MOSbius: Custom integrated circuit for hands-on circuit design educationCU25175Custom CMOS IC + PCB lets students prototyping real transistor-level circuits on a breadboard, bridging simulation and lab practice.TagsBreadboardCMOSDebuggingInventorsPeter KingetManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-03-07
Non-invasive laser therapy for cytokine modulation and corneal inflammation managementCU18315Femtosecond laser therapy non-invasively modulates corneal cytokines to reduce inflammation and keratocyte apoptosis, preserving tissue.TagsAnalgesicAntibioticApoptosisInventorsSinisa VukelicManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-08-17CollectionsOphthalmology
High-resolution 3D printing using photon avalanching nanoparticlesCU23212Photon avalanching nanoparticles enable cost-effective, sub-100nm 3D printing with continuous-wave lasers and no post-processing.Tags3D printingInfraredLaserInventorsEmma XuPeter James Schuck Ph.D.ManagerGreg MaskelDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-02-01
CMOS imaging arrays for high-speed fluorescence lifetime imagingCU12003CMOS-SPAD FLIM array enables 200 fps wide-field imaging with on-chip timing, compact, cost-effective for live-cell and high-throughput assays.TagsCMOSDNA sequencingData acquisitionInventorsKenneth ShepardRyan M. FieldManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-10-09
Complete amplitude and phase spatial light modulation via miniature optical resonatorsCU19263High-precision, low-power, full-amplitude and phase optical modulation on a micrometer-scale photonic chip for visible to telecom bands.TagsAmplitudeAmplitude modulationAugmented realityInventorsGuozhen LiangHeqing HuangMichal LipsonManagerGreg MaskelDepartmentsApplied Physics & Applied MathApplied Physics & Applied Math (APAM)Electrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2022-11-09
Infrared-laser driven microdisplaysCU23211Infrared-laser driven two-layer microdisplay enables low-cost, scalable AR/VR screens with high color purity and safe biocompatible wavelengths.TagsAugmented realityContact lensGlassesInventorsAngel Fernandez-BravoEmma XuPeter James Schuck Ph.D.ManagerGreg MaskelDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-02-14
Optical super-multiplexing for molecule detection and live-cell imagingCU17371Optical materials enable super-multiplexed imaging and Raman-based barcoding for high-throughput, live-cell molecular detection.TagsChemical libraryDyeFluorescenceInventorsFanghao HuWei MinManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2023-10-20CollectionsMedical Device
Enhanced CMOS amplifier nanopore sensor for ion channel analysisCU12278Enhanced CMOS nanopore amplifier boosts high-throughput, high-resolution ion channel sensing for drug discovery and diagnostics. (136 characters)TagsAmplifierCMOSDNA sequencingInventorsJacob RosensteinKenneth ShepardSiddharth Ramakrishnan PhDManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-11-21
Machine learning-based beamforming for wireless communicationCU24175AI-driven real-time beamforming optimization for 5G/MIMO networks, reducing latency, power use, and computational load.TagsArtificial intelligenceAutomationBeamformingInventorsJeremy JohnstonShixun WuXiaodong WangManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-06-26
Multiplexing approach and associated image splitter for high-speed characterizationCU23161Combinatorial, beam-splitting multiplex immunofluorescence boosts cell-type detection, enabling high-throughput, cross-talk minimized tissue profiling.TagsAlgorithmAntibodyAssayInventorsCitlali Perez-Campos MSElizabeth HillmanMalte CasperManagerKristin NeumanDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-12-28CollectionsPlatform/Research Tool
Selective laser treatment of carbon fiber compositesCU23313Programmable laser curing creates flexible CFRP structures with predesigned bends, enabling deployable, complex aerospace and defense components.TagsCarbon fibersLaserLaunch vehicleInventorsHayley McClintockHod LipsonManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-05-27
Quantum-based channel assignments for secure wireless communicationsCU24072Entangled-qubit channel assignment secures wireless spectrum, detects tampering, and protects base-station privacy.TagsBase stationComputer securityQuantum computingInventorsDan RubensteinHenry YuenManagerGreg MaskelDepartmentsComputer ScienceDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-08-23
Compact optical generation of ultra-low-noise microwave signalsCU22190Compact, chip-scale optical oscillators deliver ultra-low-noise microwave signals with built-in noise suppression and no active electronics.TagsAnalogue electronicsData communicationHard disk driveInventorsAlexander GaetaBok Young KimJae JangManagerGreg MaskelDepartmentsApplied Physics & Applied Math (APAM)Electrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-02-27
Ultrafast laser method for tissue crosslinkingCU15164Ultrafast femtosecond laser induces collagen crosslinking non-invasively, improving corneal and cartilage biomechanics for vision and OA.TagsApoptosisBiomechanicsBiomedical engineeringInventorsSinisa VukelicManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2022-11-14CollectionsOphthalmology
Integrated silicon photonic band interleaverCU23236Integrated silicon photonic band interleaver enables tunable, high-FSR spectral multiplexing for on-chip data communication.TagsCompact spaceError correction codeIntegrated circuitInventorsAnthony RizzoAsher NovickKeren BergmanManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering andFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-02-01
Efficient and scalable bio-integrated AI system using brain organoidsCU24020Bio-integrated AI uses brain organoids and CMOS interfaces for scalable, energy-efficient reservoir computing with enhanced AI performance.TagsArtificial intelligenceAutonomous system (Internet)Brain mappingInventorsKenneth KosikKenneth ShepardManagerGreg MaskelDepartmentsElectrical EngineeringNeuroscienceDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-05-27
Ultrathin van der Waals crystals for efficient nonlinear light-matter interactionsCU24012Ultrathin periodically poled MoS2 enables broadband quasi-phase matching, high-efficiency on-chip nonlinear optics for telecom and quantum photonics.TagsBirefringenceElectromagnetic radiationLaserInventorsAndrea MariniCarino FerranteChiara TrovatelloManagerGreg MaskelDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)SPIN (SuPerconducting and other INnovative materials and devices institute)Release Date2025-02-20
Surgical imaging device for minimally invasive surgery2381An insertable, stereoscopic surgical imaging device enabling single-port, fully internal visualization with pan-tilt-zoom and lighting.TagsDepth perceptionLaparoscopyLensInventorsDennis FowlerPeter AllenManagerKristin NeumanDepartmentsComputer ScienceSurgeryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-03-06
Graphene-based optical modulator for low-power, high-sensitivity cryogenic data transmissionCU16109Graphene-based optical modulator enables ultra-low-power, high-sensitivity cryogenic-to-room-temperature data links using 1 mV signals.TagsCrosstalkData linkElectric power transmissionInventorsChristopher PhareKeren BergmanMichal LipsonManagerGreg MaskelDepartmentsElectrical and Computer EngineeringElectrical EngineeringDivisionsFu Foundation School of Engineering andFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-11-08
Wearable device for automated nutrition monitoringCU25198A non-invasive wearable using machine learning to auto-monitor dietary intake and biometric data for real-time nutrition tracking.TagsActivity trackerBiometricsCardiovascular diseaseInventorsAlexander GoldbergWeihao XuManagerJerry KokoshkaDepartmentsBiomedical EngineeringMedicineDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-04-08
Wireless implantable device for optical brain imaging in freely moving animalsCU19385Wireless implantable, fully wireless optical brain imaging probe enables high-resolution, optogenetic interrogation in freely moving animals.TagsAction potentialBrain mappingCMOSInventorsEric PollmannKenneth ShepardSajjad MoazeniManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-07-21CollectionsCNS/Neurology
Wireless ultrasound-based stimulation of the nervous systemCU21309Non-invasive, wireless ultrasound stimulates brain and vagus nerve via flexible microelectrode arrays, enabling multi-region neural interfaces.TagsArteryBaroreceptorBrainInventorsEdward Boyden PhDGiovanni FranzesiJohn StantonManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2021-05-05CollectionsCNS/NeurologyMedical Device
Composite material for biocompatible soft electronicsCU20070Biocompatible composite adhesive enabling high-resolution, non-invasive soft electronics for precise neural and bio-signal interfacing.TagsAnisotropyBiocompatibilityBiomaterialInventorsDion KhodagholyPatricia Jastrzebska-PerfectManagerDovina QuDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-04-16
Compact nanophotonic for frequency combs, high-speed phase-shifting, and microwave generationCU22198Compact on-chip nanophotonic light sources: fast phase-shifts, frequency combs, OCT, telecommunication and microwave generation.TagsIntegrated circuitLaserMetrologyInventorsAlexander GaetaAndres Gil-MolinaBok Young KimManagerGreg MaskelDepartmentsApplied Physics & Applied Math (APAM)Electrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-04-15
Chemical painting for high-throughput single-cell drug response analysisCU23332Multiplexed infrared imaging enables high-throughput, single-cell drug profiling with ML-enabled mechanism-of-action predictions.TagsCombination therapyDNA sequencingDrug discoveryInventorsWei MinXinwen LiuManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-10-16
Miniaturized multi-clamp CMOS amplifier for intracellular electrophysiology recordingCU19222Ultra-compact CMOS multi-clamp intracellular amplifier enabling high-SNR voltage/current recordings with low power.TagsAmplifierBrainCMOSInventorsKenneth ShepardKrishna JayantSiddharth ShekarManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-07-21CollectionsCNS/Neurology
Integrated AI platform for causal discovery and drug validationCU25378Cloud-based AI suite enabling causal discovery, multimodal data integration, and translational drug validation for personalized medicine.TagsAntigenArtificial intelligenceBias (statistics)InventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Photonic funnel structure for seamless fiber-to-waveguide couplingCU18261A passive 3D polymer photonic funnel enables alignment-tolerant, high-bandwidth, low-cost fiber-to-waveguide coupling for scalable nanophotonics.TagsFunnelIntegrated circuitMass productionInventorsAseema MohantyMichal LipsonOscar Adrian Jimenez GordilloManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-01-17
Photonic multiplexing and demultiplexing between free space and on-chip technologiesCU17068Photonic link between free space and on-chip devices streams, splits, and analyzes wavelengths with modular polymer waveguides.TagsLaserMultiplexingOptical communicationInventorsMichal LipsonMohammad Amin TadayonManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-02-14
Giant nonlinear optical responses from photon avalanching nanoparticlesCU21104Photon-avalanching nanoparticles enable giant nonlinear optical responses for low-power, sub-wavelength NIR super-resolution imaging.TagsConfocal microscopyDopantFluorescenceInventorsAgata KotulskaAngel Fernandez-BravoArtur BednarkiewiczManagerGreg MaskelDepartmentshttps://nanooptics.lbl.gov/Mechanical EngineeringSponsored Projects OfficeDivisionsErnest Orlando Berkeley National LaboratoryFu Foundation School of Engineering and Applied Science (SEAS)LBNLRelease Date2020-10-20
Increased wireless throughput via an IF-filterless dual-conversion receiverCU20076IF-filterless dual-conversion receiver boosts wireless throughput, improving 5G compatibility with blocker tolerance and spurious rejection.TagsActive noise controlModulationInventorsGuoxiang HanPeter KingetTanbir HaqueManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2021-02-26
Metasurface smart glass for fast and secure object recognitionCU22327A passive metasurface-based optical neural network in smart glass enables fast, secure object recognition with low power and latency.TagsArtificial neural networkComputer visionData securityInventorsCheng-Chia TsaiNanfang YuXiaoyan HuangManagerGreg MaskelDepartmentsApplied Physics & Applied MathApplied Physics & Applied Math (APAM)ECEDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-04-15
Stepwise process for the sustainable recovery of rare metals and earth elementsCU21163Recovery of gold and rare earths from electronic waste via a green, stepwise supercritical CO2 and antisolvent process. 132 charactersTagsAcidCalciumCopperInventorsAh-Hyung Alissa ParkHaonan Danny HuangPeng PengManagerDovina QuDepartmentsEarth & Environmental EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-10-30
Three-dimensional high-speed multi-fluorescence SCAPE microscopyCU21252High-speed, 3D multiplexed SCAPE microscopy enables rapid, multispectral imaging of live, moving specimens with reduced photodamage.Tags3D reconstructionFluorophoreHistologyInventorsCitlali Perez-Campos MSElizabeth HillmanGrace Sooyeon LeeManagerKristin NeumanDepartmentsBiomedical EngineeringMortimer B. Zuckerman Mind Brain Behavior InstituteDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-08-17
Ultra-compact and efficient semiconductors for nonlinear opticsCU23019Ultra-compact, efficient noncentrosymmetric MoS2 multilayers enable high nonlinear optical conversion for on-chip quantum photonics.TagsAnisotropyBirefringenceChalcogenideInventorsChiara TrovatelloDmitri N. BasovFabian MooshammerManagerGreg MaskelDepartmentsMechanical EngineeringPhysicsDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-05-02
Compact RNA-guided DNA targeting, cleavage, and transcriptional activationCU23100Compact RNA-guided DNA targeting with Cas12/TnpB family enables programmable, compact gene regulation via binding, cleavage, or transcription activation.TagsArtificial intelligenceEscherichia coliExaptationInventorsChance MeersSamuel H. SternbergManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-02-17
Model for characterizing lithium-ion battery overpotentialsCU23074A four-parameter Li-ion overpotential model improves accuracy, monitoring, and maximum power estimation by capturing diffusion dynamics.TagsDiffusionElectric batteryEnergyInventorsAlan Gen LiMatthias Preindl PhDManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-08-23
Infrared photonic crystal spectrometerM11-035A compact, robust, no-moving-parts infrared spectrometer using photonic crystal arrays for 2D wavelength resolution.TagsCryogenicsFourier-transform infrared spectroscopyInfrared spectroscopyInventorsJohn Ioannis KymissisMarshall CoxNadia PervezManagerGreg MaskelDepartmentsApplied Physics & Applied Math (APAM)Electrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-02-14
4D integrated metasurfaces for free-space wavefront generationCU22328Integrated metasurface enables four-parameter free-space beam shaping (amplitude, phase, polarization orientation/ellipticity) for chip-to-space photonics.TagsAmplitudeAugmented realityCoatingInventorsAdam Overvig PhDAndrea AluHeqing HuangManagerGreg MaskelDepartmentsApplied Physics & Applied MathApplied Physics & Applied Math (APAM)Photonics InitiativeDivisionsAdvanced Science Research CenterFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-04-15CollectionsMedical Device
Circularly polarized microwave fields for quantum state controlCU23364Planar cloverleaf antennas enable precise, tunable circularly polarized microwave fields for quantum state control and simulations.TagsAmplitudeCircular polarizationDipoleInventorsIan StevensonNiccolo BigagliSebastian Will Ph.D.ManagerGreg MaskelDepartmentsPhysicsDivisionsFaculty of the Arts & SciencesRelease Date2024-04-08
Genome-wide qPCR with increased primer multiplexity for diagnostics and drug screeningCU23284A qPCR platform using optically barcoded beads enables genome-wide multiplex expression analysis (100–10,000 targets) faster and cheaper.TagsAcidChain reactionHigh-throughput screeningInventorsNaixin QianWei MinZhilun ZhaoManagerDovina QuDepartmentsChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-10-16
Humidity-responsive textiles for adaptive moisture managementCU22375Humidity-responsive textiles dynamically adjust breathability via reversible hygromorphing, passively regulating moisture and comfort without power.TagsElastic modulusHumidityLipid bilayerInventorsOzgur SahinYocheved UngarManagerDovina QuDepartmentsApplied Physics & Applied Math (APAM)Biological SciencesDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-02-14
Circuits for wireless communication on multiple frequency bandsCU17161A compact quadrature hybrid circuit enables multi-band wireless transceivers, simplifying antennas and boosting bandwidth.TagsAmplifierBasebandCartesian coordinate systemInventorsJianxun ZhuPeter KingetManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-04-16
Light-based signature platform for deepfake preventionCU26073VeriLight embeds imperceptible light-based signatures in live video to verify authenticity and resist deepfake manipulation.TagsArtificial intelligenceDeepfakeDigital watermarkingInventorsHadleigh Eden Silver SchwartzXia ZhouXiaofeng YanManagerDovina QuDepartmentsComputer ScienceDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-11-20
Optical in situ nucleotide sequence detection using combinatorial hybridizationCU24118High-throughput optical CRISPR screening with combinatorial hybridization enables scalable, cost-efficient, multi-omic readouts in situ.TagsBreast cancerCRISPRCohort studyInventorsJellert GaublommeManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2026-01-29CollectionsGenomics & Multi-Omics
CMOS-based radio frequency circulator for full-duplex communication systemsCU16158CMOS non-magnetic circulator enables full-duplex IC integration with high isolation, small form factor, and cost reduction.TagsHard disk driveIntegrated circuitMagnetic fieldInventorsHarish KrishnaswamyNegar ReiskarimianManagerGreg MaskelDepartmentsElectrical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2016-12-08
Humanoid-robot capable of facial co-expressionCU24301A soft-skinned humanoid robot predicts and synchronizes facial expressions in real time, enhancing natural human-robot interaction.TagsAnimatronicsAnthropomorphismAugmented realityInventorsHod LipsonYuhang HuManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-02-03
Heterochiral translators for nuclease-resistant DNA computingCU19156Heterochiral DNA logic circuits convert D-DNA/RNA inputs to nuclease-resistant L-DNA outputs, enabling biorthogonal, intracellular sensing.TagsBiomarkerChiralityDNA nanotechnologyInventorsDarko StefanovicMatthew R. LakinMilan N. Stojanovic M.D.ManagerJerry KokoshkaDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)STC.UNMRelease Date2026-02-20
High throughput, automated method for chromatin profiling using low-cell input samplesCU23333Automated, high-throughput ChIP-seq profiling from low-cell inputs enables scalable chromatin mapping and clinical diagnostics.TagsAutomationChIP sequencingChromatinInventorsAaron VinyManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-03-13
Natural language processing tool for cognitive scoring in Alzheimer's Disease patientsCU25391NLP platform predicts MMSE scores from unstructured clinical notes, enabling retrospective cognitive assessment in Alzheimer’s patients.TagsEHealthElectronic health recordHigh-throughput screeningInventorsBetina Ross S IdnayChunhua WengFangyi ChenManagerJoan MartinezDepartmentsBiomedical InformaticsDivisionsColumbia University Medical Center ( CUMColumbia University Medical Center (CUMC)Release Date2025-07-31
