry KokoshkaDepartmentsPathologyDivisionsColumbia University Medical Center (CUMC)Release Date2015-12-09
Low-tech, minimally invasive localized brain drug delivery systemCU14052Portable, MRI-free, single-transducer brain BBB opening using intermediate-frequency ultrasound for targeted, low-tech drug delivery.TagsDrug deliveryBlood–brain barrierCavitationInventorsElisa KonofagouFabrice MarquetTobias TeichertManagerDovina QuDepartmentsBiomedical EngineeringBiomedical InformaticsNeuroscienceDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-08-25
Targeted drug delivery with focused ultrasound induced blood-brain barrier openingCU14035Acoustically activated nanodroplets enable focused ultrasound–mediated blood-brain barrier opening for targeted brain drug delivery.TagsDrug deliveryAcousticsBlood vesselInventorsChen ChenElisa KonofagouManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-09-16
Focused ultrasound system for localized drug delivery across the blood brain barrier2039Focused ultrasound with microbubbles locally and reversibly opens the BBB, enabling targeted brain drug delivery and CNS research.TagsDrug deliveryApertureBlood–brain barrierInventorsElisa KonofagouJames Junesik J. ChoiMathieu PernotManagerDovina QuDepartmentsBiomedical EngineeringNeurologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2014-09-15
